Table of Contents

December 1999; 291 (3)

Articles

Select this article
- William W. Fleming
1999 Torald Sollman Award Lecture: Cellular Adaptation: Journey from Smooth Muscle Cells to Neurons
J Pharmacol Exp Ther December 1, 1999 291:925-931
Select this article
- Elizabeth I. Tietz,
- Xu J. Zeng,
- Shanyi Chen,
- Scott M. Lilly,
- Howard C. Rosenberg,
- and Peter Kometiani
Antagonist-Induced Reversal of Functional and Structural Measures of Hippocampal Benzodiazepine Tolerance
J Pharmacol Exp Ther December 1, 1999 291:932-942
Select this article
- Christiane Mourre,
- Marina N. Chernova,
- Marie-France Martin-Eauclaire,
- Richard Bessone,
- Guy Jacquet,
- Maurice Gola,
- Seth. L. Alper,
- and Marcel Crest
Distribution in Rat Brain of Binding Sites of Kaliotoxin, a Blocker of Kv1.1 and Kv1.3 α-Subunits
J Pharmacol Exp Ther December 1, 1999 291:943-952
Select this article
- Gloria M. Su,
- Rachel M. Sefton,
- and Michael Murray
Down-Regulation of Rat Hepatic Microsomal Cytochromes P-450 in Microvesicular Steatosis Induced by Orotic Acid
J Pharmacol Exp Ther December 1, 1999 291:953-959
Select this article
- Ana M. Castejon,
- Ximena Paez,
- Luis Hernandez,
- and Luigi X. Cubeddu
Use of Intravenous Microdialysis to Monitor Changes in Serotonin Release and Metabolism Induced by Cisplatin in Cancer Patients: Comparative Effects of Granisetron and Ondansetron
J Pharmacol Exp Ther December 1, 1999 291:960-966
Select this article
- Rajiv Kumar,
- Ronald W. Joyner,
- Padmini Komalavilas,
- and Thomas M. Lincoln
Analysis of Expression of cGMP-Dependent Protein Kinase in Rabbit Heart Cells
J Pharmacol Exp Ther December 1, 1999 291:967-975
Select this article
- Masaaki Ito,
- Yutaka Hirata,
- Hideshi Nakamura,
- and Yasushi Ohizumi
Xestoquinone, Isolated from Sea Sponge, Causes Ca²⁺Release through Sulfhydryl Modification from Skeletal Muscle Sarcoplasmic Reticulum
J Pharmacol Exp Ther December 1, 1999 291:976-981
Select this article
- Christophe Junot,
- Laurence Nicolet,
- Eric Ezan,
- Marie-Francoise Gonzales,
- Joel Menard,
- and Michel Azizi
Effect of Angiotensin-Converting Enzyme Inhibition on Plasma, Urine, and Tissue Concentrations of Hemoregulatory Peptide Acetyl-Ser-Asp-Lys-Pro in Rats
J Pharmacol Exp Ther December 1, 1999 291:982-987
Select this article
- Akira Nishiyama,
- Akira Miyatake,
- Yasuharu Aki,
- Toshiki Fukui,
- Matlubur Rahman,
- Shoji Kimura,
- and Youichi Abe
Adenosine A₁ Receptor Antagonist KW-3902 Prevents Hypoxia-Induced Renal Vasoconstriction
J Pharmacol Exp Ther December 1, 1999 291:988-993
Select this article
- Shigeto Yamada,
- Mutsuo Harano,
- Naoko Annoh,
- and Masatoshi Tanaka
Dopamine D₃ Receptors Modulate Evoked Dopamine Release from Slices of Rat Nucleus Accumbens Via Muscarinic Receptors, But Not from the Striatum
J Pharmacol Exp Ther December 1, 1999 291:994-998
Select this article
- Qian Li,
- Christine Wichems,
- Armin Heils,
- Louis D. Van de Kar,
- Klaus-Peter Lesch,
- and Dennis L. Murphy
Reduction of 5-Hydroxytryptamine (5-HT)_1A-Mediated Temperature and Neuroendocrine Responses and 5-HT_1A Binding Sites in 5-HT Transporter Knockout Mice
J Pharmacol Exp Ther December 1, 1999 291:999-1007
Select this article
- Yong-Xiang Wang,
- S. Scott Bowersox,
- Mark Pettus,
- and Da Gao
Antinociceptive Properties of Fenfluramine, a Serotonin Reuptake Inhibitor, in a Rat Model of Neuropathy
J Pharmacol Exp Ther December 1, 1999 291:1008-1016
Select this article
- L. Fenart,
- A. Casanova,
- B. Dehouck,
- C. Duhem,
- S. Slupek,
- R. Cecchelli,
- and D. Betbeder
Evaluation of Effect of Charge and Lipid Coating on Ability of 60-nm Nanoparticles to Cross an In Vitro Model of the Blood-Brain Barrier
J Pharmacol Exp Ther December 1, 1999 291:1017-1022
Select this article
- Salvatore Guarini,
- Carla Bazzani,
- Maria Michela Cainazzo,
- Chiara Mioni,
- Giuseppe Ferrazza,
- Anna Valeria Vergoni,
- Helgi B. Schiöth,
- Jarl E. S. Wikberg,
- and Alfio Bertolini
Evidence That Melanocortin 4 Receptor Mediates Hemorrhagic Shock Reversal Caused by Melanocortin Peptides
J Pharmacol Exp Ther December 1, 1999 291:1023-1027
Select this article
- Frederick Jia-Pei Miao and
- Jon D. Levine
Neural and Endocrine Mechanisms Mediating Noxious Stimulus-Induced Inhibition of Bradykinin Plasma Extravasation in the Rat
J Pharmacol Exp Ther December 1, 1999 291:1028-1037
Select this article
- Jiang-Yong Min,
- Steffen Sandmann,
- Achim Meissner,
- Thomas Unger,
- and Ruediger Simon
Differential Effects of Mibefradil, Verapamil, and Amlodipine on Myocardial Function and Intracellular Ca²⁺ Handling in Rats with Chronic Myocardial Infarction
J Pharmacol Exp Ther December 1, 1999 291:1038-1044
Select this article
- Roger A. Gallegos,
- Rong-Sheng Lee,
- José R. Criado,
- Steven J. Henriksen,
- and Scott C. Steffensen
Adaptive Responses of γ-Aminobutyric Acid Neurons in the Ventral Tegmental Area to Chronic Ethanol
J Pharmacol Exp Ther December 1, 1999 291:1045-1053
Select this article
- Hugh E. Criswell,
- Thomas J. McCown,
- Zhen Ming,
- Robert A. Mueller,
- and George R. Breese
Interactive Role for Neurosteroids in Ethanol Enhancement of γ-Aminobutyric Acid-Gated Currents from Dissociated Substantia Nigra Reticulata Neurons
J Pharmacol Exp Ther December 1, 1999 291:1054-1059
Select this article
- P. Zia-Amirhosseini,
- E. Minthorn,
- L. J. Benincosa,
- T. K. Hart,
- C. S. Hottenstein,
- L. A. P. Tobia,
- and C. B. Davis
Pharmacokinetics and Pharmacodynamics of SB-240563, a Humanized Monoclonal Antibody Directed to Human Interleukin-5, in Monkeys
J Pharmacol Exp Ther December 1, 1999 291:1060-1067
Select this article
- Wei Tang,
- Ralph A. Stearns,
- Gloria Y. Kwei,
- Susan A. Iliff,
- Randall R. Miller,
- Marjorie A. Egan,
- Nathan X. Yu,
- Dennis C. Dean,
- Sanjeev Kumar,
- Magang Shou,
- Jiunn H. Lin,
- and Thomas A. Baillie
Interaction of Diclofenac and Quinidine in Monkeys: Stimulation of Diclofenac Metabolism
J Pharmacol Exp Ther December 1, 1999 291:1068-1074
Select this article
- A. Banan,
- S. Choudhary,
- Y. Zhang,
- J. Z. Fields,
- and A. Keshavarzian
Ethanol-Induced Barrier Dysfunction and Its Prevention by Growth Factors in Human Intestinal Monolayers: Evidence for Oxidative and Cytoskeletal Mechanisms
J Pharmacol Exp Ther December 1, 1999 291:1075-1085
Select this article
- Pierre Moine and
- Jean Xavier Mazoit
Streptococcus pneumoniae Pneumonia in Mice: Optimal Amoxicillin Dosing Predicted from a Pharmacokinetic-Pharmacodynamic Model
J Pharmacol Exp Ther December 1, 1999 291:1086-1092
Select this article
- J. R. Traynor,
- L. Guo,
- A. Coop,
- J. W. Lewis,
- and J. H. Woods
Ring-Constrained Orvinols as Analogs of Buprenorphine: Differences in Opioid Activity Related to Configuration of C₂₀ Hydroxyl Group
J Pharmacol Exp Ther December 1, 1999 291:1093-1099
Select this article
- Jan F. Gummert,
- Markus J. Barten,
- Steve W. Sherwood,
- Teun van Gelder,
- and Randall E. Morris
Pharmacodynamics of Immunosuppression by Mycophenolic Acid: Inhibition of Both Lymphocyte Proliferation and Activation Correlates with Pharmacokinetics
J Pharmacol Exp Ther December 1, 1999 291:1100-1112
Select this article
- M. C. Holden Ko,
- Mark D. Johnson,
- Eduardo R. Butelman,
- Kurt J. Willmont,
- Henry I. Mosberg,
- and James H. Woods
Intracisternal Nor-Binaltorphimine Distinguishes Central and Peripheral κ-Opioid Antinociception in Rhesus Monkeys
J Pharmacol Exp Ther December 1, 1999 291:1113-1120
Select this article
- Kimihiro Matsunaga,
- Keigo Nakatani,
- Masahiro Murakami,
- Katsumi Yamaguchi,
- and Yasushi Ohizumi
Powerful Activation of Skeletal Muscle Actomyosin ATPase by Goniodomin A Is Highly Sensitive to Troponin/Tropomyosin Complex
J Pharmacol Exp Ther December 1, 1999 291:1121-1126
Select this article
- Ying Lu,
- Michael J. Marks,
- and Allan C. Collins
Desensitization of Nicotinic Agonist-Induced [³H]γ-Aminobutyric Acid Release from Mouse Brain Synaptosomes Is Produced by Subactivating Concentrations of Agonists
J Pharmacol Exp Ther December 1, 1999 291:1127-1134
Select this article
- Karen Alexander,
- Wende Niforatos,
- Bruce Bianchi,
- Edward C. Burgard,
- Kevin J. Lynch,
- Elizabeth A. Kowaluk,
- Michael F. Jarvis,
- and Tim van Biesen
Allosteric Modulation and Accelerated Resensitization of Human P2X₃ Receptors by Cibacron Blue
J Pharmacol Exp Ther December 1, 1999 291:1135-1142
Select this article
- Evangelos D. Michelakis,
- E. Kenneth Weir,
- Daniel P. Nelson,
- Helen L. Reeve,
- Simona Tolarova,
- and Stephen L. Archer
Dexfenfluramine Elevates Systemic Blood Pressure by Inhibiting Potassium Currents in Vascular Smooth Muscle Cells
J Pharmacol Exp Ther December 1, 1999 291:1143-1149
Select this article
- Richard W. Lambrecht,
- Otto S. Gildemeister,
- Joyce A. Pepe,
- Kristina D. Tortorelli,
- Alyssa Williams,
- and Herbert L. Bonkovsky
Effects of Antidepressants and Benzodiazepine-Type Anxiolytic Agents on Hepatic Porphyrin Accumulation in Primary Cultures of Chick Embryo Liver Cells
J Pharmacol Exp Ther December 1, 1999 291:1150-1155
Select this article
- Amy C. Herring and
- Norbert E. Kaminski
Cannabinol-Mediated Inhibition of Nuclear Factor-κB, cAMP Response Element-Binding Protein, and Interleukin-2 Secretion by Activated Thymocytes
J Pharmacol Exp Ther December 1, 1999 291:1156-1163
Select this article
- David J. J. Waugh,
- Robert J. Gaivin,
- Derek S. Damron,
- Paul A. Murray,
- and Dianne M. Perez
Binding, Partial Agonism, and Potentiation of α₁-Adrenergic Receptor Function by Benzodiazepines: A Potential Site of Allosteric Modulation
J Pharmacol Exp Ther December 1, 1999 291:1164-1171
Select this article
- Susanne Keffel,
- Martina Schmidt,
- Angela Bischoff,
- and Martin C. Michel
Neuropeptide-Y Stimulation of Extracellular Signal-Regulated Kinases in Human Erythroleukemia Cells
J Pharmacol Exp Ther December 1, 1999 291:1172-1178
Select this article
- A. Banes,
- J. A. Florian,
- and S. W. Watts
Mechanisms of 5-Hydroxytryptamine_2A Receptor Activation of the Mitogen-Activated Protein Kinase Pathway in Vascular Smooth Muscle
J Pharmacol Exp Ther December 1, 1999 291:1179-1187
Select this article
- A. M. Mamoon,
- J. Smith,
- R. C. Baker,
- and J. M. Farley
Activation of Protein Kinase A Increases Phospholipase D Activity and Inhibits Phospholipase D Activation by Acetylcholine in Tracheal Smooth Muscle
J Pharmacol Exp Ther December 1, 1999 291:1188-1195
Select this article
- Neal L. Benowitz,
- Eliseo J. Perez-Stable,
- Irving Fong,
- Gunnard Modin,
- Brenda Herrera,
- and Peyton Jacob III
Ethnic Differences in N-Glucuronidation of Nicotine and Cotinine
J Pharmacol Exp Ther December 1, 1999 291:1196-1203
Select this article
- Richard B. Kim,
- Brenda Leake,
- Mirjana Cvetkovic,
- Mark M. Roden,
- Jessica Nadeau,
- Andrew Walubo,
- and Grant R. Wilkinson
Modulation by Drugs of Human Hepatic Sodium-Dependent Bile Acid Transporter (Sodium Taurocholate Cotransporting Polypeptide) Activity
J Pharmacol Exp Ther December 1, 1999 291:1204-1209
Select this article
- Rommel G. Tirona,
- Eugene Tan,
- Galina Meier,
- and K. Sandy Pang
Uptake and Glutathione Conjugation of Ethacrynic Acid and Efflux of the Glutathione Adduct by Periportal and Perivenous Rat Hepatocytes
J Pharmacol Exp Ther December 1, 1999 291:1210-1219
Select this article
- Gilles J. Rivière,
- Kelly A. Byrnes,
- W. Brooks Gentry,
- and S. Michael Owens
Spontaneous Locomotor Activity and Pharmacokinetics of Intravenous Methamphetamine and Its Metabolite Amphetamine in the Rat
J Pharmacol Exp Ther December 1, 1999 291:1220-1226
Select this article
- Junji Ichikawa and
- Herbert Y. Meltzer
R(+)-8-OH-DPAT, a Serotonin_1A Receptor Agonist, Potentiated S(−)-Sulpiride-Induced Dopamine Release in Rat Medial Prefrontal Cortex and Nucleus Accumbens But Not Striatum
J Pharmacol Exp Ther December 1, 1999 291:1227-1232
Select this article
- James K. Rowlett,
- Roger D. Spealman,
- and Snjezana Lelas
Discriminative Stimulus Effects of Zolpidem in Squirrel Monkeys: Comparison with Conventional Benzodiazepines and Sedative-Hypnotics
J Pharmacol Exp Ther December 1, 1999 291:1233-1241
Select this article
- Rajash K. Handa,
- Joseph W. Harding,
- and Steven M. Simasko
Characterization and Function of the Bovine Kidney Epithelial Angiotensin Receptor Subtype 4 Using Angiotensin IV and Divalinal Angiotensin IV as Receptor Ligands
J Pharmacol Exp Ther December 1, 1999 291:1242-1249
Select this article
- Yuji Odagaki,
- Nobuyuki Nishi,
- Shin Nakagawa,
- and Tsukasa Koyama
Activation of G Proteins by Neuropeptide Y and γ-Aminobutyric Acid_B Receptor Agonists in Rat Cerebral Cortical Membranes through Distinct Modes of Action
J Pharmacol Exp Ther December 1, 1999 291:1250-1256
Select this article
- Brandi J. Smith and
- Warren K. Bickel
Flumazenil Discrimination by Humans under a Two-Response and a Novel-Response Procedure
J Pharmacol Exp Ther December 1, 1999 291:1257-1268
Select this article
- Emiko L. Kreklau,
- Chandrika Kurpad,
- David A. Williams,
- and Leonard C. Erickson
Prolonged Inhibition ofO ⁶-Methylguanine DNA Methyltransferase in Human Tumor Cells by O ⁶-Benzylguanine In Vitro and In Vivo
J Pharmacol Exp Ther December 1, 1999 291:1269-1275
Select this article
- Atsumi Nitta,
- Megumi Ito,
- Hidefumi Fukumitsu,
- Makoto Ohmiya,
- Hisanori Ito,
- Ayako Sometani,
- Hiroshi Nomoto,
- Yoshiko Furukawa,
- and Shoei Furukawa
4-Methylcatechol Increases Brain-Derived Neurotrophic Factor Content and mRNA Expression in Cultured Brain Cells and in Rat Brain In Vivo
J Pharmacol Exp Ther December 1, 1999 291:1276-1283
Select this article
- M. I. Damaj,
- W. Glassco,
- M. Dukat,
- and B. R. Martin
Pharmacological Characterization of Nicotine-Induced Seizures in Mice
J Pharmacol Exp Ther December 1, 1999 291:1284-1291
Select this article
- Ester Alvino,
- Rita Pepponi,
- Elena Pagani,
- Pedro Miguel Lacal,
- Corrado Nunziata,
- Enzo Bonmassar,
- and Stefania D'Atri
O ⁶-Benzylguanine Enhances the In Vitro Immunotoxic Activity of Temozolomide on Natural or Antigen-Dependent Immunity
J Pharmacol Exp Ther December 1, 1999 291:1292-1300
Select this article
- Fatih M. Uckun,
- Kelly Bellomy,
- Karen O'Neill,
- Yoav Messinger,
- Trista Johnson,
- and Chun-Lin Chen
Toxicity, Biological Activity, and Pharmacokinetics of TXU (Anti-CD7)-Pokeweed Antiviral Protein in Chimpanzees and Adult Patients Infected with Human Immunodeficiency Virus
J Pharmacol Exp Ther December 1, 1999 291:1301-1307
Select this article
- Tom C. Krejcie,
- Thomas K. Henthorn,
- W. Brooks Gentry,
- Claus U. Niemann,
- Cheri Enders-Klein,
- Colin A. Shanks,
- and Michael J. Avram
Modifications of Blood Volume Alter the Disposition of Markers of Blood Volume, Extracellular Fluid, and Total Body Water
J Pharmacol Exp Ther December 1, 1999 291:1308-1316
Select this article
- Kimberly E. Vanover,
- Dale M. Edgar,
- Wesley F. Seidel,
- Derk J. Hogenkamp,
- David B. Fick,
- Nancy C. Lan,
- Kelvin W. Gee,
- and Richard B. Carter
Response-Rate Suppression in Operant Paradigm as Predictor of Soporific Potency in Rats and Identification of Three Novel Sedative-Hypnotic Neuroactive Steroids
J Pharmacol Exp Ther December 1, 1999 291:1317-1323
Select this article
- Min Jiang,
- Wen Dun,
- Jing-Song Fan,
- and Gea-Ny Tseng
Use-Dependent ‘Agonist’ Effect of Azimilide on the HERG Channel
J Pharmacol Exp Ther December 1, 1999 291:1324-1336
Select this article
- Lori Manzel,
- Lucjan Strekowski,
- Fyaz M. D. Ismail,
- Jerry C. Smith,
- and Donald E. Macfarlane
Antagonism of Immunostimulatory CpG-Oligodeoxynucleotides by 4-Aminoquinolines and Other Weak Bases: Mechanistic Studies
J Pharmacol Exp Ther December 1, 1999 291:1337-1347
Select this article
- Miechelle L. O'Brien,
- Bojana Vulevic,
- Seema Freer,
- Jonathan Boyd,
- Hongxie Shen,
- and Kenneth D. Tew
Glutathione Peptidomimetic Drug Modulator of Multidrug Resistance-Associated Protein
J Pharmacol Exp Ther December 1, 1999 291:1348-1355
Select this article
- Timothy P. Reilly,
- Rodger D. MacArthur,
- Marti J. Farrough,
- Lawrence R. Crane,
- Patrick M. Woster,
- and Craig K. Svensson
Is Hydroxylamine-Induced Cytotoxicity a Valid Marker for Hypersensitivity Reactions to Sulfamethoxazole in Human Immunodeficiency Virus-Infected Individuals?
J Pharmacol Exp Ther December 1, 1999 291:1356-1364
Select this article
- Simone Sbrenna,
- Matteo Marti,
- Michele Morari,
- Girolamo Calo,
- Remo Guerrini,
- Lorenzo Beani,
- and Clementina Bianchi
l-Glutamate and γ-Aminobutyric Acid Efflux from Rat Cerebrocortical Synaptosomes: Modulation by κ- and μ- but Not δ- and Opioid Receptor Like-1 Receptors
J Pharmacol Exp Ther December 1, 1999 291:1365-1371
Select this article
- Shiling Hu,
- Shuya Wang,
- and Beth E. Dunning
Tissue Selectivity of Antidiabetic Agent Nateglinide: Study on Cardiovascular and β-Cell K_ATP Channels
J Pharmacol Exp Ther December 1, 1999 291:1372-1379
Select this article
- Alison M. Badger,
- Simon M. Blake,
- Robert A. Dodds,
- Don E. Griswold,
- Barbara A. Swift,
- David J. Rieman,
- George B. Stroup,
- Sandra J. Hoffman,
- and Maxine Gowen
Idoxifene, a Novel Selective Estrogen Receptor Modulator, Is Effective in a Rat Model of Adjuvant-Induced Arthritis
J Pharmacol Exp Ther December 1, 1999 291:1380-1386
- Michael Vasko and
- Jerry Gebhart
ASPET Meeting Report: Meeting Report for the ASPET–Ray Fuller Symposium: Cellular Mechanisms and Novel Strategies for Pain Control
J Pharmacol Exp Ther December 1, 1999 291:1387-1388
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Current Issue

November 2009, 331 (2)

Articles

1999 Torald Sollman Award Lecture: Cellular Adaptation: Journey from Smooth Muscle Cells to Neurons

Antagonist-Induced Reversal of Functional and Structural Measures of Hippocampal Benzodiazepine Tolerance

Distribution in Rat Brain of Binding Sites of Kaliotoxin, a Blocker of Kv1.1 and Kv1.3 α-Subunits

Down-Regulation of Rat Hepatic Microsomal Cytochromes P-450 in Microvesicular Steatosis Induced by Orotic Acid

Use of Intravenous Microdialysis to Monitor Changes in Serotonin Release and Metabolism Induced by Cisplatin in Cancer Patients: Comparative Effects of Granisetron and Ondansetron

Analysis of Expression of cGMP-Dependent Protein Kinase in Rabbit Heart Cells

Xestoquinone, Isolated from Sea Sponge, Causes Ca2+Release through Sulfhydryl Modification from Skeletal Muscle Sarcoplasmic Reticulum

Effect of Angiotensin-Converting Enzyme Inhibition on Plasma, Urine, and Tissue Concentrations of Hemoregulatory Peptide Acetyl-Ser-Asp-Lys-Pro in Rats

Adenosine A1 Receptor Antagonist KW-3902 Prevents Hypoxia-Induced Renal Vasoconstriction

Dopamine D3 Receptors Modulate Evoked Dopamine Release from Slices of Rat Nucleus Accumbens Via Muscarinic Receptors, But Not from the Striatum

Reduction of 5-Hydroxytryptamine (5-HT)1A-Mediated Temperature and Neuroendocrine Responses and 5-HT1A Binding Sites in 5-HT Transporter Knockout Mice

Antinociceptive Properties of Fenfluramine, a Serotonin Reuptake Inhibitor, in a Rat Model of Neuropathy

Evaluation of Effect of Charge and Lipid Coating on Ability of 60-nm Nanoparticles to Cross an In Vitro Model of the Blood-Brain Barrier

Evidence That Melanocortin 4 Receptor Mediates Hemorrhagic Shock Reversal Caused by Melanocortin Peptides

Neural and Endocrine Mechanisms Mediating Noxious Stimulus-Induced Inhibition of Bradykinin Plasma Extravasation in the Rat

Differential Effects of Mibefradil, Verapamil, and Amlodipine on Myocardial Function and Intracellular Ca2+ Handling in Rats with Chronic Myocardial Infarction

Adaptive Responses of γ-Aminobutyric Acid Neurons in the Ventral Tegmental Area to Chronic Ethanol

Interactive Role for Neurosteroids in Ethanol Enhancement of γ-Aminobutyric Acid-Gated Currents from Dissociated Substantia Nigra Reticulata Neurons

Pharmacokinetics and Pharmacodynamics of SB-240563, a Humanized Monoclonal Antibody Directed to Human Interleukin-5, in Monkeys

Interaction of Diclofenac and Quinidine in Monkeys: Stimulation of Diclofenac Metabolism

Ethanol-Induced Barrier Dysfunction and Its Prevention by Growth Factors in Human Intestinal Monolayers: Evidence for Oxidative and Cytoskeletal Mechanisms

Streptococcus pneumoniae Pneumonia in Mice: Optimal Amoxicillin Dosing Predicted from a Pharmacokinetic-Pharmacodynamic Model

Ring-Constrained Orvinols as Analogs of Buprenorphine: Differences in Opioid Activity Related to Configuration of C20 Hydroxyl Group

Pharmacodynamics of Immunosuppression by Mycophenolic Acid: Inhibition of Both Lymphocyte Proliferation and Activation Correlates with Pharmacokinetics

Intracisternal Nor-Binaltorphimine Distinguishes Central and Peripheral κ-Opioid Antinociception in Rhesus Monkeys

Powerful Activation of Skeletal Muscle Actomyosin ATPase by Goniodomin A Is Highly Sensitive to Troponin/Tropomyosin Complex

Desensitization of Nicotinic Agonist-Induced [3H]γ-Aminobutyric Acid Release from Mouse Brain Synaptosomes Is Produced by Subactivating Concentrations of Agonists

Allosteric Modulation and Accelerated Resensitization of Human P2X3 Receptors by Cibacron Blue

Dexfenfluramine Elevates Systemic Blood Pressure by Inhibiting Potassium Currents in Vascular Smooth Muscle Cells

Effects of Antidepressants and Benzodiazepine-Type Anxiolytic Agents on Hepatic Porphyrin Accumulation in Primary Cultures of Chick Embryo Liver Cells

Cannabinol-Mediated Inhibition of Nuclear Factor-κB, cAMP Response Element-Binding Protein, and Interleukin-2 Secretion by Activated Thymocytes

Binding, Partial Agonism, and Potentiation of α1-Adrenergic Receptor Function by Benzodiazepines: A Potential Site of Allosteric Modulation

Neuropeptide-Y Stimulation of Extracellular Signal-Regulated Kinases in Human Erythroleukemia Cells

Mechanisms of 5-Hydroxytryptamine2A Receptor Activation of the Mitogen-Activated Protein Kinase Pathway in Vascular Smooth Muscle

Activation of Protein Kinase A Increases Phospholipase D Activity and Inhibits Phospholipase D Activation by Acetylcholine in Tracheal Smooth Muscle

Ethnic Differences in N-Glucuronidation of Nicotine and Cotinine

Modulation by Drugs of Human Hepatic Sodium-Dependent Bile Acid Transporter (Sodium Taurocholate Cotransporting Polypeptide) Activity

Uptake and Glutathione Conjugation of Ethacrynic Acid and Efflux of the Glutathione Adduct by Periportal and Perivenous Rat Hepatocytes

Spontaneous Locomotor Activity and Pharmacokinetics of Intravenous Methamphetamine and Its Metabolite Amphetamine in the Rat

R(+)-8-OH-DPAT, a Serotonin1A Receptor Agonist, Potentiated S(−)-Sulpiride-Induced Dopamine Release in Rat Medial Prefrontal Cortex and Nucleus Accumbens But Not Striatum

Discriminative Stimulus Effects of Zolpidem in Squirrel Monkeys: Comparison with Conventional Benzodiazepines and Sedative-Hypnotics

Characterization and Function of the Bovine Kidney Epithelial Angiotensin Receptor Subtype 4 Using Angiotensin IV and Divalinal Angiotensin IV as Receptor Ligands

Activation of G Proteins by Neuropeptide Y and γ-Aminobutyric AcidB Receptor Agonists in Rat Cerebral Cortical Membranes through Distinct Modes of Action

Flumazenil Discrimination by Humans under a Two-Response and a Novel-Response Procedure

Prolonged Inhibition ofO 6-Methylguanine DNA Methyltransferase in Human Tumor Cells by O 6-Benzylguanine In Vitro and In Vivo

4-Methylcatechol Increases Brain-Derived Neurotrophic Factor Content and mRNA Expression in Cultured Brain Cells and in Rat Brain In Vivo

Pharmacological Characterization of Nicotine-Induced Seizures in Mice

O 6-Benzylguanine Enhances the In Vitro Immunotoxic Activity of Temozolomide on Natural or Antigen-Dependent Immunity

Toxicity, Biological Activity, and Pharmacokinetics of TXU (Anti-CD7)-Pokeweed Antiviral Protein in Chimpanzees and Adult Patients Infected with Human Immunodeficiency Virus

Modifications of Blood Volume Alter the Disposition of Markers of Blood Volume, Extracellular Fluid, and Total Body Water

Response-Rate Suppression in Operant Paradigm as Predictor of Soporific Potency in Rats and Identification of Three Novel Sedative-Hypnotic Neuroactive Steroids

Use-Dependent ‘Agonist’ Effect of Azimilide on the HERG Channel

Antagonism of Immunostimulatory CpG-Oligodeoxynucleotides by 4-Aminoquinolines and Other Weak Bases: Mechanistic Studies

Glutathione Peptidomimetic Drug Modulator of Multidrug Resistance-Associated Protein

Is Hydroxylamine-Induced Cytotoxicity a Valid Marker for Hypersensitivity Reactions to Sulfamethoxazole in Human Immunodeficiency Virus-Infected Individuals?

l-Glutamate and γ-Aminobutyric Acid Efflux from Rat Cerebrocortical Synaptosomes: Modulation by κ- and μ- but Not δ- and Opioid Receptor Like-1 Receptors

Tissue Selectivity of Antidiabetic Agent Nateglinide: Study on Cardiovascular and β-Cell KATP Channels

Idoxifene, a Novel Selective Estrogen Receptor Modulator, Is Effective in a Rat Model of Adjuvant-Induced Arthritis

ASPET Meeting Report: Meeting Report for the ASPET–Ray Fuller Symposium: Cellular Mechanisms and Novel Strategies for Pain Control

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Xestoquinone, Isolated from Sea Sponge, Causes Ca²⁺Release through Sulfhydryl Modification from Skeletal Muscle Sarcoplasmic Reticulum

Adenosine A₁ Receptor Antagonist KW-3902 Prevents Hypoxia-Induced Renal Vasoconstriction

Dopamine D₃ Receptors Modulate Evoked Dopamine Release from Slices of Rat Nucleus Accumbens Via Muscarinic Receptors, But Not from the Striatum

Reduction of 5-Hydroxytryptamine (5-HT)_1A-Mediated Temperature and Neuroendocrine Responses and 5-HT_1A Binding Sites in 5-HT Transporter Knockout Mice

Differential Effects of Mibefradil, Verapamil, and Amlodipine on Myocardial Function and Intracellular Ca²⁺ Handling in Rats with Chronic Myocardial Infarction

Ring-Constrained Orvinols as Analogs of Buprenorphine: Differences in Opioid Activity Related to Configuration of C₂₀ Hydroxyl Group

Desensitization of Nicotinic Agonist-Induced [³H]γ-Aminobutyric Acid Release from Mouse Brain Synaptosomes Is Produced by Subactivating Concentrations of Agonists

Allosteric Modulation and Accelerated Resensitization of Human P2X₃ Receptors by Cibacron Blue

Binding, Partial Agonism, and Potentiation of α₁-Adrenergic Receptor Function by Benzodiazepines: A Potential Site of Allosteric Modulation

Mechanisms of 5-Hydroxytryptamine_2A Receptor Activation of the Mitogen-Activated Protein Kinase Pathway in Vascular Smooth Muscle

R(+)-8-OH-DPAT, a Serotonin_1A Receptor Agonist, Potentiated S(−)-Sulpiride-Induced Dopamine Release in Rat Medial Prefrontal Cortex and Nucleus Accumbens But Not Striatum

Activation of G Proteins by Neuropeptide Y and γ-Aminobutyric Acid_B Receptor Agonists in Rat Cerebral Cortical Membranes through Distinct Modes of Action

Prolonged Inhibition ofO ⁶-Methylguanine DNA Methyltransferase in Human Tumor Cells by O ⁶-Benzylguanine In Vitro and In Vivo

O ⁶-Benzylguanine Enhances the In Vitro Immunotoxic Activity of Temozolomide on Natural or Antigen-Dependent Immunity

Tissue Selectivity of Antidiabetic Agent Nateglinide: Study on Cardiovascular and β-Cell K_ATP Channels