Table of Contents

January 2002; 300 (1)

ANNOUNCEMENT

    • S. J. Enna

    On-Line Submission and Review

    J Pharmacol Exp Ther January 1, 2002 300:1; doi:10.1124/jpet.300.1.1

PERSPECTIVES IN PHARMACOLOGY

    • H. Möhler,
    • J. M. Fritschy,
    • and U. Rudolph

    A New Benzodiazepine Pharmacology

    J Pharmacol Exp Ther January 1, 2002 300:2-8; doi:10.1124/jpet.300.1.2

CELLULAR AND MOLECULAR

    • Elfrida R. Grant,
    • Adrienne E. Dubin,
    • Sui-Po Zhang,
    • Robert A. Zivin,
    • and Zhong Zhong

    Simultaneous Intracellular Calcium and Sodium Flux Imaging in Human Vanilloid Receptor 1 (VR1)-Transfected Human Embryonic Kidney Cells: A Method to Resolve Ionic Dependence of VR1-Mediated Cell Death

    J Pharmacol Exp Ther January 1, 2002 300:9-17; doi:10.1124/jpet.300.1.9
    • Gerald F. Davies,
    • Pamela J. McFie,
    • Ramji L. Khandelwal,
    • and William J. Roesler

    Unique Ability of Troglitazone to Up-Regulate Peroxisome Proliferator-Activated Receptor-γ Expression in Hepatocytes

    J Pharmacol Exp Ther January 1, 2002 300:72-77; doi:10.1124/jpet.300.1.72
    • Bruce A. Waldrop,
    • Diana Mastalerz,
    • Michael T. Piascik,
    • and Ginell R. Post

    α1B- and α1D-Adrenergic Receptors Exhibit Different Requirements for Agonist and Mitogen-Activated Protein Kinase Activation to Regulate Growth Responses in Rat 1 Fibroblasts

    J Pharmacol Exp Ther January 1, 2002 300:83-90; doi:10.1124/jpet.300.1.83
    • Jiefa Wang,
    • Lei Wang,
    • Jodi L. Anderson,
    • Nancy A. Schulte,
    • and Myron L. Toews

    Regulatory Properties of α1B-Adrenergic Receptors Defective in Coupling to Phosphoinositide Hydrolysis

    J Pharmacol Exp Ther January 1, 2002 300:134-141; doi:10.1124/jpet.300.1.134
    • John R. Traynor,
    • Mary J. Clark,
    • and Ann E. Remmers

    Relationship between Rate and Extent of G Protein Activation: Comparison between Full and Partial Opioid Agonists

    J Pharmacol Exp Ther January 1, 2002 300:157-161; doi:10.1124/jpet.300.1.157
    • William E. Courchesne

    Characterization of a Novel, Broad-Based Fungicidal Activity for the Antiarrhythmic Drug Amiodarone

    J Pharmacol Exp Ther January 1, 2002 300:195-199; doi:10.1124/jpet.300.1.195
    • Douglas W. P. Hay,
    • Giuseppe A. M. Giardina,
    • Don E. Griswold,
    • David C. Underwood,
    • Charles J. Kotzer,
    • Brian Bush,
    • William Potts,
    • Punam Sandhu,
    • Dave Lundberg,
    • James J. Foley,
    • Dulcie B. Schmidt,
    • Lenox D. Martin,
    • David Kilian,
    • Jeffrey J. Legos,
    • Frank C. Barone,
    • Mark A. Luttmann,
    • Mario Grugni,
    • Luca F. Raveglia,
    • and Henry M. Sarau

    Nonpeptide Tachykinin Receptor Antagonists. III. SB 235375, a Low Central Nervous System-Penetrant, Potent and Selective Neurokinin-3 Receptor Antagonist, Inhibits Citric Acid-Induced Cough and Airways Hyper-reactivity in Guinea Pigs

    J Pharmacol Exp Ther January 1, 2002 300:314-323; doi:10.1124/jpet.300.1.314
    • Hung Wu,
    • Huang-Wei Shen,
    • Tin-Feng Wu,
    • Lawrence F. Brass,
    • and Kuo-Chun Sung

    Extracellular Signal-Regulated Kinases and G Protein-Coupled Receptors in Megakaryocytic Human Erythroleukemia Cells: Selective Activation, Differential Regulation, and Dissociation from Mitogenesis

    J Pharmacol Exp Ther January 1, 2002 300:339-345; doi:10.1124/jpet.300.1.339

TOXICOLOGY

    • Jie Liu,
    • Joseph E. Saavedra,
    • Tong Lu,
    • Jian-Guo Song,
    • James Clark,
    • Michael P. Waalkes,
    • and Larry K. Keefer

    O 2-Vinyl 1-(Pyrrolidin-1-yl)diazen-1-ium-1,2-diolate Protection Againstd-Galactosamine/Endotoxin-Induced Hepatotoxicity in Mice: Genomic Analysis Using Microarrays

    J Pharmacol Exp Ther January 1, 2002 300:18-25; doi:10.1124/jpet.300.1.18
    • Robert G. Pendleton,
    • Feroz Parvez,
    • Marwa Sayed,
    • and Ralph Hillman

    Effects of Pharmacological Agents upon a Transgenic Model of Parkinson's Disease in Drosophila melanogaster

    J Pharmacol Exp Ther January 1, 2002 300:91-96; doi:10.1124/jpet.300.1.91
    • Nathan J. Cherrington,
    • Dylan P. Hartley,
    • Ning Li,
    • David R. Johnson,
    • and Curtis D. Klaassen

    Organ Distribution of Multidrug Resistance Proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and Hepatic Induction of Mrp3 by Constitutive Androstane Receptor Activators in Rats

    J Pharmacol Exp Ther January 1, 2002 300:97-104; doi:10.1124/jpet.300.1.97
    • Tara Sankar Roy,
    • Frederic J. Seidler,
    • and Theodore A. Slotkin

    Prenatal Nicotine Exposure Evokes Alterations of Cell Structure in Hippocampus and Somatosensory Cortex

    J Pharmacol Exp Ther January 1, 2002 300:124-133; doi:10.1124/jpet.300.1.124
    • Danyelle M. Townsend and
    • Marie H. Hanigan

    Inhibition of γ-Glutamyl Transpeptidase or CysteineS-Conjugate β-Lyase Activity Blocks the Nephrotoxicity of Cisplatin in Mice

    J Pharmacol Exp Ther January 1, 2002 300:142-148; doi:10.1124/jpet.300.1.142
    • James V. Bruckner,
    • Raghupathy Ramanathan,
    • K. Monica Lee,
    • and Srinivasa Muralidhara

    Mechanisms of Circadian Rhythmicity of Carbon Tetrachloride Hepatotoxicity

    J Pharmacol Exp Ther January 1, 2002 300:273-281; doi:10.1124/jpet.300.1.273

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

    • Tatiana Nanovskaya,
    • Sujal Deshmukh,
    • Monica Brooks,
    • and Mahmoud S. Ahmed

    Transplacental Transfer and Metabolism of Buprenorphine

    J Pharmacol Exp Ther January 1, 2002 300:26-33; doi:10.1124/jpet.300.1.26
    • Zhao-Qian Liu,
    • Bing Zhu,
    • Yun-Fu Tan,
    • Zhi-Rong Tan,
    • Lian-Sheng Wang,
    • Song-Lin Huang,
    • Yan Shu,
    • and Hong-Hao Zhou

    O-Dealkylation of Fluoxetine in Relation toCYP2C19 Gene Dose and Involvement of CYP3A4 in Human Liver Microsomes

    J Pharmacol Exp Ther January 1, 2002 300:105-111; doi:10.1124/jpet.300.1.105
    • Grace L. Guo,
    • Supratim Choudhuri,
    • and Curtis D. Klaassen

    Induction Profile of Rat Organic Anion Transporting Polypeptide 2 (oatp2) by Prototypical Drug-Metabolizing Enzyme Inducers That Activate Gene Expression through Ligand-Activated Transcription Factor Pathways

    J Pharmacol Exp Ther January 1, 2002 300:206-212; doi:10.1124/jpet.300.1.206
    • Takanori Hashizume,
    • Susumu Imaoka,
    • Masashi Mise,
    • Yoshiaki Terauchi,
    • Toshihiko Fujii,
    • Hisashi Miyazaki,
    • Tetsuya Kamataki,
    • and Yoshihiko Funae

    Involvement of CYP2J2 and CYP4F12 in the Metabolism of Ebastine in Human Intestinal Microsomes

    J Pharmacol Exp Ther January 1, 2002 300:298-304; doi:10.1124/jpet.300.1.298
    • R. T. Meijer,
    • R. P. Koopmans,
    • I. J. M. ten Berge,
    • and P. T. A. Schellekens

    Pharmacokinetics of Murine Anti-Human CD3 Antibodies in Man Are Determined by the Disappearance of Target Antigen

    J Pharmacol Exp Ther January 1, 2002 300:346-353; doi:10.1124/jpet.300.1.346

NEUROPHARMACOLOGY

    • Nissar A. Darmani

    The Potent Emetogenic Effects of the Endocannabinoid, 2-AG (2-Arachidonoylglycerol) Are Blocked by Δ9-Tetrahydrocannabinol and Other Cannnabinoids

    J Pharmacol Exp Ther January 1, 2002 300:34-42; doi:10.1124/jpet.300.1.34
    • Daniela Rizzi,
    • Anna Rizzi,
    • Raffaella Bigoni,
    • Valeria Camarda,
    • Giuliano Marzola,
    • Remo Guerrini,
    • Carmela De Risi,
    • Domenico Regoli,
    • and Girolamo Calo'

    [Arg14,Lys15]Nociceptin, a Highly Potent Agonist of the Nociceptin/Orphanin FQ Receptor: in Vitro and in Vivo Studies

    J Pharmacol Exp Ther January 1, 2002 300:57-63; doi:10.1124/jpet.300.1.57
    • Lars Eckardt,
    • Günter Breithardt,
    • and Wilhelm Haverkamp

    Electrophysiologic Characterization of the Antipsychotic Drug Sertindole in a Rabbit Heart Model of Torsade de Pointes: Low Torsadogenic Potential Despite QT Prolongation

    J Pharmacol Exp Ther January 1, 2002 300:64-71; doi:10.1124/jpet.300.1.64
    • Chun-Su Yuan,
    • Gang Wei,
    • Joseph F. Foss,
    • Michael O'Connor,
    • Theodore Karrison,
    • and Joachim Osinski

    Effects of Subcutaneous Methylnaltrexone on Morphine-Induced Peripherally Mediated Side Effects: A Double-Blind Randomized Placebo-Controlled Trial

    J Pharmacol Exp Ther January 1, 2002 300:118-123; doi:10.1124/jpet.300.1.118
    • Zheng-Xiong Xi,
    • David A. Baker,
    • Hui Shen,
    • Daniel S. Carson,
    • and Peter W. Kalivas

    Group II Metabotropic Glutamate Receptors Modulate Extracellular Glutamate in the Nucleus Accumbens

    J Pharmacol Exp Ther January 1, 2002 300:162-171; doi:10.1124/jpet.300.1.162
    • Maryellen Fazen Eckenhoff,
    • Kin Chan,
    • and Roderic G. Eckenhoff

    Multiple Specific Binding Targets for Inhaled Anesthetics in the Mammalian Brain

    J Pharmacol Exp Ther January 1, 2002 300:172-179; doi:10.1124/jpet.300.1.172
    • Richard A. Houghtling and
    • Barbara M. Bayer

    Rapid Elevation of Plasma Interleukin-6 by Morphine Is Dependent on Autonomic Stimulation of Adrenal Gland

    J Pharmacol Exp Ther January 1, 2002 300:213-219; doi:10.1124/jpet.300.1.213
    • Cándido Hernández-López,
    • Magı́ Farré,
    • Pere N. Roset,
    • Esther Menoyo,
    • Nieves Pizarro,
    • Jordi Ortuño,
    • Marta Torrens,
    • Jordi Camı́,
    • and Rafael de la Torre

    3,4-Methylenedioxymethamphetamine (Ecstasy) and Alcohol Interactions in Humans: Psychomotor Performance, Subjective Effects, and Pharmacokinetics

    J Pharmacol Exp Ther January 1, 2002 300:236-244; doi:10.1124/jpet.300.1.236
    • Grace C. Rossi,
    • Michael Pellegrino,
    • Randi Shane,
    • Catherine A. Abbadie,
    • Jessica Dustman,
    • Charles Jimenez,
    • Richard J. Bodnar,
    • Gavril W. Pasternak,
    • and Richard G. Allen

    Characterization of Rat Prepro-Orphanin FQ/Nociceptin(154–181): Nociceptive Processing in Supraspinal Sites

    J Pharmacol Exp Ther January 1, 2002 300:257-264; doi:10.1124/jpet.300.1.257
    • Pal Riba,
    • Yong Ben,
    • Andrew P. Smith,
    • Susanna Furst,
    • and Nancy M. Lee

    Morphine Tolerance in Spinal Cord Is Due to Interaction between μ- and δ-Receptors

    J Pharmacol Exp Ther January 1, 2002 300:265-272; doi:10.1124/jpet.300.1.265
    • Carolyn A. Fairbanks,
    • Laura S. Stone,
    • Kelley F. Kitto,
    • H. Oanh Nguyen,
    • Ivan J. Posthumus,
    • and George L. Wilcox

    α2C-Adrenergic Receptors Mediate Spinal Analgesia and Adrenergic-Opioid Synergy

    J Pharmacol Exp Ther January 1, 2002 300:282-290; doi:10.1124/jpet.300.1.282
    • J. Pintor,
    • A. Peral,
    • C. H. V. Hoyle,
    • C. Redick,
    • J. Douglass,
    • I. Sims,
    • and B. Yerxa

    Effects of Diadenosine Polyphosphates on Tear Secretion in New Zealand White Rabbits

    J Pharmacol Exp Ther January 1, 2002 300:291-297; doi:10.1124/jpet.300.1.291
    • Douglas J. Pettibone,
    • J. Fred Hess,
    • Patricia J. Hey,
    • Marlene A. Jacobson,
    • Michael Leviten,
    • Edward V. Lis,
    • Pierre J. Mallorga,
    • Danette M. Pascarella,
    • Melissa A. Snyder,
    • Jacinta B. Williams,
    • and Zhizhen Zeng

    The Effects of Deleting the Mouse Neurotensin Receptor NTR1 on Central and Peripheral Responses to Neurotensin

    J Pharmacol Exp Ther January 1, 2002 300:305-313; doi:10.1124/jpet.300.1.305
    • Klaas P. Zuideveld,
    • Nicoline Treijtel,
    • Hugo J. Maas,
    • Josy M. Gubbens-Stibbe,
    • Lambertus A. Peletier,
    • Piet H. van der Graaf,
    • and Meindert Danhof

    A Competitive Interaction Model Predicts the Effect of WAY-100,635 on the Time Course of R -(+)-8-Hydroxy-2-(di-n-propylamino)tetralin-Induced Hypothermia

    J Pharmacol Exp Ther January 1, 2002 300:330-338; doi:10.1124/jpet.300.1.330

CARDIOVASCULAR

    • Mostafa Khalid,
    • Norelyaquine Ilhami,
    • Yves Giudicelli,
    • and Jean-Pierre Dausse

    Testosterone Dependence of Salt-Induced Hypertension in Sabra Rats and Role of Renal α2-Adrenoceptor Subtypes

    J Pharmacol Exp Ther January 1, 2002 300:43-49; doi:10.1124/jpet.300.1.43
    • Priya Venkatesan,
    • Jijiang Wang,
    • Cory Evans,
    • Mustapha Irnaten,
    • and David Mendelowitz

    Nociceptin Inhibits γ-Aminobutyric Acidergic Inputs to Cardiac Parasympathetic Neurons in the Nucleus Ambiguus

    J Pharmacol Exp Ther January 1, 2002 300:78-82; doi:10.1124/jpet.300.1.78
    • Alain Deschamps,
    • Steven B. Backman,
    • Vera Novak,
    • Gilles Plourde,
    • Pierre Fiset,
    • and Daniel Chartrand

    Effects of the Anticholinesterase Edrophonium on Spectral Analysis of Heart Rate and Blood Pressure Variability in Humans

    J Pharmacol Exp Ther January 1, 2002 300:112-117; doi:10.1124/jpet.300.1.112
    • C. W. Schindler,
    • J. P. Gilman,
    • J. Bergman,
    • N. K. Mello,
    • R. L. Woosley,
    • and S. R. Goldberg

    Interactions between Cocaine and Dopamine Agonists on Cardiovascular Function in Squirrel Monkeys

    J Pharmacol Exp Ther January 1, 2002 300:180-187; doi:10.1124/jpet.300.1.180
    • Asifa Haider,
    • Rafal Olszanecki,
    • Richard Gryglewski,
    • Michal L. Schwartzman,
    • Elias Lianos,
    • Attallah Kappas,
    • Alberto Nasjletti,
    • and Nader G. Abraham

    Regulation of Cyclooxygenase by the Heme-Heme Oxygenase System in Microvessel Endothelial Cells

    J Pharmacol Exp Ther January 1, 2002 300:188-194; doi:10.1124/jpet.300.1.188
    • Chih-Chang Wei,
    • Carlos M. Ferrario,
    • K. Bridget Brosnihan,
    • Diane M. Farrell,
    • Wayne E. Bradley,
    • Ayad A. Jaffa,
    • and Louis J. Dell'Italia

    Angiotensin Peptides Modulate Bradykinin Levels in the Interstitium of the Dog Heart in Vivo

    J Pharmacol Exp Ther January 1, 2002 300:324-329; doi:10.1124/jpet.300.1.324

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

    • Christopher A. Warlick,
    • Michaeleen D. Diers,
    • John E. Wagner,
    • and R. Scott McIvor

    In Vivo Selection of Antifolate-Resistant Transgenic Hematopoietic Stem Cells in a Murine Bone Marrow Transplant Model

    J Pharmacol Exp Ther January 1, 2002 300:50-56; doi:10.1124/jpet.300.1.50
    • Patrizia Russo,
    • Cristina Ottoboni,
    • Davide Malacarne,
    • Alessandra Crippa,
    • Jean-Francois Riou,
    • and Patrick M. O'Connor

    Nonpeptidomimetic Farnesyltransferase Inhibitor RPR-115135 Increases Cytotoxicity of 5-Fluorouracil: Role of p53

    J Pharmacol Exp Ther January 1, 2002 300:220-226; doi:10.1124/jpet.300.1.220

INFLAMMATION AND IMMUNOPHARMACOLOGY

    • Liping Zhang,
    • Ying Lu,
    • Ying Chen,
    • and Karin N. Westlund

    Group I Metabotropic Glutamate Receptor Antagonists Block Secondary Thermal Hyperalgesia in Rats with Knee Joint Inflammation

    J Pharmacol Exp Ther January 1, 2002 300:149-156; doi:10.1124/jpet.300.1.149
    • Tohru Noji,
    • Makoto Takayama,
    • Mirai Mizutani,
    • Yuko Okamura,
    • Haruki Takai,
    • Akira Karasawa,
    • and Hideaki Kusaka

    KF24345, an Adenosine Uptake Inhibitor, Suppresses Lipopolysaccharide-Induced Tumor Necrosis Factor-α Production and Leukopenia via Endogenous Adenosine in Mice

    J Pharmacol Exp Ther January 1, 2002 300:200-205; doi:10.1124/jpet.300.1.200
    • Hideo Kohka Takahashi,
    • Atsushi Yoshida,
    • Hiromi Iwagaki,
    • Tadashi Yoshino,
    • Hideyuki Itoh,
    • Toshihiko Morichika,
    • Minori Yokoyama,
    • Tadaatsu Akagi,
    • Noriaki Tanaka,
    • Shuji Mori,
    • and Masahiro Nishibori

    Histamine Regulation of Interleukin-18-Initiating Cytokine Cascade Is Associated with Down-Regulation of Intercellular Adhesion Molecule-1 Expression in Human Peripheral Blood Mononuclear Cells

    J Pharmacol Exp Ther January 1, 2002 300:227-235; doi:10.1124/jpet.300.1.227
    • Rohini Ramakrishnan,
    • Debra C. DuBois,
    • Richard R. Almon,
    • Nancy A. Pyszczynski,
    • and William J. Jusko

    Pharmacodynamics and Pharmacogenomics of Methylprednisolone during 7-Day Infusions in Rats

    J Pharmacol Exp Ther January 1, 2002 300:245-256; doi:10.1124/jpet.300.1.245
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This Issue

January 2002; 300 (1)
Cover
  1. ANNOUNCEMENT
  2. PERSPECTIVES IN PHARMACOLOGY
  3. CELLULAR AND MOLECULAR
  4. TOXICOLOGY
  5. ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  6. NEUROPHARMACOLOGY
  7. CARDIOVASCULAR
  8. CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
  9. INFLAMMATION AND IMMUNOPHARMACOLOGY

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