Table of Contents

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Select this article
- Hsia-Lien Lin,
- Ute M. Kent,
- Haoming Zhang,
- Lucy Waskell,
- and Paul F. Hollenberg
The Functional Role of Threonine-205 in the Mechanism-Based Inactivation of P450 2B1 by Two Ethynyl Substrates: The Importance of the F Helix in Catalysis
J Pharmacol Exp Ther December 2004 311:855-863; published ahead of print August 9, 2004, doi:10.1124/jpet.104.071670
Select this article
- Hiromi Sakai,
- Yohei Masada,
- Hirohisa Horinouchi,
- Eiji Ikeda,
- Keitaro Sou,
- Shinji Takeoka,
- Makoto Suematsu,
- Masuhiko Takaori,
- Koichi Kobayashi,
- and Eishun Tsuchida
Physiological Capacity of the Reticuloendothelial System for the Degradation of Hemoglobin Vesicles (Artificial Oxygen Carriers) after Massive Intravenous Doses by Daily Repeated Infusions for 14 Days
J Pharmacol Exp Ther December 2004 311:874-884; published ahead of print August 5, 2004, doi:10.1124/jpet.104.073049
Select this article
- Thomas M. Polasek,
- David J. Elliot,
- Benjamin C. Lewis,
- and John O. Miners
Mechanism-Based Inactivation of Human Cytochrome P4502C8 by Drugs in Vitro
J Pharmacol Exp Ther December 2004 311:996-1007; published ahead of print August 10, 2004, doi:10.1124/jpet.104.071803
Select this article
- Adam G. Staines,
- Michael W. H. Coughtrie,
- and Brian Burchell
N-Glucuronidation of Carbamazepine in Human Tissues Is Mediated by UGT2B7
J Pharmacol Exp Ther December 2004 311:1131-1137; published ahead of print August 3, 2004, doi:10.1124/jpet.104.073114
Select this article
- M. P. Schaddelee,
- D. Groenendaal,
- J. DeJongh,
- C. G. J. Cleypool,
- A. P. IJzerman,
- A. G. De Boer,
- and M. Danhof
Population Pharmacokinetic Modeling of Blood-Brain Barrier Transport of Synthetic Adenosine A₁ Receptor Agonists
J Pharmacol Exp Ther December 2004 311:1138-1146; published ahead of print August 3, 2004, doi:10.1124/jpet.104.071308
Select this article
- Ryota Kikuchi,
- Hiroyuki Kusuhara,
- Takaaki Abe,
- Hitoshi Endou,
- and Yuichi Sugiyama
Involvement of Multiple Transporters in the Efflux of 3-Hydroxy-3-methylglutaryl-CoA Reductase Inhibitors across the Blood-Brain Barrier
J Pharmacol Exp Ther December 2004 311:1147-1153; published ahead of print August 3, 2004, doi:10.1124/jpet.104.071621
Select this article
- Joseph R. Kurian,
- Sunil U. Bajad,
- Jackie L. Miller,
- Nathaniel A. Chin,
- and Lauren A. Trepanier
NADH Cytochrome b₅ Reductase and Cytochrome b₅ Catalyze the Microsomal Reduction of Xenobiotic Hydroxylamines and Amidoximes in Humans
J Pharmacol Exp Ther December 2004 311:1171-1178; published ahead of print August 9, 2004, doi:10.1124/jpet.104.072389
Select this article
- Hiroshi Takane,
- Daisuke Kobayashi,
- Takeshi Hirota,
- Junzo Kigawa,
- Naoki Terakawa,
- Kenji Otsubo,
- and Ichiro Ieiri
Haplotype-Oriented Genetic Analysis and Functional Assessment of Promoter Variants in the MDR1 (ABCB1) Gene
J Pharmacol Exp Ther December 2004 311:1179-1187; published ahead of print July 27, 2004, doi:10.1124/jpet.104.069724
Select this article
- Keith A. Hoffmaster,
- Maciej J. Zamek-Gliszczynski,
- Gary M. Pollack,
- and Kim L. R. Brouwer
Hepatobiliary Disposition of the Metabolically Stable Opioid Peptide [d-Pen², d-Pen⁵]-Enkephalin (DPDPE): Pharmacokinetic Consequences of the Interplay between Multiple Transport Systems
J Pharmacol Exp Ther December 2004 311:1203-1210; published ahead of print August 9, 2004, doi:10.1124/jpet.104.070201

TOXICOLOGY

Select this article
- Tanya C. McCarthy,
- P. Timothy Pollak,
- Elyisha A. Hanniman,
- and Christopher J. Sinal
Disruption of Hepatic Lipid Homeostasis in Mice after Amiodarone Treatment Is Associated with Peroxisome Proliferator-Activated Receptor-αTarget Gene Activation
J Pharmacol Exp Ther December 2004 311:864-873; published ahead of print July 20, 2004, doi:10.1124/jpet.104.072785
Select this article
- Raoef Imamdi,
- Marjo de Graauw,
- and Bob van de Water
Protein Kinase C Mediates Cisplatin-Induced Loss of Adherens Junctions Followed by Apoptosis of Renal Proximal Tubular Epithelial Cells
J Pharmacol Exp Ther December 2004 311:892-903; published ahead of print September 20, 2004, doi:10.1124/jpet.104.072678

CELLULAR AND MOLECULAR

Select this article
- Anshu K. Jain,
- Scott M. Moore,
- Kiyoshi Yamaguchi,
- Thomas E. Eling,
- and Seung Joon Baek
Selective Nonsteroidal Anti-Inflammatory Drugs Induce Thymosin β-4 and Alter Actin Cytoskeletal Organization in Human Colorectal Cancer Cells
J Pharmacol Exp Ther December 2004 311:885-891; published ahead of print August 3, 2004, doi:10.1124/jpet.104.070664
Select this article
- Ji-Shi Wang,
- Fan Zhang,
- Miao Jiang,
- Mong-Heng Wang,
- Barbara A. Zand,
- Nader G. Abraham,
- Alberto Nasjletti,
- and Michal Laniado-Schwartzman
Transfection and Functional Expression of CYP4A1 and CYP4A2 Using Bicistronic Vectors in Vascular Cells and Tissues
J Pharmacol Exp Ther December 2004 311:913-920; published ahead of print July 21, 2004, doi:10.1124/jpet.104.070979
Select this article
- Masahiko Watabe and
- Toshio Nakaki
Rotenone Induces Apoptosis via Activation of Bad in Human Dopaminergic SH-SY5Y Cells
J Pharmacol Exp Ther December 2004 311:948-953; published ahead of print July 27, 2004, doi:10.1124/jpet.104.071381
Select this article
- Mariya Chhatriwala,
- R. Gnana Ravi,
- Roshni I. Patel,
- Jose L. Boyer,
- Kenneth A. Jacobson,
- and T. Kendall Harden
Induction of Novel Agonist Selectivity for the ADP-Activated P2Y₁ Receptor Versus the ADP-Activated P2Y₁₂ and P2Y₁₃ Receptors by Conformational Constraint of an ADP Analog
J Pharmacol Exp Ther December 2004 311:1038-1043; published ahead of print September 2, 2004, doi:10.1124/jpet.104.068650
Select this article
- Adrien Renaudo,
- Vanina Watry,
- Anne-Amandine Chassot,
- Gilles Ponzio,
- Jordi Ehrenfeld,
- and Olivier Soriani
Inhibition of Tumor Cell Proliferation by σ Ligands Is Associated with K⁺ Channel Inhibition and p27^kip1 Accumulation
J Pharmacol Exp Ther December 2004 311:1105-1114; published ahead of print July 26, 2004, doi:10.1124/jpet.104.072413
Select this article
- Sudhakar Misra,
- Karnam S. Murthy,
- Huiping Zhou,
- and John R. Grider
Coexpression of Y₁, Y₂, and Y₄ Receptors in Smooth Muscle Coupled to Distinct Signaling Pathways
J Pharmacol Exp Ther December 2004 311:1154-1162; published ahead of print August 12, 2004, doi:10.1124/jpet.104.071415
Select this article
- S. W. Jones,
- D. J. Baker,
- S. M. Gardiner,
- T. Bennett,
- J. A. Timmons,
- and P. L. Greenhaff
The Effect of the β₂-Adrenoceptor Agonist Prodrug BRL-47672 on Cardiovascular Function, Skeletal Muscle Myosin Heavy Chain, and MyoD Expression in the Rat
J Pharmacol Exp Ther December 2004 311:1225-1231; published ahead of print July 8, 2004, doi:10.1124/jpet.104.071589
Select this article
- Matjaz Humar,
- Nikolaos Andriopoulos,
- Soeren E. Pischke,
- Torsten Loop,
- Rene Schmidt,
- Alexander Hoetzel,
- Martin Roesslein,
- Heike L. Pahl,
- Klaus K. Geiger,
- and Benedikt H. J. Pannen
Inhibition of Activator Protein 1 by Barbiturates Is Mediated by Differential Effects on Mitogen-Activated Protein Kinases and the Small G Proteins Ras and Rac-1
J Pharmacol Exp Ther December 2004 311:1232-1240; published ahead of print July 19, 2004, doi:10.1124/jpet.104.071332

INFLAMMATION AND IMMUNOPHARMACOLOGY

Select this article
- Richard R. Harris,
- Lawrence Black,
- Sekhar Surapaneni,
- Teodozyj Kolasa,
- Sandra Majest,
- Marian T. Namovic,
- George Grayson,
- Victoria Komater,
- Denise Wilcox,
- Linda King,
- Kennan Marsh,
- Michael F. Jarvis,
- Merrill Nuss,
- Hugh Nellans,
- Lee Pruesser,
- Glenn A. Reinhart,
- Bryan Cox,
- Peer Jacobson,
- Andrew Stewart,
- Michael Coghlan,
- George Carter,
- and Randy L. Bell
ABT-963 [2-(3,4-Difluoro-phenyl)-4-(3-hydroxy-3-methyl-butoxy)-5-(4-methanesulfonyl-phenyl)-2H-pyridazin-3-one], A Highly Potent and Selective Disubstituted Pyridazinone Cyclooxgenase-2 Inhibitor
J Pharmacol Exp Ther December 2004 311:904-912; published ahead of print July 26, 2004, doi:10.1124/jpet.104.070052
Select this article
- Guillaume Morissette,
- Jean-Philippe Fortin,
- Sophie Otis,
- Johanne Bouthillier,
- and François Marceau
A Novel Nonpeptide Antagonist of the Kinin B₁ Receptor: Effects at the Rabbit Receptor
J Pharmacol Exp Ther December 2004 311:1121-1130; published ahead of print July 26, 2004, doi:10.1124/jpet.104.071266
Select this article
- Koh-ichi Yuhki,
- Akinori Ueno,
- Hiroaki Naraba,
- Fumiaki Kojima,
- Fumitaka Ushikubi,
- Shuh Narumiya,
- and Sachiko Oh-ishi
Prostaglandin Receptors EP2, EP3, and IP Mediate Exudate Formation in Carrageenin-Induced Mouse Pleurisy
J Pharmacol Exp Ther December 2004 311:1218-1224; published ahead of print August 17, 2004, doi:10.1124/jpet.104.071548
Select this article
- Ylenia Suzuki,
- Emanuela Masini,
- Cosimo Mazzocca,
- Salvatore Cuzzocrea,
- Anna Ciampa,
- Hisanori Suzuki,
- and Daniele Bani
Inhibition of Poly(ADP-Ribose) Polymerase Prevents Allergen-Induced Asthma-Like Reaction in Sensitized Guinea Pigs
J Pharmacol Exp Ther December 2004 311:1241-1248; published ahead of print July 13, 2004, doi:10.1124/jpet.104.072546
Select this article
- Hiroyuki Iwamura,
- Motohide Sato,
- and Korekiyo Wakitani
Comparative Study of Glucocorticoids, Cyclosporine A, and JTE-607 [(-)-Ethyl-N-{3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoyl}-l-phenylalaninate Dihydrochloride] in a Mouse Septic Shock Model
J Pharmacol Exp Ther December 2004 311:1256-1263; published ahead of print July 27, 2004, doi:10.1124/jpet.104.072421
Select this article
- Salvatore Cuzzocrea,
- Emanuela Mazzon,
- Rosanna Di Paola,
- Nimesh S. A. Patel,
- Tiziana Genovese,
- Carmelo Muià,
- Angelina De Sarro,
- and Christoph Thiemermann
Erythropoietin Reduces the Development of Experimental Inflammatory Bowel Disease
J Pharmacol Exp Ther December 2004 311:1272-1280; published ahead of print August 9, 2004, doi:10.1124/jpet.104.073197

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

Select this article
- Takehiko Uesugi,
- Matthias Froh,
- Erwin Gäbele,
- Fuyumi Isayama,
- Blair U. Bradford,
- Iwao Ikai,
- Yoshio Yamaoka,
- and Gavin E. Arteel
Contribution of Angiotensin II to Alcohol-Induced Pancreatic Fibrosis in Rats
J Pharmacol Exp Ther December 2004 311:921-928; published ahead of print August 17, 2004, doi:10.1124/jpet.104.071324
Select this article
- Andrew J. Hirsh,
- Juan R. Sabater,
- Andra Zamurs,
- Rick T. Smith,
- Anthony M. Paradiso,
- Sam Hopkins,
- William M. Abraham,
- and Richard C. Boucher
Evaluation of Second Generation Amiloride Analogs as Therapy for Cystic Fibrosis Lung Disease
J Pharmacol Exp Ther December 2004 311:929-938; published ahead of print July 23, 2004, doi:10.1124/jpet.104.071886
Select this article
- Xiaoming Deng,
- Sandor Szabo,
- Tetyana Khomenko,
- Martin R. Jadus,
- and Masashi Yoshida
Gene Therapy with Adenoviral Plasmids or Naked DNA of Vascular Endothelial Growth Factor and Platelet-Derived Growth Factor Accelerates Healing of Duodenal Ulcer in Rats
J Pharmacol Exp Ther December 2004 311:982-988; published ahead of print August 9, 2004, doi:10.1124/jpet.104.071464
Select this article
- Prajakta A. Sonalker,
- Stevan P. Tofovic,
- and Edwin K. Jackson
Increased Expression of the Sodium Transporter BSC-1 in Spontaneously Hypertensive Rats
J Pharmacol Exp Ther December 2004 311:1052-1061; published ahead of print August 30, 2004, doi:10.1124/jpet.104.071209
Select this article
- Julia Pinsonneault,
- Carsten Uhd Nielsen,
- and Wolfgang Sadée
Genetic Variants of the Human H⁺/Dipeptide Transporter PEPT2: Analysis of Haplotype Functions
J Pharmacol Exp Ther December 2004 311:1088-1096; published ahead of print July 28, 2004, doi:10.1124/jpet.104.073098
Select this article
- Xueying Zhao,
- John R. Falck,
- V. Raj Gopal,
- Edward W. Inscho,
- and John D. Imig
P2X Receptor-Stimulated Calcium Responses in Preglomerular Vascular Smooth Muscle Cells Involves 20-Hydroxyeicosatetraenoic Acid
J Pharmacol Exp Ther December 2004 311:1211-1217; published ahead of print August 17, 2004, doi:10.1124/jpet.104.070797
Select this article
- Stefano Fiorucci,
- Annarita Di Lorenzo,
- Barbara Renga,
- Silvana Farneti,
- Antonio Morelli,
- and Giuseppe Cirino
Nitric Oxide (NO)-Releasing Naproxen (HCT-3012 [(S)-6-Methoxy-α-methyl-2-naphthaleneacetic Acid 4-(Nitrooxy)butyl Ester]) Interactions with Aspirin in Gastric Mucosa of Arthritic Rats Reveal a Role for Aspirin-Triggered Lipoxin, Prostaglandins, and NO in Gastric Protection
J Pharmacol Exp Ther December 2004 311:1264-1271; published ahead of print August 5, 2004, doi:10.1124/jpet.104.072843

NEUROPHARMACOLOGY

Select this article
- Zi-Zhen Wu,
- Shao-Rui Chen,
- and Hui-Lin Pan
Differential Sensitivity of N- and P/Q-Type Ca²+ Channel Currents to a μ Opioid in Isolectin B -Positive and -Negative Dorsal Root Ganglion Neurons
J Pharmacol Exp Ther December 2004 311:939-947; published ahead of print July 27, 2004, doi:10.1124/jpet.104.073429
Select this article
- Miguel Díaz-Hernández,
- Jesús Sánchez-Nogueiro,
- Jesús Pintor,
- and M. Teresa Miras-Portugal
Interaction between Dinucleotide and Nicotinic Receptors in Individual Cholinergic Terminals
J Pharmacol Exp Ther December 2004 311:954-967; published ahead of print July 13, 2004, doi:10.1124/jpet.104.072249
Select this article
- L. Kantor,
- M. Zhang,
- B. Guptaroy,
- Y. H. Park,
- and M. E. Gnegy
Repeated Amphetamine Couples Norepinephrine Transporter and Calcium Channel Activities in PC12 Cells
J Pharmacol Exp Ther December 2004 311:1044-1051; published ahead of print August 30, 2004, doi:10.1124/jpet.104.071068
Select this article
- Donald W. Floyd,
- David P. Friedman,
- James B. Daunais,
- Peter J. Pierre,
- Kathleen A. Grant,
- and Brian A. McCool
Long-Term Ethanol Self-Administration by Cynomolgus Macaques Alters the Pharmacology and Expression of GABA_A Receptors in Basolateral Amygdala
J Pharmacol Exp Ther December 2004 311:1071-1079; published ahead of print July 27, 2004, doi:10.1124/jpet.104.072025
Select this article
- C. Demougeot,
- M. Van Hoecke,
- N. Bertrand,
- A. Prigent-Tessier,
- C. Mossiat,
- A. Beley,
- and C. Marie
Cytoprotective Efficacy and Mechanisms of the Liposoluble Iron Chelator 2,2′-Dipyridyl in the Rat Photothrombotic Ischemic Stroke Model
J Pharmacol Exp Ther December 2004 311:1080-1087; published ahead of print July 27, 2004, doi:10.1124/jpet.104.072744
Select this article
- Anne M. Heacock,
- Daniel Kerley,
- Grzegorz T. Gurda,
- Aaron T. VanTroostenberghe,
- and Stephen K. Fisher
Potentiation of the Osmosensitive Release of Taurine and d-Aspartate from SH-SY5Y Neuroblastoma Cells after Activation of M₃ Muscarinic Cholinergic Receptors
J Pharmacol Exp Ther December 2004 311:1097-1104; published ahead of print August 3, 2004, doi:10.1124/jpet.104.072553
Select this article
- V. Monnaert,
- D. Betbeder,
- L. Fenart,
- H. Bricout,
- A. M. Lenfant,
- C. Landry,
- R. Cecchelli,
- E. Monflier,
- and S. Tilloy
Effects of γ- and Hydroxypropyl-γ-cyclodextrins on the Transport of Doxorubicin across an in Vitro Model of Blood-Brain Barrier
J Pharmacol Exp Ther December 2004 311:1115-1120; published ahead of print July 27, 2004, doi:10.1124/jpet.104.071845

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

Select this article
- M. Nouzova,
- N. Holtan,
- M. M. Oshiro,
- R. B. Isett,
- J. L. Munoz-Rodriguez,
- A. F. List,
- M. L. Narro,
- S. J. Miller,
- N. C. Merchant,
- and B. W. Futscher
Epigenomic Changes during Leukemia Cell Differentiation: Analysis of Histone Acetylation and Cytosine Methylation Using CpG Island Microarrays
J Pharmacol Exp Ther December 2004 311:968-981; published ahead of print August 9, 2004, doi:10.1124/jpet.104.072488
Select this article
- Takashi Nozawa,
- Masato Suzuki,
- Koichi Takahashi,
- Hikaru Yabuuchi,
- Tomoji Maeda,
- Akira Tsuji,
- and Ikumi Tamai
Involvement of Estrone-3-Sulfate Transporters in Proliferation of Hormone-Dependent Breast Cancer Cells
J Pharmacol Exp Ther December 2004 311:1032-1037; published ahead of print August 24, 2004, doi:10.1124/jpet.104.071522
Select this article
- Jee Hyun Um,
- Joong Keun Kwon,
- Chi-Dug Kang,
- Mi Ju Kim,
- Dong Sik Ju,
- Jae Ho Bae,
- Dong Wan Kim,
- Byung Seon Chung,
- and Sun Hee Kim
Relationship between Antiapoptotic Molecules and Metastatic Potency and the Involvement of DNA-Dependent Protein Kinase in the Chemosensitization of Metastatic Human Cancer Cells by Epidermal Growth Factor Receptor Blockade
J Pharmacol Exp Ther December 2004 311:1062-1070; published ahead of print July 23, 2004, doi:10.1124/jpet.104.070938
Select this article
- Stephanie L. Matheson,
- James P. McNamee,
- Taiqui Wang,
- Moulay A. Alaoui-Jamali,
- Ana M. Tari,
- and Bertrand J. Jean-Claude
The Combi-Targeting Concept: Dissection of the Binary Mechanism of Action of the Combi-Triazene SMA41 in Vitro and Antitumor Activity in Vivo
J Pharmacol Exp Ther December 2004 311:1163-1170; published ahead of print September 9, 2004, doi:10.1124/jpet.104.071977

CARDIOVASCULAR

Select this article
- Luigi Sironi,
- Paolo Gelosa,
- Uliano Guerrini,
- Cristina Banfi,
- Veronica Crippa,
- Maura Brioschi,
- Elisabetta Gianazza,
- Elena Nobili,
- Anita Gianella,
- Marc de Gasparo,
- and Elena Tremoli
Anti-Inflammatory Effects of AT1 Receptor Blockade Provide End-Organ Protection in Stroke-Prone Rats Independently from Blood Pressure Fall
J Pharmacol Exp Ther December 2004 311:989-995; published ahead of print August 9, 2004, doi:10.1124/jpet.104.072066
Select this article
- Masataka Kuroda,
- Daisuke Yoshikawa,
- Koichi Nishikawa,
- Shigeru Saito,
- and Fumio Goto
Volatile Anesthetics Inhibit Calcitonin Gene-Related Peptide Receptor-Mediated Responses in Pithed Rats and Human Neuroblastoma Cells
J Pharmacol Exp Ther December 2004 311:1016-1022; published ahead of print August 5, 2004, doi:10.1124/jpet.104.071936
Select this article
- Marta Marchesi,
- Erin A. Booth,
- Treasa Davis,
- Charles L. Bisgaier,
- and Benedict R. Lucchesi
Apolipoprotein A-I_Milano and 1-Palmitoyl-2-oleoyl Phosphatidylcholine Complex (ETC-216) Protects the in Vivo Rabbit Heart from Regional Ischemia-Reperfusion Injury
J Pharmacol Exp Ther December 2004 311:1023-1031; published ahead of print September 16, 2004, doi:10.1124/jpet.104.070789
Select this article
- Yoko Takada,
- Masami Hashimoto,
- Jiro Kasahara,
- Kazuyuki Aihara,
- and Kohji Fukunaga
Cytoprotective Effect of Sodium Orthovanadate on Ischemia/Reperfusion-Induced Injury in the Rat Heart Involves Akt Activation and Inhibition of Fodrin Breakdown and Apoptosis
J Pharmacol Exp Ther December 2004 311:1249-1255; published ahead of print August 3, 2004, doi:10.1124/jpet.104.070839

BEHAVIORAL PHARMACOLOGY

Select this article
- Emily M. Jutkiewicz and
- Jack Bergman
Effects of Dopamine D₁ Ligands on Eye Blinking in Monkeys: Efficacy, Antagonism, and D₁/D₂ Interactions
J Pharmacol Exp Ther December 2004 311:1008-1015; published ahead of print August 3, 2004, doi:10.1124/jpet.104.071092
Select this article
- M. M. Hadjimarkou,
- A. Singh,
- Y. Kandov,
- Y. Israel,
- Y.-X. Pan,
- G. C. Rossi,
- G. W. Pasternak,
- and R. J. Bodnar
Opioid Receptor Involvement in Food Deprivation-Induced Feeding: Evaluation of Selective Antagonist and Antisense Oligodeoxynucleotide Probe Effects in Mice and Rats
J Pharmacol Exp Ther December 2004 311:1188-1202; published ahead of print August 27, 2004, doi:10.1124/jpet.104.071761

Erratum

Correction to “p53-Dependent Apoptotic Mechanism of a New Designer Bimetallic Compound Tri-phenyl Tin Benzimidazolethiol Copper Chloride (TPT-CuCl₂): In Vivo Studies in Wistar Rats as Well as in Vitro Studies in Human Cervical Cancer Cells”
J Pharmacol Exp Ther December 2004 311:1281
- Full Text
- Full Text (PDF)

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

The Functional Role of Threonine-205 in the Mechanism-Based Inactivation of P450 2B1 by Two Ethynyl Substrates: The Importance of the F Helix in Catalysis

Physiological Capacity of the Reticuloendothelial System for the Degradation of Hemoglobin Vesicles (Artificial Oxygen Carriers) after Massive Intravenous Doses by Daily Repeated Infusions for 14 Days

Mechanism-Based Inactivation of Human Cytochrome P4502C8 by Drugs in Vitro

N-Glucuronidation of Carbamazepine in Human Tissues Is Mediated by UGT2B7

Population Pharmacokinetic Modeling of Blood-Brain Barrier Transport of Synthetic Adenosine A1 Receptor Agonists

Involvement of Multiple Transporters in the Efflux of 3-Hydroxy-3-methylglutaryl-CoA Reductase Inhibitors across the Blood-Brain Barrier

NADH Cytochrome b5 Reductase and Cytochrome b5 Catalyze the Microsomal Reduction of Xenobiotic Hydroxylamines and Amidoximes in Humans

Haplotype-Oriented Genetic Analysis and Functional Assessment of Promoter Variants in the MDR1 (ABCB1) Gene

Hepatobiliary Disposition of the Metabolically Stable Opioid Peptide [d-Pen2, d-Pen5]-Enkephalin (DPDPE): Pharmacokinetic Consequences of the Interplay between Multiple Transport Systems

TOXICOLOGY

Disruption of Hepatic Lipid Homeostasis in Mice after Amiodarone Treatment Is Associated with Peroxisome Proliferator-Activated Receptor-αTarget Gene Activation

Protein Kinase C Mediates Cisplatin-Induced Loss of Adherens Junctions Followed by Apoptosis of Renal Proximal Tubular Epithelial Cells

CELLULAR AND MOLECULAR

Selective Nonsteroidal Anti-Inflammatory Drugs Induce Thymosin β-4 and Alter Actin Cytoskeletal Organization in Human Colorectal Cancer Cells

Transfection and Functional Expression of CYP4A1 and CYP4A2 Using Bicistronic Vectors in Vascular Cells and Tissues

Rotenone Induces Apoptosis via Activation of Bad in Human Dopaminergic SH-SY5Y Cells

Induction of Novel Agonist Selectivity for the ADP-Activated P2Y1 Receptor Versus the ADP-Activated P2Y12 and P2Y13 Receptors by Conformational Constraint of an ADP Analog

Inhibition of Tumor Cell Proliferation by σ Ligands Is Associated with K+ Channel Inhibition and p27kip1 Accumulation

Coexpression of Y1, Y2, and Y4 Receptors in Smooth Muscle Coupled to Distinct Signaling Pathways

The Effect of the β2-Adrenoceptor Agonist Prodrug BRL-47672 on Cardiovascular Function, Skeletal Muscle Myosin Heavy Chain, and MyoD Expression in the Rat

Inhibition of Activator Protein 1 by Barbiturates Is Mediated by Differential Effects on Mitogen-Activated Protein Kinases and the Small G Proteins Ras and Rac-1

INFLAMMATION AND IMMUNOPHARMACOLOGY

ABT-963 [2-(3,4-Difluoro-phenyl)-4-(3-hydroxy-3-methyl-butoxy)-5-(4-methanesulfonyl-phenyl)-2H-pyridazin-3-one], A Highly Potent and Selective Disubstituted Pyridazinone Cyclooxgenase-2 Inhibitor

A Novel Nonpeptide Antagonist of the Kinin B1 Receptor: Effects at the Rabbit Receptor

Prostaglandin Receptors EP2, EP3, and IP Mediate Exudate Formation in Carrageenin-Induced Mouse Pleurisy

Inhibition of Poly(ADP-Ribose) Polymerase Prevents Allergen-Induced Asthma-Like Reaction in Sensitized Guinea Pigs

Comparative Study of Glucocorticoids, Cyclosporine A, and JTE-607 [(-)-Ethyl-N-{3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoyl}-l-phenylalaninate Dihydrochloride] in a Mouse Septic Shock Model

Erythropoietin Reduces the Development of Experimental Inflammatory Bowel Disease

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

Contribution of Angiotensin II to Alcohol-Induced Pancreatic Fibrosis in Rats

Evaluation of Second Generation Amiloride Analogs as Therapy for Cystic Fibrosis Lung Disease

Gene Therapy with Adenoviral Plasmids or Naked DNA of Vascular Endothelial Growth Factor and Platelet-Derived Growth Factor Accelerates Healing of Duodenal Ulcer in Rats

Increased Expression of the Sodium Transporter BSC-1 in Spontaneously Hypertensive Rats

Genetic Variants of the Human H+/Dipeptide Transporter PEPT2: Analysis of Haplotype Functions

P2X Receptor-Stimulated Calcium Responses in Preglomerular Vascular Smooth Muscle Cells Involves 20-Hydroxyeicosatetraenoic Acid

Nitric Oxide (NO)-Releasing Naproxen (HCT-3012 [(S)-6-Methoxy-α-methyl-2-naphthaleneacetic Acid 4-(Nitrooxy)butyl Ester]) Interactions with Aspirin in Gastric Mucosa of Arthritic Rats Reveal a Role for Aspirin-Triggered Lipoxin, Prostaglandins, and NO in Gastric Protection

NEUROPHARMACOLOGY

Differential Sensitivity of N- and P/Q-Type Ca2+ Channel Currents to a μ Opioid in Isolectin B -Positive and -Negative Dorsal Root Ganglion Neurons

Interaction between Dinucleotide and Nicotinic Receptors in Individual Cholinergic Terminals

Repeated Amphetamine Couples Norepinephrine Transporter and Calcium Channel Activities in PC12 Cells

Long-Term Ethanol Self-Administration by Cynomolgus Macaques Alters the Pharmacology and Expression of GABAA Receptors in Basolateral Amygdala

Cytoprotective Efficacy and Mechanisms of the Liposoluble Iron Chelator 2,2′-Dipyridyl in the Rat Photothrombotic Ischemic Stroke Model

Potentiation of the Osmosensitive Release of Taurine and d-Aspartate from SH-SY5Y Neuroblastoma Cells after Activation of M3 Muscarinic Cholinergic Receptors

Effects of γ- and Hydroxypropyl-γ-cyclodextrins on the Transport of Doxorubicin across an in Vitro Model of Blood-Brain Barrier

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

Epigenomic Changes during Leukemia Cell Differentiation: Analysis of Histone Acetylation and Cytosine Methylation Using CpG Island Microarrays

Involvement of Estrone-3-Sulfate Transporters in Proliferation of Hormone-Dependent Breast Cancer Cells

Relationship between Antiapoptotic Molecules and Metastatic Potency and the Involvement of DNA-Dependent Protein Kinase in the Chemosensitization of Metastatic Human Cancer Cells by Epidermal Growth Factor Receptor Blockade

The Combi-Targeting Concept: Dissection of the Binary Mechanism of Action of the Combi-Triazene SMA41 in Vitro and Antitumor Activity in Vivo

CARDIOVASCULAR

Anti-Inflammatory Effects of AT1 Receptor Blockade Provide End-Organ Protection in Stroke-Prone Rats Independently from Blood Pressure Fall

Volatile Anesthetics Inhibit Calcitonin Gene-Related Peptide Receptor-Mediated Responses in Pithed Rats and Human Neuroblastoma Cells

Apolipoprotein A-IMilano and 1-Palmitoyl-2-oleoyl Phosphatidylcholine Complex (ETC-216) Protects the in Vivo Rabbit Heart from Regional Ischemia-Reperfusion Injury

Cytoprotective Effect of Sodium Orthovanadate on Ischemia/Reperfusion-Induced Injury in the Rat Heart Involves Akt Activation and Inhibition of Fodrin Breakdown and Apoptosis

BEHAVIORAL PHARMACOLOGY

Effects of Dopamine D1 Ligands on Eye Blinking in Monkeys: Efficacy, Antagonism, and D1/D2 Interactions

Opioid Receptor Involvement in Food Deprivation-Induced Feeding: Evaluation of Selective Antagonist and Antisense Oligodeoxynucleotide Probe Effects in Mice and Rats

Erratum

Correction to “p53-Dependent Apoptotic Mechanism of a New Designer Bimetallic Compound Tri-phenyl Tin Benzimidazolethiol Copper Chloride (TPT-CuCl2): In Vivo Studies in Wistar Rats as Well as in Vitro Studies in Human Cervical Cancer Cells”

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Population Pharmacokinetic Modeling of Blood-Brain Barrier Transport of Synthetic Adenosine A₁ Receptor Agonists

NADH Cytochrome b₅ Reductase and Cytochrome b₅ Catalyze the Microsomal Reduction of Xenobiotic Hydroxylamines and Amidoximes in Humans

Hepatobiliary Disposition of the Metabolically Stable Opioid Peptide [d-Pen², d-Pen⁵]-Enkephalin (DPDPE): Pharmacokinetic Consequences of the Interplay between Multiple Transport Systems

Induction of Novel Agonist Selectivity for the ADP-Activated P2Y₁ Receptor Versus the ADP-Activated P2Y₁₂ and P2Y₁₃ Receptors by Conformational Constraint of an ADP Analog

Inhibition of Tumor Cell Proliferation by σ Ligands Is Associated with K⁺ Channel Inhibition and p27^kip1 Accumulation

Coexpression of Y₁, Y₂, and Y₄ Receptors in Smooth Muscle Coupled to Distinct Signaling Pathways

The Effect of the β₂-Adrenoceptor Agonist Prodrug BRL-47672 on Cardiovascular Function, Skeletal Muscle Myosin Heavy Chain, and MyoD Expression in the Rat

A Novel Nonpeptide Antagonist of the Kinin B₁ Receptor: Effects at the Rabbit Receptor

Genetic Variants of the Human H⁺/Dipeptide Transporter PEPT2: Analysis of Haplotype Functions

Differential Sensitivity of N- and P/Q-Type Ca²+ Channel Currents to a μ Opioid in Isolectin B -Positive and -Negative Dorsal Root Ganglion Neurons

Long-Term Ethanol Self-Administration by Cynomolgus Macaques Alters the Pharmacology and Expression of GABA_A Receptors in Basolateral Amygdala

Potentiation of the Osmosensitive Release of Taurine and d-Aspartate from SH-SY5Y Neuroblastoma Cells after Activation of M₃ Muscarinic Cholinergic Receptors

Apolipoprotein A-I_Milano and 1-Palmitoyl-2-oleoyl Phosphatidylcholine Complex (ETC-216) Protects the in Vivo Rabbit Heart from Regional Ischemia-Reperfusion Injury

Effects of Dopamine D₁ Ligands on Eye Blinking in Monkeys: Efficacy, Antagonism, and D₁/D₂ Interactions

Correction to “p53-Dependent Apoptotic Mechanism of a New Designer Bimetallic Compound Tri-phenyl Tin Benzimidazolethiol Copper Chloride (TPT-CuCl₂): In Vivo Studies in Wistar Rats as Well as in Vitro Studies in Human Cervical Cancer Cells”