Table of Contents

• Mansour V. Shirbacheh,
• Xiaoping Ren,
• Jon W. Jones,
• Warren C. Breidenbach,
• Anthony W. Jevans,
• G. Rafael Fernandez-Botran,
• Claudio Maldonado,
• John H. Barker,
• and Scott A. Gruber

Pharmacokinetic Advantage of Intra-arterial Cyclosporin A Delivery to Vascularly Isolated Rabbit Forelimb. I. Model Development

• Mansour V. Shirbacheh,
• Thomas A. Harralson,
• Jon W. Jones,
• Warren C. Breidenbach,
• Anthony W. Jevans,
• Claudio Maldonado,
• John H. Barker,
• and Scott A. Gruber

Pharmacokinetic Advantage of Intra-arterial Cyclosporin A Delivery to Vascularly Isolated Rabbit Forelimb. II. Dose Dependence

• Mansour V. Shirbacheh,
• Jon W. Jones,
• Thomas A. Harralson,
• Jean Edelstein,
• Taskin Tecimer,
• Warren C. Breidenbach,
• Anthony W. Jevans,
• Claudio Maldonado,
• John H. Barker,
• and Scott A. Gruber

Pharmacokinetics of Intra-arterial Delivery of Tacrolimus to Vascularly Isolated Rabbit Forelimb

• Bruce G. Gold,
• Valerie Densmore,
• Weinian Shou,
• Martin M. Matzuk,
• and Heidi S. Gordon

Immunophilin FK506-Binding Protein 52 (Not FK506-Binding Protein 12) Mediates the Neurotrophic Action of FK506

• Andre L. Curtis,
• Luis A. Pavcovich,
• and Rita J. Valentino

Long-Term Regulation of Locus Ceruleus Sensitivity to Corticotropin-Releasing Factor by Swim Stress

• Arthur Christopoulos,
• Ann M. Parsons,
• and Esam E. El-Fakahany

Pharmacological Analysis of the Novel Mode of Interaction between Xanomeline and the M₁ Muscarinic Acetylcholine Receptor

• M. I. Damaj,
• J. E. Slemmer,
• F. I. Carroll,
• and B. R. Martin

Pharmacological Characterization of Nicotine’s Interaction with Cocaine and Cocaine Analogs

• Guei-Jane Wang,
• Xi-Chen Wu,
• Chieh-Fu Chen,
• Lie-Chwen Lin,
• Yi-Tsau Huang,
• Jie Shan,
• and Peter K. T. Pang

Vasorelaxing Action of Rutaecarpine: Effects of Rutaecarpine on Calcium Channel Activities in Vascular Endothelial and Smooth Muscle Cells

• Mehri Zareie,
• Ralph Brattsand,
• Philip M. Sherman,
• Derek M. McKay,
• and Mary H. Perdue

Improved Effects of Novel Glucocorticosteroids on Immune-Induced Epithelial Pathophysiology

• Stefania Meini,
• Laura Quartara,
• Anna Rizzi,
• Riccardo Patacchini,
• Paola Cucchi,
• Alessandro Giolitti,
• Girolamo Calò,
• Domenico Regoli,
• Marco Criscuoli,
• and Carlo A. Maggi

MEN 11270, A Novel Selective Constrained Peptide Antagonist with High Affinity at the Human B₂ Kinin Receptor

• Christophe Junot,
• Joel Menard,
• Marie-Francoise Gonzales,
• Annie Michaud,
• Pierre Corvol,
• and Eric Ezan

In Vivo Assessment of Captopril Selectivity of Angiotensin I-Converting Enzyme Inhibition: Differential Inhibition of Acetyl-Ser-Asp-Lys-Pro and Angiotensin I Hydrolysis

• M. Nishikibe,
• H. Ohta,
• M. Okada,
• K. Ishikawa,
• T. Hayama,
• T. Fukuroda,
• K. Noguchi,
• M. Saito,
• T. Kanoh,
• S. Ozaki,
• T. Kamei,
• K. Hara,
• D. William,
• S. Kivlighn,
• S. Krause,
• R. Gabel,
• G. Zingaro,
• N. Nolan,
• J. O’Brien,
• F. Clayton,
• J. Lynch,
• D. Pettibone,
• and P. Siegl

Pharmacological Properties of J-104132 (L-753,037), a Potent, Orally Active, Mixed ET_A/ET_B Endothelin Receptor Antagonist

• Joshua B. Owolabi,
• Geihan Rizkalla,
• Ashok Tehim,
• Gregory M. Ross,
• Richard J. Riopelle,
• Rajender Kamboj,
• Michael Ossipov,
• Di Bian,
• Sandara Wegert,
• Frank Porreca,
• and David K. H. Lee

Characterization of Antiallodynic Actions of ALE-0540, a Novel Nerve Growth Factor Receptor Antagonist, in the Rat

• Paul G. Lysko,
• Joseph Weinstock,
• Christine L. Webb,
• Mary E. Brawner,
• and Nabil A. Elshourbagy

Identification of a Small-Molecule, Nonpeptide Macrophage Scavenger Receptor Antagonist

• Weilie Zhang,
• Violetta Klimek,
• Joshua T. Farley,
• Meng-Yang Zhu,
• and Gregory A. Ordway

α_2C Adrenoceptors Inhibit Adenylyl Cyclase in Mouse Striatum: Potential Activation by Dopamine

• Richard J. Hendrickson,
• Paul A. Cahill,
• James V. Sitzmann,
• and Eileen M. Redmond

Ethanol Enhances Basal and Flow-Stimulated Nitric Oxide Synthase Activity In Vitro by Activating an Inhibitory Guanine Nucleotide Binding Protein

• Minoru Tsuda,
• Takashi Sekine,
• Michio Takeda,
• Seok Ho Cha,
• Yoshikatsu Kanai,
• Miyako Kimura,
• and Hitoshi Endou

Transport of Ochratoxin A by Renal Multispecific Organic Anion Transporter 1

• Wolfgang Wick,
• Cornelia Grimmel,
• Bettina Wagenknecht,
• Johannes Dichgans,
• and Michael Weller

Betulinic Acid-Induced Apoptosis in Glioma Cells: A Sequential Requirement for New Protein Synthesis, Formation of Reactive Oxygen Species, and Caspase Processing

• Vı́ctor Cortés,
• M.Verónica Donoso,
• Nelson Brown,
• Rodrigo Fanjul,
• Claudia López,
• Alain Fournier,
• and J. Pablo Huidobro-Toro

Synergism between Neuropeptide Y and Norepinephrine Highlights Sympathetic Cotransmission: Studies in Rat Arterial Mesenteric Bed with Neuropeptide Y, Analogs, and BIBP 3226

• Sam R. J. Hoare,
• Gerda de Vries,
• and Ted B. Usdin

Measurement of Agonist and Antagonist Ligand-Binding Parameters at the Human Parathyroid Hormone Type 1 Receptor: Evaluation of Receptor States and Modulation by Guanine Nucleotide

• Yasuyuki Furukawa,
• Yusuke Miyashita,
• Koichi Nakajima,
• Masamichi Hirose,
• Fumio Kurogouchi,
• and Shigetoshi Chiba

Effects of Verapamil, Zatebradine, and E-4031 on the Pacemaker Location and Rate in Response to Sympathetic Stimulation in Dog Hearts

• T. Weiser,
• M. Brenner,
• R. Palluk,
• W. D. Bechtel,
• A. Ceci,
• A. Brambilla,
• H. A. Ensinger,
• A. Sagrada,
• and M. Wienrich

BIIR 561 CL: A Novel Combined Antagonist of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptors and Voltage-Dependent Sodium Channels with Anticonvulsive and Neuroprotective Properties

• Hendrée E. Jones,
• George E. Bigelow,
• and Kenzie L. Preston

Assessment of Opioid Partial Agonist Activity with a Three-Choice Hydromorphone Dose-Discrimination Procedure

• Claudio Bucolo,
• Gabriele Campana,
• Rosanna Di Toro,
• Silvia Cacciaguerra,
• and Santi Spampinato

ς₁ Recognition Sites in Rabbit Iris-Ciliary Body: Topical ς₁-Site Agonists Lower Intraocular Pressure

• Benjamin Kest,
• Sonya G. Wilson,
• and Jeffrey S. Mogil

Sex Differences in Supraspinal Morphine Analgesia Are Dependent on Genotype

• Jin Chen,
• Richard Lin,
• Zhuo-Wei Hu,
• and Brian B. Hoffman

α₁-Adrenergic Receptor Activation of c-fos Expression in Transfected Rat-1 Fibroblasts: Role of Ca²⁺ 

• Peter J. Henry and
• Sarah H. King

Typical Endothelin ET_A Receptors Mediate Atypical Endothelin-1-Induced Contractions in Sheep Isolated Tracheal Smooth Muscle

• Francois J. Roman,
• Sandrine Lanet,
• Jacques Hamon,
• Gilles Brunelle,
• Anne Maurin,
• Pascal Champeroux,
• Serge Richard,
• Nicole Alessandri,
• and Maurice Gola

Pharmacological Properties of Trimebutine and N-Monodesmethyltrimebutine

• R. William Vandivier,
• Alec Eidsath,
• Steven M. Banks,
• Hugh L. Preas II,
• Stephen B. Leighton,
• Paul J. Godin,
• Anthony F. Suffredini,
• and Robert L. Danner

Down-Regulation of Nitric Oxide Production by Ibuprofen in Human Volunteers

• William R. Mancini,
• Elizabeth R. Glaze,
• Philip L. Stetson,
• and Harry S. Greenberg

Sensitization of 1,3-bis(2-Chloroethyl)-1-nitrosourea and Cisplatin Cytotoxicity by 5-Bromo-2′-deoxyuridine in Human Glioma

• Alexandra Wojdan,
• Chris Freeden,
• Morgan Woods,
• George Oshiro,
• Walter Spinelli,
• Thomas J. Colatsky,
• Jeffrey H. Sheldon,
• N. Wesley Norton,
• Dawn Warga,
• Madelene M. Antane,
• Schuyler A. Antane,
• John A. Butera,
• and Thomas M. Argentieri

Comparison of the Potassium Channel Openers, WAY-133537, ZD6169, and Celikalim on Isolated Bladder Tissue and In Vivo Bladder Instability in Rat

• David J. J. Waugh,
• Charles S. Bockman,
• D. David Smith,
• and Peter W. Abel

Limitations in Using Peptide Drugs to Characterize Calcitonin Gene-Related Peptide Receptors

• Cecilia J. Hillard,
• Sukumar Manna,
• Marcie J. Greenberg,
• Ralph DiCamelli,
• Ruth A. Ross,
• Lesley A. Stevenson,
• Vicki Murphy,
• Roger G. Pertwee,
• and William B. Campbell

Synthesis and Characterization of Potent and Selective Agonists of the Neuronal Cannabinoid Receptor (CB1)

• Nancy A. Ator and
• Roland R. Griffiths

Drug Discrimination Analysis of Partial Agonists at the Benzodiazepine Site. I. Differential Effects of U-78875 Across Training Conditions in Baboons and Rats

• Susan M. Cibulsky and
• William A. Sather

Block by Ruthenium Red of Cloned Neuronal Voltage-Gated Calcium Channels

• Diana J. Walker and
• James P. Zacny

Subjective, Psychomotor, and Physiological Effects of Cumulative Doses of Opioid μ Agonists in Healthy Volunteers

• Daniel H.S. Lee,
• J. Philip Macintyre,
• Gareth R. Taylor,
• Elizabeth Wang,
• Richard K. Plante,
• Susanna S.C. Tam,
• Barbara L. Pope,
• and Catherine Y. Lau

Tepoxalin Enhances the Activity of an Antioxidant, Pyrrolidine Dithiocarbamate, in Attenuating Tumor Necrosis Factor α-Induced Apoptosis in WEHI 164 Cells

• L. Lacinová,
• R. H. An,
• J. Xia,
• H. Ito,
• N. Klugbauer,
• D. Triggle,
• F. Hofmann,
• and R. S. Kass

Distinctions in the Molecular Determinants of Charged and Neutral Dihydropyridine Block of L-Type Calcium Channels

• Jörg Knapp,
• Peter Bokník,
• Iva Lüss,
• Sabine Huke,
• Bettina Linck,
• Hartmut Lüss,
• Frank U. Müller,
• Thorsten Müller,
• Peter Nacke,
• Thomas Noll,
• Hans M. Piper,
• Wilhelm Schmitz,
• Ute Vahlensieck,
• and Joachim Neumann

The Protein Phosphatase Inhibitor Cantharidin Alters Vascular Endothelial Cell Permeability

• Marci E. Schaner,
• Juan Wang,
• Lei Zhang,
• Sheng-Fang Su,
• Karin M. Gerstin,
• and Kathleen M. Giacomini

Functional Characterization of a Human Purine-Selective, Na⁺-Dependent Nucleoside Transporter (hSPNT1) in a Mammalian Expression System

• Elsebet Ø. Nielsen,
• Thomas Varming,
• Claus Mathiesen,
• Leif H. Jensen,
• Arne Møller,
• Alex H. Gouliaev,
• Frank Wätjen,
• and Jørgen Drejer

SPD 502: A Water-Soluble and In Vivo Long-Lasting Ampa Antagonist with Neuroprotective Activity

• R. C. Hogg,
• C. Trequattrini,
• L. Catacuzzeno,
• A. Petris,
• F. Franciolini,
• and D. J. Adams

Mechanisms of Verapamil Inhibition of Action Potential Firing in Rat Intracardiac Ganglion Neurons

• Julie A. Coffield,
• Nabil M. Bakry,
• Andrew B. Maksymowych,
• and Lance L. Simpson

Characterization of a Vertebrate Neuromuscular Junction That Demonstrates Selective Resistance to Botulinum Toxin

• Guilherme Suarez-Kurtz,
• Rosane Vianna-Jorge,
• Bianca F. Pereira,
• Maria Luisa Garcia,
• and Gregory J. Kaczorowski

Peptidyl Inhibitors of Shaker-Type K_v1 Channels Elicit Twitches in Guinea Pig Ileum by Blocking K_v1.1 at Enteric Nervous System and Enhancing Acetylcholine Release

• Yu-Nien Sun,
• Hye Jung Lee,
• Richard R. Almon,
• and William J. Jusko

A Pharmacokinetic/Pharmacodynamic Model for Recombinant Human Growth Hormone Effects on Induction of Insulin-Like Growth Factor I in Monkeys

• Masayuki Tanahashi,
• Sunao Hara,
• Makoto Yoshida,
• Mizue Suzuki-Kusaba,
• Hiroaki Hisa,
• and Susumu Satoh

Effects of Rolipram and Cilostamide on Renal Functions and Cyclic AMP Release in Anesthetized Dogs

• Kyoji Taguchi,
• Masatoshi Kato,
• Jun Kikuta,
• Kenji Abe,
• Toshiyuki Chikuma,
• Iku Utsunomiya,
• and Tadashi Miyatake

The Effects of Morphine-Induced Increases in Extracellular Acetylcholine Levels in the Rostral Ventrolateral Medulla of Rat

• David C. Perry,
• Martha I. Dávila-Garcı́a,
• Craig A. Stockmeier,
• and Kenneth J. Kellar

Increased Nicotinic Receptors in Brains from Smokers: Membrane Binding and Autoradiography Studies

• David G. Le Couteur,
• Haruyo Hickey,
• Peta J. Harvey,
• Jill Gready,
• and Allan J. McLean

Hepatic Artery Flow and Propranolol Metabolism in Perfused Cirrhotic Rat Liver

• Michelle H. McGowan,
• Paul Russell,
• Deborah A. Carper,
• and David Lichtstein

Na⁺, K⁺-ATPase Inhibitors Down-Regulate Gene Expression of the Intracellular Signaling Protein 14-3-3 in Rat Lens

• R. Lisa Popp,
• Ronald L. Lickteig,
• and David M. Lovinger

Factors That Enhance Ethanol Inhibition of N-Methyl-d-Aspartate Receptors in Cerebellar Granule Cells

• Shizuo Yamada,
• Takashi Ohkura,
• Yoshiharu Deguchi,
• and Ryohei Kimura

In Vivo Measurement by [³H]Tamsulosin of α₁ Adrenoceptors in Rat Tissues in Relation to the Pharmacokinetics

• Michael L. Berger and
• Patrick Rebernik

Zinc and Ifenprodil Allosterically Inhibit Two Separate Polyamine-Sensitive Sites atN-Methyl-d-Aspartate Receptor Complex

• Xingrong Liu,
• Edward L. LeCluyse,
• Kenneth R. Brouwer,
• Ruth M. Lightfoot,
• Jacqueline I. Lee,
• and Kim L. R. Brouwer

Use of Ca²⁺ Modulation to Evaluate Biliary Excretion in Sandwich-Cultured Rat Hepatocytes

• Jue Tan,
• Olga Zelenaia,
• Dana Correale,
• Jeffrey D. Rothstein,
• and Michael B. Robinson

Expression of the GLT-1 Subtype of Na⁺-Dependent Glutamate Transporter: Pharmacological Characterization and Lack of Regulation by Protein Kinase C

• Vladimir Mastyugin,
• Eleanor Aversa,
• Albino Bonazzi,
• Christina Vafaes,
• Paul Mieyal,
• and Michal Laniado Schwartzman

Hypoxia-Induced Production of 12-Hydroxyeicosanoids in the Corneal Epithelium: Involvement of a Cytochrome P-4504B1 Isoform

• Kathleen L. McCoy,
• Marina Matveyeva,
• Steven J. Carlisle,
• and Guy A. Cabral

Cannabinoid Inhibition of the Processing of Intact Lysozyme by Macrophages: Evidence for CB2 Receptor Participation

• Laura A. Walsh,
• Ming Li,
• Tai-Jun Zhao,
• Ted H. Chiu,
• and Howard C. Rosenberg

Acute Pentylenetetrazol Injection Reduces Rat GABA_AReceptor mRNA Levels and GABA Stimulation of Benzodiazepine Binding with No Effect on Benzodiazepine Binding Site Density

• Isabelle Morin,
• Wen Qing Li,
• Suming Su,
• Mushtaq Ahmad,
• and Muhammad Zafarullah

Induction of Stromelysin Gene Expression by Tumor Necrosis Factor α Is Inhibited by Dexamethasone, Salicylate, and N-Acetylcysteine in Synovial Fibroblasts

• Jillian H. Broadbear,
• Gail Winger,
• Theodore J. Cicero,
• and James H. Woods

Effects of Self-Administered Cocaine on Plasma Adrenocorticotropic Hormone and Cortisol in Male Rhesus Monkeys

• Monica R. Brzezinski,
• Helene Boutelet-Bochan,
• Richard E. Person,
• Alan G. Fantel,
• and Mont R. Juchau

Catalytic Activity and Quantitation of Cytochrome P-450 2E1 in Prenatal Human Brain

• Irit Shefler,
• Rony Seger,
• and Ronit Sagi-Eisenberg

Gi-Mediated Activation of Mitogen-Activated Protein Kinase (MAPK) Pathway by Receptor Mimetic Basic Secretagogues of Connective Tissue-Type Mast Cells: Bifurcation of Arachidonic Acid-Induced Release Upstream of MAPK

• Gianvincenzo Barba,
• Michael J. Mullen,
• Anne Donald,
• and Raymond J. MacAllister

Determinants of the Response of Human Blood Vessels to Nitric Oxide Donors In Vivo

• James B. Wiesner,
• Bheemarao G. Ugarkar,
• Angelo J. Castellino,
• Jerzy Barankiewicz,
• David P. Dumas,
• Harry E. Gruber,
• Alan C. Foster,
• and Mark D. Erion

Adenosine Kinase Inhibitors as a Novel Approach to Anticonvulsant Therapy

• F. Gasparini,
• V. Bruno,
• G. Battaglia,
• S. Lukic,
• T. Leonhardt,
• W. Inderbitzin,
• D. Laurie,
• B. Sommer,
• M. A. Varney,
• S. D. Hess,
• E. C. Johnson,
• R. Kuhn,
• S. Urwyler,
• D. Sauer,
• C. Portet,
• M. Schmutz,
• F. Nicoletti,
• and P. J. Flor

(R,S)-4-Phosphonophenylglycine, a Potent and Selective Group III Metabotropic Glutamate Receptor Agonist, Is Anticonvulsive and Neuroprotective In Vivo

• Mari Yotsu-Yamashita,
• Atsuko Sugimoto,
• Akira Takai,
• and Takeshi Yasumoto

Effects of Specific Modifications of Several Hydroxyls of Tetrodotoxin on Its Affinity to Rat Brain Membrane

Correction for vol. 288, p. 597