Table of Contents

February 2003; 304 (2)

PERSPECTIVES IN PHARMACOLOGY

    • Stata Norton

    Experimental Therapeutics in the Renaissance

    J Pharmacol Exp Ther February 1, 2003 304:489-492; doi:10.1124/jpet.102.042291
    • Yoichi Osawa,
    • Ezra R. Lowe,
    • Andrew C. Everett,
    • Anwar Y. Dunbar,
    • and Scott S. Billecke

    Proteolytic Degradation of Nitric Oxide Synthase: Effect of Inhibitors and Role of hsp90-Based Chaperones

    J Pharmacol Exp Ther February 1, 2003 304:493-497; doi:10.1124/jpet.102.035055

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

    • Markus Forsberg,
    • Marko Lehtonen,
    • Minna Heikkinen,
    • Jouko Savolainen,
    • Tomi Järvinen,
    • and Pekka T. Männistö

    Pharmacokinetics and Pharmacodynamics of Entacapone and Tolcapone after Acute and Repeated Administration: A Comparative Study in the Rat

    J Pharmacol Exp Ther February 1, 2003 304:498-506; doi:10.1124/jpet.102.042846
    • Maarten T. Huisman,
    • Johan W. Smit,
    • Hugh R. Wiltshire,
    • Jos H. Beijnen,
    • and Alfred H. Schinkel

    Assessing Safety and Efficacy of Directed P-Glycoprotein Inhibition to Improve the Pharmacokinetic Properties of Saquinavir Coadministered with Ritonavir

    J Pharmacol Exp Ther February 1, 2003 304:596-602; doi:10.1124/jpet.102.044388
    • Yoshihisa Shitara,
    • Tomoo Itoh,
    • Hitoshi Sato,
    • Albert P. Li,
    • and Yuichi Sugiyama

    Inhibition of Transporter-Mediated Hepatic Uptake as a Mechanism for Drug-Drug Interaction between Cerivastatin and Cyclosporin A

    J Pharmacol Exp Ther February 1, 2003 304:610-616; doi:10.1124/jpet.102.041921
    • Elaine M. Leslie,
    • Raymond J. Bowers,
    • Roger G. Deeley,
    • and Susan P. C. Cole

    Structural Requirements for Functional Interaction of Glutathione Tripeptide Analogs with the Human Multidrug Resistance Protein 1 (MRP1)

    J Pharmacol Exp Ther February 1, 2003 304:643-653; doi:10.1124/jpet.102.044073
    • Janne Hukkanen,
    • Teemu Väisänen,
    • Arja Lassila,
    • Ritva Piipari,
    • Sisko Anttila,
    • Olavi Pelkonen,
    • Hannu Raunio,
    • and Jukka Hakkola

    Regulation of CYP3A5 by Glucocorticoids and Cigarette Smoke in Human Lung-Derived Cells

    J Pharmacol Exp Ther February 1, 2003 304:745-752; doi:10.1124/jpet.102.038208
    • Seong Hoon Jang,
    • M. Guillaume Wientjes,
    • and Jessie L.-S. Au

    Interdependent Effect of P-Glycoprotein-Mediated Drug Efflux and Intracellular Drug Binding on Intracellular Paclitaxel Pharmacokinetics: Application of Computational Modeling

    J Pharmacol Exp Ther February 1, 2003 304:773-780; doi:10.1124/jpet.102.044172
    • Banmeet S. Anand,
    • Jignesh Patel,
    • and Ashim K. Mitra

    Interactions of the Dipeptide Ester Prodrugs of Acyclovir with the Intestinal Oligopeptide Transporter: Competitive Inhibition of Glycylsarcosine Transport in Human Intestinal Cell Line-Caco-2

    J Pharmacol Exp Ther February 1, 2003 304:781-791; doi:10.1124/jpet.102.044313
    • Maciej J. Zamek-Gliszczynski,
    • Hao Xiong,
    • Nita J. Patel,
    • Ryan Z. Turncliff,
    • Gary M. Pollack,
    • and Kim L. R. Brouwer

    Pharmacokinetics of 5 (and 6)-Carboxy-2′,7′-Dichlorofluorescein and Its Diacetate Promoiety in the Liver

    J Pharmacol Exp Ther February 1, 2003 304:801-809; doi:10.1124/jpet.102.044107

CARDIOVASCULAR

    • Adebayo O. Oyekan

    Contributions of Nitric Oxide and Prostanoids and Their Signaling Pathways to the Renal Medullary Vasodilator Effect of U46619 (9-11-Dideoxy-11α,9a-Epoxymethano-Prostaglandin F2a) in the Rat

    J Pharmacol Exp Ther February 1, 2003 304:507-512; doi:10.1124/jpet.102.040170
    • J. Lorrain,
    • L. Millet,
    • I. Lechaire,
    • S. Lochot,
    • P. Ferrari,
    • C. Visconte,
    • M. Sainte-Marie,
    • C. Lunven,
    • C. N. Berry,
    • P. Schaeffer,
    • J.-M. Herbert,
    • and S. E. O'Connor

    Antithrombotic Properties of SSR182289A, a New, Orally Active Thrombin Inhibitor

    J Pharmacol Exp Ther February 1, 2003 304:567-574; doi:10.1124/jpet.102.044610
    • Hongkui Jin,
    • Renhui Yang,
    • Wei Li,
    • Annie K. Ogasawara,
    • Ralph Schwall,
    • David A. Eberhard,
    • Zhong Zheng,
    • David Kahn,
    • and Nicholas F. Paoni

    Early Treatment with Hepatocyte Growth Factor Improves Cardiac Function in Experimental Heart Failure Induced by Myocardial Infarction

    J Pharmacol Exp Ther February 1, 2003 304:654-660; doi:10.1124/jpet.102.041772
    • Han Choe,
    • Yu-Kyung Lee,
    • Yong-Tae Lee,
    • Huhn Choe,
    • Seong-Hoon Ko,
    • Chan-Uhng Joo,
    • Min-Ho Kim,
    • Gong-Soo Kim,
    • Jae-Soon Eun,
    • Jong-Hyun Kim,
    • Soo-Wan Chae,
    • and Yong-Geun Kwak

    Papaverine Blocks hKv1.5 Channel Current and Human Atrial Ultrarapid Delayed Rectifier K+ Currents

    J Pharmacol Exp Ther February 1, 2003 304:706-712; doi:10.1124/jpet.102.042770
    • Shailaja Kalyankrishna and
    • Kafait U. Malik

    Norepinephrine-Induced Stimulation of p38 Mitogen-Activated Protein Kinase Is Mediated by Arachidonic Acid Metabolites Generated by Activation of Cytosolic Phospholipase A2 in Vascular Smooth Muscle Cells

    J Pharmacol Exp Ther February 1, 2003 304:761-772; doi:10.1124/jpet.102.040949
    • Shinji Takai,
    • Hiroshi Sakonjo,
    • Kohzo Fukuda,
    • Denan Jin,
    • Masato Sakaguchi,
    • Keiichi Kamoshita,
    • Koichi Ishida,
    • Yoshikazu Sukenaga,
    • and Mizuo Miyazaki

    A Novel Chymase Inhibitor, 2-(5-Formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[{3,4-dioxo-1-phenyl-7-(2-pyridyloxy)}-2-heptyl]acetamide (NK3201), Suppressed Intimal Hyperplasia after Balloon Injury

    J Pharmacol Exp Ther February 1, 2003 304:841-844; doi:10.1124/jpet.102.042580
    • Claudia K. Derian,
    • Bruce P. Damiano,
    • Michael F. Addo,
    • Andrew L. Darrow,
    • Michael R. D'Andrea,
    • Mark Nedelman,
    • Han-Cheng Zhang,
    • Bruce E. Maryanoff,
    • and Patricia Andrade-Gordon

    Blockade of the Thrombin Receptor Protease-Activated Receptor-1 with a Small-Molecule Antagonist Prevents Thrombus Formation and Vascular Occlusion in Nonhuman Primates

    J Pharmacol Exp Ther February 1, 2003 304:855-861; doi:10.1124/jpet.102.042663
    • Ignacio Moreno,
    • Ricardo Caballero,
    • Teresa González,
    • Cristina Arias,
    • Carmen Valenzuela,
    • Isabel Iriepa,
    • Enrique Gálvez,
    • Juan Tamargo,
    • and Eva Delpón

    Effects of Irbesartan on Cloned Potassium Channels Involved in Human Cardiac Repolarization

    J Pharmacol Exp Ther February 1, 2003 304:862-873; doi:10.1124/jpet.102.042325

NEUROPHARMACOLOGY

    • Satoshi Takeo,
    • Tomoko Fukatsu,
    • Keiko Miyake-Takagi,
    • Norio Takagi,
    • Makiko Niimura,
    • Akira Nagakura,
    • Tsuyoshi Ando,
    • and Kouichi Tanonaka

    Persistent Effects of Delayed Treatment with Nefiracetam on the Water Maze Task in Rats with Sustained Cerebral Ischemia

    J Pharmacol Exp Ther February 1, 2003 304:513-523; doi:10.1124/jpet.102.043653
    • J. P. Beekwilder,
    • M. E. O'Leary,
    • L. P. van den Broek,
    • G. Th. H. Van Kempen,
    • D. L. Ypey,
    • and R. J. Van den Berg

    Kv1.1 Channels of Dorsal Root Ganglion Neurons Are Inhibited byn-Butyl-p-aminobenzoate, a Promising Anesthetic for the Treatment of Chronic Pain

    J Pharmacol Exp Ther February 1, 2003 304:531-538; doi:10.1124/jpet.102.042135
    • Ai-Ming Yu,
    • Camille P. Granvil,
    • Robert L. Haining,
    • Kristopher W. Krausz,
    • Javier Corchero,
    • Adrian Küpfer,
    • Jeffrey R. Idle,
    • and Frank J. Gonzalez

    The Relative Contribution of Monoamine Oxidase and Cytochrome P450 Isozymes to the Metabolic Deamination of the Trace Amine Tryptamine

    J Pharmacol Exp Ther February 1, 2003 304:539-546; doi:10.1124/jpet.102.043786
    • Sonya G. Wilson,
    • Shad B. Smith,
    • Elissa J. Chesler,
    • Kimberly A. Melton,
    • Jeremiah J. Haas,
    • Bryan Mitton,
    • Kate Strasburg,
    • Lawrence Hubert,
    • Sandra L. Rodriguez-Zas,
    • and Jeffrey S. Mogil

    The Heritability of Antinociception: Common Pharmacogenetic Mediation of Five Neurochemically Distinct Analgesics

    J Pharmacol Exp Ther February 1, 2003 304:547-559; doi:10.1124/jpet.102.041889
    • Leela Cherian,
    • Geeta Chacko,
    • Clay Goodman,
    • and Claudia S. Robertson

    Neuroprotective Effects ofl -Arginine Administration after Cortical Impact Injury in Rats: Dose Response and Time Window

    J Pharmacol Exp Ther February 1, 2003 304:617-623; doi:10.1124/jpet.102.043430
    • Keiko Hosohata,
    • Eva V. Varga,
    • Josue Alfaro-Lopez,
    • Xuejun Tang,
    • Todd W. Vanderah,
    • Frank Porreca,
    • Victor J. Hruby,
    • William R. Roeske,
    • and Henry I. Yamamura

    (2S,3R)β-Methyl-2′,6′-dimethyltyrosine-l-tetrahydroisoquinoline-3-carboxylic acid [(2S,3R)TMT-l-Tic-OH] Is a Potent, Selective δ-Opioid Receptor Antagonist in Mouse Brain

    J Pharmacol Exp Ther February 1, 2003 304:683-688; doi:10.1124/jpet.102.042929
    • Daya S. Gupta and
    • Alan R. Gintzler

    Influence of Ovarian Sex Steroids on Spinal Methionine-Enkephalin Release: Comparison with Dynorphin Reveals Asymmetrical Regulation

    J Pharmacol Exp Ther February 1, 2003 304:738-744; doi:10.1124/jpet.102.042689
    • Catherine Mytilineou,
    • Ruth H. Walker,
    • Ruth JnoBaptiste,
    • and C. Warren Olanow

    Levodopa Is Toxic to Dopamine Neurons in an in Vitro but Not an in Vivo Model of Oxidative Stress

    J Pharmacol Exp Ther February 1, 2003 304:792-800; doi:10.1124/jpet.102.042267
    • Shigeyuki Chaki,
    • Shiho Hirota,
    • Takeo Funakoshi,
    • Yoshiko Suzuki,
    • Sayoko Suetake,
    • Taketoshi Okubo,
    • Takaaki Ishii,
    • Atsuro Nakazato,
    • and Shigeru Okuyama

    Anxiolytic-Like and Antidepressant-Like Activities of MCL0129 (1-[(S)-2-(4-Fluorophenyl)-2-(4-isopropylpiperadin-1-yl)ethyl]-4-[4-(2-methoxynaphthalen-1-yl)butyl]piperazine), a Novel and Potent Nonpeptide Antagonist of the Melanocortin-4 Receptor

    J Pharmacol Exp Ther February 1, 2003 304:818-826; doi:10.1124/jpet.102.044826
    • Camilla I. Svensson,
    • Yosup Rew,
    • Shelle Malkmus,
    • Peter W. Schiller,
    • Joseph P. Taulane,
    • Murray Goodman,
    • and Tony L. Yaksh

    Systemic and Spinal Analgesic Activity of a δ-Opioid-Selective Lanthionine Enkephalin Analog

    J Pharmacol Exp Ther February 1, 2003 304:827-832; doi:10.1124/jpet.102.039750
    • Elena V. Batrakova,
    • Shu Li,
    • Valery Yu Alakhov,
    • Donald W. Miller,
    • and Alexander V. Kabanov

    Optimal Structure Requirements for Pluronic Block Copolymers in Modifying P-glycoprotein Drug Efflux Transporter Activity in Bovine Brain Microvessel Endothelial Cells

    J Pharmacol Exp Ther February 1, 2003 304:845-854; doi:10.1124/jpet.102.043307

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

    • Monika Hitzl,
    • Kathrin Klein,
    • Ulrich M. Zanger,
    • Peter Fritz,
    • Andreas K. Nüssler,
    • Peter Neuhaus,
    • and Martin F. Fromm

    Influence of Omeprazole on Multidrug Resistance Protein 3 Expression in Human Liver

    J Pharmacol Exp Ther February 1, 2003 304:524-530; doi:10.1124/jpet.102.043547
    • Carlotta E. Groves,
    • Lynn Muñoz,
    • Andrew Bahn,
    • Gerhard Burckhardt,
    • and Stephen H. Wright

    Interaction of Cysteine Conjugates with Human and Rabbit Organic Anion Transporter 1

    J Pharmacol Exp Ther February 1, 2003 304:560-566; doi:10.1124/jpet.102.043455
    • Peter W. Stengel and
    • Marlene L. Cohen

    M1 Receptor-Mediated Nitric Oxide-Dependent Relaxation Unmasked in Stomach Fundus from M3 Receptor Knockout Mice

    J Pharmacol Exp Ther February 1, 2003 304:675-682; doi:10.1124/jpet.102.042283
    • Kenta Nishiki,
    • Shuichi Tsuruoka,
    • Atsuhiro Kawaguchi,
    • Kohichi Sugimoto,
    • George J. Schwartz,
    • Makoto Suzuki,
    • Masashi Imai,
    • and Akio Fujimura

    Inhibition of Rho-Kinase Reduces Renal Na-H Exchanger Activity and Causes Natriuresis in Rat

    J Pharmacol Exp Ther February 1, 2003 304:723-728; doi:10.1124/jpet.102.041871
    • Tong Wang

    The Effects of the Potassium Channel Opener Minoxidil on Renal Electrolytes Transport in the Loop of Henle

    J Pharmacol Exp Ther February 1, 2003 304:833-840; doi:10.1124/jpet.102.043380

CELLULAR AND MOLECULAR

    • Baoyong Sun,
    • Carol R. Sterling,
    • and A. William Tank

    Chronic Nicotine Treatment Leads to Sustained Stimulation of Tyrosine Hydroxylase Gene Transcription Rate in Rat Adrenal Medulla

    J Pharmacol Exp Ther February 1, 2003 304:575-588; doi:10.1124/jpet.102.043596
    • Rita Pepponi,
    • Giancarlo Marra,
    • Maria Pia Fuggetta,
    • Sabrina Falcinelli,
    • Elena Pagani,
    • Enzo Bonmassar,
    • Josef Jiricny,
    • and Stefania D'Atri

    The Effect of O 6-Alkylguanine-DNA Alkyltransferase and Mismatch Repair Activities on the Sensitivity of Human Melanoma Cells to Temozolomide, 1,3-bis(2-Chloroethyl)1-nitrosourea, and Cisplatin

    J Pharmacol Exp Ther February 1, 2003 304:661-668; doi:10.1124/jpet.102.043950
    • Peter D. Ward,
    • Hui Ouyang,
    • and Dhiren R. Thakker

    Role of Phospholipase C-β in the Modulation of Epithelial Tight Junction Permeability

    J Pharmacol Exp Ther February 1, 2003 304:689-698; doi:10.1124/jpet.102.043638
    • Efstathia Giannopoulou,
    • Panagiotis Katsoris,
    • Dimitris Kardamakis,
    • and Evangelia Papadimitriou

    Amifostine Inhibits Angiogenesis in Vivo

    J Pharmacol Exp Ther February 1, 2003 304:729-737; doi:10.1124/jpet.102.042838
    • Min Huang,
    • Yanhong Wang,
    • Susan B. Cogut,
    • Beverly S. Mitchell,
    • and Lee M. Graves

    Inhibition of Nucleoside Transport by Protein Kinase Inhibitors

    J Pharmacol Exp Ther February 1, 2003 304:753-760; doi:10.1124/jpet.102.044214
    • Dirk Gründemann,
    • Christian Hahne,
    • Reinhard Berkels,
    • and Edgar Schömig

    Agmatine Is Efficiently Transported by Non-Neuronal Monoamine Transporters Extraneuronal Monoamine Transporter (EMT) and Organic Cation Transporter 2 (OCT2)

    J Pharmacol Exp Ther February 1, 2003 304:810-817; doi:10.1124/jpet.102.044404
    • Stefanie De Schepper,
    • Hélène Bruwiere,
    • Tinne Verhulst,
    • Ulf Steller,
    • Luc Andries,
    • Walter Wouters,
    • Michel Janicot,
    • Janine Arts,
    • and Jim Van heusden

    Inhibition of Histone Deacetylases by Chlamydocin Induces Apoptosis and Proteasome-Mediated Degradation of Survivin

    J Pharmacol Exp Ther February 1, 2003 304:881-888; doi:10.1124/jpet.102.042903

INFLAMMATION AND IMMUNOPHARMACOLOGY

    • David M. Aronoff,
    • Olivier Boutaud,
    • Lawrence J. Marnett,
    • and John A. Oates

    Inhibition of Prostaglandin H2 Synthases by Salicylate Is Dependent on the Oxidative State of the Enzymes

    J Pharmacol Exp Ther February 1, 2003 304:589-595; doi:10.1124/jpet.102.042853
    • Toshihiko Morichika,
    • Hideo Kohka Takahashi,
    • Hiromi Iwagaki,
    • Tadashi Yoshino,
    • Ryuji Tamura,
    • Minori Yokoyama,
    • Shuji Mori,
    • Tadaatsu Akagi,
    • Masahiro Nishibori,
    • and Noriaki Tanaka

    Histamine Inhibits Lipopolysaccharide-Induced Tumor Necrosis Factor-α Production in an Intercellular Adhesion Molecule-1- and B7.1-Dependent Manner

    J Pharmacol Exp Ther February 1, 2003 304:624-633; doi:10.1124/jpet.102.042515
    • Hideo Kohka Takahashi,
    • Toshihiko Morichika,
    • Hiromi Iwagaki,
    • Tadashi Yoshino,
    • Ryuji Tamura,
    • Shinnya Saito,
    • Shuji Mori,
    • Tadaatsu Akagi,
    • Noriaki Tanaka,
    • and Masahiro Nishibori

    Effect of β2-Adrenergic Receptor Stimulation on Interleukin-18-Induced Intercellular Adhesion Molecule-1 Expression and Cytokine Production

    J Pharmacol Exp Ther February 1, 2003 304:634-642; doi:10.1124/jpet.102.042622
    • Douglas C. McVey,
    • Patricia C. Schmid,
    • Harald H. O. Schmid,
    • and Steven R. Vigna

    Endocannabinoids Induce Ileitis in Rats via the Capsaicin Receptor (VR1)

    J Pharmacol Exp Ther February 1, 2003 304:713-722; doi:10.1124/jpet.102.043893

BEHAVIORAL PHARMACOLOGY

    • Mikhail Kalinichev and
    • Stephen G. Holtzman

    Changes in Urination/Defecation, Auditory Startle Response, and Startle-Induced Ultrasonic Vocalizations in Rats Undergoing Morphine Withdrawal: Similarities and Differences between Acute and Chronic Dependence

    J Pharmacol Exp Ther February 1, 2003 304:603-609; doi:10.1124/jpet.102.044206
    • David A. Gutman,
    • Michael J. Owens,
    • Kelly H. Skelton,
    • K. V. Thrivikraman,
    • and Charles B. Nemeroff

    The Corticotropin-Releasing Factor1 Receptor Antagonist R121919 Attenuates the Behavioral and Endocrine Responses to Stress

    J Pharmacol Exp Ther February 1, 2003 304:874-880; doi:10.1124/jpet.102.042788

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

    • Satoru Koyanagi,
    • Hiroo Nakagawa,
    • Yukako Kuramoto,
    • Shigehiro Ohdo,
    • Shinji Soeda,
    • and Hiroshi Shimeno

    Optimizing the Dosing Schedule of TNP-470 [O-(Chloroacetyl-carbamoyl) Fumagillol] Enhances Its Antitumor and Antiangiogenic Efficacies

    J Pharmacol Exp Ther February 1, 2003 304:669-674; doi:10.1124/jpet.102.043562
    • Monika Wierdl,
    • Christopher L. Morton,
    • Linda C. Harris,
    • Mary K. Danks,
    • John D. Schuetz,
    • and Philip M. Potter

    p53-Mediated Regulation of Expression of a Rabbit Liver Carboxylesterase Confers Sensitivity to 7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11)

    J Pharmacol Exp Ther February 1, 2003 304:699-705; doi:10.1124/jpet.102.044149
    • Lynn O. Post,
    • Dorothy E. Farrell,
    • Carol V. Cope,
    • John D. Baker,
    • and Michael J. Myers

    The Effect of Endotoxin and Dexamethasone on Enrofloxacin Pharmacokinetic Parameters in Swine

    J Pharmacol Exp Ther February 1, 2003 304:889-895; doi:10.1124/jpet.102.042416
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This Issue

February 2003; 304 (2)
Cover
  1. PERSPECTIVES IN PHARMACOLOGY
  2. ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  3. CARDIOVASCULAR
  4. NEUROPHARMACOLOGY
  5. GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  6. CELLULAR AND MOLECULAR
  7. INFLAMMATION AND IMMUNOPHARMACOLOGY
  8. BEHAVIORAL PHARMACOLOGY
  9. CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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