Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
Improving the in Vitro Prediction of in Vivo Central Nervous System Penetration: Integrating Permeability, P-glycoprotein Efflux, and Free Fractions in Blood and Brain
Scott G. Summerfield, Alexander J. Stevens, Leanne Cutler, Maria del Carmen Osuna, Beverley Hammond, Sac-Pham Tang, Ann Hersey, David J. Spalding and Phil Jeffrey
Journal of Pharmacology and Experimental Therapeutics March 2006, 316 (3) 1282-1290; DOI: https://doi.org/10.1124/jpet.105.092916
Scott G. Summerfield
Drug Metabolism and Pharmacokinetics Department, Neurology and Gastrointestinal Centre of Excellence for Drug Discovery, GlaxoSmithKline R&D, Harlow, Essex, United Kingdom (S.G.S., A.J.S., L.C., M.d.C.O., B.H., S.-P.T., D.J.S., P.J.); and Computational Chemistry, GlaxoSmithKline Medicines Research Centre, Stevenage, Hertfordshire, United Kingdom (A.H.)
Alexander J. Stevens
Drug Metabolism and Pharmacokinetics Department, Neurology and Gastrointestinal Centre of Excellence for Drug Discovery, GlaxoSmithKline R&D, Harlow, Essex, United Kingdom (S.G.S., A.J.S., L.C., M.d.C.O., B.H., S.-P.T., D.J.S., P.J.); and Computational Chemistry, GlaxoSmithKline Medicines Research Centre, Stevenage, Hertfordshire, United Kingdom (A.H.)
Leanne Cutler
Drug Metabolism and Pharmacokinetics Department, Neurology and Gastrointestinal Centre of Excellence for Drug Discovery, GlaxoSmithKline R&D, Harlow, Essex, United Kingdom (S.G.S., A.J.S., L.C., M.d.C.O., B.H., S.-P.T., D.J.S., P.J.); and Computational Chemistry, GlaxoSmithKline Medicines Research Centre, Stevenage, Hertfordshire, United Kingdom (A.H.)
Maria del Carmen Osuna
Drug Metabolism and Pharmacokinetics Department, Neurology and Gastrointestinal Centre of Excellence for Drug Discovery, GlaxoSmithKline R&D, Harlow, Essex, United Kingdom (S.G.S., A.J.S., L.C., M.d.C.O., B.H., S.-P.T., D.J.S., P.J.); and Computational Chemistry, GlaxoSmithKline Medicines Research Centre, Stevenage, Hertfordshire, United Kingdom (A.H.)
Beverley Hammond
Drug Metabolism and Pharmacokinetics Department, Neurology and Gastrointestinal Centre of Excellence for Drug Discovery, GlaxoSmithKline R&D, Harlow, Essex, United Kingdom (S.G.S., A.J.S., L.C., M.d.C.O., B.H., S.-P.T., D.J.S., P.J.); and Computational Chemistry, GlaxoSmithKline Medicines Research Centre, Stevenage, Hertfordshire, United Kingdom (A.H.)
Sac-Pham Tang
Drug Metabolism and Pharmacokinetics Department, Neurology and Gastrointestinal Centre of Excellence for Drug Discovery, GlaxoSmithKline R&D, Harlow, Essex, United Kingdom (S.G.S., A.J.S., L.C., M.d.C.O., B.H., S.-P.T., D.J.S., P.J.); and Computational Chemistry, GlaxoSmithKline Medicines Research Centre, Stevenage, Hertfordshire, United Kingdom (A.H.)
Ann Hersey
Drug Metabolism and Pharmacokinetics Department, Neurology and Gastrointestinal Centre of Excellence for Drug Discovery, GlaxoSmithKline R&D, Harlow, Essex, United Kingdom (S.G.S., A.J.S., L.C., M.d.C.O., B.H., S.-P.T., D.J.S., P.J.); and Computational Chemistry, GlaxoSmithKline Medicines Research Centre, Stevenage, Hertfordshire, United Kingdom (A.H.)
David J. Spalding
Drug Metabolism and Pharmacokinetics Department, Neurology and Gastrointestinal Centre of Excellence for Drug Discovery, GlaxoSmithKline R&D, Harlow, Essex, United Kingdom (S.G.S., A.J.S., L.C., M.d.C.O., B.H., S.-P.T., D.J.S., P.J.); and Computational Chemistry, GlaxoSmithKline Medicines Research Centre, Stevenage, Hertfordshire, United Kingdom (A.H.)
Phil Jeffrey
Drug Metabolism and Pharmacokinetics Department, Neurology and Gastrointestinal Centre of Excellence for Drug Discovery, GlaxoSmithKline R&D, Harlow, Essex, United Kingdom (S.G.S., A.J.S., L.C., M.d.C.O., B.H., S.-P.T., D.J.S., P.J.); and Computational Chemistry, GlaxoSmithKline Medicines Research Centre, Stevenage, Hertfordshire, United Kingdom (A.H.)
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Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
Improving the in Vitro Prediction of in Vivo Central Nervous System Penetration: Integrating Permeability, P-glycoprotein Efflux, and Free Fractions in Blood and Brain
Scott G. Summerfield, Alexander J. Stevens, Leanne Cutler, Maria del Carmen Osuna, Beverley Hammond, Sac-Pham Tang, Ann Hersey, David J. Spalding and Phil Jeffrey
Journal of Pharmacology and Experimental Therapeutics March 1, 2006, 316 (3) 1282-1290; DOI: https://doi.org/10.1124/jpet.105.092916
Research ArticleABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
Improving the in Vitro Prediction of in Vivo Central Nervous System Penetration: Integrating Permeability, P-glycoprotein Efflux, and Free Fractions in Blood and Brain
Scott G. Summerfield, Alexander J. Stevens, Leanne Cutler, Maria del Carmen Osuna, Beverley Hammond, Sac-Pham Tang, Ann Hersey, David J. Spalding and Phil Jeffrey
Journal of Pharmacology and Experimental Therapeutics March 1, 2006, 316 (3) 1282-1290; DOI: https://doi.org/10.1124/jpet.105.092916
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