Table of Contents

March 2001; 296 (3)

PERSPECTIVES IN PHARMACOLOGY

Select this article
- Karl K. Rozman and
- John Doull
The Role of Time as a Quantifiable Variable of Toxicity and the Experimental Conditions When Haber's c ×t Product Can Be Observed: Implications for Therapeutics
J Pharmacol Exp Ther March 1, 2001 296:663-668

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

Select this article
- Char-Chang Shieh,
- Jianlin Feng,
- Steven A. Buckner,
- Jorge D. Brioni,
- Michael J. Coghlan,
- James P. Sullivan,
- and Murali Gopalakrishnan
Functional Implication of Spare ATP-Sensitive K⁺Channels in Bladder Smooth Muscle Cells
J Pharmacol Exp Ther March 1, 2001 296:669-675
Select this article
- Shuichi Sato,
- Akiyoshi Ohtake,
- Hiroshi Matsushima,
- Chikashi Saitoh,
- Shinji Usuda,
- and Keiji Miyata
Pharmacological Effect of Tamsulosin in Relation to Dog Plasma and Tissue Concentrations: Prostatic and Urethral Retention Possibly Contributes to Uroselectivity of Tamsulosin
J Pharmacol Exp Ther March 1, 2001 296:697-703
Select this article
- Ganesh Prasanna,
- Adnan Dibas,
- Christina Hulet,
- and Thomas Yorio
Inhibition of Na⁺/K⁺-ATPase by Endothelin-1 in Human Nonpigmented Ciliary Epithelial Cells
J Pharmacol Exp Ther March 1, 2001 296:966-971
Select this article
- Rodney F. Minchin,
- Denise Carpenter,
- and Rebecca J. Orr
Polyinosinic Acid and Polycationic Liposomes Attenuate the Hepatic Clearance of Circulating Plasmid DNA
J Pharmacol Exp Ther March 1, 2001 296:1006-1012
Select this article
- Hiroyuki Konomi,
- Charmaine M. Woods,
- Adrian C. B. Meedeniya,
- Lynne C. Giles,
- James Toouli,
- and Gino T. P. Saccone
Effects of Diaspirin Cross-linked Hemoglobin on Motor Function of the Duodenum and Biliary System in the Australian Brush-Tailed Possum in Vivo
J Pharmacol Exp Ther March 1, 2001 296:1067-1073
Select this article
- Mahin D. Maines,
- James F. Ewing,
- Tian J. Huang,
- and Nariman Panahian
Nuclear Localization of Biliverdin Reductase in the Rat Kidney: Response to Nephrotoxins That Induce Heme Oxygenase-1
J Pharmacol Exp Ther March 1, 2001 296:1091-1097

CARDIOVASCULAR

Select this article
- Gaétan Thibault,
- Patrick Tardif,
- and Geneviève Lapalme
Comparative Specificity of Platelet α_IIbβ₃ Integrin Antagonists
J Pharmacol Exp Ther March 1, 2001 296:690-696
Select this article
- Jennifer C. Sullivan and
- Cathy A. Davison
Gender Differences in the Effect of Age on Electrical Field Stimulation (EFS)-Induced Adrenergic Vasoconstriction in Rat Mesenteric Resistance Arteries
J Pharmacol Exp Ther March 1, 2001 296:782-788
Select this article
- Mark E. Anderson,
- Alexander Mazur,
- Tao Yang,
- and Dan M. Roden
Potassium Current Antagonist Properties and Proarrhythmic Consequences of Quinolone Antibiotics
J Pharmacol Exp Ther March 1, 2001 296:806-810
Select this article
- Peter W. Stengel and
- Marlene L. Cohen
Low-Affinity M₂ Receptor Binding State Mediates Mouse Atrial Bradycardia: Comparative Effects of Carbamylcholine and the M₁ Receptor Agonists Sabcomeline and Xanomeline
J Pharmacol Exp Ther March 1, 2001 296:818-824
Select this article
- Sandra Filippi,
- Astrid Parenti,
- Sandra Donnini,
- Harris J. Granger,
- Alessandro Fazzini,
- and Fabrizio Ledda
α_1D-Adrenoceptors Cause Endothelium-Dependent Vasodilatation in the Rat Mesenteric Vascular Bed
J Pharmacol Exp Ther March 1, 2001 296:869-875
Select this article
- Manuela Tramontana,
- Alessandro Lecci,
- Stefania Meini,
- Xavier Montserrat,
- Jaume Pascual,
- Sandro Giuliani,
- Laura Quartara,
- and Carlo Alberto Maggi
Differences between Peptide and Nonpeptide B₂Bradykinin Receptor Antagonists in Blocking Bronchoconstriction and Hypotension Induced by Bradykinin in Anesthetized Guinea Pigs
J Pharmacol Exp Ther March 1, 2001 296:1051-1057
Select this article
- Chi Dae Kim,
- Hyung Hwan Kim,
- Yong Ki Kim,
- Yong Keun Kwak,
- Sun-Ok Kim,
- Sung-Eun Yoo,
- and Ki Whan Hong
Antiangiogenic Effect of KR31372 in Rat Sponge Implant Model
J Pharmacol Exp Ther March 1, 2001 296:1085-1090

CELLULAR AND MOLECULAR

Select this article
- Eugenia Bloch-Shilderman,
- Hao Jiang,
- Saleh Abu-Raya,
- Michal Linial,
- and Philip Lazarovici
Involvement of Extracellular Signal-Regulated Kinase (ERK) in Pardaxin-Induced Dopamine Release from PC12 Cells
J Pharmacol Exp Ther March 1, 2001 296:704-711
Select this article
- Sarinee Kalandakanond and
- Julie A. Coffield
Cleavage of Intracellular Substrates of Botulinum Toxins A, C, and D in a Mammalian Target Tissue
J Pharmacol Exp Ther March 1, 2001 296:749-755
Select this article
- Nambi Aiyar,
- Robert A. Daines,
- Jyoti Disa,
- Pamela A. Chambers,
- Charles F. Sauermelch,
- Marie-J. Quiniou,
- Nassirah Khandoudi,
- Bernard Gout,
- Stephen A. Douglas,
- and Robert N. Willette
Pharmacology of SB-273779, a Nonpeptide Calcitonin Gene-Related Peptide 1 Receptor Antagonist
J Pharmacol Exp Ther March 1, 2001 296:768-775
Select this article
- Suzanne Doolen and
- Nancy R. Zahniser
Protein Tyrosine Kinase Inhibitors Alter Human Dopamine Transporter Activity in Xenopus Oocytes
J Pharmacol Exp Ther March 1, 2001 296:931-938
Select this article
- A. D. Hibell,
- K. M. Thompson,
- M. Xing,
- P. P. A. Humphrey,
- and A. D. Michel
Complexities of Measuring Antagonist Potency at P2X₇Receptor Orthologs
J Pharmacol Exp Ther March 1, 2001 296:947-957
Select this article
- Sarinee Kalandakanond and
- Julie A. Coffield
Cleavage of SNAP-25 by Botulinum Toxin Type A Requires Receptor-Mediated Endocytosis, pH-Dependent Translocation, and Zinc
J Pharmacol Exp Ther March 1, 2001 296:980-986
Select this article
- Kelley L. Morse,
- Jiang Behan,
- Thomas M. Laz,
- Robert E. West, Jr.,
- Scott A. Greenfeder,
- John C. Anthes,
- Shelby Umland,
- Yuntao Wan,
- R. William Hipkin,
- Waldemar Gonsiorek,
- Niu Shin,
- Eric L. Gustafson,
- Xudong Qiao,
- Suke Wang,
- Joseph A. Hedrick,
- Jonathan Greene,
- Marvin Bayne,
- and Frederick J. Monsma, Jr.
Cloning and Characterization of a Novel Human Histamine Receptor
J Pharmacol Exp Ther March 1, 2001 296:1058-1066

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

Select this article
- Zhong-Ping Chen,
- Zhi-Min Wang,
- Christopher A. Carter,
- Michael C. Alley,
- Gérard Mohr,
- and Lawrence C. Panasci
Both Extraneuronal Monoamine Transporter and O ⁶ -Methylguanine-DNA Methyltransferase Expression Influence the Antitumor Efficacy of 2-Chloroethyl-3-sarcosinamide- 1-nitrosourea in Human Tumor Xenografts
J Pharmacol Exp Ther March 1, 2001 296:712-715
Select this article
- Yi Xu,
- W. Kent Hansen,
- Thomas A. Rosenquist,
- David A. Williams,
- Melissa Limp-Foster,
- and Mark R. Kelley
Protection of Mammalian Cells against Chemotherapeutic Agents Thiotepa, 1,3-N,N′-Bis(2-chloroethyl)-N-nitrosourea, and Mafosfamide Using the DNA Base Excision Repair Genes Fpg and α-hOgg1: Implications for Protective Gene Therapy Applications
J Pharmacol Exp Ther March 1, 2001 296:825-831
Select this article
- Stephanie L. Matheson,
- James McNamee,
- and Bertrand J. Jean-Claude
Design of a Chimeric 3-Methyl-1,2,3-triazene with Mixed Receptor Tyrosine Kinase and DNA Damaging Properties: A Novel Tumor Targeting Strategy
J Pharmacol Exp Ther March 1, 2001 296:832-840
Select this article
- Anthony E. Pegg,
- Karina Goodtzova,
- Natalia A. Loktionova,
- Sreenivas Kanugula,
- Gary T. Pauly,
- and Robert C. Moschel
Inactivation of HumanO ⁶-Alkylguanine-DNA Alkyltransferase by Modified Oligodeoxyribonucleotides Containing O ⁶-Benzylguanine
J Pharmacol Exp Ther March 1, 2001 296:958-965
Select this article
- Seong Hoon Jang,
- M. Guillaume Wientjes,
- and Jessie L.-S. Au
Enhancement of Paclitaxel Delivery to Solid Tumors by Apoptosis-Inducing Pretreatment: Effect of Treatment Schedule
J Pharmacol Exp Ther March 1, 2001 296:1035-1042

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Select this article
- Masayo Yamazaki,
- William E. Neway,
- Tomoyuki Ohe,
- I-Wu Chen,
- Janice F. Rowe,
- Jerome H. Hochman,
- Masato Chiba,
- and Jiunn H. Lin
In Vitro Substrate Identification Studies for P-glycoprotein-Mediated Transport: Species Difference and Predictability of in Vivo Results
J Pharmacol Exp Ther March 1, 2001 296:723-735
Select this article
- Leslie L. Muldoon,
- Shannan L. Walker-Rosenfeld,
- Christopher Hale,
- Shawna E. Purcell,
- Lisa C. Bennett,
- and Edward A. Neuwelt
Rescue from Enhanced Alkylator-Induced Cell Death with Low Molecular Weight Sulfur-Containing Chemoprotectants
J Pharmacol Exp Ther March 1, 2001 296:797-805
Select this article
- Richard S. Geary,
- Tanya A. Watanabe,
- LoAnne Truong,
- Sue Freier,
- Elena A. Lesnik,
- Namir B. Sioufi,
- Henri Sasmor,
- Muthiah Manoharan,
- and Arthur A. Levin
Pharmacokinetic Properties of 2′-O-(2-Methoxyethyl)-Modified Oligonucleotide Analogs in Rats
J Pharmacol Exp Ther March 1, 2001 296:890-897
Select this article
- Richard S. Geary,
- Oleg Khatsenko,
- Keith Bunker,
- Rosanne Crooke,
- Max Moore,
- Todd Burckin,
- LoAnne Truong,
- Henri Sasmor,
- and Arthur A. Levin
Absolute Bioavailability of 2′-O-(2-Methoxyethyl)-Modified Antisense Oligonucleotides following Intraduodenal Instillation in Rats
J Pharmacol Exp Ther March 1, 2001 296:898-904
Select this article
- Tom C. Krejcie,
- Zhao Wang,
- and Michael J. Avram
Drug-Induced Hemodynamic Perturbations Alter the Disposition of Markers of Blood Volume, Extracellular Fluid, and Total Body Water
J Pharmacol Exp Ther March 1, 2001 296:922-930

INFLAMMATION AND IMMUNOPHARMACOLOGY

Select this article
- Stefano Bellosta,
- Monica Canavesi,
- Elda Favari,
- Luciano Cominacini,
- Giovanni Gaviraghi,
- Remo Fumagalli,
- Rodolfo Paoletti,
- and Franco Bernini
Lacidipine Modulates the Secretion of Matrix Metalloproteinase-9 by Human Macrophages
J Pharmacol Exp Ther March 1, 2001 296:736-743
Select this article
- Juan J. Moreno
Antiflammin-2 Prevents HL-60 Adhesion to Endothelial Cells and Prostanoid Production Induced by Lipopolysaccharides
J Pharmacol Exp Ther March 1, 2001 296:884-889
Select this article
- John J. E. Haddad,
- Bared Safieh-Garabedian,
- Nayef E. Saadé,
- and Stephen C. Land
Thiol Regulation of Pro-Inflammatory Cytokines Reveals a Novel Immunopharmacological Potential of Glutathione in the Alveolar Epithelium
J Pharmacol Exp Ther March 1, 2001 296:996-1005

ENDOCRINE AND REPRODUCTIVE

Select this article
- Mar Trujillo,
- Luz Candenas,
- Cristina G. Cintado,
- Josefina Magraner,
- Javier Fernandez,
- Julio D. Martín,
- and Francisco M. Pinto
Hormonal Regulation of the Contractile Response Induced by Okadaic Acid in the Rat Uterus
J Pharmacol Exp Ther March 1, 2001 296:841-848
Select this article
- Jack H. Mendelson,
- Michelle B. Sholar,
- Arthur J. Siegel,
- and Nancy K. Mello
Effects of Cocaine on Luteinizing Hormone in Women during the Follicular and Luteal Phases of the Menstrual Cycle and in Men
J Pharmacol Exp Ther March 1, 2001 296:972-979

Current Issue

November 2009, 331 (2)

PERSPECTIVES IN PHARMACOLOGY

The Role of Time as a Quantifiable Variable of Toxicity and the Experimental Conditions When Haber's c ×t Product Can Be Observed: Implications for Therapeutics

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

Functional Implication of Spare ATP-Sensitive K+Channels in Bladder Smooth Muscle Cells

Pharmacological Effect of Tamsulosin in Relation to Dog Plasma and Tissue Concentrations: Prostatic and Urethral Retention Possibly Contributes to Uroselectivity of Tamsulosin

Inhibition of Na+/K+-ATPase by Endothelin-1 in Human Nonpigmented Ciliary Epithelial Cells

Polyinosinic Acid and Polycationic Liposomes Attenuate the Hepatic Clearance of Circulating Plasmid DNA

Effects of Diaspirin Cross-linked Hemoglobin on Motor Function of the Duodenum and Biliary System in the Australian Brush-Tailed Possum in Vivo

Nuclear Localization of Biliverdin Reductase in the Rat Kidney: Response to Nephrotoxins That Induce Heme Oxygenase-1

NEUROPHARMACOLOGY

Evidence for Involvement of Central 5-HT4 Receptors in Cholinergic Function Associated with Cognitive Processes: Behavioral, Electrophysiological, and Neurochemical Studies

Modulation of Recombinant Small-Conductance Ca2+-Activated K+ Channels by the Muscle Relaxant Chlorzoxazone and Structurally Related Compounds

Correlation between Molecular Volume and Effects of n-Alcohols on Human Neuronal Nicotinic Acetylcholine Receptors Expressed in Xenopus Oocytes

Influence of Maternal Milk on Functional Activation of δ-Opioid Receptors in Postnatal Rats

Coadministration of Intrathecal Strychnine and Bicuculline Effects Synergistic Allodynia in the Rat: An Isobolographic Analysis

Regulation of the Vesicular Monoamine Transporter-2: A Novel Mechanism for Cocaine and Other Psychostimulants

Opioid-Mediated Facilitation of Long-Term Depression in Rat Hippocampus

Titer-Dependent Antagonism of Cocaine following Active Immunization in Rhesus Monkeys

Heterosynaptic Transformation of GABAergic Gating in the Hippocampus and Effects of Carbonic Anhydrase Inhibition

Dissociation of Nicotine Tolerance from Tobacco Dependence in Humans

Effects of Chronic Ethanol Intake and Its Withdrawal on the Expression and Phosphorylation of the CREB Gene Transcription Factor in Rat Cortex

Locomotor Effects of Acute and Repeated Threshold Doses of Amphetamine and Methylphenidate: Relative Roles of Dopamine and Norepinephrine

Pharmacological Characterization of Locomotor Sensitization Induced by Chronic Phencyclidine Administration

Fipronil Modulation of γ-Aminobutyric AcidAReceptors in Rat Dorsal Root Ganglion Neurons

Antinociceptive Effects of δ-Opioid Agonists in Rhesus Monkeys: Effects on Chemically Induced Thermal Hypersensitivity

Modifications of the Serotonergic System in Mice Lacking Serotonin Transporters: An in Vivo Electrophysiological Study

Novel Pyrazole Cannabinoids: Insights into CB1Receptor Recognition and Activation

Lobeline Inhibits the Neurochemical and Behavioral Effects of Amphetamine

Coexpression of P2X3 and P2X2 Receptor Subunits in Varying Amounts Generates Heterogeneous Populations of P2X Receptors That Evoke a Spectrum of Agonist Responses Comparable to That Seen in Sensory Neurons

Selective Dopamine Receptor Stimulation Differentially Affects [3H]Arachidonic Acid Incorporation, a Surrogate Marker for Phospholipase A2-Mediated Neurotransmitter Signal Transduction, in a Rodent Model of Parkinson's Disease

CARDIOVASCULAR

Comparative Specificity of Platelet αIIbβ3 Integrin Antagonists

Gender Differences in the Effect of Age on Electrical Field Stimulation (EFS)-Induced Adrenergic Vasoconstriction in Rat Mesenteric Resistance Arteries

Potassium Current Antagonist Properties and Proarrhythmic Consequences of Quinolone Antibiotics

Low-Affinity M2 Receptor Binding State Mediates Mouse Atrial Bradycardia: Comparative Effects of Carbamylcholine and the M1 Receptor Agonists Sabcomeline and Xanomeline

α1D-Adrenoceptors Cause Endothelium-Dependent Vasodilatation in the Rat Mesenteric Vascular Bed

Differences between Peptide and Nonpeptide B2Bradykinin Receptor Antagonists in Blocking Bronchoconstriction and Hypotension Induced by Bradykinin in Anesthetized Guinea Pigs

Antiangiogenic Effect of KR31372 in Rat Sponge Implant Model

CELLULAR AND MOLECULAR

Involvement of Extracellular Signal-Regulated Kinase (ERK) in Pardaxin-Induced Dopamine Release from PC12 Cells

Cleavage of Intracellular Substrates of Botulinum Toxins A, C, and D in a Mammalian Target Tissue

Pharmacology of SB-273779, a Nonpeptide Calcitonin Gene-Related Peptide 1 Receptor Antagonist

Protein Tyrosine Kinase Inhibitors Alter Human Dopamine Transporter Activity in Xenopus Oocytes

Complexities of Measuring Antagonist Potency at P2X7Receptor Orthologs

Cleavage of SNAP-25 by Botulinum Toxin Type A Requires Receptor-Mediated Endocytosis, pH-Dependent Translocation, and Zinc

Cloning and Characterization of a Novel Human Histamine Receptor

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

Both Extraneuronal Monoamine Transporter and O 6 -Methylguanine-DNA Methyltransferase Expression Influence the Antitumor Efficacy of 2-Chloroethyl-3-sarcosinamide- 1-nitrosourea in Human Tumor Xenografts

Protection of Mammalian Cells against Chemotherapeutic Agents Thiotepa, 1,3-N,N′-Bis(2-chloroethyl)-N-nitrosourea, and Mafosfamide Using the DNA Base Excision Repair Genes Fpg and α-hOgg1: Implications for Protective Gene Therapy Applications

Design of a Chimeric 3-Methyl-1,2,3-triazene with Mixed Receptor Tyrosine Kinase and DNA Damaging Properties: A Novel Tumor Targeting Strategy

Inactivation of HumanO 6-Alkylguanine-DNA Alkyltransferase by Modified Oligodeoxyribonucleotides Containing O 6-Benzylguanine

Enhancement of Paclitaxel Delivery to Solid Tumors by Apoptosis-Inducing Pretreatment: Effect of Treatment Schedule

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

In Vitro Substrate Identification Studies for P-glycoprotein-Mediated Transport: Species Difference and Predictability of in Vivo Results

Rescue from Enhanced Alkylator-Induced Cell Death with Low Molecular Weight Sulfur-Containing Chemoprotectants

Pharmacokinetic Properties of 2′-O-(2-Methoxyethyl)-Modified Oligonucleotide Analogs in Rats

Absolute Bioavailability of 2′-O-(2-Methoxyethyl)-Modified Antisense Oligonucleotides following Intraduodenal Instillation in Rats

Drug-Induced Hemodynamic Perturbations Alter the Disposition of Markers of Blood Volume, Extracellular Fluid, and Total Body Water

INFLAMMATION AND IMMUNOPHARMACOLOGY

Lacidipine Modulates the Secretion of Matrix Metalloproteinase-9 by Human Macrophages

Antiflammin-2 Prevents HL-60 Adhesion to Endothelial Cells and Prostanoid Production Induced by Lipopolysaccharides

Thiol Regulation of Pro-Inflammatory Cytokines Reveals a Novel Immunopharmacological Potential of Glutathione in the Alveolar Epithelium

ENDOCRINE AND REPRODUCTIVE

Hormonal Regulation of the Contractile Response Induced by Okadaic Acid in the Rat Uterus

Effects of Cocaine on Luteinizing Hormone in Women during the Follicular and Luteal Phases of the Menstrual Cycle and in Men

This Issue

Current Issue

Functional Implication of Spare ATP-Sensitive K⁺Channels in Bladder Smooth Muscle Cells

Inhibition of Na⁺/K⁺-ATPase by Endothelin-1 in Human Nonpigmented Ciliary Epithelial Cells

Evidence for Involvement of Central 5-HT₄ Receptors in Cholinergic Function Associated with Cognitive Processes: Behavioral, Electrophysiological, and Neurochemical Studies

Modulation of Recombinant Small-Conductance Ca²⁺-Activated K⁺ Channels by the Muscle Relaxant Chlorzoxazone and Structurally Related Compounds

Fipronil Modulation of γ-Aminobutyric Acid_AReceptors in Rat Dorsal Root Ganglion Neurons

Novel Pyrazole Cannabinoids: Insights into CB₁Receptor Recognition and Activation

Coexpression of P2X₃ and P2X₂ Receptor Subunits in Varying Amounts Generates Heterogeneous Populations of P2X Receptors That Evoke a Spectrum of Agonist Responses Comparable to That Seen in Sensory Neurons

Selective Dopamine Receptor Stimulation Differentially Affects [³H]Arachidonic Acid Incorporation, a Surrogate Marker for Phospholipase A₂-Mediated Neurotransmitter Signal Transduction, in a Rodent Model of Parkinson's Disease

Comparative Specificity of Platelet α_IIbβ₃ Integrin Antagonists

Low-Affinity M₂ Receptor Binding State Mediates Mouse Atrial Bradycardia: Comparative Effects of Carbamylcholine and the M₁ Receptor Agonists Sabcomeline and Xanomeline

α_1D-Adrenoceptors Cause Endothelium-Dependent Vasodilatation in the Rat Mesenteric Vascular Bed

Differences between Peptide and Nonpeptide B₂Bradykinin Receptor Antagonists in Blocking Bronchoconstriction and Hypotension Induced by Bradykinin in Anesthetized Guinea Pigs

Complexities of Measuring Antagonist Potency at P2X₇Receptor Orthologs

Both Extraneuronal Monoamine Transporter and O ⁶ -Methylguanine-DNA Methyltransferase Expression Influence the Antitumor Efficacy of 2-Chloroethyl-3-sarcosinamide- 1-nitrosourea in Human Tumor Xenografts

Inactivation of HumanO ⁶-Alkylguanine-DNA Alkyltransferase by Modified Oligodeoxyribonucleotides Containing O ⁶-Benzylguanine