Ligand Discovery Using Small Molecule Microarrays
- Address correspondence to:
Dr. Samie R. Jaffrey, Department of Pharmacology, Weill Medical College, Cornell University, 1300 York Avenue, Box 70, New York, NY 10021. E-mail: srj2003{at}med.cornell.edu
Abstract
Small molecule microarrays have recently been used to identify ligands for several proteins, and several themes regarding screening strategies and limitations have emerged. In this review, some of the technical issues related to the manufacture and screening of small molecule microarrays, as well as prospects for small molecule microarrays in several areas of drug discovery and chemistry, are discussed.
Footnotes
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This work was supported by a grant from the New York Academy of Medicine, Speaker's Fund for Biomedical Research.
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doi:10.1124/jpet.104.076943.
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ABBREVIATIONS: AP, alkaline phosphatase; HIV, human immunodeficiency virus; PNA, PNA, protein nucleic acid.
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- Received August 31, 2004.
- Accepted November 9, 2004.
- The American Society for Pharmacology and Experimental Therapeutics
