Table of Contents

June 2002; 301 (3)

PERSPECTIVES IN PHARMACOLOGY

    • Nick E. Goeders

    Stress and Cocaine Addiction

    J Pharmacol Exp Ther June 1, 2002 301:785-789; doi:10.1124/jpet.301.3.785
    • Billy R. Martin

    Identification of the Endogenous Cannabinoid System through Integrative Pharmacological Approaches

    J Pharmacol Exp Ther June 1, 2002 301:790-796; doi:10.1124/jpet.301.3.790

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

    • Atsushi Enomoto,
    • Michio Takeda,
    • Minoru Shimoda,
    • Shinichi Narikawa,
    • Yukari Kobayashi,
    • Yasuna Kobayashi,
    • Toshinori Yamamoto,
    • Takashi Sekine,
    • Seok Ho Cha,
    • Toshimitsu Niwa,
    • and Hitoshi Endou

    Interaction of Human Organic Anion Transporters 2 and 4 with Organic Anion Transport Inhibitors

    J Pharmacol Exp Ther June 1, 2002 301:797-802; doi:10.1124/jpet.301.3.797
    • Cathaleen Shu,
    • Hong Shen,
    • Nathan S. Teuscher,
    • Philip J. Lorenzi,
    • Richard F. Keep,
    • and David E. Smith

    Role of PEPT2 in Peptide/Mimetic Trafficking at the Blood-Cerebrospinal Fluid Barrier: Studies in Rat Choroid Plexus Epithelial Cells in Primary Culture

    J Pharmacol Exp Ther June 1, 2002 301:820-829; doi:10.1124/jpet.301.3.820
    • Nagendra S. Ningaraj,
    • Mamatha Rao,
    • Kazuhiro Hashizume,
    • Kamlesh Asotra,
    • and Keith L. Black

    Regulation of Blood-Brain Tumor Barrier Permeability by Calcium-Activated Potassium Channels

    J Pharmacol Exp Ther June 1, 2002 301:838-851; doi:10.1124/jpet.301.3.838
    • Chitra Sridar,
    • Ute M. Kent,
    • Lisa M. Notley,
    • Elizabeth M. J. Gillam,
    • and Paul F. Hollenberg

    Effect of Tamoxifen on the Enzymatic Activity of Human Cytochrome CYP2B6

    J Pharmacol Exp Ther June 1, 2002 301:945-952; doi:10.1124/jpet.301.3.945
    • Elizabeth Fox,
    • Peter M. Bungay,
    • John Bacher,
    • Cynthia L. McCully,
    • Robert L. Dedrick,
    • and Frank M. Balis

    Zidovudine Concentration in Brain Extracellular Fluid Measured by Microdialysis: Steady-State and Transient Results in Rhesus Monkey

    J Pharmacol Exp Ther June 1, 2002 301:1003-1011; doi:10.1124/jpet.301.3.1003
    • Camille P. Granvil,
    • Kristopher W. Krausz,
    • Harry V. Gelboin,
    • Jeffrey R. Idle,
    • and Frank J. Gonzalez

    4-Hydroxylation of Debrisoquine by Human CYP1A1 and Its Inhibition by Quinidine and Quinine

    J Pharmacol Exp Ther June 1, 2002 301:1025-1032; doi:10.1124/jpet.301.3.1025
    • Thomayant Prueksaritanont,
    • Jamie J. Zhao,
    • Bennett Ma,
    • Brad A. Roadcap,
    • Cuyue Tang,
    • Yue Qiu,
    • Lida Liu,
    • Jiunn H. Lin,
    • Paul G. Pearson,
    • and Thomas A. Baillie

    Mechanistic Studies on Metabolic Interactions between Gemfibrozil and Statins

    J Pharmacol Exp Ther June 1, 2002 301:1042-1051; doi:10.1124/jpet.301.3.1042
    • Daniel Y. Hung,
    • Ping Chang,
    • Kee Cheung,
    • Brett McWhinney,
    • Paul P. Masci,
    • Michael Weiss,
    • and Michael S. Roberts

    Cationic Drug Pharmacokinetics in Diseased Livers Determined by Fibrosis Index, Hepatic Protein Content, Microsomal Activity, and Nature of Drug

    J Pharmacol Exp Ther June 1, 2002 301:1079-1087; doi:10.1124/jpet.301.3.1079

CELLULAR AND MOLECULAR

    • Yutaro Obara,
    • Takashi Aoki,
    • Masayoshi Kusano,
    • and Yasushi Ohizumi

    β-Eudesmol Induces Neurite Outgrowth in Rat Pheochromocytoma Cells Accompanied by an Activation of Mitogen-Activated Protein Kinase

    J Pharmacol Exp Ther June 1, 2002 301:803-811; doi:10.1124/jpet.301.3.803
    • A. Banan,
    • J. Z. Fields,
    • A. Farhadi,
    • D. A. Talmage,
    • L. Zhang,
    • and A. Keshavarzian

    The β1 Isoform of Protein Kinase C Mediates the Protective Effects of Epidermal Growth Factor on the Dynamic Assembly of F-Actin Cytoskeleton and Normalization of Calcium Homeostasis in Human Colonic Cells

    J Pharmacol Exp Ther June 1, 2002 301:852-866; doi:10.1124/jpet.301.3.852
    • A. R. West,
    • H. Moore,
    • and A. A. Grace

    Direct Examination of Local Regulation of Membrane Activity in Striatal and Prefrontal Cortical Neurons in Vivo Using Simultaneous Intracellular Recording and Microdialysis

    J Pharmacol Exp Ther June 1, 2002 301:867-877; doi:10.1124/jpet.301.3.867
    • Ruth A. Ross,
    • Susan J. Craib,
    • Lesley A. Stevenson,
    • Roger G. Pertwee,
    • Andrea Henderson,
    • John Toole,
    • and Heather C. Ellington

    Pharmacological Characterization of the Anandamide Cyclooxygenase Metabolite: Prostaglandin E2 Ethanolamide

    J Pharmacol Exp Ther June 1, 2002 301:900-907; doi:10.1124/jpet.301.3.900
    • Youn J. Lee,
    • Annayya R. Aroor,
    • and Shivendra D. Shukla

    Temporal Activation of p42/44 Mitogen-Activated Protein Kinase and c-Jun N-Terminal Kinase by Acetaldehyde in Rat Hepatocytes and Its Loss after Chronic Ethanol Exposure

    J Pharmacol Exp Ther June 1, 2002 301:908-914; doi:10.1124/jpet.301.3.908
    • Shawn D. Spencer,
    • Oluseyi Abdul,
    • Robert J. Schulingkamp,
    • and Robert B. Raffa

    Toward the Design of Ribonuclease (RNase) Inhibitors: Ion Effects on the Thermodynamics of Binding of 2′-CMP to RNase A

    J Pharmacol Exp Ther June 1, 2002 301:925-929; doi:10.1124/jpet.301.3.925
    • Eugenia Bloch-Shilderman,
    • Saleh Abu-Raya,
    • Victoria Trembovler,
    • Hassia Boschwitz,
    • Arie Gruzman,
    • Michal Linial,
    • and Philip Lazarovici

    Pardaxin Stimulation of Phospholipases A2 and Their Involvement in Exocytosis in PC-12 Cells

    J Pharmacol Exp Ther June 1, 2002 301:953-962; doi:10.1124/jpet.301.3.953
    • Jan Jakubı́k,
    • Stanislav Tuček,
    • and Esam E. El-Fakahany

    Allosteric Modulation by Persistent Binding of Xanomeline of the Interaction of Competitive Ligands with the M1 Muscarinic Acetylcholine Receptor

    J Pharmacol Exp Ther June 1, 2002 301:1033-1041; doi:10.1124/jpet.301.3.1033
    • E. E. Daniel,
    • T. J. Bowes,
    • and J. Jury

    Roles of Guanylate Cyclase in Responses to Myogenic and Neural Nitric Oxide in Canine Lower Esophageal Sphincter

    J Pharmacol Exp Ther June 1, 2002 301:1111-1118; doi:10.1124/jpet.301.3.1111

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

    • Hidekazu Toyobuku,
    • Yoshimichi Sai,
    • Ikumi Tamai,
    • and Akira Tsuji

    Enhanced Delivery of Drugs to the Liver by Adenovirus-Mediated Heterologous Expression of the Human Oligopeptide Transporter PEPT1

    J Pharmacol Exp Ther June 1, 2002 301:812-819; doi:10.1124/jpet.301.3.812

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

    • Eleni Papakonstantinou,
    • Michael Roth,
    • Michael Tamm,
    • Oliver Eickelberg,
    • Andre P. Perruchoud,
    • and George Karakiulakis

    Hypoxia Differentially Enhances the Effects of Transforming Growth Factor-β Isoforms on the Synthesis and Secretion of Glycosaminoglycans by Human Lung Fibroblasts

    J Pharmacol Exp Ther June 1, 2002 301:830-837; doi:10.1124/jpet.301.3.830
    • Brian J. Dewar,
    • Blair U. Bradford,
    • and Ronald G. Thurman

    Nicotine Increases Hepatic Oxygen Uptake in the Isolated Perfused Rat Liver by Inhibiting Glycolysis

    J Pharmacol Exp Ther June 1, 2002 301:930-937; doi:10.1124/jpet.301.3.930
    • Brigitta M. Peskar,
    • Karlheinz Ehrlich,
    • and Bernhard A. Peskar

    Role of ATP-Sensitive Potassium Channels in Prostaglandin-Mediated Gastroprotection in the Rat

    J Pharmacol Exp Ther June 1, 2002 301:969-974; doi:10.1124/jpet.301.3.969
    • Timothy D. Westfall,
    • Gerald P. McCafferty,
    • Mark Pullen,
    • Susan Gruver,
    • Anthony C. Sulpizio,
    • V. Nambi Aiyar,
    • Jyoti Disa,
    • Lisa C. Contino,
    • Ishrat J. Mannan,
    • and J. Paul Hieble

    Characterization of Neuromedin U Effects in Canine Smooth Muscle

    J Pharmacol Exp Ther June 1, 2002 301:987-992; doi:10.1124/jpet.301.3.987
    • R. J. Kok,
    • R. F. G. Haverdings,
    • F. Grijpstra,
    • J. Koiter,
    • F. Moolenaar,
    • D. de Zeeuw,
    • and D. K. F. Meijer

    Targeting of Captopril to the Kidney Reduces Renal Angiotensin-Converting Enzyme Activity without Affecting Systemic Blood Pressure

    J Pharmacol Exp Ther June 1, 2002 301:1139-1143; doi:10.1124/jpet.301.3.1139

ENDOCRINE AND REPRODUCTIVE

    • T. J. McCarthy,
    • W. A. Banks,
    • C. L. Farrell,
    • S. Adamu,
    • C. P. Derdeyn,
    • A. Z. Snyder,
    • R. Laforest,
    • D. C. Litzinger,
    • D. Martin,
    • C. P. LeBel,
    • and M. J. Welch

    Positron Emission Tomography Shows that Intrathecal Leptin Reaches the Hypothalamus in Baboons

    J Pharmacol Exp Ther June 1, 2002 301:878-883; doi:10.1124/jpet.301.3.878

TOXICOLOGY

    • Martijn Rooseboom,
    • Gerben Schaaf,
    • Jan N. M. Commandeur,
    • Nico P. E. Vermeulen,
    • and Johanna Fink-Gremmels

    β-Lyase-Dependent Attenuation of Cisplatin-Mediated Toxicity by Selenocysteine Se-Conjugates in Renal Tubular Cell Lines

    J Pharmacol Exp Ther June 1, 2002 301:884-892; doi:10.1124/jpet.301.3.884
    • Elizabeth C. Brown,
    • Daniel S. Perrien,
    • Terry W. Fletcher,
    • David J. Irby,
    • James Aronson,
    • Guan G. Gao,
    • William J. Hogue,
    • Robert A. Skinner,
    • Larry J. Suva,
    • Martin J. J. Ronis,
    • Reza Hakkak,
    • Thomas M. Badger,
    • and Charles K. Lumpkin, Jr.

    Skeletal Toxicity Associated with Chronic Ethanol Exposure in a Rat Model Using Total Enteral Nutrition

    J Pharmacol Exp Ther June 1, 2002 301:1132-1138; doi:10.1124/jpet.301.3.1132

CARDIOVASCULAR

    • Susan Ji,
    • Toshimasa Tosaka,
    • Bernard H. Whitfield,
    • Alexander N. Katchman,
    • Abdurrahman Kandil,
    • Bjoern C. Knollmann,
    • and Steven N. Ebert

    Differential Rate Responses to Nicotine in Rat Heart: Evidence for Two Classes of Nicotinic Receptors

    J Pharmacol Exp Ther June 1, 2002 301:893-899; doi:10.1124/jpet.301.3.893
    • Hong Yan Zhang,
    • Bradley C. McPherson,
    • Huiping Liu,
    • Timir Baman,
    • Steven S. McPherson,
    • Peter Rock,
    • and Zhenhai Yao

    Role of Nitric-Oxide Synthase, Free Radicals, and Protein Kinase C δ in Opioid-Induced Cardioprotection

    J Pharmacol Exp Ther June 1, 2002 301:1012-1019; doi:10.1124/jpet.301.3.1012
    • Luke J. Janssen and
    • Tracy Tazzeo

    Involvement of TP and EP3 Receptors in Vasoconstrictor Responses to Isoprostanes in Pulmonary Vasculature

    J Pharmacol Exp Ther June 1, 2002 301:1060-1066; doi:10.1124/jpet.301.3.1060
    • James K. Hennan,
    • Ting-Ting Hong,
    • Ardamanpal K. Shergill,
    • Edward M. Driscoll,
    • Alan D. Cardin,
    • and Benedict R. Lucchesi

    Intimatan Prevents Arterial and Venous Thrombosis in a Canine Model of Deep Vessel Wall Injury

    J Pharmacol Exp Ther June 1, 2002 301:1151-1156; doi:10.1124/jpet.301.3.1151

BEHAVIORAL PHARMACOLOGY

    • S. A. Varvel and
    • A. H. Lichtman

    Evaluation of CB1 Receptor Knockout Mice in the Morris Water Maze

    J Pharmacol Exp Ther June 1, 2002 301:915-924; doi:10.1124/jpet.301.3.915
    • Kelly P. Cosgrove and
    • Marilyn E. Carroll

    Effects of Bremazocine on Self-Administration of Smoked Cocaine Base and Orally Delivered Ethanol, Phencyclidine, Saccharin, and Food in Rhesus Monkeys: A Behavioral Economic Analysis

    J Pharmacol Exp Ther June 1, 2002 301:993-1002; doi:10.1124/jpet.301.3.993

NEUROPHARMACOLOGY

    • Adam W. Hendricson,
    • C. L. Alek Miao,
    • Melanie J. Lippmann,
    • and Richard A. Morrisett

    Ifenprodil and Ethanol Enhance NMDA Receptor-Dependent Long-Term Depression

    J Pharmacol Exp Ther June 1, 2002 301:938-944; doi:10.1124/jpet.301.3.938
    • S. M. Rawls,
    • Jose Cabassa,
    • Ellen B. Geller,
    • and Martin W. Adler

    CB1 Receptors in the Preoptic Anterior Hypothalamus Regulate WIN 55212-2 [(4,5-Dihydro-2-methyl-4(4-morpholinylmethyl)-1-(1-naphthalenyl-carbonyl)-6H-pyrrolo[3,2,1ij]quinolin-6-one]-Induced Hypothermia

    J Pharmacol Exp Ther June 1, 2002 301:963-968; doi:10.1124/jpet.301.3.963
    • Herbert M. Himmel,
    • Thomas Kiss,
    • Sebestyén J. Borvendeg,
    • Clemens Gillen,
    • and Peter Illes

    The Arginine-Rich Hexapeptide R4W2 Is a Stereoselective Antagonist at the Vanilloid Receptor 1: A Ca2+ Imaging Study in Adult Rat Dorsal Root Ganglion Neurons

    J Pharmacol Exp Ther June 1, 2002 301:981-986; doi:10.1124/jpet.301.3.981
    • Amy C. Porter,
    • John-Michael Sauer,
    • Michael D. Knierman,
    • Gerald W. Becker,
    • Michael J. Berna,
    • Jingqi Bao,
    • George G. Nomikos,
    • Petra Carter,
    • Frank P. Bymaster,
    • Andrea Baker Leese,
    • and Christian C. Felder

    Characterization of a Novel Endocannabinoid, Virodhamine, with Antagonist Activity at the CB1 Receptor

    J Pharmacol Exp Ther June 1, 2002 301:1020-1024; doi:10.1124/jpet.301.3.1020
    • Francisco Sala,
    • José Mulet,
    • Seok Choi,
    • Se-Yeon Jung,
    • Seung-Yeol Nah,
    • Hyewhon Rhim,
    • Luis Miguel Valor,
    • Manuel Criado,
    • and Salvador Sala

    Effects of Ginsenoside Rg2 on Human Neuronal Nicotinic Acetylcholine Receptors

    J Pharmacol Exp Ther June 1, 2002 301:1052-1059; doi:10.1124/jpet.301.3.1052
    • Badia Ferzaz,
    • Emmanuel Brault,
    • Genevieve Bourliaud,
    • Jean-Pierre Robert,
    • Gilles Poughon,
    • Yves Claustre,
    • Franck Marguet,
    • Philippe Liere,
    • Michael Schumacher,
    • Jean-Pierre Nowicki,
    • Jacqueline Fournier,
    • Benoit Marabout,
    • Mireille Sevrin,
    • Pascal George,
    • Philippe Soubrie,
    • Jesus Benavides,
    • and Bernard Scatton

    SSR180575 (7-Chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide), a Peripheral Benzodiazepine Receptor Ligand, Promotes Neuronal Survival and Repair

    J Pharmacol Exp Ther June 1, 2002 301:1067-1078; doi:10.1124/jpet.301.3.1067
    • Lincoln H. Wilkins, Jr.,
    • Aaron Haubner,
    • Joshua T. Ayers,
    • Peter A. Crooks,
    • and Linda P. Dwoskin

    N-n-Alkylnicotinium Analogs, A Novel Class of Nicotinic Receptor Antagonist: Inhibition ofS(−)-Nicotine-Evoked [3H]Dopamine Overflow from Superfused Rat Striatal Slices

    J Pharmacol Exp Ther June 1, 2002 301:1088-1096; doi:10.1124/jpet.301.3.1088
    • Eugen Davids,
    • Kehong Zhang,
    • Nora S. Kula,
    • Frank I. Tarazi,
    • and Ross J. Baldessarini

    Effects of Norepinephrine and Serotonin Transporter Inhibitors on Hyperactivity Induced by Neonatal 6-Hydroxydopamine Lesioning in Rats

    J Pharmacol Exp Ther June 1, 2002 301:1097-1102; doi:10.1124/jpet.301.3.1097
    • Stacy L. Sell and
    • Charles P. France

    Cocaine and Amphetamine Attenuate the Discriminative Stimulus Effects of Naltrexone in Opioid-Dependent Rhesus Monkeys

    J Pharmacol Exp Ther June 1, 2002 301:1103-1110; doi:10.1124/jpet.301.3.1103
    • Xu-Feng Zhang,
    • Donald C. Cooper,
    • and Francis J. White

    Repeated Cocaine Treatment Decreases Whole-Cell Calcium Current in Rat Nucleus Accumbens Neurons

    J Pharmacol Exp Ther June 1, 2002 301:1119-1125; doi:10.1124/jpet.301.3.1119
    • Eugenii A. Rabiner,
    • Martin R. Wilkins,
    • Federico Turkheimer,
    • Roger N. Gunn,
    • Joanna Udo de Haes,
    • Michiel de Vries,
    • and Paul M. Grasby

    5-Hydroxytryptamine1A Receptor Occupancy by Novel Full Antagonist 2-[4-[4-(7-Chloro-2,3-dihydro-1,4-benzdioxyn-5-yl)-1-piperazinyl]butyl]-1,2-benzisothiazol-3-(2H)-one-1,1-dioxide: A [11C][O-methyl-3H]-N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide Trihydrochloride (WAY-100635) Positron Emission Tomography Study in Humans

    J Pharmacol Exp Ther June 1, 2002 301:1144-1150; doi:10.1124/jpet.301.3.1144
    • David M. Mottola,
    • Jason D. Kilts,
    • Mechelle M. Lewis,
    • Hilary S. Connery,
    • Q. David Walker,
    • Sara R. Jones,
    • Raymond G. Booth,
    • Deborah K. Hyslop,
    • Monford Piercey,
    • R. Mark Wightman,
    • Cindy P. Lawler,
    • David E. Nichols,
    • and Richard B. Mailman

    Functional Selectivity of Dopamine Receptor Agonists. I. Selective Activation of Postsynaptic Dopamine D2 Receptors Linked to Adenylate Cyclase

    J Pharmacol Exp Ther June 1, 2002 301:1166-1178; doi:10.1124/jpet.301.3.1166
    • Jason D. Kilts,
    • Hilary S. Connery,
    • Elaine G. Arrington,
    • Mechelle M. Lewis,
    • Cindy P. Lawler,
    • Gerry S. Oxford,
    • Karen L. O'Malley,
    • Richard D. Todd,
    • Bonita L. Blake,
    • David E. Nichols,
    • and Richard B. Mailman

    Functional Selectivity of Dopamine Receptor Agonists. II. Actions of Dihydrexidine in D2L Receptor-Transfected MN9D Cells and Pituitary Lactotrophs

    J Pharmacol Exp Ther June 1, 2002 301:1179-1189; doi:10.1124/jpet.301.3.1179
    • Michael H. Baumann,
    • Mario A. Ayestas,
    • Lawrence G. Sharpe,
    • David B. Lewis,
    • Kenner C. Rice,
    • and Richard B. Rothman

    Persistent Antagonism of Methamphetamine-Induced Dopamine Release in Rats Pretreated with GBR12909 Decanoate

    J Pharmacol Exp Ther June 1, 2002 301:1190-1197; doi:10.1124/jpet.301.3.1190

INFLAMMATION AND IMMUNOPHARMACOLOGY

    • Sergio Pablo Sardi,
    • Verónica Rey-Ares,
    • Virginia Andrea Pujol-Lereis,
    • Santiago Alejo Serrano,
    • and Rodolfo Pedro Rothlin

    Further Pharmacological Evidence of Nuclear Factor-κB Pathway Involvement in Bradykinin B1 Receptor-Sensitized Responses in Human Umbilical Vein

    J Pharmacol Exp Ther June 1, 2002 301:975-980; doi:10.1124/jpet.301.3.975
    • Seung Joon Baek,
    • Leigh C. Wilson,
    • Chang-Ho Lee,
    • and Thomas E. Eling

    Dual Function of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Inhibition of Cyclooxygenase and Induction of NSAID-Activated Gene

    J Pharmacol Exp Ther June 1, 2002 301:1126-1131; doi:10.1124/jpet.301.3.1126
    • Kenji Okajima,
    • Naoaki Harada,
    • and Mitsuhiro Uchiba

    Ranitidine Reduces Ischemia/Reperfusion-Induced Liver Injury in Rats by Inhibiting Neutrophil Activation

    J Pharmacol Exp Ther June 1, 2002 301:1157-1165; doi:10.1124/jpet.301.3.1157
« Previous | Next Issue »

This Issue

June 2002; 301 (3)
Cover
  1. PERSPECTIVES IN PHARMACOLOGY
  2. ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  3. CELLULAR AND MOLECULAR
  4. CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
  5. GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  6. ENDOCRINE AND REPRODUCTIVE
  7. TOXICOLOGY
  8. CARDIOVASCULAR
  9. BEHAVIORAL PHARMACOLOGY
  10. NEUROPHARMACOLOGY
  11. INFLAMMATION AND IMMUNOPHARMACOLOGY

Find articles in this issue containing these words:

Current Issue

  1. November 2009, 331 (2)
  1. Current Issue
  1. Alert me to new issues of JPET