Table of Contents

March 2005; 312 (3)

PERSPECTIVES IN PHARMACOLOGY

    • Bernard Le Foll and
    • Steven R. Goldberg

    Cannabinoid CB1 Receptor Antagonists as Promising New Medications for Drug Dependence

    J Pharmacol Exp Ther March 2005 312:875-883; published ahead of print November 3, 2004, doi:10.1124/jpet.104.077974

CELLULAR AND MOLECULAR

    • Stephen Hsu,
    • Tetsuya Yamamoto,
    • James Borke,
    • Douglas S. Walsh,
    • Baldev Singh,
    • Sushma Rao,
    • Kamatani Takaaki,
    • Nam Nah-Do,
    • Carol Lapp,
    • David Lapp,
    • Emily Foster,
    • Wendy B. Bollag,
    • Jill Lewis,
    • John Wataha,
    • Tokio Osaki,
    • and George Schuster

    Green Tea Polyphenol-Induced Epidermal Keratinocyte Differentiation Is Associated with Coordinated Expression of p57/KIP2 and Caspase 14

    J Pharmacol Exp Ther March 2005 312:884-890; published ahead of print November 10, 2004, doi:10.1124/jpet.104.076075
    • JangJa Hong,
    • Aya Yokomakura,
    • Yasuhiro Nakano,
    • Hyun Seung Ban,
    • Kenji Ishihara,
    • Jong-Woong Ahn,
    • OkPyo Zee,
    • and Kazuo Ohuchi

    Induction of Nitric Oxide Production by the Cytostatic Macrolide Apicularen A [2,4-Heptadienamide, N-[(1E)-3-[(3S,5R,7R,9S)-3,4,5,6,7,8,9,10-octahydro-7,14 Dihydroxy-1-oxo-5,9-epoxy-1H-2-benzoxacyclododecin-3-yl]-1 propenyl]-, (2Z,4Z)-(9CI)] and Possible Role of Nitric Oxide in Apicularen A-Induced Apoptosis in RAW 264.7 Cells

    J Pharmacol Exp Ther March 2005 312:968-977; published ahead of print November 23, 2004, doi:10.1124/jpet.104.077248
    • Khosrow Kashfi,
    • Simona Borgo,
    • Jennie L. Williams,
    • Jie Chen,
    • Jianjun Gao,
    • Athanasios Glekas,
    • Francesca Benedini,
    • Piero del Soldato,
    • and Basil Rigas

    Positional Isomerism Markedly Affects the Growth Inhibition of Colon Cancer Cells by Nitric Oxide-Donating Aspirin in Vitro and in Vivo

    J Pharmacol Exp Ther March 2005 312:978-988; published ahead of print November 4, 2004, doi:10.1124/jpet.104.075994
    • Jianjun Gao,
    • Khosrow Kashfi,
    • and Basil Rigas

    In Vitro Metabolism of Nitric Oxide-Donating Aspirin: The Effect of Positional Isomerism

    J Pharmacol Exp Ther March 2005 312:989-997; published ahead of print November 4, 2004, doi:10.1124/jpet.104.076190
    • Fang Li and
    • Kafait U. Malik

    Angiotensin II-Induced Akt Activation through the Epidermal Growth Factor Receptor in Vascular Smooth Muscle Cells Is Mediated by Phospholipid Metabolites Derived by Activation of Phospholipase D

    J Pharmacol Exp Ther March 2005 312:1043-1054; published ahead of print November 3, 2004, doi:10.1124/jpet.104.076588
    • Dana S. Hutchinson,
    • Masaaki Sato,
    • Bronwyn A. Evans,
    • Arthur Christopoulos,
    • and Roger J. Summers

    Evidence for Pleiotropic Signaling at the Mouse β3-Adrenoceptor Revealed by SR59230A [3-(2-Ethylphenoxy)-1-[(1,S)-1,2,3,4-tetrahydronapth-1-ylamino]-2S-2-propanol Oxalate]

    J Pharmacol Exp Ther March 2005 312:1064-1074; published ahead of print December 1, 2004, doi:10.1124/jpet.104.076901
    • Wendy B. Bollag,
    • Xiaofeng Zhong,
    • M. Ernest Dodd,
    • David M. Hardy,
    • Xiangjian Zheng,
    • and W. Thomas Allred

    Phospholipase D Signaling and Extracellular Signal-Regulated Kinase-1 and -2 Phosphorylation (Activation) Are Required for Maximal Phorbol Ester-Induced Transglutaminase Activity, a Marker of Keratinocyte Differentiation

    J Pharmacol Exp Ther March 2005 312:1223-1231; published ahead of print November 10, 2004, doi:10.1124/jpet.104.075622
    • Virginie Bourlier,
    • Alexia Zakaroff-Girard,
    • Sandra De Barros,
    • Christophe Pizzacalla,
    • Véronique Durand de Saint Front,
    • Max Lafontan,
    • Anne Bouloumié,
    • and Jean Galitzky

    Protease Inhibitor Treatments Reveal Specific Involvement of Matrix Metalloproteinase-9 in Human Adipocyte Differentiation

    J Pharmacol Exp Ther March 2005 312:1272-1279; published ahead of print November 10, 2004, doi:10.1124/jpet.104.077263

CARDIOVASCULAR

    • Chun-Yang Xiao,
    • Min Chen,
    • Zsuzsanna Zsengellér,
    • Hongshan Li,
    • Levente Kiss,
    • Márk Kollai,
    • and Csaba Szabó

    Poly(ADP-Ribose) Polymerase Promotes Cardiac Remodeling, Contractile Failure, and Translocation of Apoptosis-Inducing Factor in a Murine Experimental Model of Aortic Banding and Heart Failure

    J Pharmacol Exp Ther March 2005 312:891-898; published ahead of print November 2, 2004, doi:10.1124/jpet.104.077164
    • Agostino Virdis,
    • Rocchina Colucci,
    • Matteo Fornai,
    • Corrado Blandizzi,
    • Emiliano Duranti,
    • Stefania Pinto,
    • Nunzia Bernardini,
    • Cristina Segnani,
    • Luca Antonioli,
    • Stefano Taddei,
    • Antonio Salvetti,
    • and Mario Del Tacca

    Cyclooxygenase-2 Inhibition Improves Vascular Endothelial Dysfunction in a Rat Model of Endotoxic Shock: Role of Inducible Nitric-Oxide Synthase and Oxidative Stress

    J Pharmacol Exp Ther March 2005 312:945-953; published ahead of print November 16, 2004, doi:10.1124/jpet.104.077644
    • Kumkum Ganguly,
    • Tatiana Krasik,
    • Sandra Medinilla,
    • Khalil Bdeir,
    • Douglas B. Cines,
    • Vladimir R. Muzykantov,
    • and Juan Carlos Murciano

    Blood Clearance and Activity of Erythrocyte-Coupled Fibrinolytics

    J Pharmacol Exp Ther March 2005 312:1106-1113; published ahead of print November 3, 2004, doi:10.1124/jpet.104.075770
    • Olga Vitseva,
    • David A. Flockhart,
    • Yan Jin,
    • Sonia Varghese,
    • and Jane E. Freedman

    The Effects of Tamoxifen and Its Metabolites on Platelet Function and Release of Reactive Oxygen Intermediates

    J Pharmacol Exp Ther March 2005 312:1144-1150; published ahead of print October 27, 2004, doi:10.1124/jpet.104.076315
    • Sally Purdom and
    • Qin M. Chen

    Epidermal Growth Factor Receptor-Dependent and -Independent Pathways in Hydrogen Peroxide-Induced Mitogen-Activated Protein Kinase Activation in Cardiomyocytes and Heart Fibroblasts

    J Pharmacol Exp Ther March 2005 312:1179-1186; published ahead of print December 1, 2004, doi:10.1124/jpet.104.077057
    • Yau-Chi Chan,
    • Fung-Ping Leung,
    • Xiaoqiang Yao,
    • Chi-Wai Lau,
    • Paul M. Vanhoutte,
    • and Yu Huang

    Raloxifene Relaxes Rat Pulmonary Arteries and Veins: Roles of Gender, Endothelium, and Antagonism of Ca2+ Influx

    J Pharmacol Exp Ther March 2005 312:1266-1271; published ahead of print November 18, 2004, doi:10.1124/jpet.104.077990
    • Raquel Binda Pereira,
    • Carmem Luíza Sartório,
    • Dalton Valentim Vassallo,
    • and Ivanita Stefanon

    Differences in Tail Vascular Bed Reactivity in Rats with and without Heart Failure following Myocardial Infarction

    J Pharmacol Exp Ther March 2005 312:1321-1325; published ahead of print November 23, 2004, doi:10.1124/jpet.104.077701
    • Hai Wang,
    • Chao-Liang Long,
    • and Ying-Li Zhang

    A New ATP-Sensitive Potassium Channel Opener Reduces Blood Pressure and Reverses Cardiovascular Remodeling in Experimental Hypertension

    J Pharmacol Exp Ther March 2005 312:1326-1333; published ahead of print November 3, 2004, doi:10.1124/jpet.104.078220

NEUROPHARMACOLOGY

    • Bo Hu and
    • Fang Zheng

    Differential Effects on Current Kinetics by Point Mutations in the lurcher Motif of NR1/NR2A Receptors

    J Pharmacol Exp Ther March 2005 312:899-904; published ahead of print October 22, 2004, doi:10.1124/jpet.104.077388
    • Oliver Stiedl,
    • Michael Meyer,
    • Olaf Jahn,
    • Sven Ove Ögren,
    • and Joachim Spiess

    Corticotropin-Releasing Factor Receptor 1 and Central Heart Rate Regulation in Mice during Expression of Conditioned Fear

    J Pharmacol Exp Ther March 2005 312:905-916; published ahead of print November 10, 2004, doi:10.1124/jpet.104.075820
    • Hasan Palandoken,
    • Kolbot By,
    • Manu Hegde,
    • William R. Harley,
    • Fredric A. Gorin,
    • and Michael H. Nantz

    Amiloride Peptide Conjugates: Prodrugs for Sodium-Proton Exchange Inhibition

    J Pharmacol Exp Ther March 2005 312:961-967; published ahead of print October 27, 2004, doi:10.1124/jpet.104.076984
    • Leo H. Wang,
    • Andrew J. Paden,
    • and Eugene M. Johnson, Jr.

    Mixed-Lineage Kinase Inhibitors Require the Activation of Trk Receptors to Maintain Long-Term Neuronal Trophism and Survival

    J Pharmacol Exp Ther March 2005 312:1007-1019; published ahead of print November 3, 2004, doi:10.1124/jpet.104.077800
    • Laurent Bardin,
    • Marie-Bernadette Assié,
    • Martine Pélissou,
    • Isabelle Royer-Urios,
    • Adrian Newman-Tancredi,
    • Jean-Paul Ribet,
    • François Sautel,
    • Wouter Koek,
    • and Francis C. Colpaert

    Dual, Hyperalgesic, and Analgesic Effects of the High-Efficacy 5-Hydroxytryptamine 1A (5-HT1A) Agonist F 13640 [(3-Chloro-4-fluoro-phenyl)-[4-fluoro-4-{[(5-methyl-pyridin-2-ylmethyl)-amino]-methyl}piperidin-1-yl]methanone, Fumaric Acid Salt]: Relationship with 5-HT1A Receptor Occupancy and Kinetic Parameters

    J Pharmacol Exp Ther March 2005 312:1034-1042; published ahead of print November 4, 2004, doi:10.1124/jpet.104.077669
    • Hiroyuki Watanabe,
    • Daisuke Nakayama,
    • Kanenori Ito,
    • Chizuko Watanabe,
    • Hirokazu Mizoguchi,
    • Tsutomu Fujimura,
    • Kimie Murayama,
    • Shunsuke Kawamura,
    • Takumi Sato,
    • Chikai Sakurada,
    • Tsukasa Sakurada,
    • and Shinobu Sakurada

    A Tyr-W-MIF-1 Analog Containing D-Pro2 Acts as a Selective μ2-Opioid Receptor Antagonist in the Mouse

    J Pharmacol Exp Ther March 2005 312:1075-1081; published ahead of print November 23, 2004, doi:10.1124/jpet.104.075697
    • Peter H. Wu,
    • Wolfgang Poelchen,
    • and William R. Proctor

    Differential GABAB Receptor Modulation of Ethanol Effects on GABAA Synaptic Activity in Hippocampal CA1 Neurons

    J Pharmacol Exp Ther March 2005 312:1082-1089; published ahead of print December 22, 2004, doi:10.1124/jpet.104.075663
    • Giacomo Carrà,
    • Anna Rizzi,
    • Remo Guerrini,
    • Timothy A. Barnes,
    • John McDonald,
    • Christopher P. Hebbes,
    • Flora Mela,
    • Velga A. Kenigs,
    • Giuliano Marzola,
    • Daniela Rizzi,
    • Elaine Gavioli,
    • Silvia Zucchini,
    • Domenico Regoli,
    • Michele Morari,
    • Severo Salvadori,
    • David J. Rowbotham,
    • David G. Lambert,
    • Daniel R. Kapusta,
    • and Girolamo Calo'

    [(pF)Phe4,Arg14,Lys15]N/OFQ-NH2 (UFP-102), a Highly Potent and Selective Agonist of the Nociceptin/Orphanin FQ Receptor

    J Pharmacol Exp Ther March 2005 312:1114-1123; published ahead of print October 27, 2004, doi:10.1124/jpet.104.077339
    • Mayuko Oda,
    • Norihito Kitagawa,
    • Bang-Xiang Yang,
    • Tadahide Totoki,
    • and Masatoshi Morimoto

    Quantitative and Fiber-Selective Evaluation of Dose-Dependent Nerve Blockade by Intrathecal Lidocaine in Rats

    J Pharmacol Exp Ther March 2005 312:1132-1137; published ahead of print November 30, 2004, doi:10.1124/jpet.104.076893
    • Yasco Aracava,
    • Edna F. R. Pereira,
    • Alfred Maelicke,
    • and Edson X. Albuquerque

    Memantine Blocks α7* Nicotinic Acetylcholine Receptors More Potently Than N-Methyl-D-aspartate Receptors in Rat Hippocampal Neurons

    J Pharmacol Exp Ther March 2005 312:1195-1205; published ahead of print November 2, 2004, doi:10.1124/jpet.104.077172
    • M. Hajós,
    • R. S. Hurst,
    • W. E. Hoffmann,
    • M. Krause,
    • T. M. Wall,
    • N. R. Higdon,
    • and V. E. Groppi

    The Selective α7 Nicotinic Acetylcholine Receptor Agonist PNU-282987 [N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide Hydrochloride] Enhances GABAergic Synaptic Activity in Brain Slices and Restores Auditory Gating Deficits in Anesthetized Rats

    J Pharmacol Exp Ther March 2005 312:1213-1222; published ahead of print November 2, 2004, doi:10.1124/jpet.104.076968
    • Maia Terashvili,
    • Hsiang-en Wu,
    • Randy J. Leitermann,
    • Han-Sen Sun,
    • Andrew D. Clithero,
    • and Leon F. Tseng

    Differential Mechanisms of Antianalgesia Induced by Endomorphin-1 and Endomorphin-2 in the Ventral Periaqueductal Gray of the Rat

    J Pharmacol Exp Ther March 2005 312:1257-1265; published ahead of print November 12, 2004, doi:10.1124/jpet.104.076224
    • Mahboubeh Tavakoli-Nezhad and
    • David K. Pitts

    Postnatal Inorganic Lead Exposure Reduces Midbrain Dopaminergic Impulse Flow and Decreases Dopamine D1 Receptor Sensitivity in Nucleus Accumbens Neurons

    J Pharmacol Exp Ther March 2005 312:1280-1288; published ahead of print November 18, 2004, doi:10.1124/jpet.104.076166
    • Ying-Jun Cao,
    • Carol S. Surowy,
    • and Pamela S. Puttfarcken

    Nicotinic Acetylcholine Receptor-Mediated [3H]Dopamine Release from Hippocampus

    J Pharmacol Exp Ther March 2005 312:1298-1304; published ahead of print November 12, 2004, doi:10.1124/jpet.104.076794
    • Fernando J. Nasif,
    • Kyriaki Sidiropoulou,
    • Xiu-Ti Hu,
    • and Francis J. White

    Repeated Cocaine Administration Increases Membrane Excitability of Pyramidal Neurons in the Rat Medial Prefrontal Cortex

    J Pharmacol Exp Ther March 2005 312:1305-1313; published ahead of print December 1, 2004, doi:10.1124/jpet.104.075184
    • Emily M. Jutkiewicz,
    • Nicholas P. Walker,
    • John E. Folk,
    • Kenner C. Rice,
    • Philip S. Portoghese,
    • James H. Woods,
    • and John R. Traynor

    Comparison of Peptidic and Nonpeptidic δ-Opioid Agonists on Guanosine 5′-O-(3-[35S]thio)triphosphate ([35S]GTPγS) Binding in Brain Slices from Sprague-Dawley Rats

    J Pharmacol Exp Ther March 2005 312:1314-1320; published ahead of print December 1, 2004, doi:10.1124/jpet.104.078741

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

    • Shih-Wei Wang,
    • Shiow-Lin Pan,
    • Jih-Hwa Guh,
    • Hui-Ling Chen,
    • Dong-Ming Huang,
    • Ya-Ling Chang,
    • Sheng-Chu Kuo,
    • Fang-Yu Lee,
    • and Che-Ming Teng

    YC-1 [3-(5′-Hydroxymethyl-2′-furyl)-1-benzyl Indazole] Exhibits a Novel Antiproliferative Effect and Arrests the Cell Cycle in G0-G1 in Human Hepatocellular Carcinoma Cells

    J Pharmacol Exp Ther March 2005 312:917-925; published ahead of print November 3, 2004, doi:10.1124/jpet.104.077230

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

    • Ann-Charlotte Egnell,
    • J. Brian Houston,
    • and C. Scott Boyer

    Predictive Models of CYP3A4 Heteroactivation: In Vitro-in Vivo Scaling and Pharmacophore Modeling

    J Pharmacol Exp Ther March 2005 312:926-937; published ahead of print November 30, 2004, doi:10.1124/jpet.104.078519
    • Sean C. Semple,
    • Troy O. Harasym,
    • Kathy A. Clow,
    • Steven M. Ansell,
    • Sandra K. Klimuk,
    • and Michael J. Hope

    Immunogenicity and Rapid Blood Clearance of Liposomes Containing Polyethylene Glycol-Lipid Conjugates and Nucleic Acid

    J Pharmacol Exp Ther March 2005 312:1020-1026; published ahead of print November 3, 2004, doi:10.1124/jpet.104.078113
    • Yan-Fei Xin,
    • Xiang-Jun Zhou,
    • Xi Cheng,
    • and Yong-Xiang Wang

    Renal d-Amino Acid Oxidase Mediates Chiral Inversion of NG-Nitro-d-arginine

    J Pharmacol Exp Ther March 2005 312:1090-1096; published ahead of print October 20, 2004, doi:10.1124/jpet.104.077123
    • Mary F. Paine,
    • Anne B. Criss,
    • and Paul B. Watkins

    Two Major Grapefruit Juice Components Differ in Time to Onset of Intestinal CYP3A4 Inhibition

    J Pharmacol Exp Ther March 2005 312:1151-1160; published ahead of print October 14, 2004, doi:10.1124/jpet.104.076836
    • Seonghee Park and
    • Patrick J. Sinko

    P-Glycoprotein and Mutlidrug Resistance-Associated Proteins Limit the Brain Uptake of Saquinavir in Mice

    J Pharmacol Exp Ther March 2005 312:1249-1256; published ahead of print November 4, 2004, doi:10.1124/jpet.104.076216

INFLAMMATION AND IMMUNOPHARMACOLOGY

    • Toshihiko Yamauchi,
    • Akira Ishibashi,
    • Kohdoh Shikata,
    • Naoki Tokuhara,
    • Ken-ichiro Seino,
    • Seiichi Kobayashi,
    • and Mitsuo Nagai

    Effect of E6060 [4-{5-[7-Fluoro-4-(trifluoromethyl)benzo[b]furan-2-yl]-1H-2-pyrrolyl}benzoic Acid], a Novel Subtype-Selective Retinoid, on Lupus-Like Nephritis in Female (NZBxNZW)F1 Mice

    J Pharmacol Exp Ther March 2005 312:938-944; published ahead of print December 22, 2004, doi:10.1124/jpet.104.075598
    • Yoshiki Shiraishi,
    • Koichiro Asano,
    • Takeshi Nakajima,
    • Tsuyoshi Oguma,
    • Yusuke Suzuki,
    • Tetsuya Shiomi,
    • Koichi Sayama,
    • Kyoko Niimi,
    • Misa Wakaki,
    • Junko Kagyo,
    • Eiji Ikeda,
    • Hiroyuki Hirai,
    • Kazuhiro Yamaguchi,
    • and Akitoshi Ishizaka

    Prostaglandin D2-Induced Eosinophilic Airway Inflammation Is Mediated by CRTH2 Receptor

    J Pharmacol Exp Ther March 2005 312:954-960; published ahead of print November 4, 2004, doi:10.1124/jpet.104.078212
    • Yusheng Han,
    • Joshua A. Englert,
    • Runkuan Yang,
    • Russell L. Delude,
    • and Mitchell P. Fink

    Ethyl Pyruvate Inhibits Nuclear Factor-κB-Dependent Signaling by Directly Targeting p65

    J Pharmacol Exp Ther March 2005 312:1097-1105; published ahead of print November 3, 2004, doi:10.1124/jpet.104.079707
    • Jong Soon Kang,
    • Yeo Dae Yoon,
    • Ig Jun Cho,
    • Mi Hwa Han,
    • Chang Woo Lee,
    • Song-Kyu Park,
    • and Hwan Mook Kim

    Glabridin, an Isoflavan from Licorice Root, Inhibits Inducible Nitric-Oxide Synthase Expression and Improves Survival of Mice in Experimental Model of Septic Shock

    J Pharmacol Exp Ther March 2005 312:1187-1194; published ahead of print November 10, 2004, doi:10.1124/jpet.104.077107
    • James K. Gierse,
    • Yan Zhang,
    • William F. Hood,
    • Mark C. Walker,
    • Jennifer S. Trigg,
    • Timothy J. Maziasz,
    • Carol M. Koboldt,
    • Jerry L. Muhammad,
    • Ben S. Zweifel,
    • Jaime L. Masferrer,
    • Peter C. Isakson,
    • and Karen Seibert

    Valdecoxib: Assessment of Cyclooxygenase-2 Potency and Selectivity

    J Pharmacol Exp Ther March 2005 312:1206-1212; published ahead of print October 19, 2004, doi:10.1124/jpet.104.076877
    • So Youn Park,
    • Jeong Hyun Lee,
    • Yong Ki Kim,
    • Chi Dae Kim,
    • Byung Yong Rhim,
    • Won Suk Lee,
    • and Ki Whan Hong

    Cilostazol Prevents Remnant Lipoprotein Particle-Induced Monocyte Adhesion to Endothelial Cells by Suppression of Adhesion Molecules and Monocyte Chemoattractant Protein-1 Expression via Lectin-Like Receptor for Oxidized Low-Density Lipoprotein Receptor Activation

    J Pharmacol Exp Ther March 2005 312:1241-1248; published ahead of print November 3, 2004, doi:10.1124/jpet.104.077826

TOXICOLOGY

    • Jose M. Jimenez-Lopez and
    • Arthur I. Cederbaum

    Protein Kinase C Signaling as a Survival Pathway against CYP2E1-Derived Oxidative Stress and Toxicity in HepG2 Cells

    J Pharmacol Exp Ther March 2005 312:998-1006; published ahead of print October 19, 2004, doi:10.1124/jpet.104.076737
    • Michael D. Aleo,
    • Colleen M. Doshna,
    • and Kimberly A. Navetta

    Ciglitazone-Induced Lenticular Opacities in Rats: In Vivo and Whole Lens Explant Culture Evaluation

    J Pharmacol Exp Ther March 2005 312:1027-1033; published ahead of print November 2, 2004, doi:10.1124/jpet.104.076950

BEHAVIORAL PHARMACOLOGY

    • Carrie K. Jones,
    • Elizabeth Lutz Eberle,
    • David B. Shaw,
    • David L. McKinzie,
    • and Harlan E. Shannon

    Pharmacologic Interactions between the Muscarinic Cholinergic and Dopaminergic Systems in the Modulation of Prepulse Inhibition in Rats

    J Pharmacol Exp Ther March 2005 312:1055-1063; published ahead of print December 1, 2004, doi:10.1124/jpet.104.075887
    • E. L. Lane,
    • S. Cheetham,
    • and P. Jenner

    Dopamine Uptake Inhibitor-Induced Rotation in 6-Hydroxydopamine-Lesioned Rats Involves Both D1 and D2 Receptors but Is Modulated through 5-Hydroxytryptamine and Noradrenaline Receptors

    J Pharmacol Exp Ther March 2005 312:1124-1131; published ahead of print November 12, 2004, doi:10.1124/jpet.104.076554
    • Sharon Bingham,
    • Paul J. Beswick,
    • Chas Bountra,
    • Terry Brown,
    • Ian B. Campbell,
    • Iain P. Chessell,
    • Nick Clayton,
    • Sue D. Collins,
    • Philip T. Davey,
    • Helen Goodland,
    • Norman Gray,
    • Claudine Haslam,
    • Jonathan P. Hatcher,
    • A. Jacqueline Hunter,
    • Fiona Lucas,
    • Graham Murkitt,
    • Alan Naylor,
    • Elizabeth Pickup,
    • Becky Sargent,
    • Scott G. Summerfield,
    • Alexander Stevens,
    • Sharon C. Stratton,
    • and Joanne Wiseman

    The Cyclooxygenase-2 Inhibitor GW406381X [2-(4-Ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]-pyrazolo[1,5-b]pyridazine] Is Effective in Animal Models of Neuropathic Pain and Central Sensitization

    J Pharmacol Exp Ther March 2005 312:1161-1169; published ahead of print November 30, 2004, doi:10.1124/jpet.104.075267
    • Buyean Lee,
    • Donna M. Platt,
    • James K. Rowlett,
    • Adepero S. Adewale,
    • and Roger D. Spealman

    Attenuation of Behavioral Effects of Cocaine by the Metabotropic Glutamate Receptor 5 Antagonist 2-Methyl-6-(phenylethynyl)-pyridine in Squirrel Monkeys: Comparison with Dizocilpine

    J Pharmacol Exp Ther March 2005 312:1232-1240; published ahead of print November 18, 2004, doi:10.1124/jpet.104.078733
    • James K. Rowlett,
    • Joshua S. Rodefer,
    • and Roger D. Spealman

    Self-Administration of Cocaine-Opioid Combinations by Rhesus Monkeys: Evaluation of the Role of μ Receptor Efficacy Using Labor Supply Analysis

    J Pharmacol Exp Ther March 2005 312:1289-1297; published ahead of print November 18, 2004, doi:10.1124/jpet.104.076646

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

    • Cemil Göçmen,
    • Ben Giesselman,
    • and William C. de Groat

    Effect of Neocuproine, a Copper(I) Chelator, on Rat Bladder Function

    J Pharmacol Exp Ther March 2005 312:1138-1143; published ahead of print October 22, 2004, doi:10.1124/jpet.104.076398
    • Nimesh S. A. Patel,
    • Prabal K. Chatterjee,
    • Rosanna Di Paola,
    • Emanuela Mazzon,
    • Domenico Britti,
    • Angelina De Sarro,
    • Salvatore Cuzzocrea,
    • and Christoph Thiemermann

    Endogenous Interleukin-6 Enhances the Renal Injury, Dysfunction, and Inflammation Caused by Ischemia/Reperfusion

    J Pharmacol Exp Ther March 2005 312:1170-1178; published ahead of print November 30, 2004, doi:10.1124/jpet.104.078659

Erratum

  • Correction to “DiPOA ([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic Acid), a Novel, Systematically Available, and Peripherally Restricted Mu Opioid Agonist with Antihyperalgesic Activity: II. In Vivo Pharmacological Characterization in the Rat”

    J Pharmacol Exp Ther March 2005 312:1334

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Effect of INO-1001 on collagen accumulation in aortic banded mouse hearts. See the article by Xiao et al. on page 891 of this issue.

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This Issue

March 2005; 312 (3)
Cover
  1. PERSPECTIVES IN PHARMACOLOGY
  2. CELLULAR AND MOLECULAR
  3. CARDIOVASCULAR
  4. NEUROPHARMACOLOGY
  5. CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
  6. ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  7. INFLAMMATION AND IMMUNOPHARMACOLOGY
  8. TOXICOLOGY
  9. BEHAVIORAL PHARMACOLOGY
  10. GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  11. Erratum

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