Abstract
1. All barbituric acid derivatives tested caused loss of tonus of the excised strips of intestine, uterus and ureters.
2. Sodium benzyl succinate and sodium dibenzyl phosphate although possessing some tonus relaxing properties are not as effective as the barbituric acid derivatives.
3. Change in pH of the fluid bathing the tissue is an important factor in the response of the tissue to drugs and must be considered in studying the action of drugs upon all excised strips of tissue.
4. Decreased pH of the fluid bathing the strips of intestine, uterus and ureters causes a lowered tonus and may cause it to disappear entirely. Increasing the pH results in heightened tonus of these same tissues.
Footnotes
- Received September 13, 1926.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.