Analysis of Differential Substrate Selectivities of CYP2B6 and CYP2E1 by Site-Directed Mutagenesis and Molecular Modeling

Dr. James R. Halpert, Professor and Chairman, Department of Pharmacology and Toxicology, The University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555-1031. E-mail: jhalpert{at}utmb.edu

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Article usage: December 2002 to December 2019

	Abstract	Full	Pdf
Dec 2002	29	29	62
Jan 2003	22	84	100
Feb 2003	6	43	34
Mar 2003	14	48	39
Apr 2003	6	22	28
May 2003	9	13	16
Jun 2003	3	19	22
Jul 2003	14	32	16
Aug 2003	12	25	17
Sep 2003	6	21	14
Oct 2003	10	13	14
Nov 2003	15	27	14
Dec 2003	8	8	15
Jan 2004	12	29	19
Feb 2004	15	32	29
Mar 2004	12	36	17
Apr 2004	18	44	20
May 2004	15	30	22
Jun 2004	15	30	15
Jul 2004	18	25	14
Aug 2004	20	41	9
Sep 2004	15	44	18
Oct 2004	19	44	31
Nov 2004	18	44	15
Dec 2004	22	46	10
Jan 2005	18	94	13
Feb 2005	13	53	17
Mar 2005	16	46	17
Apr 2005	2	34	16
May 2005	8	42	22
Jun 2005	9	24	13
Jul 2005	6	18	9
Aug 2005	7	25	11
Sep 2005	1	22	6
Oct 2005	15	63	26
Nov 2005	10	26	18
Dec 2005	12	31	13
Jan 2006	8	37	18
Feb 2006	8	36	14
Mar 2006	8	41	31
Apr 2006	4	16	6
May 2006	18	20	12
Jun 2006	9	18	16
Jul 2006	5	13	10
Aug 2006	5	12	2
Sep 2006	4	23	10
Oct 2006	13	31	25
Nov 2006	10	19	15
Dec 2006	3	12	7
Jan 2007	4	22	26
Feb 2007	4	17	19
Mar 2007	10	30	21
Apr 2007	4	15	11
May 2007	2	16	11
Jun 2007	9	17	13
Jul 2007	8	16	11
Aug 2007	2	12	4
Sep 2007	5	14	12
Oct 2007	3	17	21
Nov 2007	1	16	13
Dec 2007	0	11	2
Jan 2008	2	8	4
Feb 2008	4	18	5
Mar 2008	5	17	12
Apr 2008	4	18	12
May 2008	1	9	8
Jun 2008	5	16	8
Jul 2008	12	23	11
Aug 2008	13	18	12
Sep 2008	9	16	10
Oct 2008	25	20	16
Nov 2008	20	16	11
Dec 2008	8	13	9
Jan 2009	4	7	4
Feb 2009	6	8	4
Mar 2009	7	15	7
Apr 2009	8	6	3
May 2009	2	4	2
Jun 2009	6	9	5
Jul 2009	4	16	6
Aug 2009	8	17	8
Sep 2009	10	12	10
Oct 2009	9	7	3
Nov 2009	7	5	7
Dec 2009	7	0	5
Jan 2010	9	4	4
Feb 2010	14	6	6
Mar 2010	11	8	7
Apr 2010	14	6	7
May 2010	17	7	4
Jun 2010	17	18	9
Jul 2010	11	4	6
Aug 2010	12	5	8
Sep 2010	4	6	7
Oct 2010	13	4	10
Nov 2010	7	4	5
Dec 2010	8	6	7
Jan 2011	9	5	5
Feb 2011	16	4	9
Mar 2011	14	11	8
Apr 2011	12	17	13
May 2011	11	18	9
Jun 2011	17	7	12
Jul 2011	17	7	8
Aug 2011	9	7	20
Sep 2011	5	7	6
Oct 2011	25	7	7
Nov 2011	28	8	13
Dec 2011	10	13	20
Jan 2012	15	12	22
Feb 2012	10	2	4
Mar 2012	28	19	18
Apr 2012	14	12	11
May 2012	9	8	3
Jun 2012	9	8	10
Jul 2012	10	9	15
Aug 2012	8	12	26
Sep 2012	5	2	12
Oct 2012	8	3	11
Nov 2012	5	5	12
Dec 2012	6	3	12
Jan 2013	7	7	12
Feb 2013	7	6	13
Mar 2013	4	6	9
Apr 2013	12	5	15
May 2013	7	3	15
Jun 2013	4	3	8
Jul 2013	3	0	5
Aug 2013	4	6	13
Sep 2013	10	4	7
Oct 2013	7	3	17
Nov 2013	3	2	8
Dec 2013	2	3	3
Jan 2014	2	3	6
Feb 2014	6	3	8
Mar 2014	8	5	9
Apr 2014	3	2	4
May 2014	11	3	6
Jun 2014	7	6	5
Jul 2014	10	5	2
Aug 2014	9	6	4
Sep 2014	5	4	8
Oct 2014	4	4	5
Nov 2014	2	2	2
Dec 2014	5	3	3
Jan 2015	2	11	1
Feb 2015	7	4	5
Mar 2015	10	8	13
Apr 2015	6	3	3
May 2015	5	8	6
Jun 2015	5	12	4
Jul 2015	5	5	11
Aug 2015	4	2	2
Sep 2015	15	6	4
Oct 2015	5	4	2
Nov 2015	7	1	5
Dec 2015	4	5	5
Jan 2016	4	11	4
Feb 2016	8	6	6
Mar 2016	20	21	8
Apr 2016	12	15	4
May 2016	9	8	3
Jun 2016	7	8	2
Jul 2016	3	4	4
Aug 2016	4	6	9
Sep 2016	6	8	2
Oct 2016	5	15	13
Nov 2016	0	9	7
Dec 2016	0	11	2
Jan 2017	2	10	3
Feb 2017	0	11	3
Mar 2017	2	14	8
Apr 2017	2	27	9
May 2017	1	11	10
Jun 2017	1	8	5
Jul 2017	2	8	4
Aug 2017	0	10	8
Sep 2017	0	12	5
Oct 2017	0	13	4
Nov 2017	1	26	1
Dec 2017	0	27	2
Jan 2018	3	253	9
Feb 2018	0	26	2
Mar 2018	5	16	6
Apr 2018	2	17	4
May 2018	1	11	5
Jun 2018	0	10	3
Jul 2018	0	9	5
Aug 2018	0	11	7
Sep 2018	0	3	1
Oct 2018	1	46	4
Nov 2018	0	7	3
Dec 2018	3	0	0
Jan 2019	11	1	1
Feb 2019	1	0	0
Mar 2019	6	0	0
Apr 2019	20	2	1
May 2019	15	11	1
Jun 2019	5	1	3
Jul 2019	6	0	0
Aug 2019	10	1	1
Sep 2019	16	1	1
Oct 2019	9	0	0
Nov 2019	21	0	0
Dec 2019	8	0	0