In the above article [Walker EA and Young AM (2002)J Pharmacol Exp Ther302:101–110], Figs. 1 and4 were transposed. The correct figure layout and corresponding legends are printed below.
Figure 1
Clocinnamox antagonism of the stimulus and rate-decreasing effects of morphine in normal (left panels) and morphine-tolerant rats (center and right panels) trained to discriminate 3.2 mg/kg morphine from saline. Ordinate, upper panels, percentage of total responses on the morphine-appropriate lever. Ordinate, lower panels, response rate expressed as a percentage of response rates from the saline training day before testing or repeated morphine treatment. Saline control values ranged from 0.34 to 1.4 responses/s. Data from rats making fewer than 15 total responses were included in the response-rate panels but not the discrimination panels. Abscissae, cumulative doses of morphine in milligrams per kilogram. Points above S represent the effects of a saline injection administered before the determination of the morphine dose-response curves. Left panels, effects of 24-h pretreatment of 10 mg/kg clocinnamox in normal rats (n = 5). Center panels, effects of 20 mg/kg per day morphine treatment for 6 days alone or 12 days with a 24-h pretreatment of 3.2 mg/kg clocinnamox (n = 7). Right panels, effects of 20 mg/kg per day morphine treatment for 6 days alone or 12 days with a 24-h pretreatment of 10 mg/kg clocinnamox (n = 6). In all panels, open circles represent the effects of morphine alone in two tests conducted before clocinnamox or repeated morphine treatment. All dose-response curves after repeated morphine treatment were determined 36 h after the last morphine injection on day 6. Vertical lines represent S.E.M.
Figure 4
Clocinnamox antagonism of the stimulus and rate-decreasing effects of nalbuphine in normal (left panels) and morphine-tolerant rats (center and right panels) trained to discriminate 3.2 mg/kg morphine from saline. Ordinate, lower panels, saline control values ranged from 0.40 to 1.8 responses/s. Abscissae, cumulative doses of nalbuphine in milligrams per kilogram. Points above S represent the effects of a saline injection administered before the determination of the nalbuphine dose-response curves. Left panels, effects of 24-h pretreatment of 10 mg/kg clocinnamox in normal rats (n = 6). Center panels, effects of 10 mg/kg per day morphine treatment for 6 days alone or 12 days with a 24-h pretreatment of 3.2 mg/kg clocinnamox (n = 9). Right panels, effects of 10 mg/kg per day morphine treatment for 6 days alone or 12 days with a 24-h pretreatment of 10 mg/kg clocinnamox (n = 6). In all panels, open circles represent the effects of nalbuphine alone. Other details as in Fig. 1.
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