Table of Contents

July 2004; 310 (1)

PERSPECTIVES IN PHARMACOLOGY

    • Roxanne A. Vaughan

    Phosphorylation and Regulation of Psychostimulant-Sensitive Neurotransmitter Transporters

    J Pharmacol Exp Ther July 2004 310:1-7; published ahead of print April 2, 2004, doi:10.1124/jpet.103.052423

CELLULAR AND MOLECULAR

    • Peter T. Toth,
    • Dongjun Ren,
    • and Richard J. Miller

    Regulation of CXCR4 Receptor Dimerization by the Chemokine SDF-1α and the HIV-1 Coat Protein gp120: A Fluorescence Resonance Energy Transfer (FRET) Study

    J Pharmacol Exp Ther July 2004 310:8-17; published ahead of print March 10, 2004, doi:10.1124/jpet.103.064956
    • Run-Hua Liu,
    • Masanari Mizuta,
    • and Shigeru Matsukura

    The Expression and Functional Role of Nicotinic Acetylcholine Receptors in Rat Adipocytes

    J Pharmacol Exp Ther July 2004 310:52-58; published ahead of print March 1, 2004, doi:10.1124/jpet.103.065037
    • Medhane G. Cumbay and
    • Val J. Watts

    Novel Regulatory Properties of Human Type 9 Adenylate Cyclase

    J Pharmacol Exp Ther July 2004 310:108-115; published ahead of print March 2, 2004, doi:10.1124/jpet.104.065748
    • Mary J. Clark,
    • Richard R. Neubig,
    • and John R. Traynor

    Endogenous Regulator of G Protein Signaling Proteins Suppress Gαo-Dependent, μ-Opioid Agonist-Mediated Adenylyl Cyclase Supersensitization

    J Pharmacol Exp Ther July 2004 310:215-222; published ahead of print March 10, 2004, doi:10.1124/jpet.103.064824
    • Angel Y. F. Kam,
    • Anthony S. L. Chan,
    • and Yung H. Wong

    κ-Opioid Receptor Signals through Src and Focal Adhesion Kinase to Stimulate c-Jun N-Terminal Kinases in Transfected COS-7 Cells and Human Monocytic THP-1 Cells

    J Pharmacol Exp Ther July 2004 310:301-310; published ahead of print March 2, 2004, doi:10.1124/jpet.104.065078
    • Guillaume Morissette,
    • Emmanuel Moreau,
    • René C.-Gaudreault,
    • and François Marceau

    Massive Cell Vacuolization Induced by Organic Amines Such as Procainamide

    J Pharmacol Exp Ther July 2004 310:395-406; published ahead of print March 8, 2004, doi:10.1124/jpet.104.066084

TOXICOLOGY

    • Jie Liu,
    • Wei Qu,
    • Joseph E. Saavedra,
    • and Michael P. Waalkes

    The Nitric Oxide Donor, O2-Vinyl 1-(Pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (V-PYRRO/NO), Protects against Cadmium-Induced Hepatotoxicity in Mice

    J Pharmacol Exp Ther July 2004 310:18-24; published ahead of print March 9, 2004, doi:10.1124/jpet.103.065003
    • Erik J. Martin and
    • Poh-Gek Forkert

    Evidence That 1,1-Dichloroethylene Induces Apoptotic Cell Death in Murine Liver

    J Pharmacol Exp Ther July 2004 310:33-42; published ahead of print March 17, 2004, doi:10.1124/jpet.104.066019
    • Amin A. Nanji,
    • Andrew J. Dannenberg,
    • Kalle Jokelainen,
    • and Nathan M. Bass

    Alcoholic Liver Injury in the Rat Is Associated with Reduced Expression of Peroxisome Proliferator-α (PPARα)-Regulated Genes and Is Ameliorated by PPARα Activation

    J Pharmacol Exp Ther July 2004 310:417-424; published ahead of print March 11, 2004, doi:10.1124/jpet.103.064717

NEUROPHARMACOLOGY

    • Sonia Carboni,
    • Agnes Hiver,
    • Cedric Szyndralewiez,
    • Pascale Gaillard,
    • Jean-Pierre Gotteland,
    • and Pierre-Alain Vitte

    AS601245 (1,3-Benzothiazol-2-yl (2-{[2-(3-pyridinyl) ethyl] amino}-4 pyrimidinyl) Acetonitrile): A c-Jun NH2-Terminal Protein Kinase Inhibitor with Neuroprotective Properties

    J Pharmacol Exp Ther July 2004 310:25-32; published ahead of print February 26, 2004, doi:10.1124/jpet.103.064246
    • Yahong Zhang,
    • Thackery S. Gray,
    • Deborah N. D'Souza,
    • Gonzalo A. Carrasco,
    • Katerina J. Damjanoska,
    • Bertalan Dudas,
    • Francisca Garcia,
    • Gina M. Zainelli,
    • Nicole R. Sullivan Hanley,
    • George Battaglia,
    • Nancy A. Muma,
    • and Louis D. Van de Kar

    Desensitization of 5-HT1A Receptors by 5-HT2A Receptors in Neuroendocrine Neurons in Vivo

    J Pharmacol Exp Ther July 2004 310:59-66; published ahead of print April 2, 2004, doi:10.1124/jpet.103.062224
    • Yingxian Xiao and
    • Kenneth J. Kellar

    The Comparative Pharmacology and Up-Regulation of Rat Neuronal Nicotinic Receptor Subtype Binding Sites Stably Expressed in Transfected Mammalian Cells

    J Pharmacol Exp Ther July 2004 310:98-107; published ahead of print March 11, 2004, doi:10.1124/jpet.104.066787
    • Adrian Sculptoreanu,
    • Naoki Yoshimura,
    • and William C. de Groat

    KW-7158 [(2S)-(+)-3,3,3-Trifluoro-2-hydroxy-2-methyl-N-(5,5,10-trioxo-4,10-dihydrothieno[3,2-c][1]benzothiepin-9-yl)propanamide] Enhances A-Type K+ Currents in Neurons of the Dorsal Root Ganglion of the Adult Rat

    J Pharmacol Exp Ther July 2004 310:159-168; published ahead of print March 9, 2004, doi:10.1124/jpet.104.065409
    • Xilong Zhao,
    • Jay Z. Yeh,
    • Vincent L. Salgado,
    • and Toshio Narahashi

    Fipronil Is a Potent Open Channel Blocker of Glutamate-Activated Chloride Channels in Cockroach Neurons

    J Pharmacol Exp Ther July 2004 310:192-201; published ahead of print March 10, 2004, doi:10.1124/jpet.104.065516
    • D. S. Reddy,
    • D. C. Castaneda,
    • B. W. O'Malley,
    • and M. A. Rogawski

    Anticonvulsant Activity of Progesterone and Neurosteroids in Progesterone Receptor Knockout Mice

    J Pharmacol Exp Ther July 2004 310:230-239; published ahead of print February 24, 2004, doi:10.1124/jpet.104.065268
    • Hsiang-En Wu,
    • Jonathan Thompson,
    • Han-Sen Sun,
    • Randy J. Leitermann,
    • James M. Fujimoto,
    • and Leon F. Tseng

    Nonopioidergic Mechanism Mediating Morphine-Induced Antianalgesia in the Mouse Spinal Cord

    J Pharmacol Exp Ther July 2004 310:240-246; published ahead of print March 3, 2004, doi:10.1124/jpet.104.065334
    • Mária Szücs,
    • Krisztina Boda,
    • and Alan R. Gintzler

    Dual Effects of DAMGO [d-Ala2,N-Me-Phe4,Gly5-ol]-Enkephalin and CTAP (D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2) on Adenylyl Cyclase Activity: Implications for μ-Opioid Receptor Gs Coupling

    J Pharmacol Exp Ther July 2004 310:256-262; published ahead of print March 2, 2004, doi:10.1124/jpet.104.066837
    • Michael P. Hill,
    • Paula Ravenscroft,
    • Erwan Bezard,
    • Alan R. Crossman,
    • Jonathan M. Brotchie,
    • Anne Michel,
    • Renee Grimée,
    • and Henrik Klitgaard

    Levetiracetam Potentiates the Antidyskinetic Action of Amantadine in the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-Lesioned Primate Model of Parkinson's Disease

    J Pharmacol Exp Ther July 2004 310:386-394; published ahead of print March 5, 2004, doi:10.1124/jpet.104.066191
    • Michael F. Jarvis,
    • Bruce Bianchi,
    • John T. Uchic,
    • Jayne Cartmell,
    • Chih-Hung Lee,
    • Michael Williams,
    • and Connie Faltynek

    [3H]A-317491, a Novel High-Affinity Non-Nucleotide Antagonist That Specifically Labels Human P2X2/3 and P2X3 Receptors

    J Pharmacol Exp Ther July 2004 310:407-416; published ahead of print March 15, 2004, doi:10.1124/jpet.103.064907

CARDIOVASCULAR

    • Ying Xia and
    • Morris Karmazyn

    Obligatory Role for Endogenous Endothelin in Mediating the Hypertrophic Effects of Phenylephrine and Angiotensin II in Neonatal Rat Ventricular Myocytes: Evidence for Two Distinct Mechanisms for Endothelin Regulation

    J Pharmacol Exp Ther July 2004 310:43-51; published ahead of print March 8, 2004, doi:10.1124/jpet.104.065185
    • Md. Shah Amran,
    • Keitaro Hashimoto,
    • and Nobuo Homma

    Effects of Sodium-Calcium Exchange Inhibitors, KB-R7943 and SEA0400, on Aconitine-Induced Arrhythmias in Guinea Pigs in Vivo, in Vitro, and in Computer Simulation Studies

    J Pharmacol Exp Ther July 2004 310:83-89; published ahead of print March 17, 2004, doi:10.1124/jpet.104.066951
    • Christopher G. Sobey,
    • Jane M. Weiler,
    • Mirna Boujaoude,
    • and Owen L. Woodman

    Effect of Short-Term Phytoestrogen Treatment in Male Rats on Nitric Oxide-Mediated Responses of Carotid and Cerebral Arteries: Comparison with 17β-Estradiol

    J Pharmacol Exp Ther July 2004 310:135-140; published ahead of print March 30, 2004, doi:10.1124/jpet.103.063255
    • Javier Angulo,
    • Pedro Cuevas,
    • Begoña Cuevas,
    • Sandeep Gupta,
    • and Iñigo Sáenz de Tejada

    Mechanisms for the Inhibition of Genital Vascular Responses by Antidepressants in a Female Rabbit Model

    J Pharmacol Exp Ther July 2004 310:141-149; published ahead of print March 19, 2004, doi:10.1124/jpet.103.063362
    • Eric R. Gross,
    • Anna K. Hsu,
    • and Garrett J. Gross

    Acute Aspirin Treatment Abolishes, whereas Acute Ibuprofen Treatment Enhances Morphine-Induced Cardioprotection: Role of 12-Lipoxygenase

    J Pharmacol Exp Ther July 2004 310:185-191; published ahead of print March 1, 2004, doi:10.1124/jpet.103.064667
    • Fraser D. Russell,
    • Philip Kearns,
    • Istvan Toth,
    • and Peter Molenaar

    Urotensin-II-Converting Enzyme Activity of Furin and Trypsin in Human Cells in Vitro

    J Pharmacol Exp Ther July 2004 310:209-214; published ahead of print March 8, 2004, doi:10.1124/jpet.104.065425
    • Bjorn C. Knollmann,
    • Mathew C. Casimiro,
    • Alexander N. Katchman,
    • Syevda G. Sirenko,
    • Tilmann Schober,
    • Qi Rong,
    • Karl Pfeifer,
    • and Steven N. Ebert

    Isoproterenol Exacerbates a Long QT Phenotype in Kcnq1-Deficient Neonatal Mice: Possible Roles for Human-Like Kcnq1 Isoform 1 and Slow Delayed Rectifier K+ Current

    J Pharmacol Exp Ther July 2004 310:311-318; published ahead of print March 5, 2004, doi:10.1124/jpet.103.063743
    • Mark A. Pullen,
    • David P Brooks,
    • and Richard M. Edwards

    Characterization of the Neutralizing Activity of Digoxin-Specific Fab toward Ouabain-Like Steroids

    J Pharmacol Exp Ther July 2004 310:319-325; published ahead of print February 24, 2004, doi:10.1124/jpet.104.065250
    • Travis C. Jackson,
    • Zaichuan Mi,
    • and Edwin K. Jackson

    Modulation of Cyclic AMP Production by Signal Transduction Pathways in Preglomerular Microvessels and Microvascular Smooth Muscle Cells

    J Pharmacol Exp Ther July 2004 310:349-358; published ahead of print April 15, 2004, doi:10.1124/jpet.103.063081

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

    • Manu Hegde,
    • Jane Roscoe,
    • Peter Cala,
    • and Fredric Gorin

    Amiloride Kills Malignant Glioma Cells Independent of Its Inhibition of the Sodium-Hydrogen Exchanger

    J Pharmacol Exp Ther July 2004 310:67-74; published ahead of print March 9, 2004, doi:10.1124/jpet.103.065029

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

    • Daphne Chan,
    • Brenda Knie,
    • Rada Boskovic,
    • and Gideon Koren

    Placental Handling of Fatty Acid Ethyl Esters: Perfusion and Subcellular Studies

    J Pharmacol Exp Ther July 2004 310:75-82; published ahead of print March 5, 2004, doi:10.1124/jpet.104.066597
    • Yoshiharu Deguchi,
    • Yu Naito,
    • Sumio Ohtsuki,
    • Yusaku Miyakawa,
    • Kazuhiro Morimoto,
    • Ken-ichi Hosoya,
    • Shinobu Sakurada,
    • and Tetsuya Terasaki

    Blood-Brain Barrier Permeability of Novel [d-Arg2]Dermorphin (1-4) Analogs: Transport Property Is Related to the Slow Onset of Antinociceptive Activity in the Central Nervous System

    J Pharmacol Exp Ther July 2004 310:177-184; published ahead of print March 18, 2004, doi:10.1124/jpet.103.064006
    • N. H. Al-Huniti,
    • J. A. Widness,
    • R. L. Schmidt,
    • and P. Veng-Pedersen

    Pharmacokinetic/Pharmacodynamic Analysis of Paradoxal Regulation of Erythropoietin Production in Acute Anemia

    J Pharmacol Exp Ther July 2004 310:202-208; published ahead of print February 26, 2004, doi:10.1124/jpet.104.066027
    • Rong Hu,
    • Vidya Hebbar,
    • Bok-Ryang Kim,
    • Chi Chen,
    • Bozena Winnik,
    • Brian Buckley,
    • Patricia Soteropoulos,
    • Peter Tolias,
    • Ronald P. Hart,
    • and A.-N. Tony Kong

    In Vivo Pharmacokinetics and Regulation of Gene Expression Profiles by Isothiocyanate Sulforaphane in the Rat

    J Pharmacol Exp Ther July 2004 310:263-271; published ahead of print February 26, 2004, doi:10.1124/jpet.103.064261
    • Anna L. Blobaum,
    • Ute M. Kent,
    • William L. Alworth,
    • and Paul F. Hollenberg

    Novel Reversible Inactivation of Cytochrome P450 2E1 T303A by tert-Butyl Acetylene: The Role of Threonine 303 in Proton Delivery to the Active Site of Cytochrome P450 2E1

    J Pharmacol Exp Ther July 2004 310:281-290; published ahead of print February 26, 2004, doi:10.1124/jpet.104.065508
    • Anshul Gupta,
    • Yi Zhang,
    • Jashvant D. Unadkat,
    • and Qingcheng Mao

    HIV Protease Inhibitors Are Inhibitors but Not Substrates of the Human Breast Cancer Resistance Protein (BCRP/ABCG2)

    J Pharmacol Exp Ther July 2004 310:334-341; published ahead of print March 8, 2004, doi:10.1124/jpet.104.065342
    • Patrick J. Sinko,
    • Jeevan R. Kunta,
    • Helen H. Usansky,
    • and Barbara A. Perry

    Differentiation of Gut and Hepatic First Pass Metabolism and Secretion of Saquinavir in Ported Rabbits

    J Pharmacol Exp Ther July 2004 310:359-366; published ahead of print March 5, 2004, doi:10.1124/jpet.103.064394
    • Eun Ju Jeong,
    • Huimin Lin,
    • and Ming Hu

    Disposition Mechanisms of Raloxifene in the Human Intestinal Caco-2 Model

    J Pharmacol Exp Ther July 2004 310:376-385; published ahead of print March 12, 2004, doi:10.1124/jpet.103.063925

INFLAMMATION AND IMMUNOPHARMACOLOGY

    • Stephen J. Getting,
    • Clara Di Filippo,
    • Connie W. Lam,
    • Francesco Rossi,
    • and Michele D'Amico

    Investigation into the Potential Anti-Inflammatory Effects of Endothelin Antagonists in a Murine Model of Experimental Monosodium Urate Peritonitis

    J Pharmacol Exp Ther July 2004 310:90-97; published ahead of print March 2, 2004, doi:10.1124/jpet.104.065573
    • Balazs Veres,
    • Balazs Radnai,
    • Ferenc Gallyas, Jr.,
    • Gabor Varbiro,
    • Zoltan Berente,
    • Erzsebet Osz,
    • and Balazs Sumegi

    Regulation of Kinase Cascades and Transcription Factors by a Poly(ADP-Ribose) Polymerase-1 Inhibitor, 4-Hydroxyquinazoline, in Lipopolysaccharide-Induced Inflammation in Mice

    J Pharmacol Exp Ther July 2004 310:247-255; published ahead of print March 3, 2004, doi:10.1124/jpet.104.065151
    • Keisuke Takeshita,
    • Kevin B. Bacon,
    • and Florian Gantner

    Critical Role of L-Selectin and Histamine H4 Receptor in Zymosan-Induced Neutrophil Recruitment from the Bone Marrow: Comparison with Carrageenan

    J Pharmacol Exp Ther July 2004 310:272-280; published ahead of print March 2, 2004, doi:10.1124/jpet.103.063776
    • R. William Hipkin,
    • Gregory Deno,
    • Jay Fine,
    • Yongliang Sun,
    • Brian Wilburn,
    • Xuedong Fan,
    • Waldemar Gonsiorek,
    • and Maria T. Wiekowski

    Cloning and Pharmacological Characterization of CXCR1 and CXCR2 from Macaca fascicularis

    J Pharmacol Exp Ther July 2004 310:291-300; published ahead of print March 17, 2004, doi:10.1124/jpet.103.063131

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

    • Tomasz Brzozowski,
    • Peter C. Konturek,
    • Anthony P. Moran,
    • Robert Pajdo,
    • Slawomir Kwiecien,
    • Stanislaw J. Konturek,
    • Zbigniew Sliwowski,
    • Danuta Drozdowicz,
    • Wieslaw W. Pawlik,
    • and Eckhart G. Hahn

    Involvement of Capsaicin-Sensitive Afferent Nerves and Cholecystokinin 2/Gastrin Receptors in Gastroprotection and Adaptation of Gastric Mucosa to Helicobacter pylori-Lipopolysaccharide

    J Pharmacol Exp Ther July 2004 310:116-125; published ahead of print March 15, 2004, doi:10.1124/jpet.104.065128
    • Brian S. Cummings,
    • Gilbert R. Kinsey,
    • Laura J. C. Bolchoz,
    • and Rick G. Schnellmann

    Identification of Caspase-Independent Apoptosis in Epithelial and Cancer Cells

    J Pharmacol Exp Ther July 2004 310:126-134; published ahead of print March 17, 2004, doi:10.1124/jpet.104.065862
    • Vincent Lagente,
    • Emmanuel Naline,
    • Isabelle Guenon,
    • Marianne Corbel,
    • Elisabeth Boichot,
    • Jean-Luc Burgaud,
    • Piero Del Soldato,
    • and Charles Advenier

    A Nitric Oxide-Releasing Salbutamol Elicits Potent Relaxant and Anti-Inflammatory Activities

    J Pharmacol Exp Ther July 2004 310:367-375; published ahead of print April 14, 2004, doi:10.1124/jpet.103.061739

BEHAVIORAL PHARMACOLOGY

    • Ellen A. Walker,
    • Mitchell J. Picker,
    • Arthur Granger,
    • and Linda A. Dykstra

    Effects of Opioids in Morphine-Treated Pigeons Trained to Discriminate among Morphine, the Low-Efficacy Agonist Nalbuphine, and Saline

    J Pharmacol Exp Ther July 2004 310:150-158; published ahead of print March 25, 2004, doi:10.1124/jpet.103.058503
    • M. C. H. Ko,
    • M. S. Song,
    • T. Edwards,
    • H. Lee,
    • and N. N. Naughton

    The Role of Central μ Opioid Receptors in Opioid-Induced Itch in Primates

    J Pharmacol Exp Ther July 2004 310:169-176; published ahead of print March 25, 2004, doi:10.1124/jpet.103.061101
    • Toni L. Jones and
    • Linda S. Sorkin

    Calcium-Permeable α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/Kainate Receptors Mediate Development, but Not Maintenance, of Secondary Allodynia Evoked by First-Degree Burn in the Rat

    J Pharmacol Exp Ther July 2004 310:223-229; published ahead of print March 8, 2004, doi:10.1124/jpet.103.064741
    • Todd W. Vanderah,
    • Claudio D. Schteingart,
    • Jerzy Trojnar,
    • Jean-Louis Junien,
    • Josephine Lai,
    • and Pierre J.-M. Riviere

    FE200041 (d-Phe-d-Phe-d-Nle-d-Arg-NH2): A Peripheral Efficacious κ Opioid Agonist with Unprecedented Selectivity

    J Pharmacol Exp Ther July 2004 310:326-333; published ahead of print March 1, 2004, doi:10.1124/jpet.104.065391
    • James K. Rowlett,
    • Donna M. Platt,
    • and Roger D. Spealman

    Cocaine-Like Discriminative Stimulus Effects of Heroin: Modulation by Selective Monoamine Transport Inhibitors

    J Pharmacol Exp Ther July 2004 310:342-348; published ahead of print February 25, 2004, doi:10.1124/jpet.104.065631

Cover image

Cover image expansion

Schematic diagram of DAT, NET, and SERT structures and potential phosphorylation sites. See the article by Vaughan on page 1 of this issue.

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This Issue

July 2004; 310 (1)
Cover
  1. PERSPECTIVES IN PHARMACOLOGY
  2. CELLULAR AND MOLECULAR
  3. TOXICOLOGY
  4. NEUROPHARMACOLOGY
  5. CARDIOVASCULAR
  6. CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
  7. ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  8. INFLAMMATION AND IMMUNOPHARMACOLOGY
  9. GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  10. BEHAVIORAL PHARMACOLOGY

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