Table of Contents

December 2000; 295 (3)

PERSPECTIVES IN PHARMACOLOGY

    • Mark J. Millan

    Improving the Treatment of Schizophrenia: Focus on Serotonin (5-HT)1A Receptors

    J Pharmacol Exp Ther December 1, 2000 295:853-861
    • Geoffrey Burnstock and
    • Michael Williams

    P2 Purinergic Receptors: Modulation of Cell Function and Therapeutic Potential

    J Pharmacol Exp Ther December 1, 2000 295:862-869

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

    • Anne-Cécile Hellin,
    • Mohamed Bentires-Alj,
    • Myriam Verlaet,
    • Valérie Benoit,
    • Jacques Gielen,
    • Vincent Bours,
    • and Marie-Paule Merville

    Roles of Nuclear Factor-κB, p53, and p21/WAF1 in Daunomycin-Induced Cell Cycle Arrest and Apoptosis

    J Pharmacol Exp Ther December 1, 2000 295:870-878
    • Sonia Zorzet,
    • Alberta Bergamo,
    • Moreno Cocchietto,
    • Alenka Sorc,
    • Barbara Gava,
    • Enzo Alessio,
    • Elisabetta Iengo,
    • and Gianni Sava

    Lack of In Vitro Cytotoxicity, Associated to Increased G2-M Cell Fraction and Inhibition of Matrigel Invasion, May Predict In Vivo-Selective Antimetastasis Activity of Ruthenium Complexes

    J Pharmacol Exp Ther December 1, 2000 295:927-933

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

    • Harold G. Preiksaitis,
    • Pawel S. Krysiak,
    • Tom Chrones,
    • Vaishnav Rajgopal,
    • and Lisanne G. Laurier

    Pharmacological and Molecular Characterization of Muscarinic Receptor Subtypes in Human Esophageal Smooth Muscle

    J Pharmacol Exp Ther December 1, 2000 295:879-888
    • Ravi Malaviya,
    • Chun-Lin Chen,
    • Christopher Navara,
    • Rama Malaviya,
    • Xing-Ping Liu,
    • Margaret Keenan,
    • Barbara Waurzyniak,
    • and Fatih M. Uckun

    Treatment of Allergic Asthma by Targeting Janus Kinase 3-Dependent Leukotriene Synthesis in Mast Cells with 4-(3′,5′-Dibromo-4′-hydroxyphenyl)amino-6,7-dimethoxyquinazoline (WHI-P97)

    J Pharmacol Exp Ther December 1, 2000 295:912-926
    • Renee C. Paige,
    • Fred H. Royce,
    • Charles G. Plopper,
    • and Alan R. Buckpitt

    Long-Term Exposure to Ozone Increases Acute Pulmonary Centriacinar Injury by 1-Nitronaphthalene: I. Region-Specific Enzyme Activity

    J Pharmacol Exp Ther December 1, 2000 295:934-941
    • Renee C. Paige,
    • Viviana Wong,
    • and Charles G. Plopper

    Long-Term Exposure to Ozone Increases Acute Pulmonary Centriacinar Injury by 1-Nitronaphthalene: II. Quantitative Histopathology

    J Pharmacol Exp Ther December 1, 2000 295:942-950
    • Motonori Aoki,
    • Masahiro Fukunaga,
    • Minetake Kitagawa,
    • Kazumi Hayashi,
    • Tatsuaki Morokata,
    • Go Ishikawa,
    • Satoshi Kubo,
    • and Toshimitsu Yamada

    Effect of a Novel Anti-Inflammatory Compound, YM976, on Antigen-Induced Eosinophil Infiltration into the Lungs in Rats, Mice, and Ferrets

    J Pharmacol Exp Ther December 1, 2000 295:1149-1155

CELLULAR AND MOLECULAR

    • Asavari Wagle and
    • Jai Pal Singh

    Fibroblast Growth Factor Protects Nitric Oxide-Induced Apoptosis in Neuronal SHSY-5Y Cells

    J Pharmacol Exp Ther December 1, 2000 295:889-895
    • Anthony S. L. Chan and
    • Yung H. Wong

    Regulation of c-Jun N-Terminal Kinase by the ORL1Receptor through Multiple G Proteins

    J Pharmacol Exp Ther December 1, 2000 295:1094-1100
    • Barry L. Tepperman,
    • Qing Chang,
    • and Brian D. Soper

    Protein Kinase C Mediates Lipopolysaccharide- and Phorbol-Induced Nitric-Oxide Synthase Activity and Cellular Injury in the Rat Colon

    J Pharmacol Exp Ther December 1, 2000 295:1249-1257

CARDIOVASCULAR

    • Jiale He,
    • Yuhui Xiao,
    • Carlos A. Casiano,
    • and Lubo Zhang

    Role of Mitochondrial Cytochrome c in Cocaine-Induced Apoptosis in Coronary Artery Endothelial Cells

    J Pharmacol Exp Ther December 1, 2000 295:896-903
    • Charles V. Jackson,
    • Blanche D. Bailey,
    • and Timothy J. Shetler

    Pharmacological Profile of Recombinant, Human Activated Protein C (LY203638) in a Canine Model of Coronary Artery Thrombosis

    J Pharmacol Exp Ther December 1, 2000 295:967-971
    • Paola Dorigo,
    • Maura Floreani,
    • Giovanni Santostasi,
    • Ildebrando Maragno,
    • Daniela Danieli-Betto,
    • Elena Germinario,
    • Sebastiano Marciani Magno,
    • Gianpaolo Primofiore,
    • Anna Maria Marini,
    • and Federico Da Settimo

    Pharmacological Characterization of a New Ca2+Sensitizer

    J Pharmacol Exp Ther December 1, 2000 295:994-1004
    • Rui M. V. Abreu,
    • Dario J. S. L. Santos,
    • and António J. M. Moreno

    Effects of Carvedilol and Its Analog BM-910228 on Mitochondrial Function and Oxidative Stress

    J Pharmacol Exp Ther December 1, 2000 295:1022-1030
    • Eiji Sasaki,
    • Yasutaka Tanahashi,
    • Yasundo Yamasaki,
    • Nobuyuki Oda,
    • Yoshihisa Nozawa,
    • Hiroshi Terakawa,
    • Kazuhisa Miyoshi,
    • Yoshiyuki Muranaka,
    • Hidekazu Miyake,
    • and Naosuke Matsuura

    Inhibitory Effect of TAS-301, a New Synthesized Constrictive Remodeling Regulator, on Renarrowing after Balloon Overstretch Injury of Porcine Coronary Artery

    J Pharmacol Exp Ther December 1, 2000 295:1043-1050
    • Klara Brixius,
    • Uwe Mehlhorn,
    • Wilhelm Bloch,
    • and Robert H. G. Schwinger

    Different Effect of the Ca2+ Sensitizers EMD 57033 and CGP 48506 on Cross-Bridge Cycling in Human Myocardium

    J Pharmacol Exp Ther December 1, 2000 295:1284-1290

TOXICOLOGY

    • Norisato Ikebe,
    • Takaaki Akaike,
    • Yoichi Miyamoto,
    • Kazuyuki Hayashida,
    • Jun Yoshitake,
    • Michio Ogawa,
    • and Hiroshi Maeda

    Protective Effect of S-Nitrosylated α1-Protease Inhibitor on Hepatic Ischemia-Reperfusion Injury

    J Pharmacol Exp Ther December 1, 2000 295:904-911
    • Lisa Imamura,
    • Hiroshi Hasegawa,
    • Kaori Kurashina,
    • Ayako Hamanishi,
    • Akiko Tabuchi,
    • and Masaaki Tsuda

    Repression of Activity-Dependent c-fos and Brain-Derived Neurotrophic Factor mRNA Expression by Pyrethroid Insecticides Accompanying a Decrease in Ca2+ Influx into Neurons

    J Pharmacol Exp Ther December 1, 2000 295:1175-1182

NEUROPHARMACOLOGY

    • Meng-Yang Zhu,
    • Susan Shamburger,
    • Jing Li,
    • and Gregory A. Ordway

    Regulation of the Human Norepinephrine Transporter by Cocaine and Amphetamine

    J Pharmacol Exp Ther December 1, 2000 295:951-959
    • Iain J. McFadyen,
    • Katarzyna Sobczyk-Kojiro,
    • Michael J. Schaefer,
    • Jeffrey C. Ho,
    • John R. Omnaas,
    • Henry I. Mosberg,
    • and John R. Traynor

    Tetrapeptide Derivatives of [d-Pen2,d-Pen5]-Enkephalin (DPDPE) Lacking an N-Terminal Tyrosine Residue Are Agonists at the μ-Opioid Receptor

    J Pharmacol Exp Ther December 1, 2000 295:960-966
    • Ken A. Witt,
    • Jason D. Huber,
    • Richard D. Egleton,
    • and Thomas P. Davis

    Insulin Enhancement of Opioid Peptide Transport across the Blood-Brain Barrier and Assessment of Analgesic Effect

    J Pharmacol Exp Ther December 1, 2000 295:972-978
    • Richard M. Allen and
    • Linda A. Dykstra

    Attenuation of μ-Opioid Tolerance and Cross-Tolerance by the Competitive N-Methyl-d-aspartate Receptor Antagonist LY235959 Is Related to Tolerance and Cross-Tolerance Magnitude

    J Pharmacol Exp Ther December 1, 2000 295:1012-1021
    • Alexander Kuzmin,
    • Johan Sandin,
    • Lars Terenius,
    • and Sven-Ove Ögren

    Dose- and Time-Dependent Bimodal Effects of κ-Opioid Agonists on Locomotor Activity in Mice

    J Pharmacol Exp Ther December 1, 2000 295:1031-1042
    • Gerard R. Dawson,
    • Keith A. Wafford,
    • Alison Smith,
    • George R. Marshall,
    • Peter J. Bayley,
    • James M. Schaeffer,
    • Peter T. Meinke,
    • and R. M. McKernan

    Anticonvulsant and Adverse Effects of Avermectin Analogs in Mice Are Mediated through the γ-Aminobutyric AcidA Receptor

    J Pharmacol Exp Ther December 1, 2000 295:1051-1060
    • Mitchel A. Kling,
    • Richard E. Carson,
    • Lisa Borg,
    • Alan Zametkin,
    • John A. Matochik,
    • James Schluger,
    • Peter Herscovitch,
    • Kenner C. Rice,
    • Ann Ho,
    • William C. Eckelman,
    • and Mary Jeanne Kreek

    Opioid Receptor Imaging with Positron Emission Tomography and [18F]Cyclofoxy in Long-Term, Methadone-Treated Former Heroin Addicts

    J Pharmacol Exp Ther December 1, 2000 295:1070-1076
    • Ryan R. Metzger,
    • Heather M. Haughey,
    • Diana G. Wilkins,
    • James W. Gibb,
    • Glen R. Hanson,
    • and Annette E. Fleckenstein

    Methamphetamine-Induced Rapid Decrease in Dopamine Transporter Function: Role of Dopamine and Hyperthermia ,

    J Pharmacol Exp Ther December 1, 2000 295:1077-1085
    • David J. Dooley,
    • Cindy M. Donovan,
    • and Thomas A. Pugsley

    Stimulus-Dependent Modulation of [3H]Norepinephrine Release from Rat Neocortical Slices by Gabapentin and Pregabalin

    J Pharmacol Exp Ther December 1, 2000 295:1086-1093
    • Maciej Gasior,
    • Maria Jaszyna,
    • Jamie Peters,
    • and Steven R. Goldberg

    Changes in the Ambulatory Activity and Discriminative Stimulus Effects of Psychostimulant Drugs in Rats Chronically Exposed to Caffeine: Effect of Caffeine Dose

    J Pharmacol Exp Ther December 1, 2000 295:1101-1111
    • Vera C. Campbell,
    • William L. Dewey,
    • and Sandra P. Welch

    Comparison of [3H]Glyburide Binding with Opiate Analgesia, Tolerance, and Dependence in ICR and Swiss-Webster Mice

    J Pharmacol Exp Ther December 1, 2000 295:1112-1119
    • John F. Cryan and
    • Irwin Lucki

    Antidepressant-Like Behavioral Effects Mediated by 5-Hydroxytryptamine2C Receptors

    J Pharmacol Exp Ther December 1, 2000 295:1120-1126
    • Theodore J. Baird,
    • Shi-Xian Deng,
    • Donald W. Landry,
    • Gail Winger,
    • and James H. Woods

    Natural and Artificial Enzymes Against Cocaine. I. Monoclonal Antibody 15A10 and the Reinforcing Effects of Cocaine in Rats ,

    J Pharmacol Exp Ther December 1, 2000 295:1127-1134
    • Graeme L. Fraser,
    • Amynah A. Pradhan,
    • Paul B. S. Clarke,
    • and Claes Wahlestedt

    Supraspinal Antinociceptive Response to [d-Pen2,5]-Enkephalin (DPDPE) Is Pharmacologically Distinct from That to Other δ-Agonists in the Rat

    J Pharmacol Exp Ther December 1, 2000 295:1135-1141
    • Stacy E. Foran,
    • Daniel B. Carr,
    • Andrzej W. Lipkowski,
    • Iwona Maszczynska,
    • James E. Marchand,
    • Aleksandra Misicka,
    • Martin Beinborn,
    • Alan S. Kopin,
    • and Richard M. Kream

    Inhibition of Morphine Tolerance Development by a Substance P-Opioid Peptide Chimera

    J Pharmacol Exp Ther December 1, 2000 295:1142-1148
    • Andrew J. Grottick,
    • Paul J. Fletcher,
    • and Guy A. Higgins

    Studies to Investigate the Role of 5-HT2C Receptors on Cocaine- and Food-Maintained Behavior

    J Pharmacol Exp Ther December 1, 2000 295:1183-1191
    • Mark J. Millan,
    • Anne Dekeyne,
    • Adrian Newman-Tancredi,
    • Didier Cussac,
    • Valérie Audinot,
    • Graeme Milligan,
    • Delphine Duqueyroix,
    • Sylvie Girardon,
    • Jimmy Mullot,
    • Jean A. Boutin,
    • Jean-Paul Nicolas,
    • Anne Renouard-Try,
    • Jean-Michel Lacoste,
    • and Alex Cordi

    S18616, a Highly Potent, Spiroimidazoline Agonist at α2-Adrenoceptors: I. Receptor Profile, Antinociceptive and Hypothermic Actions in Comparison with Dexmedetomidine and Clonidine

    J Pharmacol Exp Ther December 1, 2000 295:1192-1205
    • Mark J. Millan,
    • Françoise Lejeune,
    • Alain Gobert,
    • Mauricette Brocco,
    • Agnés Auclair,
    • Catherine Bosc,
    • Jean-Michel Rivet,
    • Jean-Michel Lacoste,
    • Alex Cordi,
    • and Anne Dekeyne

    S18616, a Highly Potent Spiroimidazoline Agonist at α2-Adrenoceptors: II. Influence on Monoaminergic Transmission, Motor Function, and Anxiety in Comparison with Dexmedetomidine and Clonidine

    J Pharmacol Exp Ther December 1, 2000 295:1206-1222
    • Gregg D. Stanwood,
    • Roman P. Artymyshyn,
    • Mei-Ping Kung,
    • Hank F. Kung,
    • Irwin Lucki,
    • and Paul McGonigle

    Quantitative Autoradiographic Mapping of Rat Brain Dopamine D3 Binding with [125I]7-OH-PIPAT: Evidence for the Presence of D3 Receptors on Dopaminergic and Nondopaminergic Cell Bodies and Terminals

    J Pharmacol Exp Ther December 1, 2000 295:1223-1231
    • Gregg D. Stanwood,
    • Irwin Lucki,
    • and Paul McGonigle

    Differential Regulation of Dopamine D2 and D3 Receptors by Chronic Drug Treatments

    J Pharmacol Exp Ther December 1, 2000 295:1232-1240
    • Doodipala S. Reddy and
    • Michael A. Rogawski

    Chronic Treatment with the Neuroactive Steroid Ganaxolone in the Rat Induces Anticonvulsant Tolerance to Diazepam but Not to Itself

    J Pharmacol Exp Ther December 1, 2000 295:1241-1248
    • Lance R. Molnar,
    • William W. Fleming,
    • and David A. Taylor

    Alterations in Neuronal γ-Aminobutyric AcidAReceptor Responsiveness in Genetic Models of Seizure Susceptibility with Different Expression Patterns

    J Pharmacol Exp Ther December 1, 2000 295:1258-1266
    • Will P. J. M. Spooren,
    • Annick Vassout,
    • Hans C. Neijt,
    • Rainer Kuhn,
    • Fabrizio Gasparini,
    • Silvain Roux,
    • Roger D. Porsolt,
    • and Conrad Gentsch

    Anxiolytic-Like Effects of the Prototypical Metabotropic Glutamate Receptor 5 Antagonist 2-Methyl-6-(phenylethynyl)pyridine in Rodents

    J Pharmacol Exp Ther December 1, 2000 295:1267-1275

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

    • Alfonso Lampen,
    • Silke Meyer,
    • Thomas Arnhold,
    • and Heinz Nau

    Metabolism of Vitamin A and Its Active Metabolite All-trans-retinoic Acid in Small Intestinal Enterocytes

    J Pharmacol Exp Ther December 1, 2000 295:979-985
    • Hideyuki Yamada,
    • Hiromi Matsunaga,
    • Kazuhiro Tsuji,
    • Sanae Matsumoto,
    • Midori Yamamoto,
    • Yuji Ishii,
    • Curtis J. Omiecinski,
    • and Kazuta Oguri

    Sequence Analyses of CYP2B Genes and Catalytic Profiles for P450s in Qdj:Sprague-Dawley Rats That Lack Response to the Phenobarbital-Mediated Induction of CYP2B2

    J Pharmacol Exp Ther December 1, 2000 295:986-993
    • Safaa Ibrahim,
    • James Peggins,
    • Alan Knapton,
    • Thomas Licht,
    • and Adorjan Aszalos

    Influence of Antipsychotic, Antiemetic, and Ca2+Channel Blocker Drugs on the Cellular Accumulation of the Anticancer Drug Daunorubicin: P-glycoprotein Modulation

    J Pharmacol Exp Ther December 1, 2000 295:1276-1283

ENDOCRINE AND REPRODUCTIVE

    • Shigeki Nakamura,
    • Takahiro Hirano,
    • Kenji Tsujimae,
    • Masashi Aoyama,
    • Kazumi Kondo,
    • Yoshitaka Yamamura,
    • Toyoki Mori,
    • and Michiaki Tominaga

    Antidiuretic Effects of a Nonpeptide Vasopressin V2-Receptor Agonist, OPC-51803, Administered Orally to Rats

    J Pharmacol Exp Ther December 1, 2000 295:1005-1011

INFLAMMATION AND IMMUNOPHARMACOLOGY

    • Elizabeth A. Capper,
    • Amy K. Roshak,
    • Brian J. Bolognese,
    • Patricia L. Podolin,
    • Timothy Smith,
    • David L. Dewitt,
    • Karen M. Anderson,
    • and Lisa A. Marshall

    Modulation of Human Monocyte Activities by Tranilast, SB 252218, a Compound Demonstrating Efficacy in Restenosis

    J Pharmacol Exp Ther December 1, 2000 295:1061-1069
    • Michael F. Jarvis,
    • Haixia Yu,
    • Kathy Kohlhaas,
    • Karen Alexander,
    • Chih-Hung Lee,
    • Mequin Jiang,
    • Shripad S. Bhagwat,
    • Michael Williams,
    • and Elizabeth A. Kowaluk

    ABT-702 (4-Amino-5-(3-bromophenyl)-7-(6-morpholinopyridin-3-yl)pyrido[2,3-d]pyrimidine), a Novel Orally Effective Adenosine Kinase Inhibitor with Analgesic and Anti-Inflammatory Properties: I. In Vitro Characterization and Acute Antinociceptive Effects in the Mouse

    J Pharmacol Exp Ther December 1, 2000 295:1156-1164
    • Elizabeth A. Kowaluk,
    • Joe Mikusa,
    • Carol T. Wismer,
    • Chang Z. Zhu,
    • Edmund Schweitzer,
    • James J. Lynch,
    • Chih-Hung Lee,
    • Meiqun Jiang,
    • Shripad S. Bhagwat,
    • Arthur Gomtsyan,
    • Jeff McKie,
    • Bryan F. Cox,
    • James Polakowski,
    • Glenn Reinhart,
    • Michael Williams,
    • and Michael F. Jarvis

    ABT-702 (4-Amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine), a Novel Orally Effective Adenosine Kinase Inhibitor with Analgesic and Anti-Inflammatory Properties. II. In Vivo Characterization in the Rat

    J Pharmacol Exp Ther December 1, 2000 295:1165-1174

ASPET MEETING REPORT

    • Anthony R. Porcari and
    • Ronald J. Shebuski

    Meeting Report of the ASPET Colloquium: Functional Genomics

    J Pharmacol Exp Ther December 1, 2000 295:1291-1295
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This Issue

December 2000; 295 (3)
Cover
  1. PERSPECTIVES IN PHARMACOLOGY
  2. CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
  3. GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  4. CELLULAR AND MOLECULAR
  5. CARDIOVASCULAR
  6. TOXICOLOGY
  7. NEUROPHARMACOLOGY
  8. ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
  9. ENDOCRINE AND REPRODUCTIVE
  10. INFLAMMATION AND IMMUNOPHARMACOLOGY
  11. ASPET MEETING REPORT

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