Table of Contents

DRUG METABOLISM AND DISPOSITION

Select this article
- Katsunori Nakamura,
- Tsuyoshi Yokoi,
- Takao Kodama,
- Kazuaki Inoue,
- Kazuo Nagashima,
- Noriaki Shimada,
- Toshiaki Shimizu,
- and Tetsuya Kamataki
Oxidation of Histamine H1 Antagonist Mequitazine is Catalyzed by Cytochrome P450 2D6 in Human Liver Microsomes
J Pharmacol Exp Ther February 1, 1998 284:437-442
Select this article
- O. E. Della Paschoa,
- J. W. Mandema,
- R. A. Voskuyl,
- and M. Danhof
Pharmacokinetic-Pharmacodynamic Modeling of the Anticonvulsant and Electroencephalogram Effects of Phenytoin in Rats
J Pharmacol Exp Ther February 1, 1998 284:460-466
Select this article
- Wanping Geng,
- Andreas J. Schwab,
- Tohru Horie,
- Carl A. Goresky,
- and K. Sandy Pang
Hepatic Uptake of Bromosulfophthalein-Glutathione in Perfused Eisai Hyperbilirubinemic Mutant Rat Liver: A Multiple-Indicator Dilution Study
J Pharmacol Exp Ther February 1, 1998 284:480-492
Select this article
- Marc Levine,
- Eva Y. W. Law,
- Stelvio M. Bandiera,
- Thomas K. H. Chang,
- and Gail D. Bellward
In Vivo Cimetidine Inhibits Hepatic CYP2C6 and CYP2C11 but Not CYP1A1 in Adult Male Rats ^,
J Pharmacol Exp Ther February 1, 1998 284:493-499
Select this article
- Hiroyuki Sasabe,
- Yukio Kato,
- Akira Tsuji,
- and Yuichi Sugiyama
Stereoselective Hepatobiliary Transport of the Quinolone Antibiotic Grepafloxacin and Its Glucuronide in the Rat
J Pharmacol Exp Ther February 1, 1998 284:661-668
Select this article
- M. Teresa Donato,
- M. José Gómez-Lechón,
- Ramiro Jover,
- Toshikazu Nakamura,
- and José V. Castell
Human Hepatocyte Growth Factor Down-regulates the Expression of Cytochrome P450 Isozymes in Human Hepatocytes in Primary Culture
J Pharmacol Exp Ther February 1, 1998 284:760-767

PULMONARY PHARMACOLOGY

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- Randy S. Sprague,
- Alan H. Stephenson,
- Lorraine Mcmurdo,
- and Andrew J. Lonigro
Nitric Oxide Opposes Phorbol Ester-Induced Increases in Pulmonary Microvascular Permeability in Dogs
J Pharmacol Exp Ther February 1, 1998 284:443-448
Select this article
- Isabelle Gorenne,
- Carlos Labat,
- Jean-Pierre Gascard,
- Xavier Norel,
- Nabila Nashashibi,
- and Charles Brink
Leukotriene D₄ Contractions in Human Airways are Blocked by SK&F 96365, an Inhibitor of Receptor-Mediated Calcium Entry
J Pharmacol Exp Ther February 1, 1998 284:549-552
Select this article
- Douglas W. P. Hay,
- Mark A. Luttmann,
- Mark A. Pullen,
- and Ponnal Nambi
Functional and Binding Characterization of Endothelin Receptors in Human Bronchus: Evidence for a Novel Endothelin B Receptor Subtype?
J Pharmacol Exp Ther February 1, 1998 284:669-677

ENDOCRINE PHARMACOLOGY

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- Marcos R. Difalco,
- Line Dufresne,
- and Luis Fernando Congote
Efficacy of an Insulin-Like Growth Factor-Interleukin-3 Fusion Protein in Reversing the Hematopoietic Toxicity Associated with Azidothymidine in Mice
J Pharmacol Exp Ther February 1, 1998 284:449-454

ANALGESIA AND DRUGS OF ABUSE

Select this article
- Yuri Kolesnikov,
- Subash Jain,
- Roger Wilson,
- and Gavril W. Pasternak
Lack of Morphine and Enkephalin Tolerance in 129/SvEv Mice: Evidence for a NMDA Receptor Defect
J Pharmacol Exp Ther February 1, 1998 284:455-459
Select this article
- Laura M. Harrison,
- Abba J. Kastin,
- and James E. Zadina
Tyr-W-MIF-1 Attenuates Down-Regulation of Opiate Receptors in SH-SY5Y Human Neuroblastoma Cells
J Pharmacol Exp Ther February 1, 1998 284:611-617
Select this article
- David P. D. Woldbye,
- Kristian Klemp,
- and Torsten M. Madsen
Neuropeptide Y Attenuates Naloxone-Precipitated Morphine Withdrawal via Y5-like Receptors
J Pharmacol Exp Ther February 1, 1998 284:633-636
Select this article
- Stuart A. Dunbar and
- Istvan J. Pulai
Repetitive Opioid Abstinence Causes Progressive Hyperalgesia Sensitive to N-Methyl-d-aspartate Receptor Blockade in the Rat
J Pharmacol Exp Ther February 1, 1998 284:678-686

NEUROPHARMACOLOGY

Select this article
- Masayasu Takahashi,
- Jian Wei Ni,
- Sachiko Kawasaki-Yatsugi,
- Takashi Toya,
- Sin-Ichi Yatsugi,
- Masao Shimizu-Sasamata,
- Kazuo Koshiya,
- Jun-Ichi Shishikura,
- Shuichi Sakamoto,
- and Tokio Yamaguchi
YM872, a Novel Selective α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Receptor Antagonist, Reduces Brain Damage after Permanent Focal Cerebral Ischemia in Cats
J Pharmacol Exp Ther February 1, 1998 284:467-473
Select this article
- Russell A. Wilke,
- Shyue-Fang Hsu,
- and Meyer B. Jackson
Dopamine D₄ Receptor Mediated Inhibition of Potassium Current in Neurohypophysial Nerve Terminals
J Pharmacol Exp Ther February 1, 1998 284:542-548
Select this article
- David T. Ault,
- Julie M. Radeff,
- and Linda L. Werling
Modulation of [³H]Dopamine Release from Rat Nucleus Accumbens by Neuropeptide Y May Involve a Sigma ₁-like Receptor
J Pharmacol Exp Ther February 1, 1998 284:553-560
Select this article
- L. Kantor and
- M. E. Gnegy
Protein Kinase C Inhibitors Block Amphetamine-Mediated Dopamine Release in Rat Striatal Slices
J Pharmacol Exp Ther February 1, 1998 284:592-598
Select this article
- Catherine Mytilineou,
- Efthimia Kototos Leonardi,
- Pheona Radcliffe,
- Esa H. Heinonen,
- Shan-Kuo Han,
- Peter Werner,
- Gerald Cohen,
- and C. Warren Olanow
Deprenyl and Desmethylselegiline Protect Mesencephalic Neurons from Toxicity Induced by Glutathione Depletion
J Pharmacol Exp Ther February 1, 1998 284:700-706
Select this article
- Lauren P. Shearman and
- Jerrold S. Meyer
Norepinephrine Transporters in Rat Placenta Labeled with [³H]Nisoxetine
J Pharmacol Exp Ther February 1, 1998 284:736-743

BEHAVIORAL PHARMACOLOGY

Select this article
- Wolfgang Löscher,
- Dagmar Hönack,
- and Chris Rundfeldt
Antiepileptogenic Effects of the Novel Anticonvulsant Levetiracetam (ucb L059) in the Kindling Model of Temporal Lobe Epilepsy
J Pharmacol Exp Ther February 1, 1998 284:474-479
Select this article
- Peter Clausing,
- Glenn D. Newport,
- and John F. Bowyer
Fenfluramine and Norfenfluramine Levels in Brain Microdialysate, Brain Tissue and Plasma of Rats Administered Doses ofd-Fenfluramine Known to Deplete 5-Hydroxytryptamine Levels in Brain
J Pharmacol Exp Ther February 1, 1998 284:618-624
Select this article
- David R. Helton,
- Joseph P. Tizzano,
- James A. Monn,
- Darryle D. Schoepp,
- and Mary Jeanne Kallman
Anxiolytic and Side-Effect Profile of LY354740: A Potent, Highly Selective, Orally Active Agonist for Group II Metabotropic Glutamate Receptors
J Pharmacol Exp Ther February 1, 1998 284:651-660

CELLULAR AND MOLECULAR PHARMACOLOGY

Select this article
- Ildiko Kovacs,
- Henry I. Yamamura,
- Sue L. Waite,
- Eva V. Varga,
- and William R. Roeske
Pharmacological Comparison of the Cloned Human and Rat M2 Muscarinic Receptor Genes Expressed in the Murine Fibroblast (B82) Cell Line
J Pharmacol Exp Ther February 1, 1998 284:500-507
Select this article
- G. Jeglitsch,
- K. Rein,
- D. G. Baden,
- and D. J. Adams
Brevetoxin-3 (PbTx-3) and Its Derivatives Modulate Single Tetrodotoxin-Sensitive Sodium Channels in Rat Sensory Neurons
J Pharmacol Exp Ther February 1, 1998 284:516-525
Select this article
- Ying Ruan,
- Hong Kan,
- Jean-Hugues Parmentier,
- Soghra Fatima,
- Lee F. Allen,
- and Kafait U. Malik
Alpha-1A Adrenergic Receptor Stimulation with Phenylephrine Promotes Arachidonic Acid Release by Activation of Phospholipase D in Rat-1 Fibroblasts: Inhibition by Protein Kinase A
J Pharmacol Exp Ther February 1, 1998 284:576-585
Select this article
- Lihjen Sun,
- Louis H. Philipson,
- and Richard J. Miller
Regulation of K⁺ and Ca⁺⁺ Channels by a Family of Neuropeptide Y Receptors
J Pharmacol Exp Ther February 1, 1998 284:625-632
Select this article
- Murielle Rinaldi-Carmona,
- Francis Barth,
- José Millan,
- Jean-Marie Derocq,
- Pierre Casellas,
- Christian Congy,
- Didier Oustric,
- Martine Sarran,
- Monsif Bouaboula,
- Bernard Calandra,
- Marielle Portier,
- David Shire,
- Jean-Claude Brelière,
- and Gérard Le Fur
SR 144528, the First Potent and Selective Antagonist of the CB2 Cannabinoid Receptor
J Pharmacol Exp Ther February 1, 1998 284:644-650
Select this article
- Sherry L. Purkerson and
- Lincoln T. Potter
Use of Antimuscarinic Toxins To Facilitate Studies of Striatal m4 Muscarinic Receptors
J Pharmacol Exp Ther February 1, 1998 284:707-713
Select this article
- Paul W. Young,
- Derek R. Buckle,
- Barrie C. C. Cantello,
- Helen Chapman,
- John C. Clapham,
- Paul J. Coyle,
- David Haigh,
- Richard M. Hindley,
- Julie C. Holder,
- Howard Kallender,
- Alison J. Latter,
- Kenneth W. M. Lawrie,
- Danuta Mossakowska,
- Gregory J. Murphy,
- Lynne Roxbee Cox,
- and Stephen A. Smith
Identification of High-Affinity Binding Sites for the Insulin Sensitizer Rosiglitazone (BRL-49653) in Rodent and Human Adipocytes Using a Radioiodinated Ligand for Peroxisomal Proliferator-Activated Receptor γ
J Pharmacol Exp Ther February 1, 1998 284:751-759
Select this article
- Douglas W. Sapp and
- Hermes H. Yeh
Ethanol-GABA_A Receptor Interactions: A Comparison between Cell Lines and Cerebellar Purkinje Cells
J Pharmacol Exp Ther February 1, 1998 284:768-776
Select this article
- Kenneth A. Stauderman,
- L. Scott Mahaffy,
- Michael Akong,
- Gönül Veliçelebi,
- Laura E. Chavez-Noriega,
- James H. Crona,
- Edwin C. Johnson,
- Kathryn J. Elliott,
- Alison Gillespie,
- Richard T. Reid,
- Pamala Adams,
- Michael M. Harpold,
- and Janis Corey-Naeve
Characterization of Human Recombinant Neuronal Nicotinic Acetylcholine Receptor Subunit Combinations α2β4, α3β4 and α4β4 Stably Expressed in HEK293 Cells
J Pharmacol Exp Ther February 1, 1998 284:777-789

CARDIOVASCULAR PHARMACOLOGY

Select this article
- Hiromu Kawasaki,
- Makoto Takenaga,
- Hiroaki Araki,
- Kojirou Futagami,
- and Yutaka Gomita
Angiotensin Inhibits Neurotransmission of Calcitonin Gene-Related Peptide-Containing Vasodilator Nerves in Mesenteric Artery of Spontaneously Hypertensive Rats
J Pharmacol Exp Ther February 1, 1998 284:508-515
Select this article
- Zhenguo Liu,
- M. Audrey Rudd,
- Jane E. Freedman,
- and Joseph Loscalzo
S-Transnitrosation Reactions Are Involved in the Metabolic Fate and Biological Actions of Nitric Oxide
J Pharmacol Exp Ther February 1, 1998 284:526-534
Select this article
- Giuseppe Alloatti,
- Claudia Penna,
- Maria Pia Gallo,
- Renzo C. Levi,
- Ezio Bombardelli,
- and Giovanni Appendino
Differential Effects of Paclitaxel and Derivatives on Guinea Pig Isolated Heart and Papillary Muscle
J Pharmacol Exp Ther February 1, 1998 284:561-567
Select this article
- Eugene Patterson,
- Lianmin Ma,
- Bela Szabo,
- Casey P. Robinson,
- and Udho Thadani
Ovariectomy and Estrogen-Induced Alterations in Myocardial Contractility in Female Rabbits: Role of the L-Type Calcium Channel
J Pharmacol Exp Ther February 1, 1998 284:586-591
Select this article
- Kishor M. Wasan,
- Manisha Ramaswamy,
- Wesley Wong,
- and P. Haydn Pritchard
Lipid Transfer Protein I Facilitated Transfer of Cyclosporine from Low- to High-Density Lipoproteins is Only Partially Dependent on its Cholesteryl Ester Transfer Activity
J Pharmacol Exp Ther February 1, 1998 284:599-605
Select this article
- Lifan Zhao and
- Randall L. Tackett
Oxidized Low-Density Lipoprotein Inhibits Acetylcholine-Induced Vasorelaxation and Increases 5-HT-Induced Vasoconstriction in Isolated Human Saphenous Vein
J Pharmacol Exp Ther February 1, 1998 284:637-643
Select this article
- Peter Baluk,
- Natasha W. Fine,
- Holly A. Thomas,
- Edward T. Wei,
- and Donald M. Mcdonald
Anti-inflammatory Mystixin Peptides Inhibit Plasma Leakage Without Blocking Endothelial Gap Formation
J Pharmacol Exp Ther February 1, 1998 284:693-699
Select this article
- W. Zhang,
- L. Edvinsson,
- and Tony J-F. Lee
Mechanism of Nicotine-Induced Relaxation in the Porcine Basilar Artery
J Pharmacol Exp Ther February 1, 1998 284:790-797

DEVELOPMENTAL PHARMACOLOGY

Select this article
- John A. Ring,
- Hany Ghabrial,
- Michael S. Ching,
- Arthur Shulkes,
- Richard A. Smallwood,
- and Denis J. Morgan
Propranolol Elimination by Right and Left Fetal Liver: Studies in the Intact Isolated Perfused Fetal Sheep Liver
J Pharmacol Exp Ther February 1, 1998 284:535-541

GASTROINTESTINAL PHARMACOLOGY

Select this article
- Cormac T. Taylor,
- Steven J. Lisco,
- Christopher S. Awtrey,
- and Sean P. Colgan
Hypoxia Inhibits Cyclic Nucleotide-Stimulated Epithelial Ion Transport: Role for Nucleotide Cyclases as Oxygen Sensors
J Pharmacol Exp Ther February 1, 1998 284:568-575
Select this article
- Satoshi Aiko,
- John Fuseler,
- and Matthew B. Grisham
Effects of Nitric Oxide Synthase Inhibition or Sulfasalazine on the Spontaneous Colitis Observed in HLA-B27 Transgenic Rats
J Pharmacol Exp Ther February 1, 1998 284:722-727
Select this article
- Pascal Nicole,
- Kai Du,
- Alain Couvineau,
- and Marc Laburthe
Site-Directed Mutagenesis of Human Vasoactive Intestinal Peptide Receptor Subtypes VIP1 and VIP2: Evidence for Difference in the Structure-Function Relationship
J Pharmacol Exp Ther February 1, 1998 284:744-750

RENAL PHARMACOLOGY

Select this article
- Laura Trumper,
- Liliana A. Monasterolo,
- and M. Mónica Elías
Probenecid Protects against In VivoAcetaminophen-Induced Nephrotoxicity in Male Wistar Rats
J Pharmacol Exp Ther February 1, 1998 284:606-610

IMMUNOPHARMACOLOGY

Select this article
- Jeffrey R. Jackson,
- Brian Bolognese,
- Leonard Hillegass,
- Shouki Kassis,
- Jerry Adams,
- Don E. Griswold,
- and James D. Winkler
Pharmacological Effects of SB 220025, a Selective Inhibitor of P38 Mitogen-Activated Protein Kinase, in Angiogenesis and Chronic Inflammatory Disease Models
J Pharmacol Exp Ther February 1, 1998 284:687-692

PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS

Select this article
- Daniel S. Fletcher,
- W. Richard Widmer,
- Silvi Luell,
- Amy Christen,
- Chad Orevillo,
- Shrenik Shah,
- and Denise Visco
Therapeutic Administration of a Selective Inhibitor of Nitric Oxide Synthase Does Not Ameliorate the Chronic Inflammation and Tissue Damage Associated with Adjuvant-Induced Arthritis in Rats
J Pharmacol Exp Ther February 1, 1998 284:714-721

CHEMOTHERAPY/GENE THERAPY

Select this article
- Masahiko Kurokawa,
- Toyoharu Hozumi,
- Purusotam Basnet,
- Michio Nakano,
- Shigetoshi Kadota,
- Tuneo Namba,
- Takashi Kawana,
- and Kimiyasu Shiraki
Purification and Characterization of Eugeniin as an Anti-herpesvirus Compound from Geum japonicum andSyzygium aromaticum
J Pharmacol Exp Ther February 1, 1998 284:728-735

DRUG METABOLISM AND DISPOSITION

Oxidation of Histamine H1 Antagonist Mequitazine is Catalyzed by Cytochrome P450 2D6 in Human Liver Microsomes

Pharmacokinetic-Pharmacodynamic Modeling of the Anticonvulsant and Electroencephalogram Effects of Phenytoin in Rats

Hepatic Uptake of Bromosulfophthalein-Glutathione in Perfused Eisai Hyperbilirubinemic Mutant Rat Liver: A Multiple-Indicator Dilution Study

In Vivo Cimetidine Inhibits Hepatic CYP2C6 and CYP2C11 but Not CYP1A1 in Adult Male Rats ,

Stereoselective Hepatobiliary Transport of the Quinolone Antibiotic Grepafloxacin and Its Glucuronide in the Rat

Human Hepatocyte Growth Factor Down-regulates the Expression of Cytochrome P450 Isozymes in Human Hepatocytes in Primary Culture

PULMONARY PHARMACOLOGY

Nitric Oxide Opposes Phorbol Ester-Induced Increases in Pulmonary Microvascular Permeability in Dogs

Leukotriene D4 Contractions in Human Airways are Blocked by SK&F 96365, an Inhibitor of Receptor-Mediated Calcium Entry

Functional and Binding Characterization of Endothelin Receptors in Human Bronchus: Evidence for a Novel Endothelin B Receptor Subtype?

ENDOCRINE PHARMACOLOGY

Efficacy of an Insulin-Like Growth Factor-Interleukin-3 Fusion Protein in Reversing the Hematopoietic Toxicity Associated with Azidothymidine in Mice

ANALGESIA AND DRUGS OF ABUSE

Lack of Morphine and Enkephalin Tolerance in 129/SvEv Mice: Evidence for a NMDA Receptor Defect

Tyr-W-MIF-1 Attenuates Down-Regulation of Opiate Receptors in SH-SY5Y Human Neuroblastoma Cells

Neuropeptide Y Attenuates Naloxone-Precipitated Morphine Withdrawal via Y5-like Receptors

Repetitive Opioid Abstinence Causes Progressive Hyperalgesia Sensitive to N-Methyl-d-aspartate Receptor Blockade in the Rat

NEUROPHARMACOLOGY

YM872, a Novel Selective α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Receptor Antagonist, Reduces Brain Damage after Permanent Focal Cerebral Ischemia in Cats

Dopamine D4 Receptor Mediated Inhibition of Potassium Current in Neurohypophysial Nerve Terminals

Modulation of [3H]Dopamine Release from Rat Nucleus Accumbens by Neuropeptide Y May Involve a Sigma 1-like Receptor

Protein Kinase C Inhibitors Block Amphetamine-Mediated Dopamine Release in Rat Striatal Slices

Deprenyl and Desmethylselegiline Protect Mesencephalic Neurons from Toxicity Induced by Glutathione Depletion

Norepinephrine Transporters in Rat Placenta Labeled with [3H]Nisoxetine

BEHAVIORAL PHARMACOLOGY

Antiepileptogenic Effects of the Novel Anticonvulsant Levetiracetam (ucb L059) in the Kindling Model of Temporal Lobe Epilepsy

Fenfluramine and Norfenfluramine Levels in Brain Microdialysate, Brain Tissue and Plasma of Rats Administered Doses ofd-Fenfluramine Known to Deplete 5-Hydroxytryptamine Levels in Brain

Anxiolytic and Side-Effect Profile of LY354740: A Potent, Highly Selective, Orally Active Agonist for Group II Metabotropic Glutamate Receptors

CELLULAR AND MOLECULAR PHARMACOLOGY

Pharmacological Comparison of the Cloned Human and Rat M2 Muscarinic Receptor Genes Expressed in the Murine Fibroblast (B82) Cell Line

Brevetoxin-3 (PbTx-3) and Its Derivatives Modulate Single Tetrodotoxin-Sensitive Sodium Channels in Rat Sensory Neurons

Alpha-1A Adrenergic Receptor Stimulation with Phenylephrine Promotes Arachidonic Acid Release by Activation of Phospholipase D in Rat-1 Fibroblasts: Inhibition by Protein Kinase A

Regulation of K+ and Ca++ Channels by a Family of Neuropeptide Y Receptors

SR 144528, the First Potent and Selective Antagonist of the CB2 Cannabinoid Receptor

Use of Antimuscarinic Toxins To Facilitate Studies of Striatal m4 Muscarinic Receptors

Identification of High-Affinity Binding Sites for the Insulin Sensitizer Rosiglitazone (BRL-49653) in Rodent and Human Adipocytes Using a Radioiodinated Ligand for Peroxisomal Proliferator-Activated Receptor γ

Ethanol-GABAA Receptor Interactions: A Comparison between Cell Lines and Cerebellar Purkinje Cells

Characterization of Human Recombinant Neuronal Nicotinic Acetylcholine Receptor Subunit Combinations α2β4, α3β4 and α4β4 Stably Expressed in HEK293 Cells

CARDIOVASCULAR PHARMACOLOGY

Angiotensin Inhibits Neurotransmission of Calcitonin Gene-Related Peptide-Containing Vasodilator Nerves in Mesenteric Artery of Spontaneously Hypertensive Rats

S-Transnitrosation Reactions Are Involved in the Metabolic Fate and Biological Actions of Nitric Oxide

Differential Effects of Paclitaxel and Derivatives on Guinea Pig Isolated Heart and Papillary Muscle

Ovariectomy and Estrogen-Induced Alterations in Myocardial Contractility in Female Rabbits: Role of the L-Type Calcium Channel

Lipid Transfer Protein I Facilitated Transfer of Cyclosporine from Low- to High-Density Lipoproteins is Only Partially Dependent on its Cholesteryl Ester Transfer Activity

Oxidized Low-Density Lipoprotein Inhibits Acetylcholine-Induced Vasorelaxation and Increases 5-HT-Induced Vasoconstriction in Isolated Human Saphenous Vein

Anti-inflammatory Mystixin Peptides Inhibit Plasma Leakage Without Blocking Endothelial Gap Formation

Mechanism of Nicotine-Induced Relaxation in the Porcine Basilar Artery

DEVELOPMENTAL PHARMACOLOGY

Propranolol Elimination by Right and Left Fetal Liver: Studies in the Intact Isolated Perfused Fetal Sheep Liver

GASTROINTESTINAL PHARMACOLOGY

Hypoxia Inhibits Cyclic Nucleotide-Stimulated Epithelial Ion Transport: Role for Nucleotide Cyclases as Oxygen Sensors

Effects of Nitric Oxide Synthase Inhibition or Sulfasalazine on the Spontaneous Colitis Observed in HLA-B27 Transgenic Rats

Site-Directed Mutagenesis of Human Vasoactive Intestinal Peptide Receptor Subtypes VIP1 and VIP2: Evidence for Difference in the Structure-Function Relationship

RENAL PHARMACOLOGY

Probenecid Protects against In VivoAcetaminophen-Induced Nephrotoxicity in Male Wistar Rats

IMMUNOPHARMACOLOGY

Pharmacological Effects of SB 220025, a Selective Inhibitor of P38 Mitogen-Activated Protein Kinase, in Angiogenesis and Chronic Inflammatory Disease Models

PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS

Therapeutic Administration of a Selective Inhibitor of Nitric Oxide Synthase Does Not Ameliorate the Chronic Inflammation and Tissue Damage Associated with Adjuvant-Induced Arthritis in Rats

CHEMOTHERAPY/GENE THERAPY

Purification and Characterization of Eugeniin as an Anti-herpesvirus Compound from Geum japonicum andSyzygium aromaticum

This Issue

Current Issue

In Vivo Cimetidine Inhibits Hepatic CYP2C6 and CYP2C11 but Not CYP1A1 in Adult Male Rats ^,

Leukotriene D₄ Contractions in Human Airways are Blocked by SK&F 96365, an Inhibitor of Receptor-Mediated Calcium Entry

Dopamine D₄ Receptor Mediated Inhibition of Potassium Current in Neurohypophysial Nerve Terminals

Modulation of [³H]Dopamine Release from Rat Nucleus Accumbens by Neuropeptide Y May Involve a Sigma ₁-like Receptor

Norepinephrine Transporters in Rat Placenta Labeled with [³H]Nisoxetine

Regulation of K⁺ and Ca⁺⁺ Channels by a Family of Neuropeptide Y Receptors

Ethanol-GABA_A Receptor Interactions: A Comparison between Cell Lines and Cerebellar Purkinje Cells