Table of Contents

PERSPECTIVES IN PHARMACOLOGY

Select this article
- Roberto Levi and
- Neil C. E. Smith
Histamine H₃-Receptors: A New Frontier in Myocardial Ischemia
J Pharmacol Exp Ther March 1, 2000 292:825-830

CARDIOVASCULAR

Select this article
- Ravi A. Shankar,
- Kalman Hideg,
- Jay L. Zweier,
- and Periannan Kuppusamy
Targeted Antioxidant Properties ofN-[(Tetramethyl-3-pyrroline-3-carboxamido)propyl]phthalimide and Its Nitroxide Metabolite in Preventing Postischemic Myocardial Injury
J Pharmacol Exp Ther March 1, 2000 292:838-845
Select this article
- Peter W. Stengel,
- Jesus Gomeza,
- Jurgen Wess,
- and Marlene L. Cohen
M₂ and M₄ Receptor Knockout Mice: Muscarinic Receptor Function in Cardiac and Smooth Muscle In Vitro
J Pharmacol Exp Ther March 1, 2000 292:877-885
Select this article
- Xin-Liang Ma,
- Feng Gao,
- Bernard L. Lopez,
- Theodore A. Christopher,
- and Jakob Vinten-Johansen
Peroxynitrite, a Two-Edged Sword in Post-Ischemic Myocardial Injury—Dichotomy of Action in Crystalloid- Versus Blood-Perfused Hearts
J Pharmacol Exp Ther March 1, 2000 292:912-920
Select this article
- Mervyn B. Forman,
- João V. Vitola,
- Carlos E. Velasco,
- John J. Murray,
- Raghvendra K. Dubey,
- and Edwin K. Jackson
Sustained Reduction in Myocardial Reperfusion Injury with an Adenosine Receptor Antagonist: Possible Role of the Neutrophil Chemoattractant Response
J Pharmacol Exp Ther March 1, 2000 292:929-938
Select this article
- Mahmoud M. El-Mas and
- Abdel A. Abdel-Rahman
Radiotelemetric Evaluation of Hemodynamic Effects of Long-Term Ethanol in Spontaneously Hypertensive and Wistar-Kyoto Rats
J Pharmacol Exp Ther March 1, 2000 292:944-951
Select this article
- Carla Nau,
- Margaret Seaver,
- Sho-Ya Wang,
- and Ging Kuo Wang
Block of Human Heart hH1 Sodium Channels by Amitriptyline
J Pharmacol Exp Ther March 1, 2000 292:1015-1023
Select this article
- Hantz C. Hercule and
- Adebayo O. Oyekan
Cytochrome P450 ω/ω-1 Hydroxylase-Derived Eicosanoids Contribute to Endothelin_A and Endothelin_BReceptor-Mediated Vasoconstriction to Endothelin-1 in the Rat Preglomerular Arteriole
J Pharmacol Exp Ther March 1, 2000 292:1153-1160

CELLULAR AND MOLECULAR

Select this article
- Graeme Griffin,
- Qing Tao,
- and Mary E. Abood
Cloning and Pharmacological Characterization of the Rat CB₂ Cannabinoid Receptor
J Pharmacol Exp Ther March 1, 2000 292:886-894
Select this article
- Bertold J. Vilner and
- Wayne D. Bowen
Modulation of Cellular Calcium by Sigma-2 Receptors: Release from Intracellular Stores in Human SK-N-SH Neuroblastoma Cells
J Pharmacol Exp Ther March 1, 2000 292:900-911
Select this article
- Chung-Ren Jan,
- Lee-Wei Chen,
- and Ming-Wei Lin
Ca²⁺ Mobilization Evoked by Chloroform in Madin-Darby Canine Kidney Cells
J Pharmacol Exp Ther March 1, 2000 292:995-1001
Select this article
- Ramesh Kekuda,
- Frederick H. Leibach,
- Todd C. Furesz,
- Carl H. Smith,
- and Vadivel Ganapathy
Polarized Distribution of Interleukin-1 Receptors and Their Role in Regulation of Serotonin Transporter in Placenta
J Pharmacol Exp Ther March 1, 2000 292:1032-1041
Select this article
- Jin-Song Bian,
- Wei-Min Zhang,
- Jian-Ming Pei,
- and Tak-Ming Wong
The Role of Phosphodiesterase in Mediating the Effect of Protein Kinase C on Cyclic AMP Accumulation upon κ-Opioid Receptor Stimulation in the Rat Heart
J Pharmacol Exp Ther March 1, 2000 292:1065-1070

ENDOCRINE AND REPRODUCTIVE

Select this article
- Songwei Wu,
- Min Zhang,
- Pamela A. Vest,
- Arin Bhattacharjee,
- Li Liu,
- and Ming Li
A Mibefradil Metabolite Is a Potent Intracellular Blocker of L-Type Ca²⁺ Currents in Pancreatic β-Cells
J Pharmacol Exp Ther March 1, 2000 292:939-943

TOXICOLOGY

Select this article
- Yasuhiro Masubuchi,
- Shoko Yamada,
- and Toshiharu Horie
Possible Mechanism of Hepatocyte Injury Induced by Diphenylamine and Its Structurally Related Nonsteroidal Anti-Inflammatory Drugs
J Pharmacol Exp Ther March 1, 2000 292:982-987

INFLAMMATION AND IMMUNOPHARMACOLOGY

Select this article
- Alfonso Oriente,
- Neal S. Fedarko,
- Sarah E. Pacocha,
- Shau-Ku Huang,
- Lawrence M. Lichtenstein,
- and David M. Essayan
Interleukin-13 Modulates Collagen Homeostasis in Human Skin and Keloid Fibroblasts
J Pharmacol Exp Ther March 1, 2000 292:988-994
Select this article
- Irmgard Tegeder,
- Werner Neupert,
- Hans Gühring,
- and Gerd Geisslinger
Effects of Selective and Unselective Cyclooxygenase Inhibitors on Prostanoid Release from Various Rat Organs
J Pharmacol Exp Ther March 1, 2000 292:1161-1168

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

Select this article
- Mark J. Dresser,
- Andrew T. Gray,
- and Kathleen M. Giacomini
Kinetic and Selectivity Differences between Rodent, Rabbit, and Human Organic Cation Transporters (OCT1)
J Pharmacol Exp Ther March 1, 2000 292:1146-1152

Erratum

J Pharmacol Exp Ther March 1, 2000 292:1175
- Full Text
- Full Text (PDF)

PERSPECTIVES IN PHARMACOLOGY

Histamine H3-Receptors: A New Frontier in Myocardial Ischemia

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION

Anti-Phencyclidine Monoclonal Antibodies Provide Long-Term Reductions in Brain Phencyclidine Concentrations during Chronic Phencyclidine Administration in Rats

Disposition of Dodecanedioic Acid in Humans

Structure-Pharmacokinetics Relationship of Series of Aminosteroidal Neuromuscular Blocking Agents in the Cat

c-Myc Antisense Limits Rat Liver Regeneration and Indicates Role for c-Myc in Regulating Cytochrome P-450 3A Activity

Carrier-Mediated Uptake of the Endogenous Cannabinoid Anandamide in RBL-2H3 Cells

Metabolite Anion Carriers Mediate the Uptake of the Anionic Drug Fluorescein in Renal Cortical Mitochondria

Induction of Cytochrome P-450 1A2 by Oxidized Tryptophan in Hepa lclc7 Cells

Effects of Age on In Vitro Midazolam Biotransformation in Male CD-1 Mouse Liver Microsomes

Disposition of Methamphetamine and Its Metabolite Amphetamine in Brain and Other Tissues in Rats after Intravenous Administration

Targeting Rat Anti-Mouse Transferrin Receptor Monoclonal Antibodies through Blood-Brain Barrier in Mouse

Accelerated Blood Clearance and Altered Biodistribution of Repeated Injections of Sterically Stabilized Liposomes

Suppression of a High-Affinity Transport System for Manganese in Cadmium-Resistant Metallothionein-Null Cells

Benazeprilat Disposition and Effect in Dogs Revisited with a Pharmacokinetic/Pharmacodynamic Modeling Approach

New Insights on Effect of Kidney Insufficiency on Disposition of Angiotensin-Converting Enzyme Inhibitors: Case of Enalapril and Benazepril in Dogs

Quantitative Prediction of Metabolic Inhibition of Midazolam by Erythromycin, Diltiazem, and Verapamil in Rats: Implication of Concentrative Uptake of Inhibitors into Liver

CARDIOVASCULAR

Targeted Antioxidant Properties ofN-[(Tetramethyl-3-pyrroline-3-carboxamido)propyl]phthalimide and Its Nitroxide Metabolite in Preventing Postischemic Myocardial Injury

M2 and M4 Receptor Knockout Mice: Muscarinic Receptor Function in Cardiac and Smooth Muscle In Vitro

Peroxynitrite, a Two-Edged Sword in Post-Ischemic Myocardial Injury—Dichotomy of Action in Crystalloid- Versus Blood-Perfused Hearts

Sustained Reduction in Myocardial Reperfusion Injury with an Adenosine Receptor Antagonist: Possible Role of the Neutrophil Chemoattractant Response

Radiotelemetric Evaluation of Hemodynamic Effects of Long-Term Ethanol in Spontaneously Hypertensive and Wistar-Kyoto Rats

Block of Human Heart hH1 Sodium Channels by Amitriptyline

Cytochrome P450 ω/ω-1 Hydroxylase-Derived Eicosanoids Contribute to EndothelinA and EndothelinBReceptor-Mediated Vasoconstriction to Endothelin-1 in the Rat Preglomerular Arteriole

NEUROPHARMACOLOGY

Central Administration of Methamphetamine Synergizes with Metabolic Inhibition to Deplete Striatal Monoamines

Inhibitors of Phospholipase C Prevent Glutamate Neurotoxicity in Primary Cultures of Cerebellar Neurons

6-NO2-Norepinephrine Increases Norepinephrine Release and Inhibits Norepinephrine Uptake in Rat Spinal Synaptosomes

D2, but Not D1 Dopamine Receptor Agonists Potentiate Cannabinoid-Induced Sedation in Nonhuman Primates ,

Effects of Intracavernous Administration of Selective Antagonists of α1-Adrenoceptor Subtypes on Erection in Anesthetized Rats and Dogs

Probable Involvement of the 5-Hydroxytryptamine4Receptor in Methotrexate-Induced Delayed Emesis in Dogs

Reward and Somatic Changes during Precipitated Nicotine Withdrawal in Rats: Centrally and Peripherally Mediated Effects ,

Inhibition by Intracellular Mg2+ of RecombinantN-Methyl-d-aspartate Receptors Expressed in Chinese Hamster Ovary Cells

Regulation of Extracellular Concentrations of 5-Hydroxytryptamine (5-HT) in Mouse Striatum by 5-HT1A and 5-HT1B Receptors

Ligand-Induced Changes in Surface μ-Opioid Receptor Number: Relationship to G Protein Activation?

Imidazoline-Binding Domains on Monoamine Oxidase B and Subpopulations of Enzyme

Native N-Methyl-d-aspartate Receptors Containing NR2A and NR2B Subunits Have Pharmacologically Distinct Competitive Antagonist Binding Sites

CELLULAR AND MOLECULAR

Cloning and Pharmacological Characterization of the Rat CB2 Cannabinoid Receptor

Modulation of Cellular Calcium by Sigma-2 Receptors: Release from Intracellular Stores in Human SK-N-SH Neuroblastoma Cells

Ca2+ Mobilization Evoked by Chloroform in Madin-Darby Canine Kidney Cells

Polarized Distribution of Interleukin-1 Receptors and Their Role in Regulation of Serotonin Transporter in Placenta

The Role of Phosphodiesterase in Mediating the Effect of Protein Kinase C on Cyclic AMP Accumulation upon κ-Opioid Receptor Stimulation in the Rat Heart

ENDOCRINE AND REPRODUCTIVE

A Mibefradil Metabolite Is a Potent Intracellular Blocker of L-Type Ca2+ Currents in Pancreatic β-Cells

TOXICOLOGY

Possible Mechanism of Hepatocyte Injury Induced by Diphenylamine and Its Structurally Related Nonsteroidal Anti-Inflammatory Drugs

INFLAMMATION AND IMMUNOPHARMACOLOGY

Interleukin-13 Modulates Collagen Homeostasis in Human Skin and Keloid Fibroblasts

Effects of Selective and Unselective Cyclooxygenase Inhibitors on Prostanoid Release from Various Rat Organs

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

Kinetic and Selectivity Differences between Rodent, Rabbit, and Human Organic Cation Transporters (OCT1)

Erratum

This Issue

Current Issue

Histamine H₃-Receptors: A New Frontier in Myocardial Ischemia

M₂ and M₄ Receptor Knockout Mice: Muscarinic Receptor Function in Cardiac and Smooth Muscle In Vitro

Cytochrome P450 ω/ω-1 Hydroxylase-Derived Eicosanoids Contribute to Endothelin_A and Endothelin_BReceptor-Mediated Vasoconstriction to Endothelin-1 in the Rat Preglomerular Arteriole

6-NO₂-Norepinephrine Increases Norepinephrine Release and Inhibits Norepinephrine Uptake in Rat Spinal Synaptosomes

D₂, but Not D₁ Dopamine Receptor Agonists Potentiate Cannabinoid-Induced Sedation in Nonhuman Primates ,

Effects of Intracavernous Administration of Selective Antagonists of α₁-Adrenoceptor Subtypes on Erection in Anesthetized Rats and Dogs

Probable Involvement of the 5-Hydroxytryptamine₄Receptor in Methotrexate-Induced Delayed Emesis in Dogs

Inhibition by Intracellular Mg²⁺ of RecombinantN-Methyl-d-aspartate Receptors Expressed in Chinese Hamster Ovary Cells

Regulation of Extracellular Concentrations of 5-Hydroxytryptamine (5-HT) in Mouse Striatum by 5-HT_1A and 5-HT_1B Receptors

Cloning and Pharmacological Characterization of the Rat CB₂ Cannabinoid Receptor

Ca²⁺ Mobilization Evoked by Chloroform in Madin-Darby Canine Kidney Cells

A Mibefradil Metabolite Is a Potent Intracellular Blocker of L-Type Ca²⁺ Currents in Pancreatic β-Cells