Table of Contents

September 1997; 282 (3)

DRUG METABOLISM AND DISPOSITION

    • Zhen-Yu Wu,
    • B. Mark Smithers,
    • and Michael S. Roberts

    Tissue and Perfusate Pharmacokinetics of Melphalan in Isolated Perfused Rat Hindlimb

    J Pharmacol Exp Ther September 1, 1997 282:1131-1138
    • Josephine M. Glover,
    • Janet M. Leeds,
    • Timothy G. K. Mant,
    • Dipti Amin,
    • Daniel L. Kisner,
    • Joan E. Zuckerman,
    • Richard S. Geary,
    • Arthur A. Levin,
    • and William R. Shanahan, Jr.

    Phase I Safety and Pharmacokinetic Profile of an Intercellular Adhesion Molecule-1 Antisense Oligodeoxynucleotide (ISIS 2302)

    J Pharmacol Exp Ther September 1, 1997 282:1173-1180
    • Jing Lin and
    • John R. Cashman

    N-Oxygenation of Phenethylamine to the trans-Oxime by Adult Human Liver Flavin-Containing Monooxygenase and Retroreduction of Phenethylamine Hydroxylamine by Human Liver Microsomes

    J Pharmacol Exp Ther September 1, 1997 282:1269-1279
    • Jeffrey C. Stevens,
    • Rebecca B. White,
    • Shih Hsein Hsu,
    • and Michel Martinet

    Human Liver CYP2B6-Catalyzed Hydroxylation of RP 73401

    J Pharmacol Exp Ther September 1, 1997 282:1389-1395
    • Delphine Valente,
    • Marcel Delaforge,
    • Saik Urien,
    • Dominique Guivarc’H,
    • Raymond Vienet,
    • Jean-Marc Grognet,
    • and Eric Ezan

    Metabolite Involvement in Bromocriptine-Induced Prolactin Inhibition in Rats

    J Pharmacol Exp Ther September 1, 1997 282:1418-1424
    • Yasuhiro Masubuchi,
    • Takashi Iwasa,
    • Shin Hosokawa,
    • Tokuji Suzuki,
    • Toshiharu Horie,
    • Susumu Imaoka,
    • Yoshihiko Funae,
    • and Shizuo Narimatsu

    Selective Deficiency of Debrisoquine 4-Hydroxylase Activity in Mouse Liver Microsomes

    J Pharmacol Exp Ther September 1, 1997 282:1435-1441
    • Ger-Jan Sanderink,
    • Bruno Bournique,
    • Jeffrey Stevens,
    • Martine Petry,
    • and Michel Martinet

    Involvement of Human CYP1A Isoenzymes in the Metabolism and Drug Interactions of Riluzole In Vitro

    J Pharmacol Exp Ther September 1, 1997 282:1465-1472
    • Katsuko Takasawa,
    • Tetsuya Terasaki,
    • Hiroshi Suzuki,
    • Tsuyoshi Ooie,
    • and Yuichi Sugiyama

    Distributed Model Analysis of 3′-Azido-3′-Deoxythymidine and 2′,3′-Dideoxyinosine Distribution in Brain Tissue and Cerebrospinal Fluid

    J Pharmacol Exp Ther September 1, 1997 282:1509-1517
    • Jörg Huwyler,
    • Jing Yang,
    • and William M. Pardridge

    Receptor Mediated Delivery of Daunomycin Using Immunoliposomes: Pharmacokinetics and Tissue Distribution in the Rat

    J Pharmacol Exp Ther September 1, 1997 282:1541-1546
    • E. S. Messina,
    • R. F. Tyndale,
    • and E. M. Sellers

    A Major Role for CYP2A6 in Nicotine C-Oxidation by Human Liver Microsomes

    J Pharmacol Exp Ther September 1, 1997 282:1608-1614

NEUROPHARMACOLOGY

    • Andrea Köppen,
    • Jochen Klein,
    • Christina Erb,
    • and Konrad Löffelholz

    Acetylcholine Release and Choline Availability in Rat Hippocampus: Effects of Exogenous Choline and Nicotinamide

    J Pharmacol Exp Ther September 1, 1997 282:1139-1145
    • Wei Tang,
    • Jan Palaty,
    • and Frank S. Abbott

    Time Course of α-Fluorinated Valproic Acid in Mouse Brain and Serum and its Effect on Synaptosomal γ-Aminobutyric Acid Levels in Comparison to Valproic Acid

    J Pharmacol Exp Ther September 1, 1997 282:1163-1172
    • Marike Lancel,
    • Johannes Faulhaber,
    • Thomas Schiffelholz,
    • Elena Romeo,
    • Flavia Di Michele,
    • Florian Holsboer,
    • and Rainer Rupprecht

    Allopregnanolone Affects Sleep in a Benzodiazepine-Like Fashion

    J Pharmacol Exp Ther September 1, 1997 282:1213-1218
    • Robert E. Joseph, Jr.,
    • Wei-Jen Tsai,
    • Li-I Tsao,
    • Tsung-Ping Su,
    • and Edward J. Cone

    In Vitro Characterization of Cocaine Binding Sites in Human Hair

    J Pharmacol Exp Ther September 1, 1997 282:1228-1241
    • George P. Brown,
    • Ke Yang,
    • Ouathek Ouerfelli,
    • Kelly M. Standifer,
    • David Byrd,
    • and Gavril W. Pasternak

    3H-Morphine-6β-Glucuronide Binding in Brain Membranes and an MOR-1-Transfected Cell Line

    J Pharmacol Exp Ther September 1, 1997 282:1291-1297
    • Si-Jia Zhu,
    • Michael P. Kavanaugh,
    • Mark S. Sonders,
    • Susan G. Amara,
    • and Nancy R. Zahniser

    Activation of Protein Kinase C Inhibits Uptake, Currents and Binding Associated with the Human Dopamine Transporter Expressed inXenopus Oocytes

    J Pharmacol Exp Ther September 1, 1997 282:1358-1365
    • Zhiming Zhang,
    • Yasuyuki Miyoshi,
    • Paul A. Lapchak,
    • Frank Collins,
    • Dana Hilt,
    • Carl Lebel,
    • Richard Kryscio,
    • and Don M. Gash

    Dose Response to Intraventricular Glial Cell Line-Derived Neurotrophic Factor Administration in Parkinsonian Monkeys

    J Pharmacol Exp Ther September 1, 1997 282:1396-1401
    • Stuart B. Mazzone,
    • Colin F. Hinrichsen,
    • and Dominic P. Geraghty

    Substance P Receptors in Brain Stem Respiratory Centers of the Rat: Regulation of NK1 Receptors by Hypoxia

    J Pharmacol Exp Ther September 1, 1997 282:1547-1556
    • Q. Li,
    • N. A. Muma,
    • G. Battaglia,
    • and L. D. Van De Kar

    A Desensitization of Hypothalamic 5-HT1A Receptors by Repeated Injections of Paroxetine: Reduction in the Levels of Gi and Go Proteins and Neuroendocrine Responses, but Not in the Density of 5-HT1AReceptors

    J Pharmacol Exp Ther September 1, 1997 282:1581-1590
    • Glenn T. Gobbel,
    • Thelma Y.-Y. Chan,
    • and Pak H. Chan

    Nitric Oxide- and Superoxide-Mediated Toxicity in Cerebral Endothelial Cells

    J Pharmacol Exp Ther September 1, 1997 282:1600-1607
    • Christopher S. Breivogel,
    • Laura J. Sim,
    • and Steven R. Childers

    Regional Differences in Cannabinoid Receptor/G-protein Coupling in Rat Brain

    J Pharmacol Exp Ther September 1, 1997 282:1632-1642

CELLULAR AND MOLECULAR PHARMACOLOGY

    • Mitsutoshi Kimura and
    • Masahiko Ogihara

    Proliferation of Adult Rat Hepatocytes by Hepatocyte Growth Factor Is Potentiated by Both Phenylephrine and Metaproterenol

    J Pharmacol Exp Ther September 1, 1997 282:1146-1154
    • Chao-Sheng Huang,
    • Jin-Ho Song,
    • Keiichi Nagata,
    • Jay Z Yeh,
    • and Toshio Narahashi

    Effects of the Neuroprotective Agent Riluzole on the High Voltage-Activated Calcium Channels of Rat Dorsal Root Ganglion Neurons

    J Pharmacol Exp Ther September 1, 1997 282:1280-1290
    • Roberto T. Sudo and
    • Thomas E. Nelson

    Changes in Ryanodine-Induced Contractures by Stimulus Frequency in Malignant Hyperthermia Susceptible and Malignant Hyperthermia Nonsusceptible Dog Skeletal Muscle

    J Pharmacol Exp Ther September 1, 1997 282:1331-1336
    • Irina A. Omelchenko,
    • Cole S. Nelson,
    • and Charles N. Allen

    Lead Inhibition of N-Methyl-d-aspartate Receptors Containing NR2A, NR2C and NR2D Subunits

    J Pharmacol Exp Ther September 1, 1997 282:1458-1464
    • Michele Solem,
    • Thomas McMahon,
    • and Robert O. Messing

    Protein Kinase A Regulates Inhibition of N- and P/Q-type Calcium Channels by Ethanol in PC12 Cells

    J Pharmacol Exp Ther September 1, 1997 282:1487-1495
    • L. S. Aspinwall,
    • I. Bermudez,
    • L. A. King,
    • and K. A. Wafford

    The Interactions of Hexachlorocyclohexane Isomers with Human γ-Aminobutyric AcidA Receptors Expressed inXenopus Oocytes

    J Pharmacol Exp Ther September 1, 1997 282:1557-1564

RENAL PHARMACOLOGY

    • Jesper Spannow,
    • Klaus Thomsen,
    • Jørgen Søberg Petersen,
    • Ketil Haugan,
    • and Sten Christensen

    Influence of Renal Nerves and Sodium Balance on the Acute Antidiuretic Effect of Bendroflumethiazide in Rats with Diabetes Insipidus

    J Pharmacol Exp Ther September 1, 1997 282:1155-1162
    • Kathryn M. Shanahan,
    • Allan M. Evans,
    • and Roger L. Nation

    Disposition of Morphine in the Rat Isolated Perfused Kidney: Concentration Ranging Studies

    J Pharmacol Exp Ther September 1, 1997 282:1518-1525

ANALGESIA AND DRUGS OF ABUSE

    • R. Nadeson and
    • C. S. Goodchild

    Antinociceptive Properties of Propofol: Involvement of Spinal Cord γ-Aminobutyric AcidA Receptors

    J Pharmacol Exp Ther September 1, 1997 282:1181-1186
    • Mark J. Field,
    • Elizabeth F. Holloman,
    • Scott McCleary,
    • John Hughes,
    • and Lakhbir Singh

    Evaluation of Gabapentin and S-(+)-3-Isobutylgaba in a Rat Model of Postoperative Pain

    J Pharmacol Exp Ther September 1, 1997 282:1242-1246
    • H. R. Garner,
    • Timothy F. Burke,
    • C. David Lawhorn,
    • Joanne M. Stoner,
    • and William D. Wessinger

    Butorphanol-Mediated Antinociception in Mice: Partial Agonist Effects and Mu Receptor Involvement ,

    J Pharmacol Exp Ther September 1, 1997 282:1253-1261
    • Bruce Nock,
    • Michele Wich,
    • and Theodore J. Cicero

    Chronic Exposure to Morphine Increases Corticosteroid-Binding Globulin

    J Pharmacol Exp Ther September 1, 1997 282:1262-1268
    • Alice A. Larson and
    • Kelley F. Kitto

    Manipulations of Zinc in the Spinal Cord, by Intrathecal Injection of Zinc Chloride, Disodium-Calcium-EDTA, or Dipicolinic Acid, Alter Nociceptive Activity in Mice

    J Pharmacol Exp Ther September 1, 1997 282:1319-1325
    • Alice A. Larson and
    • Kelley F. Kitto

    Mutual Antagonism Between Nerve Growth Factor and Substance P N-terminal Activity on Nociceptive Activity in Mice

    J Pharmacol Exp Ther September 1, 1997 282:1345-1350
    • Juhana J. Idänpään-Heikkilä,
    • Gisèle Guilbaud,
    • and Valérie Kayser

    Prevention of Tolerance to the Antinociceptive Effects of Systemic Morphine by a Selective Cholecystokinin-B Receptor Antagonist in a Rat Model of Peripheral Neuropathy

    J Pharmacol Exp Ther September 1, 1997 282:1366-1372
    • Liza Leventhal,
    • Lesley B. Stevens,
    • Grace C. Rossi,
    • Gavril W. Pasternak,
    • and Richard J. Bodnar

    Antisense Mapping of the MOR-1 Opioid Receptor Clone: Modulation of Hyperphagia Induced by DAMGO

    J Pharmacol Exp Ther September 1, 1997 282:1402-1407
    • Carolyn A. Fairbanks and
    • George L. Wilcox

    Acute Tolerance To Spinally Administered Morphine Compares Mechanistically with Chronically Induced Morphine Tolerance

    J Pharmacol Exp Ther September 1, 1997 282:1408-1417

BEHAVIORAL PHARMACOLOGY

    • James P. Zacny,
    • Kim Conley,
    • and Jeff Galinkin

    Comparing the Subjective, Psychomotor and Physiological Effects of Intravenous Buprenorphine and Morphine in Healthy Volunteers

    J Pharmacol Exp Ther September 1, 1997 282:1187-1197
    • M. I. Damaj,
    • W. Glassco,
    • M. J. Marks,
    • B. Slobe,
    • J. R. James,
    • E. L. May,
    • J. A. Rosecrans,
    • A. C. Collins,
    • and B. R. Martin

    Pharmacological Investigation of (+)- and (−)-cis-2,3,3a,4,5,9b-Hexahydro-1-methyl-1H-pyrrolo[3,2-h]isoquinoline, a Bridged-Nicotine Analog

    J Pharmacol Exp Ther September 1, 1997 282:1425-1434
    • Nancy A. Ator and
    • Roland R. Griffiths

    Selectivity in the Generalization Profile in Baboons Trained to Discriminate Lorazepam: Benzodiazepines, Barbiturates and Other Sedative/Anxiolytics

    J Pharmacol Exp Ther September 1, 1997 282:1442-1457
    • Jesse Brodkin and
    • Joseph M. Moerschbaecher

    SR141716A Antagonizes the Disruptive Effects of Cannabinoid Ligands on Learning in Rats

    J Pharmacol Exp Ther September 1, 1997 282:1526-1532

GASTROINTESTINAL PHARMACOLOGY

    • J. L. Elmhurst,
    • P.-A. Betti,
    • and P. K. Rangachari

    Intestinal Effects of Isoprostanes: Evidence for the Involvement of Prostanoid EP and TP Receptors

    J Pharmacol Exp Ther September 1, 1997 282:1198-1205
    • D. Ghanekar,
    • E. M. Hadac,
    • E. L. Holicky,
    • and L. J. Miller

    Differences in Partial Agonist Action at Cholecystokinin Receptors of Mouse and Rat Are Dependent on Parameters Extrinsic to Receptor Structure: Molecular Cloning, Expression and Functional Characterization of the Mouse Type A Cholecystokinin Receptor

    J Pharmacol Exp Ther September 1, 1997 282:1206-1212
    • Shinichi Kato,
    • Takuya Hirata,
    • Motohiro Kitamura,
    • and Koji Takeuchi

    Gastric Hyperemic Response During Vagally Mediated Acid Secretion by TRH Analog in Rats

    J Pharmacol Exp Ther September 1, 1997 282:1351-1357
    • Jon M. Goldhill,
    • Terez Shea-Donohue,
    • Nasima Ali,
    • and Victor M. Piñeiro-Carrero

    Tachykinergic Neurotransmission Is Enhanced in Small Intestinal Circular Muscle in a Rabbit Model of Inflammation

    J Pharmacol Exp Ther September 1, 1997 282:1373-1378
    • Yuko Muto,
    • Taku Nagao,
    • and Tetsuro Urushidani

    The Putative Phospholipase C Inhibitor U73122 and Its Negative Control, U73343, Elicit Unexpected Effects on the Rabbit Parietal Cell

    J Pharmacol Exp Ther September 1, 1997 282:1379-1388
    • Elaine M. Conner,
    • Stephen Brand,
    • Jonathan M. Davis,
    • F. Stephen Laroux,
    • Vito J. Palombella,
    • John W. Fuseler,
    • David Y. Kang,
    • Robert E. Wolf,
    • and Matthew B. Grisham

    Proteasome Inhibition Attenuates Nitric Oxide Synthase Expression, VCAM-1 Transcription and the Development of Chronic Colitis

    J Pharmacol Exp Ther September 1, 1997 282:1615-1622

AUTONOMIC PHARMACOLOGY

    • Donald A. Heck and
    • David B. Bylund

    Mechanism of Down-regulation of Alpha-2 Adrenergic Receptor Subtypes

    J Pharmacol Exp Ther September 1, 1997 282:1219-1227
    • Serafim Guimarães,
    • Maria Q. Paiva,
    • and Oduvaldo Pereira

    α-Adrenoceptor-Mediated Prejunctional Effects of Chloroethylclonidine in the Canine Saphenous Vein

    J Pharmacol Exp Ther September 1, 1997 282:1326-1330
    • Donald B. Hoover and
    • David A. Neely

    Differentiation of Muscarinic Receptors Mediating Negative Chronotropic and Vasoconstrictor Responses to Acetylcholine in Isolated Rat Hearts

    J Pharmacol Exp Ther September 1, 1997 282:1337-1344
    • Sujata Persad,
    • Vijayan Elimban,
    • Jasvinder Kaila,
    • and Naranjan S. Dhalla

    Biphasic Alterations in Cardiac Beta-Adrenoceptor Signal Transduction Mechanism Due to Oxyradicals

    J Pharmacol Exp Ther September 1, 1997 282:1623-1631
    • R. S. Wagner,
    • C. J. Smith,
    • A. M. Taylor,
    • and R. A. Rhoades

    Phosphodiesterase Inhibition Improves Agonist-Induced Relaxation of Hypertensive Pulmonary Arteries

    J Pharmacol Exp Ther September 1, 1997 282:1650-1657

ENDOCRINE PHARMACOLOGY

    • Chi Yang,
    • Bumsup Lee,
    • Ter-Hsin Chen,
    • and Walter H. Hsu

    Mechanisms of Bradykinin-Induced Insulin Secretion in Clonalbeta Cell Line RINm5F

    J Pharmacol Exp Ther September 1, 1997 282:1247-1252
    • H. Neal Bramson,
    • David Hermann,
    • Kenneth W. Batchelor,
    • Frank W. Lee,
    • Michael K. James,
    • and Stephen V. Frye

    Unique Preclinical Characteristics of GG745, A Potent Dual Inhibitor of 5AR

    J Pharmacol Exp Ther September 1, 1997 282:1496-1502

IMMUNOPHARMACOLOGY

    • Gordon Todderud,
    • Xina Nair,
    • Debbie Lee,
    • Julie Alford,
    • Lynda Davern,
    • Paul Stanley,
    • Carol Bachand,
    • Philippe Lapointe,
    • Anne Marinier,
    • Alain Martel,
    • Marcel Menard,
    • John J. Wright,
    • Jurgen Bajorath,
    • Diane Hollenbaugh,
    • Alejandro Aruffo,
    • and Kenneth M. Tramposch

    BMS-190394, a Selectin Inhibitor, Prevents Rat Cutaneous Inflammatory Reactions

    J Pharmacol Exp Ther September 1, 1997 282:1298-1304

CHEMOTHERAPY/GENE THERAPY

    • Torunn Fiskerstrand,
    • Per Magne Uel,
    • and and Helga Refsum

    Folate Depletion Induced by Methotrexate Affects Methionine Synthase Activity and Its Susceptibility to Inactivation by Nitrous Oxide

    J Pharmacol Exp Ther September 1, 1997 282:1305-1311
    • Sibylle K. M. Koller-Lucae,
    • Herbert Schott,
    • and Reto A. Schwendener

    Interactions with Human Blood in Vitro and Pharmacokinetic Properties in Mice of Liposomal N4-Octadecyl-1-β-d-arabinofuranosylcytosine, A New Anticancer Drug

    J Pharmacol Exp Ther September 1, 1997 282:1572-1580

CARDIOVASCULAR PHARMACOLOGY

    • Stéphane Prié,
    • Tack Ki Leung,
    • Peter Cernacek,
    • James W. Ryan,
    • and Jocelyn Dupuis

    The Orally Active ETA Receptor Antagonist (+)-(S)-2-(4,6-dimethoxy-pyrimidin-2-yloxy)-3-methoxy-3,3-diphenyl-propionic acid (LU 135252) Prevents the Development of Pulmonary Hypertension and Endothelial Metabolic Dysfunction in Monocrotaline-Treated Rats

    J Pharmacol Exp Ther September 1, 1997 282:1312-1318
    • Shawn G. Clark and
    • Leslie C. Fuchs

    Role of Nitric Oxide and Ca++-Dependent K+ Channels in Mediating Heterogeneous Microvascular Responses to Acetylcholine in Different Vascular Beds

    J Pharmacol Exp Ther September 1, 1997 282:1473-1479
    • Masayuki Endou,
    • Yasuto Tanito,
    • and Fukuichiro Okumura

    A Comparison Between Chronotropic Effects of Neostigmine and Edrophonium in Isolated Guinea Pig Right Atrium

    J Pharmacol Exp Ther September 1, 1997 282:1480-1486
    • John C. Clapham and
    • Nicholas C. Turner

    Effects of the Glucocorticoid II Receptor Antagonist Mifepristone on Hypertension in the Obese Zucker Rat

    J Pharmacol Exp Ther September 1, 1997 282:1503-1508
    • Jose A. Gutierrez,
    • Shawn G. Clark,
    • Ararat D. Giulumian,
    • and Leslie C. Fuchs

    Superoxide Anions Contribute to Impaired Regulation of Blood Pressure by Nitric Oxide During the Development of Cardiomyopathy

    J Pharmacol Exp Ther September 1, 1997 282:1643-1649

TOXICOLOGY

    • William F. Salminen, Jr.,
    • Richard Voellmy,
    • and Stephen M. Roberts

    Differential Heat Shock Protein Induction by Acetaminophen and a Nonhepatotoxic Regioisomer, 3′-Hydroxyacetanilide, in Mouse Liver

    J Pharmacol Exp Ther September 1, 1997 282:1533-1540
    • Robert F. Stachlewitz,
    • Gavin E. Arteel,
    • James A. Raleigh,
    • Henry D. Connor,
    • Ronald P. Mason,
    • and Ronald G. Thurman

    Development and Characterization of a New Model of Tacrine-Induced Hepatotoxicity: Role of the Sympathetic Nervous System and Hypoxia-Reoxygenation

    J Pharmacol Exp Ther September 1, 1997 282:1591-1599

PULMONARY PHARMACOLOGY

    • R. B. Dowling,
    • M. Johnson,
    • P. J. Cole,
    • and R. Wilson

    The Effect of Rolipram, a Type IV Phosphodiesterase Inhibitor, onPseudomonas aeruginosa Infection of Respiratory Mucosa

    J Pharmacol Exp Ther September 1, 1997 282:1565-1571

PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS

    • Thomas Klein,
    • Felix Reutter,
    • Horst Schweer,
    • Hannsjörg W. Seyberth,
    • and Rolf M. Nüsing

    Generation of the Isoprostane 8-Epi-prostaglandin F2α In Vitro and In Vivo via the Cyclooxygenases

    J Pharmacol Exp Ther September 1, 1997 282:1658-1665
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This Issue

September 1997; 282 (3)
  1. DRUG METABOLISM AND DISPOSITION
  2. NEUROPHARMACOLOGY
  3. CELLULAR AND MOLECULAR PHARMACOLOGY
  4. RENAL PHARMACOLOGY
  5. ANALGESIA AND DRUGS OF ABUSE
  6. BEHAVIORAL PHARMACOLOGY
  7. GASTROINTESTINAL PHARMACOLOGY
  8. AUTONOMIC PHARMACOLOGY
  9. ENDOCRINE PHARMACOLOGY
  10. IMMUNOPHARMACOLOGY
  11. CHEMOTHERAPY/GENE THERAPY
  12. CARDIOVASCULAR PHARMACOLOGY
  13. TOXICOLOGY
  14. PULMONARY PHARMACOLOGY
  15. PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS

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