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Table of Contents
October 1999; 291 (1)
Articles
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Jin-Sung Choi
,
Sang June Hahn
,
Duck-Joo Rhie
,
Shin-Hee Yoon
,
Yang-Hyeok Jo
,
and
Myung-Suk Kim
Mechanism of Fluoxetine Block of Cloned Voltage-Activated Potassium Channel Kv1.3
J Pharmacol Exp Ther
October 1, 1999
291
:
1
-
6
Abstract
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Tenna Juul Jensen
and
Ove A. Nedergaard
Modulation of Norepinephrine Release from Sympathetic Neurons of the Rabbit Aorta by Prejunctional Prostanoid Receptors
J Pharmacol Exp Ther
October 1, 1999
291
:
7
-
11
Abstract
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Pilar Sánchez-Blázquez
,
Marta Rodríguez-Díaz
,
Isabel DeAntonio
,
and
Javier Garzón
Endomorphin-1 and Endomorphin-2 Show Differences in Their Activation of μ Opioid Receptor-Regulated G Proteins in Supraspinal Antinociception in Mice
J Pharmacol Exp Ther
October 1, 1999
291
:
12
-
18
Abstract
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David S. Segal
and
Ronald Kuczenski
Escalating Dose-Binge Treatment with Methylphenidate: Role of Serotonin in the Emergent Behavioral Profile
J Pharmacol Exp Ther
October 1, 1999
291
:
19
-
30
Abstract
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Esam Z. Dajani
,
Kenneth R. Larsen
,
John Taylor
,
Noura E. Dajani
,
Thomas G. Shahwan
,
Stephen D. Neeleman
,
Mark S. Taylor
,
Merril T. Dayton
,
and
G. Nabi Mir
1′,1′-Dimethylheptyl-Δ-8-tetrahydrocannabinol-11-oic Acid: A Novel, Orally Effective Cannabinoid with Analgesic and Anti-inflammatory Properties
J Pharmacol Exp Ther
October 1, 1999
291
:
31
-
38
Abstract
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G. M. Gilad
and
V. H. Gilad
Novel Polyamine Derivatives as Neuroprotective Agents
J Pharmacol Exp Ther
October 1, 1999
291
:
39
-
43
Abstract
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Jason G. Murphy
and
Raouf A. Khalil
Decreased [Ca
2+
]
i
during Inhibition of Coronary Smooth Muscle Contraction by 17β-Estradiol, Progesterone, and Testosterone
J Pharmacol Exp Ther
October 1, 1999
291
:
44
-
52
Abstract
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Ken-Ichi Hosoya
,
Hideo Ueda
,
Kwang-Jin Kim
,
and
Vincent H. L. Lee
Nucleotide Stimulation of Cl
−
Secretion in the Pigmented Rabbit Conjunctiva
J Pharmacol Exp Ther
October 1, 1999
291
:
53
-
59
Abstract
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S. Stevens Negus
,
Michael R. Brandt
,
and
Nancy K. Mello
Effects of the Long-Acting Monoamine Reuptake Inhibitor Indatraline on Cocaine Self-Administration in Rhesus Monkeys
J Pharmacol Exp Ther
October 1, 1999
291
:
60
-
69
Abstract
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Catherine Coirault
,
Olivier Langeron
,
Francine Lambert
,
François-Xavier Blanc
,
Guy Lerebours
,
Nancy Claude
,
Bruno Riou
,
Denis Chemla
,
and
Yves Lecarpentier
Impaired Skeletal Muscle Performance in the Early Stage of Cardiac Pressure Overload in Rabbits: Beneficial Effects of Angiotensin-Converting Enzyme Inhibition
J Pharmacol Exp Ther
October 1, 1999
291
:
70
-
75
Abstract
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Bradley T. Andresen
,
Delbert G. Gillespie
,
Zaichuan Mi
,
Raghvendra K. Dubey
,
and
Edwin K. Jackson
Role of Adenosine A
1
Receptors in Modulating Extracellular Adenosine Levels
J Pharmacol Exp Ther
October 1, 1999
291
:
76
-
80
Abstract
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Katsuyoshi Akiyama
,
Masachiyo Hora
,
Satoshi Tatemichi
,
Naoyuki Masuda
,
Syunji Nakamura
,
Ryoichi Yamagishi
,
and
Makio Kitazawa
KMD-3213, a Uroselective and Long-Acting α
1a
-Adrenoceptor Antagonist, Tested in a Novel Rat Model
J Pharmacol Exp Ther
October 1, 1999
291
:
81
-
91
Abstract
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James J. Galligan
Nerve Terminal Nicotinic Cholinergic Receptors on Excitatory Motoneurons in the Myenteric Plexus of Guinea Pig Intestine
J Pharmacol Exp Ther
October 1, 1999
291
:
92
-
98
Abstract
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Gene G. Kinney
,
Patricia Patino
,
Yvan Mermet-Bouvier
,
John E. Starrett, Jr
,
and
Valentin K. Gribkoff
Cognition-Enhancing Drugs Increase Stimulated Hippocampal θ Rhythm Amplitude in the Urethane-Anesthetized Rat
J Pharmacol Exp Ther
October 1, 1999
291
:
99
-
106
Abstract
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Se-Young Choi
and
Kyong-Tai Kim
Capsaicin Inhibits Phospholipase C-Mediated Ca
2+
Increase by Blocking Thapsigargin-Sensitive Store-Operated Ca
2+
Entry in PC12 Cells
J Pharmacol Exp Ther
October 1, 1999
291
:
107
-
114
Abstract
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Edwin K. Jackson
,
William A. Herzer
,
Zaichuan Mi
,
Subhash J. Vyas
,
and
Curtis K. Kost, Jr
Low-Dose Angiotensin II Reduces Urinary Cyclic AMP Excretion in Spontaneously Hypertensive, But Not Normotensive, Rats: Independence from Hypertension and Renal Hemodynamic Effects of Angiotensin
J Pharmacol Exp Ther
October 1, 1999
291
:
115
-
123
Abstract
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Zuoning Han
,
David L. Boyle
,
Karlfried R. Aupperle
,
Brydon Bennett
,
Anthony M. Manning
,
and
Gary S. Firestein
Jun N-Terminal Kinase in Rheumatoid Arthritis
J Pharmacol Exp Ther
October 1, 1999
291
:
124
-
130
Abstract
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Wolfgang Jacobsen
,
Gabriele Kirchner
,
Katrin Hallensleben
,
Laviero Mancinelli
,
Michael Deters
,
Ingelore Hackbarth
,
Karen Baner
,
Leslie Z. Benet
,
Karl-Friedrich Sewing
,
and
Uwe Christians
Small Intestinal Metabolism of the 3-Hydroxy-3-methylglutaryl-Coenzyme A Reductase Inhibitor Lovastatin and Comparison with Pravastatin
J Pharmacol Exp Ther
October 1, 1999
291
:
131
-
139
Abstract
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H. Yamamura
,
N. Nagano
,
M. Hirano
,
K. Muraki
,
M. Watanabe
,
and
Y. Imaizumi
Activation of Ca
2+
-Dependent K
+
Current by Nordihydroguaiaretic Acid in Porcine Coronary Arterial Smooth Muscle Cells
J Pharmacol Exp Ther
October 1, 1999
291
:
140
-
146
Abstract
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Jessica E. van Montfoort
,
Bruno Hagenbuch
,
Karin E. Fattinger
,
Michael Müller
,
Geny M. M. Groothuis
,
Dirk K. F. Meijer
,
and
Peter J. Meier
Polyspecific Organic Anion Transporting Polypeptides Mediate Hepatic Uptake of Amphipathic Type II Organic Cations
J Pharmacol Exp Ther
October 1, 1999
291
:
147
-
152
Abstract
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Cornelis J. J. G. Bol
,
John P. W. Vogelaar
,
and
Jaap W. Mandema
Anesthetic Profile of Dexmedetomidine Identified by Stimulus-Response and Continuous Measurements in Rats
J Pharmacol Exp Ther
October 1, 1999
291
:
153
-
160
Abstract
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Jayne Cartmell
,
James A. Monn
,
and
Darryle D. Schoepp
The Metabotropic Glutamate 2/3 Receptor Agonists LY354740 and LY379268 Selectively Attenuate Phencyclidine versus
d
-Amphetamine Motor Behaviors in Rats
J Pharmacol Exp Ther
October 1, 1999
291
:
161
-
170
Abstract
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Mitsutoshi Kimura
and
Masahiko Ogihara
Stimulation by Transforming Growth Factor-α of DNA Synthesis and Proliferation of Adult Rat Hepatocytes in Primary Cultures: Modulation by α- and β-Adrenoceptor Agonists
J Pharmacol Exp Ther
October 1, 1999
291
:
171
-
180
Abstract
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Motohiro Kitamura
,
Shinichi Sugamoto
,
Shoji Kawauchi
,
Shinichi Kato
,
and
Koji Takeuchi
Modulation by Endogenous Nitric Oxide of Acid Secretion Induced by Gastric Distention in Rats: Enhancement by Nitric Oxide Synthase Inhibitor
J Pharmacol Exp Ther
October 1, 1999
291
:
181
-
187
Abstract
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Lise A. Eliot
and
Fakhreddin Jamali
Pharmacokinetics and Pharmacodynamics of Nifedipine in Untreated and Atorvastatin-Treated Hyperlipidemic Rats
J Pharmacol Exp Ther
October 1, 1999
291
:
188
-
193
Abstract
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Michael John Mihm
,
Christen Marie Coyle
,
Liang Jing
,
and
John Anthony Bauer
Vascular Peroxynitrite Formation during Organic Nitrate Tolerance
J Pharmacol Exp Ther
October 1, 1999
291
:
194
-
198
Abstract
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Peter Gozzi
,
Ingrid Påhlman
,
Lena Palmér
,
Alvar Grönberg
,
and
and Stefan Persson
Pharmacokinetic-Pharmacodynamic Modeling of the Immunomodulating Agent Susalimod and Experimentally Induced Tumor Necrosis Factor-α Levels in the Mouse
J Pharmacol Exp Ther
October 1, 1999
291
:
199
-
203
Abstract
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Yong-Hae Han
,
Yukio Kato
,
and
Yuichi Sugiyama
Nonlinear Disposition Kinetics of a Novel Antifolate, MX-68, in Rats
J Pharmacol Exp Ther
October 1, 1999
291
:
204
-
212
Abstract
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Maurice G. Emery
,
Carole Jubert
,
Kenneth E. Thummel
,
and
Evan D. Kharasch
Duration of Cytochrome P-450 2E1 (CYP2E1) Inhibition and Estimation of Functional CYP2E1 Enzyme Half-Life after Single-Dose Disulfiram Administration in Humans
J Pharmacol Exp Ther
October 1, 1999
291
:
213
-
219
Abstract
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Casimir A. Fornal
,
Francisco J. Martin
,
Christine W. Metzler
,
and
Barry L. Jacobs
Pindolol, a Putative 5-Hydroxytryptamine
1A
Antagonist, Does Not Reverse the Inhibition of Serotonergic Neuronal Activity Induced by Fluoxetine in Awake Cats: Comparison to WAY-100635
J Pharmacol Exp Ther
October 1, 1999
291
:
220
-
228
Abstract
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Casimir A. Fornal
,
Francisco J. Martin
,
Christine W. Metzler
,
and
Barry L. Jacobs
Pindolol Suppresses Serotonergic Neuronal Activity and Does Not Block the Inhibition of Serotonergic Neurons Produced by 8-Hydroxy-2-(di-
n
-propylamino)tetralin in Awake Cats
J Pharmacol Exp Ther
October 1, 1999
291
:
229
-
238
Abstract
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Patrik Munzar
,
Michael D. Laufert
,
Scott W. Kutkat
,
Jana Nováková
,
and
Steven R. Goldberg
Effects of Various Serotonin Agonists, Antagonists, and Uptake Inhibitors on the Discriminative Stimulus Effects of Methamphetamine in Rats
J Pharmacol Exp Ther
October 1, 1999
291
:
239
-
250
Abstract
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Roberto Maggio
,
Pascaline Barbier
,
Antonella Colelli
,
Federica Salvadori
,
Graziella Demontis
,
and
Giovanni U. Corsini
G Protein-Linked Receptors: Pharmacological Evidence for the Formation of Heterodimers
J Pharmacol Exp Ther
October 1, 1999
291
:
251
-
257
Abstract
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Amruthesh C. Shivachar
and
Douglas C. Eikenburg
Differential Effects of Epinephrine and Norepinephrine on cAMP Response and G
i3
α Protein Expression in Cultured Sympathetic Neurons
J Pharmacol Exp Ther
October 1, 1999
291
:
258
-
264
Abstract
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Jonathan L. Katz
,
Theresa A. Kopajtic
,
Krista A. Myers
,
Robert J. Mitkus
,
and
Michael Chider
Behavioral Effects of Cocaine: Interactions with D1 Dopaminergic Antagonists and Agonists in Mice and Squirrel Monkeys
J Pharmacol Exp Ther
October 1, 1999
291
:
265
-
279
Abstract
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Majed Khalifa
,
Pascal Daleau
,
and
and Jacques Turgeon
Mechanism of Sodium Channel Block by Venlafaxine in Guinea Pig Ventricular Myocytes
J Pharmacol Exp Ther
October 1, 1999
291
:
280
-
284
Abstract
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Scott C. Harvey
and
Phil Skolnick
Polyamine-Like Actions of Aminoglycosides at Recombinant
N
-Methyl-
d
-Aspartate Receptors
J Pharmacol Exp Ther
October 1, 1999
291
:
285
-
291
Abstract
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W. George Lai
,
Nasir Zahid
,
and
Jack P. Uetrecht
Metabolism of Trimethoprim to a Reactive Iminoquinone Methide by Activated Human Neutrophils and Hepatic Microsomes
J Pharmacol Exp Ther
October 1, 1999
291
:
292
-
299
Abstract
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Lance R. McMahon
and
Kathryn A. Cunningham
Antagonism of 5-Hydroxytryptamine
4
Receptors Attenuates Hyperactivity Induced by Cocaine: Putative Role for 5-Hydroxytryptamine
4
Receptors in the Nucleus Accumbens Shell
J Pharmacol Exp Ther
October 1, 1999
291
:
300
-
307
Abstract
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Makoto Inoue
,
Ichiro Shimohira
,
Akira Yoshida
,
Andreas Zimmer
,
Hiroshi Takeshima
,
Tsukasa Sakurada
,
and
Hiroshi Ueda
Dose-Related Opposite Modulation by Nociceptin/Orphanin FQ of Substance P Nociception in the Nociceptors and Spinal Cord
J Pharmacol Exp Ther
October 1, 1999
291
:
308
-
313
Abstract
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Young Jin Kang
,
Young Soo Lee
,
Goun Woo Lee
,
Duck Hyung Lee
,
Jae Chun Ryu
,
Hye Sook Yun-Choi
,
and
Ki Churl Chang
Inhibition of Activation of Nuclear Factor κB Is Responsible for Inhibition of Inducible Nitric Oxide Synthase Expression by Higenamine, an Active Component of Aconite Root
J Pharmacol Exp Ther
October 1, 1999
291
:
314
-
320
Abstract
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Odile Barou
,
Marie-Hélène Lafage-Proust
,
Catherine Martel
,
Thierry Thomas
,
Fabrice Tirode
,
Norbert Laroche
,
Alain Barbier
,
Christian Alexandre
,
and
Laurence Vico
Bisphosphonate Effects in Rat Unloaded Hindlimb Bone Loss Model: Three-Dimensional Microcomputed Tomographic, Histomorphometric, and Densitometric Analyses
J Pharmacol Exp Ther
October 1, 1999
291
:
321
-
328
Abstract
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Edwin K. Jackson
,
William A. Herzer
,
Subhash J. Vyas
,
and
Curtis K. Kost, Jr
Angiotensin II-Induced Renal Vasoconstriction in Genetic Hypertension
J Pharmacol Exp Ther
October 1, 1999
291
:
329
-
334
Abstract
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Shunichi Shimizu
and
Richard J. Paul
Hypoxia and Alkalinization Inhibit Endothelium-Derived Nitric Oxide But Not Endothelium-Derived Hyperpolarizing Factor Responses in Porcine Coronary Artery
J Pharmacol Exp Ther
October 1, 1999
291
:
335
-
344
Abstract
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Tadahito Shimada
,
Naomi Watanabe
,
Yukio Ohtsuka
,
Motoya Endoh
,
Kazuo Kojima
,
Hideyuki Hiraishi
,
and
Akira Terano
Polaprezinc Down-Regulates Proinflammatory Cytokine-Induced Nuclear Factor-κB Activiation and Interleukin-8 Expression in Gastric Epithelial Cells
J Pharmacol Exp Ther
October 1, 1999
291
:
345
-
352
Abstract
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S. Barak Caine
,
S. Stevens Negus
,
Nancy K. Mello
,
and
Jack Bergman
Effects of Dopamine D
1-like
and D
2-like
Agonists in Rats that Self-Administer Cocaine
J Pharmacol Exp Ther
October 1, 1999
291
:
353
-
360
Abstract
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Pradeep K. Banerjee
,
Richard W. Olsen
,
and
O. Carter Snead III
Zinc Inhibition of γ-Aminobutyric Acid
A
Receptor Function Is Decreased in the Cerebral Cortex during Pilocarpine-Induced Status Epilepticus
J Pharmacol Exp Ther
October 1, 1999
291
:
361
-
366
Abstract
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S. N. Iyer
,
G. Gurujeyalakshmi
,
and
S. N. Giri
Effects of Pirfenidone on Transforming Growth Factor-β Gene Expression at the Transcriptional Level in Bleomycin Hamster Model of Lung Fibrosis
J Pharmacol Exp Ther
October 1, 1999
291
:
367
-
373
Abstract
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Jin Zhai
,
Michael D. Gershon
,
John H. Walsh
,
Helen C. Wong
,
and
Annette L. Kirchgessner
Inward Currents in Neurons from Newborn Guinea Pig Intestine: Mediation by 5-Hydroxytryptamine Type 3 Receptors
J Pharmacol Exp Ther
October 1, 1999
291
:
374
-
382
Abstract
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Julius D. Militante
and
John B. Lombardini
Stimulatory Effect of Taurine on Calcium Ion Uptake in Rod Outer Segments of the Rat Retina Is Independent of Taurine Uptake
J Pharmacol Exp Ther
October 1, 1999
291
:
383
-
389
Abstract
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M. I. Damaj
,
W. Glassco
,
M. D. Aceto
,
and
B. R. Martin
Antinociceptive and Pharmacological Effects of Metanicotine, a Selective Nicotinic Agonist
J Pharmacol Exp Ther
October 1, 1999
291
:
390
-
398
Abstract
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Frank C. Tortella
,
Paul Britton
,
Anthony Williams
,
Xi Chung May Lu
,
and
Amy H. Newman
Neuroprotection (Focal Ischemia) and Neurotoxicity (Electroencephalographic) Studies in Rats with AHN649, a 3-Amino Analog of Dextromethorphan and Low-Affinity
N-
Methyl-
d
-Aspartate Antagonist
J Pharmacol Exp Ther
October 1, 1999
291
:
399
-
408
Abstract
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Nora D. Volkow
,
Gene-Jack Wang
,
Joanna S. Fowler
,
Jean Logan
,
S. John Gatley
,
Cristopher Wong
,
Robert Hitzemann
,
and
Naomi R. Pappas
Reinforcing Effects of Psychostimulants in Humans Are Associated with Increases in Brain Dopamine and Occupancy of D
2
Receptors
J Pharmacol Exp Ther
October 1, 1999
291
:
409
-
415
Abstract
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Frank A. D. T. G. Wagener
,
Jean-Louis da Silva
,
Tim Farley
,
Theo de Witte
,
Attallah Kappas
,
and
Nader G. Abraham
Differential Effects of Heme Oxygenase Isoforms on Heme Mediation of Endothelial Intracellular Adhesion Molecule 1 Expression
J Pharmacol Exp Ther
October 1, 1999
291
:
416
-
423
Abstract
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Sean Ekins
,
Gianpaolo Bravi
,
James H. Wikel
,
and
Steven A. Wrighton
Three-Dimensional-Quantitative Structure Activity Relationship Analysis of Cytochrome P-450 3A4 Substrates
J Pharmacol Exp Ther
October 1, 1999
291
:
424
-
433
Abstract
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