Table of Contents

January 2004; 308 (1)

EDITORIAL

    • Rick G. Schnellmann

    Editorial

    J Pharmacol Exp Ther January 2004 308:1; published ahead of print November 6, 2003, doi:10.1124/jpet.103.062497

PERSPECTIVES IN PHARMACOLOGY

    • Johan W. Jonker and
    • Alfred H. Schinkel

    Pharmacological and Physiological Functions of the Polyspecific Organic Cation Transporters: OCT1, 2, and 3 (SLC22A1-3)

    J Pharmacol Exp Ther January 2004 308:2-9; published ahead of print October 23, 2003, doi:10.1124/jpet.103.053298

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

    • Jeffrey S. Fedan,
    • Janet A. Dowdy,
    • Richard A. Johnston,
    • and Michael R. Van Scott

    Hyperosmolar Solution Effects in Guinea Pig Airways. I. Mechanical Responses to Relative Changes in Osmolarity

    J Pharmacol Exp Ther January 2004 308:10-18; published ahead of print October 16, 2003, doi:10.1124/jpet.103.051607
    • David X.-Y. Wu,
    • Richard A. Johnston,
    • Appavoo Rengasamy,
    • Michael R. Van Scott,
    • and Jeffrey S. Fedan

    Hyperosmolar Solution Effects in Guinea Pig Airways. II. Epithelial Bioelectric Responses to Relative Changes in Osmolarity

    J Pharmacol Exp Ther January 2004 308:19-29; published ahead of print October 17, 2003, doi:10.1124/jpet.103.051615
    • Jeffrey S. Fedan,
    • Janet A. Dowdy,
    • Michael R. Van Scott,
    • David X.-Y. Wu,
    • and Richard A. Johnston

    Hyperosmolar Solution Effects in Guinea Pig Airways. III. Studies on the Identity of Epithelium-Derived Relaxing Factor in Isolated Perfused Trachea Using Pharmacological Agents

    J Pharmacol Exp Ther January 2004 308:30-36; published ahead of print October 17, 2003, doi:10.1124/jpet.103.051664
    • Richard A. Johnston,
    • Michael R. Van Scott,
    • Choudari Kommineni,
    • Lyndell L. Millecchia,
    • Juanita Dortch-Carnes,
    • and Jeffrey S. Fedan

    Hyperosmolar Solution Effects in Guinea Pig Airways. IV. Lipopolysaccharide-Induced Alterations in Airway Reactivity and Epithelial Bioelectric Responses to Methacholine and Hyperosmolarity

    J Pharmacol Exp Ther January 2004 308:37-46; published ahead of print October 17, 2003, doi:10.1124/jpet.103.051672
    • Tim Schneider,
    • Peter Hein,
    • and Martin C. Michel

    Signal Transduction Underlying Carbachol-Induced Contraction of Rat Urinary Bladder. I. Phospholipases and Ca2+ Sources

    J Pharmacol Exp Ther January 2004 308:47-53; published ahead of print October 7, 2003, doi:10.1124/jpet.103.058248
    • Marina Fleichman,
    • Tim Schneider,
    • Charlotte Fetscher,
    • and Martin C. Michel

    Signal Transduction Underlying Carbachol-Induced Contraction of Rat Urinary Bladder. II. Protein Kinases

    J Pharmacol Exp Ther January 2004 308:54-58; published ahead of print October 7, 2003, doi:10.1124/jpet.103.058255
    • Yi N. Ye,
    • Edgar S. L. Liu,
    • Vivian Y. Shin,
    • William K. K. Wu,
    • Jiing C. Luo,
    • and Chi H. Cho

    Nicotine Promoted Colon Cancer Growth via Epidermal Growth Factor Receptor, c-Src, and 5-Lipoxygenase-Mediated Signal Pathway

    J Pharmacol Exp Ther January 2004 308:66-72; published ahead of print October 20, 2003, doi:10.1124/jpet.103.058321
    • Kenichi Kanoh,
    • Tatsuo Shimura,
    • Hideki Suzuki,
    • Kenichi Nomoto,
    • Takayuki Asao,
    • and Hiroyuki Kuwano

    Antitumor Effect of a Splenic Injection of 5-Fluorouracil on Metastatic Liver Cancer in Mice

    J Pharmacol Exp Ther January 2004 308:168-174; published ahead of print October 20, 2003, doi:10.1124/jpet.103.057547
    • Kalina Venkova,
    • James C. Keith, Jr.,
    • and Beverley Greenwood-Van Meerveld

    Oral Treatment with Recombinant Human Interleukin-11 Improves Mucosal Transport in the Colon of Human Leukocyte Antigen-B27 Transgenic Rats

    J Pharmacol Exp Ther January 2004 308:206-213; published ahead of print October 20, 2003, doi:10.1124/jpet.103.058701
    • Gennadi M. Kravtsov,
    • Isabel S. S. Hwang,
    • and Fai Tang

    The Inhibitory Effect of Adrenomedullin in the Rat Ileum: Cross-Talk with β3-Adrenoceptor in the Serotonin-Induced Muscle Contraction

    J Pharmacol Exp Ther January 2004 308:241-248; published ahead of print October 20, 2003, doi:10.1124/jpet.103.057612
    • Karlheinz Ehrlich,
    • Christa Sicking,
    • Michael Respondek,
    • and Brigitta M. Peskar

    Interaction of Cyclooxygenase Isoenzymes, Nitric Oxide, and Afferent Neurons in Gastric Mucosal Defense in Rats

    J Pharmacol Exp Ther January 2004 308:277-283; published ahead of print October 20, 2003, doi:10.1124/jpet.103.057752
    • DeWayne Townsend IV,
    • Philip S. Portoghese,
    • and David R. Brown

    Characterization of Specific Opioid Binding Sites in Neural Membranes from the Myenteric Plexus of Porcine Small Intestine

    J Pharmacol Exp Ther January 2004 308:385-393; published ahead of print October 20, 2003, doi:10.1124/jpet.103.058016

CARDIOVASCULAR

    • Sean A. Cahill and
    • Gil J. Gross

    Propafenone and Its Metabolites Preferentially Inhibit IKrin Rabbit Ventricular Myocytes

    J Pharmacol Exp Ther January 2004 308:59-65; published ahead of print October 20, 2003, doi:10.1124/jpet.103.057844
    • Kathryn K. Chadman and
    • James H. Woods

    Cardiovascular Effects of Nicotine, Chlorisondamine, and Mecamylamine in the Pigeon

    J Pharmacol Exp Ther January 2004 308:73-78; published ahead of print October 17, 2003, doi:10.1124/jpet.103.057307
    • Giuseppe Rossoni,
    • Monica Gomaraschi,
    • Ferruccio Berti,
    • Cesare R. Sirtori,
    • Guido Franceschini,
    • and Laura Calabresi

    Synthetic High-Density Lipoproteins Exert Cardioprotective Effects in Myocardial Ischemia/Reperfusion Injury

    J Pharmacol Exp Ther January 2004 308:79-84; published ahead of print October 17, 2003, doi:10.1124/jpet.103.057141
    • I. Tong Mak and
    • William B. Weglicki

    Potent Antioxidant Properties of 4-Hydroxyl-propranolol

    J Pharmacol Exp Ther January 2004 308:85-90; published ahead of print October 20, 2003, doi:10.1124/jpet.103.058032
    • B. Brandts,
    • R. Borchard,
    • R. Macianskiene,
    • V. Gendviliene,
    • D. Dirkmann,
    • M. Van Bracht,
    • M. Prull,
    • M. Meine,
    • I. Wickenbrock,
    • K. Mubagwa,
    • and H.-J. Trappe

    Inhibition of G Protein-Coupled and ATP-Sensitive Potassium Currents by 2-Methyl-3-(3,5-diiodo-4-carboxymethoxybenzyl)benzofuran (KB130015), an Amiodarone Derivative

    J Pharmacol Exp Ther January 2004 308:134-142; published ahead of print October 20, 2003, doi:10.1124/jpet.103.057646
    • Vangelis Karalis,
    • Aristides Dokoumetzidis,
    • and Panos Macheras

    A Physiologically Based Approach for the Estimation of Recirculatory Parameters

    J Pharmacol Exp Ther January 2004 308:198-205; published ahead of print October 20, 2003, doi:10.1124/jpet.103.058941
    • Patrice Colin,
    • Bijan Ghaleh,
    • Xavier Monnet,
    • Luc Hittinger,
    • and Alain Berdeaux

    Effect of Graded Heart Rate Reduction with Ivabradine on Myocardial Oxygen Consumption and Diastolic Time in Exercising Dogs

    J Pharmacol Exp Ther January 2004 308:236-240; published ahead of print October 20, 2003, doi:10.1124/jpet.103.059717
    • G. Abou-Mohamed,
    • J. A. Johnson,
    • L. Jin,
    • A. B. El-Remessy,
    • K. Do,
    • W. H. Kaesemeyer,
    • R. B. Caldwell,
    • and R. W. Caldwell

    Roles of Superoxide, Peroxynitrite, and Protein Kinase C in the Development of Tolerance to Nitroglycerin

    J Pharmacol Exp Ther January 2004 308:289-299; published ahead of print October 16, 2003, doi:10.1124/jpet.103.056119
    • Zhi Su,
    • Michael Sheets,
    • Hideyuki Ishida,
    • Fenghua Li,
    • and William H. Barry

    Saxitoxin Blocks L-Type ICa

    J Pharmacol Exp Ther January 2004 308:324-329; published ahead of print October 17, 2003, doi:10.1124/jpet.103.056564
    • Alex A. Pérez-Rivera,
    • Gregory D. Fink,
    • and James J. Galligan

    Increased Reactivity of Murine Mesenteric Veins to Adrenergic Agonists: Functional Evidence Supporting Increased α1-Adrenoceptor Reserve in Veins Compared with Arteries

    J Pharmacol Exp Ther January 2004 308:350-357; published ahead of print October 30, 2003, doi:10.1124/jpet.103.056184

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

    • Hiroko Kawaguchi,
    • Yumi Matsui,
    • Yoshihiko Watanabe,
    • and Yoshinobu Takakura

    Effect of Interferon-γ on the Pharmacokinetics of Digoxin, a P-glycoprotein Substrate, Intravenously Injected into the Mouse

    J Pharmacol Exp Ther January 2004 308:91-96; published ahead of print October 20, 2003, doi:10.1124/jpet.103.057521
    • Carolyn L. Cummins,
    • Wolfgang Jacobsen,
    • Uwe Christians,
    • and Leslie Z. Benet

    CYP3A4-Transfected Caco-2 Cells as a Tool for Understanding Biochemical Absorption Barriers: Studies with Sirolimus and Midazolam

    J Pharmacol Exp Ther January 2004 308:143-155; published ahead of print October 20, 2003, doi:10.1124/jpet.103.058065
    • Tanja Richter,
    • Thomas E. Mürdter,
    • Georg Heinkele,
    • Jürgen Pleiss,
    • Stephan Tatzel,
    • Matthias Schwab,
    • Michel Eichelbaum,
    • and Ulrich M. Zanger

    Potent Mechanism-Based Inhibition of Human CYP2B6 by Clopidogrel and Ticlopidine

    J Pharmacol Exp Ther January 2004 308:189-197; published ahead of print October 16, 2003, doi:10.1124/jpet.103.056127
    • Gerhard A. Siebert,
    • Daniel Y. Hung,
    • Ping Chang,
    • and Michael S. Roberts

    Ion-Trapping, Microsomal Binding, and Unbound Drug Distribution in the Hepatic Retention of Basic Drugs

    J Pharmacol Exp Ther January 2004 308:228-235; published ahead of print October 17, 2003, doi:10.1124/jpet.103.056770
    • Norie Murayama,
    • Akiko Soyama,
    • Yoshiro Saito,
    • Yukiko Nakajima,
    • Kazuo Komamura,
    • Kazuyuki Ueno,
    • Shiro Kamakura,
    • Masafumi Kitakaze,
    • Hideo Kimura,
    • Yu-ichi Goto,
    • Osamu Saitoh,
    • Masaaki Katoh,
    • Teiichi Ohnuma,
    • Mitsuru Kawai,
    • Kenji Sugai,
    • Taisuke Ohtsuki,
    • Chieko Suzuki,
    • Narihiro Minami,
    • Shogo Ozawa,
    • and Jun-ichi Sawada

    Six Novel Nonsynonymous CYP1A2 Gene Polymorphisms: Catalytic Activities of the Naturally Occurring Variant Enzymes

    J Pharmacol Exp Ther January 2004 308:300-306; published ahead of print October 16, 2003, doi:10.1124/jpet.103.055798

CELLULAR AND MOLECULAR

    • Ki Young Kim,
    • Hwa Kyoung Shin,
    • Jeong Hyun Lee,
    • Chi Dae Kim,
    • Won Suk Lee,
    • Byung Yong Rhim,
    • Yung Woo Shin,
    • and Ki Whan Hong

    Cilostazol Enhances Casein Kinase 2 Phosphorylation and Suppresses Tumor Necrosis Factor-α-Induced Increased Phosphatase and Tensin Homolog Deleted from Chromosome 10 Phosphorylation and Apoptotic Cell Death in SK-N-SH Cells

    J Pharmacol Exp Ther January 2004 308:97-104; published ahead of print October 20, 2003, doi:10.1124/jpet.103.058768
    • Jan Jakubík,
    • Stanislav Tuček,
    • and Esam E. El-Fakahany

    Role of Receptor Protein and Membrane Lipids in Xanomeline Wash-Resistant Binding to Muscarinic M1 Receptors

    J Pharmacol Exp Ther January 2004 308:105-110; published ahead of print October 20, 2003, doi:10.1124/jpet.103.058594
    • Pamela K. Smitherman,
    • Alan J. Townsend,
    • Timothy E. Kute,
    • and Charles S. Morrow

    Role of Multidrug Resistance Protein 2 (MRP2, ABCC2) in Alkylating Agent Detoxification: MRP2 Potentiates Glutathione S-Transferase A1-1-Mediated Resistance to Chlorambucil Cytotoxicity

    J Pharmacol Exp Ther January 2004 308:260-267; published ahead of print October 20, 2003, doi:10.1124/jpet.103.057729
    • Tetsuya Yamamoto,
    • Jill Lewis,
    • John Wataha,
    • Douglas Dickinson,
    • Baldev Singh,
    • Wendy B. Bollag,
    • Eisaku Ueta,
    • Tokio Osaki,
    • Mohammad Athar,
    • George Schuster,
    • and Stephen Hsu

    Roles of Catalase and Hydrogen Peroxide in Green Tea Polyphenol-Induced Chemopreventive Effects

    J Pharmacol Exp Ther January 2004 308:317-323; published ahead of print October 20, 2003, doi:10.1124/jpet.103.058891
    • Michael T. Griffin,
    • Minoru Matsui,
    • Darakhshanda Shehnaz,
    • Khurram Z. Ansari,
    • Makoto M. Taketo,
    • Toshiya Manabe,
    • and Frederick J. Ehlert

    Muscarinic Agonist-Mediated Heterologous Desensitization in Isolated Ileum Requires Activation of Both Muscarinic M2 and M3 Receptors

    J Pharmacol Exp Ther January 2004 308:339-349; published ahead of print October 16, 2003, doi:10.1124/jpet.103.055327

BEHAVIORAL PHARMACOLOGY

    • Lance R. McMahon,
    • Stacy L. Sell,
    • and Charles P. France

    Cocaine and Other Indirect-Acting Monoamine Agonists Differentially Attenuate a Naltrexone Discriminative Stimulus in Morphine-Treated Rhesus Monkeys

    J Pharmacol Exp Ther January 2004 308:111-119; published ahead of print October 20, 2003, doi:10.1124/jpet.103.058917
    • Lawrence P. Carter,
    • Huifang Wu,
    • Weibin Chen,
    • Christopher M. Cruz,
    • R. J. Lamb,
    • Wouter Koek,
    • Andy Coop,
    • and Charles P. France

    Effects of γ-Hydroxybutyrate (GHB) on Schedule-Controlled Responding in Rats: Role of GHB and GABAB Receptors

    J Pharmacol Exp Ther January 2004 308:182-188; published ahead of print October 20, 2003, doi:10.1124/jpet.103.058909
    • Maciej Gasior,
    • Carol A. Paronis,
    • and Jack Bergman

    Modification by Dopaminergic Drugs of Choice Behavior under Concurrent Schedules of Intravenous Saline and Food Delivery in Monkeys

    J Pharmacol Exp Ther January 2004 308:249-259; published ahead of print October 16, 2003, doi:10.1124/jpet.103.052795
    • Osama M. Abo-Salem,
    • Alaa M. Hayallah,
    • Andras Bilkei-Gorzo,
    • Barbara Filipek,
    • Andreas Zimmer,
    • and Christa E. Müller

    Antinociceptive Effects of Novel A2B Adenosine Receptor Antagonists

    J Pharmacol Exp Ther January 2004 308:358-366; published ahead of print October 16, 2003, doi:10.1124/jpet.103.056036

NEUROPHARMACOLOGY

    • Feng Wang,
    • Nobuya Matsuoka,
    • Seitaro Mutoh,
    • and Shuji Kaneko

    Modulation of Ca2+Channel Currents by a Novel Antidementia DrugN-(4-Acetyl-1-piperazinyl)-p-fluorobenzamide Monohydrate (FK960) in Rat Hippocampal Neurons

    J Pharmacol Exp Ther January 2004 308:120-126; published ahead of print October 20, 2003, doi:10.1124/jpet.103.057687
    • Hiroshi Yamashita,
    • Kazushige Ohno,
    • Yoko Amada,
    • Hanae Hattori,
    • Yukiko Ozawa-Funatsu,
    • Takashi Toya,
    • Hiroshi Inami,
    • Jun-Ichi Shishikura,
    • Shuichi Sakamoto,
    • Masamichi Okada,
    • and Tokio Yamaguchi

    Effects of 2-[N-(4-Chlorophenyl)-N-methylamino]-4H-pyrido[3.2-e]-1,3-thiazin-4-one (YM928), an Orally Active α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptor Antagonist, in Models of Generalized Epileptic Seizure in Mice and Rats

    J Pharmacol Exp Ther January 2004 308:127-133; published ahead of print October 20, 2003, doi:10.1124/jpet.103.058495
    • Susan E. Hanak,
    • Erin M. Reilly,
    • Jill Wotanis,
    • Bin Zhu,
    • Claudine Pulicicchio,
    • Kathleen McMonagle-Strucko,
    • Joseph G. Wettstein,
    • and Mark D. Black

    An Electrophysiological Model of Spinal Transmission Deficits in Mouse Experimental Autoimmune Encephalomyelitis

    J Pharmacol Exp Ther January 2004 308:214-220; published ahead of print October 17, 2003, doi:10.1124/jpet.103.056994
    • Timothy A. Vortherms and
    • Val J. Watts

    Sensitization of Neuronal A2A Adenosine Receptors after Persistent D2 Dopamine Receptor Activation

    J Pharmacol Exp Ther January 2004 308:221-227; published ahead of print October 17, 2003, doi:10.1124/jpet.103.057083
    • Gin C. Hsieh,
    • Peter R. Hollingsworth,
    • Brenda Martino,
    • Renjie Chang,
    • Marc A. Terranova,
    • Alyssa B. O'Neill,
    • James J. Lynch,
    • Robert B. Moreland,
    • Diana L. Donnelly-Roberts,
    • Teodozyi Kolasa,
    • Joseph P. Mikusa,
    • Jill M. McVey,
    • Kennan C. Marsh,
    • James P. Sullivan,
    • and Jorge D. Brioni

    Central Mechanisms Regulating Penile Erection in Conscious Rats: The Dopaminergic Systems Related to the Proerectile Effect of Apomorphine

    J Pharmacol Exp Ther January 2004 308:330-338; published ahead of print October 20, 2003, doi:10.1124/jpet.103.057455
    • Lisa S. Middleton,
    • Wayne A. Cass,
    • and Linda P. Dwoskin

    Nicotinic Receptor Modulation of Dopamine Transporter Function in Rat Striatum and Medial Prefrontal Cortex

    J Pharmacol Exp Ther January 2004 308:367-377; published ahead of print October 16, 2003, doi:10.1124/jpet.103.055335

ENDOCRINE AND REPRODUCTIVE

    • Nancy K. Mello,
    • Jack H. Mendelson,
    • S. Stevens Negus,
    • and Maureen Kelly

    Ovarian Steroid Hormone Modulation of the Acute Effects of Cocaine on Luteinizing Hormone and Prolactin Levels in Ovariectomized Rhesus Monkeys

    J Pharmacol Exp Ther January 2004 308:156-167; published ahead of print October 17, 2003, doi:10.1124/jpet.103.057216

INFLAMMATION AND IMMUNOPHARMACOLOGY

    • Melvyn Lynn,
    • Y. Nancy Wong,
    • Janice L. Wheeler,
    • Richard J. Kao,
    • Carlos A. Perdomo,
    • Robert Noveck,
    • Ramon Vargas,
    • Tony D'Angelo,
    • Sandra Gotzkowsky,
    • F. Gilbert McMahon,
    • Kishor M. Wasan,
    • and Daniel P. Rossignol

    Extended in Vivo Pharmacodynamic Activity of E5564 in Normal Volunteers with Experimental Endotoxemia

    J Pharmacol Exp Ther January 2004 308:175-181; published ahead of print October 17, 2003, doi:10.1124/jpet.103.056531
    • Robin L. Thurmond,
    • Siquan Sun,
    • Clark A. Sehon,
    • Sherry M. Baker,
    • Hui Cai,
    • Yin Gu,
    • Wen Jiang,
    • Jason P. Riley,
    • Kacy N. Williams,
    • James P. Edwards,
    • and Lars Karlsson

    Identification of a Potent and Selective Noncovalent Cathepsin S Inhibitor

    J Pharmacol Exp Ther January 2004 308:268-276; published ahead of print October 17, 2003, doi:10.1124/jpet.103.056879
    • Mingchen Song,
    • John A. Kellum,
    • Hoda Kaldas,
    • and Mitchell P. Fink

    Evidence That Glutathione Depletion Is a Mechanism Responsible for the Anti-Inflammatory Effects of Ethyl Pyruvate in Cultured Lipopolysaccharide-Stimulated RAW 264.7 Cells

    J Pharmacol Exp Ther January 2004 308:307-316; published ahead of print October 20, 2003, doi:10.1124/jpet.103.056622

TOXICOLOGY

    • Ling O. Qiu,
    • Mark W. Linder,
    • Deborah M. Antonino-Green,
    • and Roland Valdes, Jr.

    Suppression of Cytochrome P450 2E1 Promoter Activity by Interferon-γ and Loss of Response Due to the -71G>T Nucleotide Polymorphism of the CYP2E1*7B Allele

    J Pharmacol Exp Ther January 2004 308:284-288; published ahead of print October 17, 2003, doi:10.1124/jpet.103.057208
    • F. Pouzaud,
    • K. Bernard-Beaubois,
    • M. Thevenin,
    • J.-M. Warnet,
    • G. Hayem,
    • and P. Rat

    In Vitro Discrimination of Fluoroquinolones Toxicity on Tendon Cells: Involvement of Oxidative Stress

    J Pharmacol Exp Ther January 2004 308:394-402; published ahead of print October 20, 2003, doi:10.1124/jpet.103.057984

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

    • Takanori Akagi,
    • Kazami Ushinohama,
    • Shoko Ikesue,
    • Eiji Yukawa,
    • Shun Higuchi,
    • Kenji Hamase,
    • Kiyoshi Zaitsu,
    • and Shigehiro Ohdo

    Chronopharmacology of Melatonin in Mice to Maximize the Antitumor Effect and Minimize the Rhythm Disturbance Effect

    J Pharmacol Exp Ther January 2004 308:378-384; published ahead of print October 16, 2003, doi:10.1124/jpet.103.055657

Cover image

Cover image expansion

Localization of OCT1 and OCT2 in kidney and liver. See the article by Jonker and Schinkel on page 2 of this issue.

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This Issue

January 2004; 308 (1)
Cover
  1. EDITORIAL
  2. PERSPECTIVES IN PHARMACOLOGY
  3. GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  4. CARDIOVASCULAR
  5. ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  6. CELLULAR AND MOLECULAR
  7. BEHAVIORAL PHARMACOLOGY
  8. NEUROPHARMACOLOGY
  9. ENDOCRINE AND REPRODUCTIVE
  10. INFLAMMATION AND IMMUNOPHARMACOLOGY
  11. TOXICOLOGY
  12. CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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