Table of Contents

• Andrea D. Eckhart and
• Walter J. Koch

Transgenic Studies of Cardiac Adrenergic Receptor Regulation

• Tinna M. Laughlin,
• Alice A. Larson,
• and George L. Wilcox

Mechanisms of Induction of Persistent Nociception by Dynorphin

• Darryle D. Schoepp

Unveiling the Functions of Presynaptic Metabotropic Glutamate Receptors in the Central Nervous System

• Edward J. Wagner,
• Oline K. Rønnekleiv,
• and Martin J. Kelly

The Noradrenergic Inhibition of an Apamin-Sensitive, Small-Conductance Ca²⁺-Activated K⁺ Channel in Hypothalamic γ-Aminobutyric Acid Neurons: Pharmacology, Estrogen Sensitivity, and Relevance to the Control of the Reproductive Axis

• A. J. Williams,
• X. M. Lu,
• B. Slusher,
• and F. C. Tortella

Electroencephalogram Analysis and Neuroprotective Profile of theN-Acetylated-α-Linked Acidic Dipeptidase Inhibitor, GPI5232, in Normal and Brain-Injured Rats ,

• Laura Rauser,
• Jason E. Savage,
• Herbert Y. Meltzer,
• and Bryan L. Roth

Inverse Agonist Actions of Typical and Atypical Antipsychotic Drugs at the Human 5-Hydroxytryptamine_2C Receptor

• Elizabeth H. Kamp,
• Daniel R. Beck,
• and G. F. Gebhart

Combinations of Neurokinin Receptor Antagonists Reduce Visceral Hyperalgesia

• Rachel L. Peltier,
• Glenn F. Guerin,
• Nandakumar Dorairaj,
• and Nick E. Goeders

Effects of Saline Substitution on Responding and Plasma Corticosterone in Rats Trained to Self-Administer Different Doses of Cocaine

• Okan Cinkilic,
• Brian F. King,
• Markus van der Giet,
• Hartmut Schlüter,
• Walter Zidek,
• and Geoffrey Burnstock

Selective Agonism of Group I P2X Receptors by Dinucleotides Dependent on a Single Adenine Moiety

• Sharon L. Walsh,
• Beth Geter-Douglas,
• Eric C. Strain,
• and George E. Bigelow

Enadoline and Butorphanol: Evaluation of κ-Agonists on Cocaine Pharmacodynamics and Cocaine Self-Administration in Humans

• Kiyonori Kishimoto,
• Shin-Ichiro Matsuo,
• Yumiko Kanemoto,
• Hitoshi Ishibashi,
• Yasuo Oyama,
• and Norio Akaike

Nanomolar Concentrations of Tri-n-butyltin Facilitate γ-Aminobutyric Acidergic Synaptic Transmission in Rat Hypothalamic Neurons

• Gloria Lee,
• Lyanne Schlichter,
• Moise Bendayan,
• and Reina Bendayan

Functional Expression of P-glycoprotein in Rat Brain Microglia

• Makoto Inoue,
• Shinobu Matsunaga,
• M. Harunor Rashid,
• Akira Yoshida,
• Kiyonobu Mizuno,
• Tsukasa Sakurada,
• Hiroshi Takeshima,
• and Hiroshi Ueda

Pronociceptive Effects of Nociceptin/Orphanin FQ (13–17) at Peripheral and Spinal Level in Mice

• Lin Xu,
• Judith A. Enyeart,
• and John J. Enyeart

Neuroprotective Agent Riluzole Dramatically Slows Inactivation of Kv1.4 Potassium Channels by a Voltage-Dependent Oxidative Mechanism

• Munehiro Shiraishi,
• Kouichiro Minami,
• Yasuhito Uezono,
• Nobuyuki Yanagihara,
• and Akio Shigematsu

Inhibition by Tramadol of Muscarinic Receptor-Induced Responses in Cultured Adrenal Medullary Cells and in Xenopus laevis Oocytes Expressing Cloned M₁Receptors

• D. M. Weiner,
• E. S. Burstein,
• N. Nash,
• G. E. Croston,
• E. A. Currier,
• K. E. Vanover,
• S. C. Harvey,
• E. Donohue,
• H. C. Hansen,
• C. M. Andersson,
• T. A. Spalding,
• D. F. C. Gibson,
• K. Krebs-Thomson,
• S. B. Powell,
• M. A. Geyer,
• U. Hacksell,
• and M. R. Brann

5-Hydroxytryptamine_2A Receptor Inverse Agonists as Antipsychotics

• Gregory G. Blakley,
• Larissa A. Pohorecky,
• and Daniel Benjamin

Bidirectional Changes in Ethanol Consumption in Rats with Site-Specific Antisense Down-Regulation of 5-Hydroxytryptamine_2A Receptors in Brain

• Bruno Bontempi,
• Kevin T. Whelan,
• Victoria B. Risbrough,
• Tadimeti S. Rao,
• Jerry J. Buccafusco,
• G. Kenneth Lloyd,
• and Frédérique Menzaghi

SIB-1553A, (±)-4-{[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio}phenol Hydrochloride, a Subtype-Selective Ligand for Nicotinic Acetylcholine Receptors with Putative Cognitive-Enhancing Properties: Effects on Working and Reference Memory Performances in Aged Rodents and Nonhuman Primates

• Thierry Canton,
• Georg Andrees Böhme,
• Alain Boireau,
• Françoise Bordier,
• Serge Mignani,
• Patrick Jimonet,
• Ghafoor Jahn,
• Mohammad Alavijeh,
• James Stygall,
• Simon Roberts,
• Clive Brealey,
• Marc Vuilhorgne,
• Marc-William Debono,
• Sylvain Le Guern,
• Michel Laville,
• Dominique Briet,
• Michel Roux,
• Jean-Marie Stutzmann,
• and Jeremy Pratt

RPR 119990, a Novel α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Antagonist: Synthesis, Pharmacological Properties, and Activity in an Animal Model of Amyotrophic Lateral Sclerosis

• Irina Fedorova,
• Akihiro Hashimoto,
• Robert A. Fecik,
• Michael P. Hedrick,
• Lumı́r O. Hanuš,
• Dale L. Boger,
• Kenner C. Rice,
• and Anthony S. Basile

Behavioral Evidence for the Interaction of Oleamide with Multiple Neurotransmitter Systems

• Yingxian Xiao,
• Richard D. Smith,
• Frank S. Caruso,
• and Kenneth J. Kellar

Blockade of Rat α3β4 Nicotinic Receptor Function by Methadone, Its Metabolites, and Structural Analogs

• So Young Seo,
• Bong-Sik Yun,
• In-Ja Ryoo,
• Jun-Sub Choi,
• Choun-Ki Joo,
• Su-Youne Chang,
• Jun-Mo Chung,
• Seikwan Oh,
• Byoung Joo Gwag,
• and Ick Dong Yoo

Complestatin Is a Noncompetitive Peptide Antagonist of N-Methyl-d-aspartate and α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/Kainate Receptors: Secure Blockade of Ischemic Neuronal Death

• Sean K. Kelley,
• Louise A. Harris,
• David Xie,
• Laura DeForge,
• Klara Totpal,
• Jeanine Bussiere,
• and Judith A. Fox

Preclinical Studies to Predict the Disposition of Apo2L/Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand in Humans: Characterization of in Vivo Efficacy, Pharmacokinetics, and Safety

• Cheng-Chung Tsao,
• Sherry J. Coulter,
• Anna Chien,
• Gang Luo,
• Natasha P. Clayton,
• Robert Maronpot,
• Joyce A. Goldstein,
• and Darryl C. Zeldin

Identification and Localization of Five CYP2Cs in Murine Extrahepatic Tissues and Their Metabolism of Arachidonic Acid to Regio- and Stereoselective Products

• Ayako Takeuchi,
• Satohiro Masuda,
• Hideyuki Saito,
• Takaaki Abe,
• and Ken-ichi Inui

Multispecific Substrate Recognition of Kidney-Specific Organic Anion Transporters OAT-K1 and OAT-K2

• Uwe Wenzel,
• Sabine Kuntz,
• and Hannelore Daniel

Flavonoids with Epidermal Growth Factor-Receptor Tyrosine Kinase Inhibitory Activity Stimulate PEPT1-Mediated Cefixime Uptake into Human Intestinal Epithelial Cells

• Yan Shu,
• Carlo L. Bello,
• Lara M. Mangravite,
• Bo Feng,
• and Kathleen M. Giacomini

Functional Characteristics and Steroid Hormone-Mediated Regulation of an Organic Cation Transporter in Madin-Darby Canine Kidney Cells

• Beverley Greenwood-Van Meerveld,
• Kalina Venkova,
• and James C. Keith, Jr.

Recombinant Human Interleukin-11 Restores Smooth Muscle Function in the Jejunum and Colon of Human Leukocyte Antigen-B27 Rats with Intestinal Inflammation

• Wei Ming Sun,
• William L. Hasler,
• Han-Chung Lien,
• Jared Montague,
• and Chung Owyang

Nizatidine Enhances the Gastrocolonic Response and the Colonic Peristaltic Reflex in Humans

• Jan Taipalensuu,
• Hans Törnblom,
• Greger Lindberg,
• Curt Einarsson,
• Folke Sjöqvist,
• Håkan Melhus,
• Per Garberg,
• Brita Sjöström,
• Bo Lundgren,
• and Per Artursson

Correlation of Gene Expression of Ten Drug Efflux Proteins of the ATP-Binding Cassette Transporter Family in Normal Human Jejunum and in Human Intestinal Epithelial Caco-2 Cell Monolayers

• Alessandro Lecci,
• Francesca Carini,
• Manuela Tramontana,
• Vincenzo D'Aranno,
• Erica Marinoni,
• Attilio Crea,
• Lionel Bueno,
• Jean Fioramonti,
• Marco Criscuoli,
• Sandro Giuliani,
• and Carlo Alberto Maggi

Nepadutant Pharmacokinetics and Dose-Effect Relationships as Tachykinin NK₂ Receptor Antagonist Are Altered by Intestinal Inflammation in Rodent Models

• Nadeem R. Janjua,
• Thomas E. N. Jonassen,
• Susanna Langhoff,
• Klaus Thomsen,
• and Sten Christensen

Role of Sodium Depletion in Acute Antidiuretic Effect of Bendroflumethiazide in Rats with Nephrogenic Diabetes Insipidus

• Nancy J. Linford,
• Yaxiong Yang,
• David G. Cook,
• and Daniel M. Dorsa

Neuronal Apoptosis Resulting from High Doses of the Isoflavone Genistein: Role for Calcium and P42/44 Mitogen-Activated Protein Kinase

• Virgile Visentin,
• Nathalie Morin,
• Emi Fontana,
• Danielle Prévot,
• Jeremie Boucher,
• Isabelle Castan,
• Philippe Valet,
• Danica Grujic,
• and Christian Carpéné

Dual Action of Octopamine on Glucose Transport into Adipocytes: Inhibition via β₃-Adrenoceptor Activation and Stimulation via Oxidation by Amine Oxidases

• Thomas Suply,
• Odile Della Zuana,
• Valérie Audinot,
• Marianne Rodriguez,
• Philippe Beauverger,
• Jacques Duhault,
• Emmanuel Canet,
• Jean-Pierre Galizzi,
• Jean-Louis Nahon,
• Nigel Levens,
• and Jean A. Boutin

SLC-1 Receptor Mediates Effect of Melanin-Concentrating Hormone on Feeding Behavior in Rat: A Structure-Activity Study

• Habib R. Ansari,
• Shahid Husain,
• and Ata A. Abdel-Latif

Activation of p42/p44 Mitogen-Activated Protein Kinase and Contraction by Prostaglandin F_2α, Ionomycin, and Thapsigargin in Cat Iris Sphincter Smooth Muscle: Inhibition by PD98059, KN-93, and Isoproterenol

• Edward F. Nemeth,
• Eric G. Delmar,
• William L. Heaton,
• Michael A. Miller,
• Lyssa D. Lambert,
• Rebecca L. Conklin,
• Maxine Gowen,
• John G. Gleason,
• Pradip K. Bhatnagar,
• and John Fox

Calcilytic Compounds: Potent and Selective Ca²⁺Receptor Antagonists That Stimulate Secretion of Parathyroid Hormone

• Michael J. Parker,
• Scott C. Harvey,
• and Charles W. Luetje

Determinants of Agonist Binding Affinity on Neuronal Nicotinic Receptor β Subunits

• Maria Wågberg,
• Anne-Heléne Jansson,
• Christer Westerlund,
• Ann-Margret Östlund-Lindqvist,
• Bengt Särnstrand,
• Håkan Bergstrand,
• and Knut Pettersson

N,N′-Diacetyl-l-cystine (DiNAC), the Disulphide Dimer of N-Acetylcysteine, Inhibits Atherosclerosis in WHHL Rabbits: Evidence for Immunomodulatory Agents as a New Approach to Prevent Atherosclerosis

• Scott Ferreira,
• William J. Crumb, Jr.,
• Carol G. Carlton,
• and Craig W. Clarkson

Effects of Cocaine and Its Major Metabolites on the HERG-Encoded Potassium Channel

• Jiesheng Kang,
• Xiao-Liang Chen,
• Lin Wang,
• and David Rampe

Interactions of the Antimalarial Drug Mefloquine with the Human Cardiac Potassium Channels KvLQT1/minK and HERG

• Richard D. Bukoski,
• Simoneque Shearin,
• William F. Jackson,
• and Mohan F. Pamarthi

Inhibition of Ca²⁺-Induced Relaxation by Oxidized Tungsten Wires and Paratungstate

• Hercule Hantz,
• Ajayi Adesuyi,
• and Oyekan Adebayo

Differential Effects of U46619 on Renal Regional Hemodynamics in the Rat: Involvement of Endothelin

• Richard L. Auten,
• Ricardo M. Richardson,
• John R. White,
• S. Nicholas Mason,
• Michael A. Vozzelli,
• and Mary H. Whorton

Nonpeptide CXCR2 Antagonist Prevents Neutrophil Accumulation in Hyperoxia-Exposed Newborn Rats

• Changlu Liu,
• Sandy J. Wilson,
• Chester Kuei,
• and Timothy W. Lovenberg

Comparison of Human, Mouse, Rat, and Guinea Pig Histamine H₄ Receptors Reveals Substantial Pharmacological Species Variation

• David G. Perregaux,
• Patricia McNiff,
• Ronald Laliberte,
• Natalie Hawryluk,
• Heather Peurano,
• Ethan Stam,
• Jim Eggler,
• Richard Griffiths,
• Mark A. Dombroski,
• and Christopher A. Gabel

Identification and Characterization of a Novel Class of Interleukin-1 Post-Translational Processing Inhibitors

• Michael J. Coffey,
• Susan M. Phare,
• and Marc Peters-Golden

Peroxynitrite-Induced Nitrotyrosination of Proteins Is Blocked by Direct 5-Lipoxygenase Inhibitor Zileuton

• Bruce S. Fischer,
• Danmei Qin,
• Kami Kim,
• and Thomas V. McDonald

Capsaicin Inhibits Jurkat T-Cell Activation by Blocking Calcium Entry Current I_CRAC

• Denis J. Dupré,
• Christian Le Gouill,
• Marek Rola-Pleszczynski,
• and Jana Staňková

Inverse Agonist Activity of Selected Ligands of Platelet-Activating Factor Receptor

Correction to “Actions of pyrethroid insecticides on sodium currents, action potentials, and contractile rhythm in isolated mammalian ventricular myocytes and perfused hearts”