Table of Contents

December 2003; 307 (3)

PERSPECTIVES IN PHARMACOLOGY

    • Arun Anantharam,
    • Steven M. Markowitz,
    • and Geoffrey W. Abbott

    Pharmacogenetic Considerations in Diseases of Cardiac Ion Channels

    J Pharmacol Exp Ther December 2003 307:831-838; published ahead of print October 15, 2003, doi:10.1124/jpet.103.054569
    • Mary C. Farach-Carson and
    • Paul J. Davis

    Steroid Hormone Interactions with Target Cells: Cross Talk between Membrane and Nuclear Pathways

    J Pharmacol Exp Ther December 2003 307:839-845; published ahead of print October 8, 2003, doi:10.1124/jpet.103.055038

CELLULAR AND MOLECULAR

    • Thomas Litman,
    • Torben Skovsgaard,
    • and Wilfred D. Stein

    Pumping of Drugs by P-Glycoprotein: A Two-Step Process?

    J Pharmacol Exp Ther December 2003 307:846-853; published ahead of print October 8, 2003, doi:10.1124/jpet.103.056960
    • Zhenhai Gao,
    • Dachuan Lei,
    • Julie Welch,
    • Kathy Le,
    • Jie Lin,
    • Song Leng,
    • and David Duhl

    Agonist-Dependent Internalization of the Human Melanocortin-4 Receptors in Human Embryonic Kidney 293 Cells

    J Pharmacol Exp Ther December 2003 307:870-877; published ahead of print October 8, 2003, doi:10.1124/jpet.103.055525
    • Erika Hamaguchi,
    • Toshinari Takamura,
    • Akiko Shimizu,
    • and Yukihiro Nagai

    Tumor Necrosis Factor-α and Troglitazone Regulate Plasminogen Activator Inhibitor Type 1 Production through Extracellular Signal-Regulated Kinase- and Nuclear Factor-κB-Dependent Pathways in Cultured Human Umbilical Vein Endothelial Cells

    J Pharmacol Exp Ther December 2003 307:987-994; published ahead of print October 8, 2003, doi:10.1124/jpet.103.054346
    • Magnus M. Berglund,
    • Douglas A. Schober,
    • Michail A. Esterman,
    • and Donald R. Gehlert

    Neuropeptide Y Y4 Receptor Homodimers Dissociate upon Agonist Stimulation

    J Pharmacol Exp Ther December 2003 307:1120-1126; published ahead of print October 9, 2003, doi:10.1124/jpet.103.055673
    • Yulin Wang,
    • Jian-Guo Li,
    • Peng Huang,
    • Wei Xu,
    • and Lee-Yuan Liu-Chen

    Differential Effects of Agonists on Adenylyl Cyclase Superactivation Mediated by the κ Opioid Receptors: Adenylyl Cyclase Superactivation Is Independent of Agonist-Induced Phosphorylation, Desensitization, Internalization, and Down-Regulation

    J Pharmacol Exp Ther December 2003 307:1127-1134; published ahead of print October 13, 2003, doi:10.1124/jpet.103.055814

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

    • Chris Baylis,
    • Elke-Astrid Atzpodien,
    • Gary Freshour,
    • and Kevin Engels

    Peroxisome Proliferator-Activated Receptor γ Agonist Provides Superior Renal Protection versus Angiotensin-Converting Enzyme Inhibition in a Rat Model of Type 2 Diabetes with Obesity

    J Pharmacol Exp Ther December 2003 307:854-860; published ahead of print October 14, 2003, doi:10.1124/jpet.103.055616
    • Edwin K. Jackson,
    • Zaichuan Mi,
    • Chongxue Zhu,
    • and Raghvendra K. Dubey

    Adenosine Biosynthesis in the Collecting Duct

    J Pharmacol Exp Ther December 2003 307:888-896; published ahead of print October 14, 2003, doi:10.1124/jpet.103.057166
    • Stephen C. Lenhard,
    • Sandhya S. Nerurkar,
    • Thomas R. Schaeffer,
    • Rosanna C. Mirabile,
    • Rogely W. Boyce,
    • David F. Adams,
    • Beat M. Jucker,
    • and Robert N. Willette

    p38 MAPK Inhibitors Ameliorate Target Organ Damage in Hypertension: Part 2. Improved Renal Function as Assessed by Dynamic Contrast-Enhanced Magnetic Resonance Imaging

    J Pharmacol Exp Ther December 2003 307:939-946; published ahead of print October 15, 2003, doi:10.1124/jpet.103.057398
    • Sutep Gonlachanvit,
    • Yen Hsueh Chen,
    • William L. Hasler,
    • Wei Ming Sun,
    • and Chung Owyang

    Ginger Reduces Hyperglycemia-Evoked Gastric Dysrhythmias in Healthy Humans: Possible Role of Endogenous Prostaglandins

    J Pharmacol Exp Ther December 2003 307:1098-1103; published ahead of print October 8, 2003, doi:10.1124/jpet.103.053421

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

    • George W. Small,
    • Sivagurunathan Somasundaram,
    • Dominic T. Moore,
    • Yue Y. Shi,
    • and Robert Z. Orlowski

    Repression of Mitogen-Activated Protein Kinase (MAPK) Phosphatase-1 by Anthracyclines Contributes to Their Antiapoptotic Activation of p44/42-MAPK

    J Pharmacol Exp Ther December 2003 307:861-869; published ahead of print October 13, 2003, doi:10.1124/jpet.103.055806

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

    • Ann-Charlotte Egnell,
    • Cecilia Eriksson,
    • Nan Albertson,
    • Brian Houston,
    • and Scott Boyer

    Generation and Evaluation of a CYP2C9 Heteroactivation Pharmacophore

    J Pharmacol Exp Ther December 2003 307:878-887; published ahead of print October 13, 2003, doi:10.1124/jpet.103.054999
    • Vishal Lamba,
    • Jatinder Lamba,
    • Kazuto Yasuda,
    • Stephen Strom,
    • Julio Davila,
    • Michael L. Hancock,
    • James D. Fackenthal,
    • Peter K. Rogan,
    • Barbara Ring,
    • Steven A. Wrighton,
    • and Erin G. Schuetz

    Hepatic CYP2B6 Expression: Gender and Ethnic Differences and Relationship to CYP2B6 Genotype and CAR (Constitutive Androstane Receptor) Expression

    J Pharmacol Exp Ther December 2003 307:906-922; published ahead of print October 9, 2003, doi:10.1124/jpet.103.054866
    • Donald E. Mager,
    • Mary A. Mascelli,
    • Neal S. Kleiman,
    • Desmond J. Fitzgerald,
    • and Darrell R. Abernethy

    Simultaneous Modeling of Abciximab Plasma Concentrations and ex Vivo Pharmacodynamics in Patients Undergoing Coronary Angioplasty

    J Pharmacol Exp Ther December 2003 307:969-976; published ahead of print October 8, 2003, doi:10.1124/jpet.103.057299
    • Dario Siccardi,
    • Lana E. Kandalaft,
    • Mark Gumbleton,
    • and Christopher McGuigan

    Stereoselective and Concentration-Dependent Polarized Epithelial Permeability of a Series of Phosphoramidate Triester Prodrugs of d4T: An in Vitro Study in Caco-2 and Madin-Darby Canine Kidney Cell Monolayers

    J Pharmacol Exp Ther December 2003 307:1112-1119; published ahead of print October 13, 2003, doi:10.1124/jpet.103.056135
    • Po-Yung Cheng,
    • Molin Wang,
    • and Edward T. Morgan

    Rapid Transcriptional Suppression of Rat Cytochrome P450 Genes by Endotoxin Treatment and Its Inhibition by Curcumin

    J Pharmacol Exp Ther December 2003 307:1205-1212; published ahead of print October 13, 2003, doi:10.1124/jpet.103.057174
    • Teruko Imai,
    • Yasushi Yoshigae,
    • Masakiyo Hosokawa,
    • Kan Chiba,
    • and Masaki Otagiri

    Evidence for the Involvement of a Pulmonary First-Pass Effect via Carboxylesterase in the Disposition of a Propranolol Ester Derivative after Intravenous Administration

    J Pharmacol Exp Ther December 2003 307:1234-1242; published ahead of print October 8, 2003, doi:10.1124/jpet.103.056499

NEUROPHARMACOLOGY

    • Pari Malherbe,
    • Vincent Mutel,
    • Clemens Broger,
    • Florent Perin-Dureau,
    • John A. Kemp,
    • Jacques Neyton,
    • Pierre Paoletti,
    • and James N. C. Kew

    Identification of Critical Residues in the Amino Terminal Domain of the Human NR2B Subunit Involved in the RO 25-6981 Binding Pocket

    J Pharmacol Exp Ther December 2003 307:897-905; published ahead of print October 8, 2003, doi:10.1124/jpet.103.056291
    • Guo-Min Zhao,
    • Xuanxuan Qian,
    • Peter W. Schiller,
    • and Hazel H. Szeto

    Comparison of [Dmt1]DALDA and DAMGO in Binding and G Protein Activation at μ, δ, and κ Opioid Receptors

    J Pharmacol Exp Ther December 2003 307:947-954; published ahead of print October 8, 2003, doi:10.1124/jpet.103.054775
    • Akinori Iwashita,
    • Takuya Maemoto,
    • Hirohisa Nakada,
    • Ichiro Shima,
    • Nobuya Matsuoka,
    • and Hiroshi Hisajima

    A Novel Potent Radical Scavenger, 8-(4-Fluorophenyl)-2-((2E)-3-phenyl-2-propenoyl)-1,2,3,4-tetrahydropyrazolo[5,1-c] [1,2,4]triazine (FR210575), Prevents Neuronal Cell Death in Cultured Primary Neurons and Attenuates Brain Injury after Focal Ischemia in Rats

    J Pharmacol Exp Ther December 2003 307:961-968; published ahead of print October 8, 2003, doi:10.1124/jpet.103.056572
    • Osamu Murasaki,
    • Muneshige Kaibara,
    • Yoshihisa Nagase,
    • Sayaka Mitarai,
    • Yoshiyuki Doi,
    • Koji Sumikawa,
    • and Kohtaro Taniyama

    Site of Action of the General Anesthetic Propofol in Muscarinic M1 Receptor-Mediated Signal Transduction

    J Pharmacol Exp Ther December 2003 307:995-1000; published ahead of print October 8, 2003, doi:10.1124/jpet.103.055772
    • Gonzalo A. Carrasco,
    • Yahong Zhang,
    • Katerina J. Damjanoska,
    • Deborah N. D'Souza,
    • Francisca Garcia,
    • George Battaglia,
    • Nancy A. Muma,
    • and Louis D. Van de Kar

    A Region-Specific Increase in Gαq And Gα11 Proteins in Brains of Rats during Cocaine Withdrawal

    J Pharmacol Exp Ther December 2003 307:1012-1019; published ahead of print October 8, 2003, doi:10.1124/jpet.103.056978
    • Donald W. Floyd,
    • Ki-Yoon Jung,
    • and Brian A. McCool

    Chronic Ethanol Ingestion Facilitates N-Methyl-d-aspartate Receptor Function and Expression in Rat Lateral/Basolateral Amygdala Neurons

    J Pharmacol Exp Ther December 2003 307:1020-1029; published ahead of print October 8, 2003, doi:10.1124/jpet.103.057505
    • Jen-Kun Cheng,
    • Robert Chang-Chih Chou,
    • Ling-Ling Hwang,
    • and Lih-Chu Chiou

    Antiallodynic Effects of Intrathecal Orexins in a Rat Model of Postoperative Pain

    J Pharmacol Exp Ther December 2003 307:1065-1071; published ahead of print October 9, 2003, doi:10.1124/jpet.103.056663
    • Paola Petrillo,
    • Ornella Angelici,
    • Sharon Bingham,
    • Giovanna Ficalora,
    • Martine Garnier,
    • Paola F. Zaratin,
    • Giuseppe Petrone,
    • Ottorino Pozzi,
    • Massimo Sbacchi,
    • Tania O. Stean,
    • Neil Upton,
    • Guillio M. Dondio,
    • and Mark A. Scheideler

    Evidence for a Selective Role of the δ-Opioid Agonist [8R-(4bS*,8aα,8aβ,12bβ)]7,10-Dimethyl-1-methoxy-11-(2-methylpropyl)oxycarbonyl 5,6,7,8,12,12b-hexahydro-(9H)-4,8-methanobenzofuro[3,2-e]pyrrolo[2,3-g]isoquinoline Hydrochloride (SB-235863) in Blocking Hyperalgesia Associated with Inflammatory and Neuropathic Pain Responses

    J Pharmacol Exp Ther December 2003 307:1079-1089; published ahead of print October 9, 2003, doi:10.1124/jpet.103.055590
    • Henry N. Nguyen,
    • Bruce A. Rasmussen,
    • and David C. Perry

    Subtype-Selective Up-Regulation by Chronic Nicotine of High-Affinity Nicotinic Receptors in Rat Brain Demonstrated by Receptor Autoradiography

    J Pharmacol Exp Ther December 2003 307:1090-1097; published ahead of print October 14, 2003, doi:10.1124/jpet.103.056408
    • Hsiang-En Wu,
    • Han-Sen Sun,
    • Moses Darpolar,
    • Randy J. Leitermann,
    • John P. Kampine,
    • and Leon F. Tseng

    Dynorphinergic Mechanism Mediating Endomorphin-2-Induced Antianalgesia in the Mouse Spinal Cord

    J Pharmacol Exp Ther December 2003 307:1135-1141; published ahead of print October 13, 2003, doi:10.1124/jpet.103.056242
    • Peter J. Gengo,
    • Hugh O. Pettit,
    • Scott J. O'Neill,
    • Ke Wei,
    • Robert McNutt,
    • Michael J. Bishop,
    • and Kwen-Jen Chang

    DPI-3290 [(+)-3-((α-R)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide]. I. A Mixed Opioid Agonist with Potent Antinociceptive Activity

    J Pharmacol Exp Ther December 2003 307:1221-1226; published ahead of print October 8, 2003, doi:10.1124/jpet.103.054361
    • Peter J. Gengo,
    • Hugh O. Pettit,
    • Scott J. O'Neill,
    • Ying Fu Su,
    • Robert McNutt,
    • and Kwen-Jen Chang

    DPI-3290 [(+)-3-((α-R)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide]. II. A Mixed Opioid Agonist with Potent Antinociceptive Activity and Limited Effects on Respiratory Function

    J Pharmacol Exp Ther December 2003 307:1227-1233; published ahead of print October 8, 2003, doi:10.1124/jpet.103.054429

TOXICOLOGY

    • Beth A. Luellen,
    • Diane B. Miller,
    • Angela C. Chisnell,
    • Dennis L. Murphy,
    • James P. O'Callaghan,
    • and Anne Milasincic Andrews

    Neuronal and Astroglial Responses to the Serotonin and Norepinephrine Neurotoxin: 1-Methyl-4-(2′-aminophenyl)-1,2,3,6-tetrahydropyridine

    J Pharmacol Exp Ther December 2003 307:923-931; published ahead of print October 15, 2003, doi:10.1124/jpet.103.055749
    • Karl B. Scheidweiler,
    • Mark A. Plessinger,
    • Jalil Shojaie,
    • Ronald W. Wood,
    • and Tai C. Kwong

    Pharmacokinetics and Pharmacodynamics of Methylecgonidine, a Crack Cocaine Pyrolyzate

    J Pharmacol Exp Ther December 2003 307:1179-1187; published ahead of print October 15, 2003, doi:10.1124/jpet.103.055434

CARDIOVASCULAR

    • Haisong Ju,
    • David J. Behm,
    • Sandyha Nerurkar,
    • Marianne E. Eybye,
    • Robin E. Haimbach,
    • Alan R. Olzinski,
    • Stephen A. Douglas,
    • and Robert N. Willette

    p38 MAPK Inhibitors Ameliorate Target Organ Damage in Hypertension: Part 1. p38 MAPK-Dependent Endothelial Dysfunction and Hypertension

    J Pharmacol Exp Ther December 2003 307:932-938; published ahead of print October 15, 2003, doi:10.1124/jpet.103.057422
    • Toshiaki Sato,
    • Taichi Takizawa,
    • Tomoaki Saito,
    • Satoru Kobayashi,
    • Yukio Hara,
    • and Haruaki Nakaya

    Amiodarone Inhibits Sarcolemmal but Not Mitochondrial KATP Channels in Guinea Pig Ventricular Cells

    J Pharmacol Exp Ther December 2003 307:955-960; published ahead of print October 8, 2003, doi:10.1124/jpet.103.055863
    • Edwin K. Jackson and
    • William A. Herzer

    Renal Extraction of Angiotensin II

    J Pharmacol Exp Ther December 2003 307:1001-1006; published ahead of print October 8, 2003, doi:10.1124/jpet.103.055236
    • James E. Jordan,
    • Steven A. Simandle,
    • Christina D. Tulbert,
    • David W. Busija,
    • and Allison W. Miller

    Fructose-Fed Rats Are Protected against Ischemia/Reperfusion Injury

    J Pharmacol Exp Ther December 2003 307:1007-1011; published ahead of print October 8, 2003, doi:10.1124/jpet.103.055970
    • Na Qiao,
    • Denis Reynaud,
    • Peter Demin,
    • Perry V. Halushka,
    • and Cecil R. Pace-Asciak

    The Thromboxane Receptor Antagonist PBT-3, a Hepoxilin Stable Analog, Selectively Antagonizes the TPα Isoform in Transfected COS-7 Cells

    J Pharmacol Exp Ther December 2003 307:1142-1147; published ahead of print October 14, 2003, doi:10.1124/jpet.103.056705
    • Pamela J. Kell,
    • Michael H. Creer,
    • Kimberley N. Crown,
    • Karin Wirsig,
    • and Jane McHowat

    Inhibition of Platelet-Activating Factor (PAF) Acetylhydrolase by Methyl Arachidonyl Fluorophosphonate Potentiates PAF Synthesis in Thrombin-Stimulated Human Coronary Artery Endothelial Cells

    J Pharmacol Exp Ther December 2003 307:1163-1170; published ahead of print October 14, 2003, doi:10.1124/jpet.103.055392
    • Hoang Thai,
    • Jason Wollmuth,
    • Steven Goldman,
    • and Mohamed Gaballa

    Angiotensin Subtype 1 Receptor (AT1) Blockade Improves Vasorelaxation in Heart Failure by Up-Regulation of Endothelial Nitric-Oxide Synthase via Activation of the AT2 Receptor

    J Pharmacol Exp Ther December 2003 307:1171-1178; published ahead of print October 14, 2003, doi:10.1124/jpet.103.054916

BEHAVIORAL PHARMACOLOGY

    • Zuzana Justinova,
    • Sergi Ferré,
    • Pavan N. Segal,
    • Katerina Antoniou,
    • Marcello Solinas,
    • Lara A. Pappas,
    • Jena L. Highkin,
    • Jörg Hockemeyer,
    • Patrik Munzar,
    • and Steven R. Goldberg

    Involvement of Adenosine A1 and A2A Receptors in the Adenosinergic Modulation of the Discriminative-Stimulus Effects of Cocaine and Methamphetamine in Rats

    J Pharmacol Exp Ther December 2003 307:977-986; published ahead of print October 13, 2003, doi:10.1124/jpet.103.056762
    • Jason N. Jaworski,
    • Marie A. Kozel,
    • Kelly B. Philpot,
    • and Michael J. Kuhar

    Intra-Accumbal Injection of CART (Cocaine-Amphetamine Regulated Transcript) Peptide Reduces Cocaine-Induced Locomotor Activity

    J Pharmacol Exp Ther December 2003 307:1038-1044; published ahead of print October 9, 2003, doi:10.1124/jpet.103.052332
    • Glenn W. Stevenson,
    • John E. Folk,
    • David C. Linsenmayer,
    • Kenner C. Rice,
    • and S. Stevens Negus

    Opioid Interactions in Rhesus Monkeys: Effects of δ + μ and δ + κ Agonists on Schedule-Controlled Responding and Thermal Nociception

    J Pharmacol Exp Ther December 2003 307:1054-1064; published ahead of print October 13, 2003, doi:10.1124/jpet.103.056515

INFLAMMATION AND IMMUNOPHARMACOLOGY

    • Ana María Vicente,
    • María Isabel Guillén,
    • Aüida Habib,
    • and María José Alcaraz

    Beneficial Effects of Heme Oxygenase-1 Up-Regulation in the Development of Experimental Inflammation Induced by Zymosan

    J Pharmacol Exp Ther December 2003 307:1030-1037; published ahead of print October 15, 2003, doi:10.1124/jpet.103.057992
    • Stephen M. Becker and
    • Kathleen L. McCoy

    Gallium Arsenide Selectively Up-Regulates Inflammatory Cytokine Expression at Exposure Site

    J Pharmacol Exp Ther December 2003 307:1045-1053; published ahead of print October 14, 2003, doi:10.1124/jpet.103.057919
    • Keisuke Takeshita,
    • Katsuya Sakai,
    • Kevin B. Bacon,
    • and Florian Gantner

    Critical Role of Histamine H4 Receptor in Leukotriene B4 Production and Mast Cell-Dependent Neutrophil Recruitment Induced by Zymosan in Vivo

    J Pharmacol Exp Ther December 2003 307:1072-1078; published ahead of print October 9, 2003, doi:10.1124/jpet.103.057489
    • Wen-Zhe Ho,
    • Chang-Jiang Guo,
    • Chun-Su Yuan,
    • Steven D. Douglas,
    • and Jonathan Moss

    Methylnaltrexone Antagonizes Opioid-Mediated Enhancement of HIV Infection of Human Blood Mononuclear Phagocytes

    J Pharmacol Exp Ther December 2003 307:1158-1162; published ahead of print October 14, 2003, doi:10.1124/jpet.103.056697
    • Hideo Kohka Takahashi,
    • Hiromi Iwagaki,
    • Ryuji Tamura,
    • Dong Xue,
    • Masahiro Sano,
    • Shuji Mori,
    • Tadashi Yoshino,
    • Noriaki Tanaka,
    • and Masahiro Nishibori

    Unique Regulation Profile of Prostaglandin E1 on Adhesion Molecule Expression and Cytokine Production in Human Peripheral Blood Mononuclear Cells

    J Pharmacol Exp Ther December 2003 307:1188-1195; published ahead of print October 15, 2003, doi:10.1124/jpet.103.056432
    • Mio Kawaguchi,
    • Fumio Kokubu,
    • Satoshi Matsukura,
    • Koushi Ieki,
    • Miho Odaka,
    • Shin Watanabe,
    • Shintaro Suzuki,
    • Mitsuru Adachi,
    • and Shau-Ku Huang

    Induction of C-X-C Chemokines, Growth-Related Oncogene α Expression, and Epithelial Cell-Derived Neutrophil-Activating Protein-78 by ML-1 (Interleukin-17F) Involves Activation of Raf1-Mitogen-Activated Protein Kinase Kinase-Extracellular Signal-Regulated Kinase 1/2 Pathway

    J Pharmacol Exp Ther December 2003 307:1213-1220; published ahead of print October 13, 2003, doi:10.1124/jpet.103.056341

ENDOCRINE AND REPRODUCTIVE

    • Rodney A. Velliquette and
    • Paul Ernsberger

    Contrasting Metabolic Effects of Antihypertensive Agents

    J Pharmacol Exp Ther December 2003 307:1104-1111; published ahead of print October 13, 2003, doi:10.1124/jpet.103.054221
    • Jing Xu,
    • Laurent Lecanu,
    • Zeqiu Han,
    • Zhixing Yao,
    • Janet Greeson,
    • and Vassilios Papadopoulos

    Inhibition of Adrenal Cortical Steroid Formation by Procaine Is Mediated by Reduction of the cAMP-Induced 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Messenger Ribonucleic Acid Levels

    J Pharmacol Exp Ther December 2003 307:1148-1157; published ahead of print October 14, 2003, doi:10.1124/jpet.103.055178
    • I-Min Liu,
    • Wang-Chuan Chen,
    • and Juei-Tang Cheng

    Mediation of β-Endorphin by Isoferulic Acid to Lower Plasma Glucose in Streptozotocin-Induced Diabetic Rats

    J Pharmacol Exp Ther December 2003 307:1196-1204; published ahead of print September 15, 2003, doi:10.1124/jpet.103.053900

Errata

  • Correction to “Inhibitor Binding to Type 4 Phosphodiesterase (PDE4) Assessed Using [3H]Piclamilast and [3H]Rolipram”

    J Pharmacol Exp Ther December 2003 307:1243

  • Correction to “Cytochrome P450 2E1 (CYP2E1) Is the Principal Enzyme Responsible for Urethane Metabolism: Comparative Studies Using CYP2E1-Null and Wild-Type Mice”

    J Pharmacol Exp Ther December 2003 307:1243

  • Correction to “Evidence That Nuclear Factor-{kappa}B Activation Is Critical in Oxidant-Induced Disruption of the Microtubule Cytoskeleton and Barrier Integrity and That Its Inactivation Is Essential in Epidermal Growth Factor-Mediated Protection of the Monolayers of Intestinal Epithelia”

    J Pharmacol Exp Ther December 2003 307:1243

Cover image

Cover image expansion

Cardiac voltage-gated ion channel subunits. See article by Anantharam et al. on page 831 of this issue.

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This Issue

December 2003; 307 (3)
Cover
  1. PERSPECTIVES IN PHARMACOLOGY
  2. CELLULAR AND MOLECULAR
  3. GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  4. CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
  5. ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  6. NEUROPHARMACOLOGY
  7. TOXICOLOGY
  8. CARDIOVASCULAR
  9. BEHAVIORAL PHARMACOLOGY
  10. INFLAMMATION AND IMMUNOPHARMACOLOGY
  11. ENDOCRINE AND REPRODUCTIVE
  12. Errata

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