Table of Contents

NEUROPHARMACOLOGY

Select this article
- Claude Guéniau and Claude Oberlander
The Kappa Opioid Agonist Niravoline Decreases Brain Edema in the Mouse Middle Cerebral Artery Occlusion Model of Stroke
J Pharmacol Exp Ther July 1, 1997 282:1-6
Select this article
- Charles R. Breese,
- Michael J. Marks,
- Judy Logel,
- Cathy E. Adams,
- Bernadette Sullivan,
- Allan C. Collins,
- and Sherry Leonard
Effect of Smoking History on [³H]Nicotine Binding in Human Postmortem Brain
J Pharmacol Exp Ther July 1, 1997 282:7-13
Select this article
- Sharon R. Grady,
- Elizabeth U. Grun,
- Michael J. Marks,
- and Allan C. Collins
Pharmacological Comparison of Transient and Persistent [³H]Dopamine Release from Mouse Striatal Synaptosomes and Response to Chronic l-Nicotine Treatment
J Pharmacol Exp Ther July 1, 1997 282:32-43
Select this article
- Shigeru Okuyama,
- Shigeyuki Chaki,
- Ryoko Yoshikawa,
- Yoshiko Suzuki,
- Shin-Ichi Ogawa,
- Yasuko Imagawa,
- Naoya Kawashima,
- Yoko Ikeda,
- Toshihito Kumagai,
- Atsuro Nakazato,
- Masashi Nagamine,
- and Kazuyuki Tomisawa
In Vitro and In Vivo Characterization of the Dopamine D₄ Receptor, Serotonin 5-HT_2AReceptor and Alpha-1 Adrenoceptor Antagonist (R)-(+)-2-Amino-4-(4-Fluorophenyl)- 5-[1-[4-(4-Fluorophenyl)-4-Oxobutyl]Pyrrolidin-3-yl]Thiazole (NRA0045)
J Pharmacol Exp Ther July 1, 1997 282:56-63
Select this article
- Jörg Huwyler,
- Gert Fricker,
- Michael Török,
- Markus Schneider,
- and Jürgen Drewe
Transport of Clonidine Across Cultured Brain Microvessel Endothelial Cells
J Pharmacol Exp Ther July 1, 1997 282:81-85
Select this article
- Mark J. Millan,
- Adrian Newman-Tancredi,
- Jean-Michel Rivet,
- Mauricette Brocco,
- Pierre Lacroix,
- Valérie Audinot,
- Laetitia Cistarelli,
- and Alain Gobert
S 15535, A Novel Benzodioxopiperazine Ligand of Serotonin (5-HT)_1A Receptors: I. Interaction with Cloned Human (h)5-HT_1A, Dopamine hD₂/hD₃ and hα_2A-Adrenergic Receptors in Relation to Modulation of Cortical Monoamine Release and Activity in Models of Potential Antidepressant Activity
J Pharmacol Exp Ther July 1, 1997 282:132-147
Select this article
- Mark J. Millan,
- Stephan Hjorth,
- Rosario Samanin,
- Rudy Schreiber,
- Robert Jaffard,
- Brigitte De Ladonchamps,
- Sylvie Veiga,
- Bertrand Goument,
- Jean-Louis Peglion,
- Michael Spedding,
- and Mauricette Brocco
S 15535, A Novel Benzodioxopiperazine Ligand of Serotonin (5-HT)_1A Receptors: II. Modulation of Hippocampal Serotonin Release in Relation to Potential Anxiolytic Properties
J Pharmacol Exp Ther July 1, 1997 282:148-161
Select this article
- A. Newman-Tancredi,
- V. Audinot,
- C. Chaput,
- and L.Verrièle and M. J. Millan
[³⁵S]Guanosine-5′-O-(3-thio)triphosphate Binding as a Measure of Efficacy at Human Recombinant Dopamine D_4.4Receptors: Actions of Antiparkinsonian and Antipsychotic Agents
J Pharmacol Exp Ther July 1, 1997 282:181-191
Select this article
- Lee E. Schechter
The Potassium Channel Blockers 4-Aminopyridine and Tetraethylammonium Increase the Spontaneous Basal Release of [³H]5-Hydroxytryptamine in Rat Hippocampal Slices
J Pharmacol Exp Ther July 1, 1997 282:262-270
Select this article
- E. R. Whittemore,
- V. I. Ilyin,
- and R. M. Woodward
Antagonism of N-Methyl-d-Aspartate Receptors by ς Site Ligands: Potency, Subtype-Selectivity and Mechanisms of Inhibition
J Pharmacol Exp Ther July 1, 1997 282:326-338
Select this article
- M. I. Damaj,
- G. S. Patrick,
- K. R. Creasy,
- and B. R. Martin
Pharmacology of Lobeline, A Nicotinic Receptor Ligand
J Pharmacol Exp Ther July 1, 1997 282:410-419
Select this article
- Lucette Garreau,
- Patrick Emond,
- Catherine Belzung,
- Denis Guilloteau,
- Yves Frangin,
- Jean-Claude Besnard,
- and Sylvie Chalon
N-(3-Iodoprop-2E-enyl)-2β-carbomethoxy-3β-(3′,4′-dichlorophenyl)nortropane (β-CDIT), a Tropane Derivative: Pharmacological Characterization as a Specific Ligand for the Dopamine Transporter in the Rodent Brain
J Pharmacol Exp Ther July 1, 1997 282:467-474

GASTROINTESTINAL PHARMACOLOGY

Select this article
- Zbigniew K. Krowicki,
- Nicole A. Nathan,
- and Pamela J. Hornby
Opposing Effects of Vasoactive Intestinal Polypeptide on Gastric Motor Function in the Dorsal Vagal Complex and the Nucleus Raphe Obscurus of the Rat
J Pharmacol Exp Ther July 1, 1997 282:14-22
Select this article
- Sushanta Chakder and
- Satish Rattan
l-Arginine Deficiency Causes Suppression of Nonadrenergic Noncholinergic Nerve-Mediated Smooth Muscle Relaxation: Role of l-Citrulline Recycling
J Pharmacol Exp Ther July 1, 1997 282:378-384
Select this article
- Xi-Long Zheng,
- Shalini Mokashi,
- and Morley D. Hollenberg
Contractile Action of Ethanol in Guinea Pig Gastric Smooth Muscle: Inhibition by Tyrosine Kinase Inhibitors and Comparison with the Contractile Action of Epidermal Growth Factor-Urogastrone
J Pharmacol Exp Ther July 1, 1997 282:485-495

CARDIOVASCULAR PHARMACOLOGY

Select this article
- Nobuyuki Ohte,
- Che-Ping Cheng,
- Makoto Suzuki,
- and William C. Little
The Cardiac Effects of Pimobendan (But Not Amrinone) Are Preserved at Rest and During Exercise in Conscious Dogs with Pacing-Induced Heart Failure
J Pharmacol Exp Ther July 1, 1997 282:23-31
Select this article
- Leif Carlsson,
- Gregory J Amos,
- Birgit Andersson,
- Lissen Drews,
- Göran Duker,
- and Gunilla Wadstedt
Electrophysiological Characterization of the Prokinetic Agents Cisapride and Mosapride in Vivo and in Vitro: Implications for Proarrhythmic Potential?
J Pharmacol Exp Ther July 1, 1997 282:220-227
Select this article
- Shinichi Fukuyama,
- Yoshimi Hirasawa,
- Yasuko Kato,
- Mie Nishio,
- Mitsuko Ohno,
- Shigetaka Nishino,
- Kazuhiro Maeda,
- Masayuki Kato,
- and Yasuhiro Kita
Structure-Activity Relationships of Spontaneous Nitric Oxide Releasers, FK409 and its Derivatives
J Pharmacol Exp Ther July 1, 1997 282:236-242
Select this article
- Arpad Tosaki and
- Dipak K. Das
Extracellular Mg⁺⁺ Manipulation Prevents the Proarrhythmic Activity of Cromakalim in Ischemic/Reperfused Diabetic Hearts
J Pharmacol Exp Ther July 1, 1997 282:309-317
Select this article
- Harald Brunv and
- and Ketil Grong
Carvedilol Retards Sudden Loss of Contraction during Early Regional Myocardial Ischemia in Feline Hearts
J Pharmacol Exp Ther July 1, 1997 282:363-368
Select this article
- John J. Lopez,
- Elazer R. Edelman,
- Alon Stamler,
- Mark G. Hibberd,
- Pottumarthi Prasad,
- Ronald P. Caputo,
- Joseph P. Carrozza,
- Pamela S. Douglas,
- Frank W. Sellke,
- and Michael Simons
Basic Fibroblast Growth Factor in a Porcine Model of Chronic Myocardial Ischemia: A Comparison of Angiographic, Echocardiographic and Coronary Flow Parameters
J Pharmacol Exp Ther July 1, 1997 282:385-390

BEHAVIORAL PHARMACOLOGY

Select this article
- S. Stevens Negus,
- Nancy K. Mello,
- Philip S. Portoghese,
- and Chai-En Lin
Effects of Kappa Opioids on Cocaine Self-Administration by Rhesus Monkeys
J Pharmacol Exp Ther July 1, 1997 282:44-55
Select this article
- Jeffrey A. Vivian,
- Helena M. T. Barros,
- Andre Manitiu,
- and Klaus A. Miczek
Ultrasonic Vocalizations In Rat Pups: Modulation at the γ-Aminobutyric Acid_A Receptor Complex and the Neurosteroid Recognition Site ^,
J Pharmacol Exp Ther July 1, 1997 282:318-325
Select this article
- Carol A. Paronis and
- James H. Woods
Ventilation in Morphine-Maintained Rhesus Monkeys. I: Effects of Naltrexone and Abstinence-Associated Withdrawal ^,
J Pharmacol Exp Ther July 1, 1997 282:348-354
Select this article
- Carol A. Paronis and
- James H. Woods
Ventilation in Morphine-Maintained Rhesus Monkeys. II: Tolerance to the Antinociceptive But Not the Ventilatory Effects of Morphine ^,
J Pharmacol Exp Ther July 1, 1997 282:355-362
Select this article
- Dale M. Edgar,
- Wesley F. Seidel,
- Kelvin W. Gee,
- Nancy C. Lan,
- George Field,
- Haiji Xia,
- Jon E. Hawkinson,
- Scott Wieland,
- Richard B. Carter,
- and Paul L. Wood
CCD-3693: An Orally Bioavailable Analog of the Endogenous Neuroactive Steroid, Pregnanolone, Demonstrates Potent Sedative Hypnotic Actions in the Rat
J Pharmacol Exp Ther July 1, 1997 282:420-429

CELLULAR AND MOLECULAR PHARMACOLOGY

Select this article
- Yukun Yuan and
- William D. Atchison
Action of Methylmercury on GABA_A Receptor-Mediated Inhibitory Synaptic Transmission Is Primarily Responsible for Its Early Stimulatory Effects on Hippocampal CA1 Excitatory Synaptic Transmission
J Pharmacol Exp Ther July 1, 1997 282:64-73
Select this article
- Jiang-Hong Ye and
- Joseph J. McArdle
Waglerin-1 Modulates γ-Aminobutyric Acid Activated Current of Murine Hypothalamic Neurons
J Pharmacol Exp Ther July 1, 1997 282:74-80
Select this article
- Annamaria De Luca,
- Sabata Pierno,
- Fedele Natuzzi,
- Carlo Franchini,
- Andrea Duranti,
- Giovanni Lentini,
- Vincenzo Tortorella,
- Harald Jockusch,
- and Diana Conte Camerino
Evaluation of the Antimyotonic Activity of Mexiletine and Some New Analogs on Sodium Currents of Single Muscle Fibers and on the Abnormal Excitability of the Myotonic ADR Mouse
J Pharmacol Exp Ther July 1, 1997 282:93-100
Select this article
- Juan Bernal,
- Jung-Ha Lee,
- Leanne L. Cribbs,
- and Edward Perez-Reyes
Full Reversal of Pb⁺⁺ Block of L-Type Ca⁺⁺ Channels Requires Treatment with Heavy Metal Antidotes
J Pharmacol Exp Ther July 1, 1997 282:172-180
Select this article
- Atsuo Tahara,
- Yuichi Tomura,
- Koh-Ichi Wada,
- Toshiyuki Kusayama,
- Junko Tsukada,
- Masahiro Takanashi,
- Takeyuki Yatsu,
- Wataru Uchida,
- and Akihiro Tanaka
Pharmacological Profile of YM087, A Novel Potent Nonpeptide Vasopressin V_1A and V₂ Receptor Antagonist,in Vitro and in Vivo
J Pharmacol Exp Ther July 1, 1997 282:301-308
Select this article
- Martha I. Dávila-García,
- John L. Musachio,
- David C. Perry,
- Yingxian Xiao,
- Andrew Horti,
- Edythe D. London,
- Robert F. Dannals,
- and Kenneth J. Kellar
[¹²⁵I]IPH, an Epibatidine Analog, Binds with High Affinity to Neuronal Nicotinic Cholinergic Receptors
J Pharmacol Exp Ther July 1, 1997 282:445-451

ANALGESIA AND DRUGS OF ABUSE

Select this article
- David D. Hood,
- Kathryn A. Mallak,
- Robert L. James,
- Robin Tuttle,
- and James C. Eisenach
Enhancement of Analgesia from Systemic Opioid in Humans by Spinal Cholinesterase Inhibition
J Pharmacol Exp Ther July 1, 1997 282:86-92
Select this article
- Scott J. O’Neill,
- Mark A. Collins,
- Hugh O. Pettit,
- Robert W. McNutt,
- and Kwen-Jen Chang
Antagonistic Modulation Between the Delta Opioid Agonist BW373U86 and the Mu Opioid Agonist Fentanyl in Mice
J Pharmacol Exp Ther July 1, 1997 282:271-277
Select this article
- Frank C. Tortella,
- Jany Rose,
- Lydia Robles,
- J. Edward Moreton,
- John Hughes,
- and John C. Hunter
EEG Spectral Analysis of the Neuroprotective KappaOpioids Enadoline and PD117302
J Pharmacol Exp Ther July 1, 1997 282:286-293
Select this article
- Carla Ghelardini,
- Nicoletta Galeotti,
- Fulvio Gualtieri,
- Cristina Bellucci,
- Dina Manetti,
- Alberto Giotti,
- Petra Malmberg-Aiello,
- Alessandro Galli,
- and Alessandro Bartolini
Antinociceptive Profile of 3-α-tropanyl-(2-Cl)-acid phenoxybutyrate (SM-21): A Novel Analgesic with a Presynaptic Cholinergic Mechanism of Action
J Pharmacol Exp Ther July 1, 1997 282:430-439

PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS

Select this article
- Bardia Askari,
- Caroline P. Bell-Quilley,
- David Fulton,
- John Quilley,
- and John C. McGiff
Analysis of Eicosanoid Mediation of the Renal Functional Effects of Hyperchloremia ^,
J Pharmacol Exp Ther July 1, 1997 282:101-107
Select this article
- H. Kan,
- Y. Ruan,
- and K. U. Malik
Signal Transduction Mechanism(s) Involved in Prostacyclin Production Elicited by Acetylcholine in Coronary Endothelial Cells of Rabbit Heart
J Pharmacol Exp Ther July 1, 1997 282:113-122
Select this article
- V. Escrig,
- A. Ubeda,
- M. L. Ferrandiz,
- J. Darias,
- J. M. Sanchez,
- M. J. Alcaraz,
- and M. Paya
Variabilin: A Dual Inhibitor of Human Secretory and Cytosolic Phospholipase A₂ With Anti-inflammatory Activity
J Pharmacol Exp Ther July 1, 1997 282:123-131
Select this article
- Karen A. Willoughby,
- Sandra F. Moore,
- Billy R. Martin,
- and Earl F. Ellis
The Biodisposition and Metabolism of Anandamide in Mice
J Pharmacol Exp Ther July 1, 1997 282:243-247
Select this article
- Adam P. Curnock,
- Peter A. Robson,
- Christopher M. Yea,
- David Moss,
- Suresh Gadher,
- T. Andrew Thomson,
- Robert Westwood,
- Erik Ruuth,
- and Richard A. Williamson
Potencies of Leflunomide and HR325 as Inhibitors of Prostaglandin Endoperoxide H Synthase-1 and -2: Comparison with Nonsteroidal Anti-Inflammatory Drugs
J Pharmacol Exp Ther July 1, 1997 282:339-347
Select this article
- Keyvan Mahboubi,
- Wilson Young,
- and Nicholas R. Ferreri
Induction of Prostaglandin Endoperoxide Synthase-2 by Serine-Threonine Phosphatase Inhibition
J Pharmacol Exp Ther July 1, 1997 282:452-458
Select this article
- Mun-Chual Rho,
- Norimichi Nakahata,
- Hideshi Nakamura,
- Akio Murai,
- and Yasushi Ohizumi
Involvement of Phospholipase C-γ2 in Activation of Mitogen-Activated Protein Kinase and Phospholipase A₂ by Zooxanthellatoxin-A in Rabbit Platelets
J Pharmacol Exp Ther July 1, 1997 282:496-504

CHEMOTHERAPY/GENE THERAPY

Select this article
- Augustine U. Orjih
Heme Polymerase Activity and the Stage Specificity of Antimalarial Action of Chloroquine
J Pharmacol Exp Ther July 1, 1997 282:108-112

DRUG METABOLISM AND DISPOSITION

Select this article
- Hiroyuki Sasabe,
- Tetsuya Terasaki,
- Akira Tsuji,
- and Yuichi Sugiyama
Carrier-Mediated Hepatic Uptake of Quinolone Antibiotics in the Rat
J Pharmacol Exp Ther July 1, 1997 282:162-171
Select this article
- Dylan Sutton,
- Alison M. Butler,
- Louise Nadin,
- and Michael Murray
Role of CYP3A4 in Human Hepatic Diltiazem N-Demethylation: Inhibition of CYP3A4 Activity by Oxidized Diltiazem Metabolites
J Pharmacol Exp Ther July 1, 1997 282:294-300
Select this article
- Linda K. Ludden,
- Thomas M. Ludden,
- Jerry M. Collins,
- Helen S. Pentikis,
- and John M. Strong
Effect of Albumin on the Estimation, In Vitro, of Phenytoin V_max and K _m Values: Implications for Clinical Correlation
J Pharmacol Exp Ther July 1, 1997 282:391-396

TOXICOLOGY

Select this article
- H. Vasken Aposhian,
- Alex Arroyo,
- Mariano E. Cebrian,
- Luz María Del Razo,
- Katherine M. Hurlbut,
- Richard C. Dart,
- Diego Gonzalez-Ramirez,
- Helmut Kreppel,
- Hernan Speisky,
- Allan Smith,
- Maria E. Gonsebatt,
- Patricia Ostrosky-Wegman,
- and Mary M. Aposhian
DMPS-Arsenic Challenge Test. I: Increased Urinary Excretion of Monomethylarsonic Acid in Humans Given Dimercaptopropane Sulfonate
J Pharmacol Exp Ther July 1, 1997 282:192-200
Select this article
- Ben-Bo Song,
- David J. Anderson,
- and Jochen Schacht
Protection from Gentamicin Ototoxicity by Iron Chelators in Guinea Pig In Vivo ^,
J Pharmacol Exp Ther July 1, 1997 282:369-377

AUTONOMIC PHARMACOLOGY

Select this article
- Elena Arteche,
- Giuseppe Strippoli,
- Gervaise Loirand,
- Pierre Pacaud,
- Luz Candenas,
- Juan-Carlos Moltó,
- Luisa Souto,
- Javier Fernandez,
- Manuel Norte,
- Julio D. Martín,
- and Jean-Pierre Savineau
An Analysis of the Mechanisms Involved in the Okadaic Acid-Induced Contraction of the Estrogen-Primed Rat Uterus
J Pharmacol Exp Ther July 1, 1997 282:201-207
Select this article
- D. J. Martin,
- P. Lluel,
- E. Guillot,
- A. Coste,
- D. Jammes,
- and I. Angel
Comparative Alpha-1 Adrenoceptor Subtype Selectivity and Functional Uroselectivity of Alpha-1 Adrenoceptor Antagonists
J Pharmacol Exp Ther July 1, 1997 282:228-235
Select this article
- Dean D. Schwartz
Activation of Alpha-2 Adrenergic Receptors Inhibits Norepinephrine Release by a Pertussis Toxin-Insensitive Pathway Independent of Changes in Cytosolic Calcium in Cultured Rat Sympathetic Neurons
J Pharmacol Exp Ther July 1, 1997 282:248-255
Select this article
- Alfred Lanzafame,
- Arthur Christopoulos,
- and Fred Mitchelson
Three Allosteric Modulators Act at a Common Site, Distinct from that of Competitive Antagonists, at Muscarinic Acetylcholine M₂ Receptors
J Pharmacol Exp Ther July 1, 1997 282:278-285
Select this article
- Yuichiro Kojima,
- Yasuhiro Tsunoda,
- and Chung Owyang
Adenosine 3′,5′-Cyclic Monophosphate-Stimulated Ca⁺⁺Efflux and Acetylcholine Release in Ileal Myenteric Plexus Are Mediated by N-Type Ca⁺⁺ Channels: Inhibition by theKappa Opioid Receptor Agonist
J Pharmacol Exp Ther July 1, 1997 282:403-409
Select this article
- Satoshi Gando,
- Yuichi Hattori,
- Yasuhiro Akaishi,
- Jun Nishihira,
- and Morio Kanno
Impaired Contractile Response to Beta Adrenoceptor Stimulation in Diabetic Rat Hearts: Alterations in BetaAdrenoceptors-G Protein-Adenylate Cyclase System and Phospholamban Phosphorylation
J Pharmacol Exp Ther July 1, 1997 282:475-484

PULMONARY PHARMACOLOGY

Select this article
- Allison Fryer,
- Yuh-Chin Huang,
- Gopna Rao,
- David Jacoby,
- Edward Mancilla,
- Richard Whorton,
- Claude A. Piantadosi,
- Thomas Kennedy,
- and John Hoidal
Selective O-Desulfation Produces Nonanticoagulant Heparin that Retains Pharmacological Activity in the Lung ^,
J Pharmacol Exp Ther July 1, 1997 282:208-219

IMMUNOPHARMACOLOGY

Select this article
- María Isolde Rudolph,
- Maria de los Angeles García,
- Marcia Sepulveda,
- Enrique Brandan,
- Karin Reinicke,
- Sandra Nicovani,
- and Leonor Villan
Ethodin: Pharmacological Evidence of the Interaction between Smooth Muscle and Mast Cells in the Myometrium
J Pharmacol Exp Ther July 1, 1997 282:256-261
Select this article
- Christopher Bolton and
- Carolyn Paul
MK-801 Limits Neurovascular Dysfunction during Experimental Allergic Encephalomyelitis
J Pharmacol Exp Ther July 1, 1997 282:397-402
Select this article
- John J. Breton and
- Marie C. Chabot-Fletcher
The Natural Product Hymenialdisine Inhibits Interleukin-8 Production in U937 Cells by Inhibition of Nuclear Factor-κB
J Pharmacol Exp Ther July 1, 1997 282:459-466
Select this article
- David M. Essayan,
- Anne Kagey-Sobotka,
- Lawrence M. Lichtenstein,
- and Shau-Ku Huang
Differential Regulation of Human Antigen-Specific Th1 and Th2 Lymphocyte Responses by Isozyme Selective Cyclic Nucleotide Phosphodiesterase Inhibitors
J Pharmacol Exp Ther July 1, 1997 282:505-512

RENAL PHARMACOLOGY

Select this article
- David S. Miller,
- Gert Fricker,
- and Juergen Drewe
p-Glycoprotein-Mediated Transport of a Fluorescent Rapamycin Derivative in Renal Proximal Tubule
J Pharmacol Exp Ther July 1, 1997 282:440-444

NEUROPHARMACOLOGY

The Kappa Opioid Agonist Niravoline Decreases Brain Edema in the Mouse Middle Cerebral Artery Occlusion Model of Stroke

Effect of Smoking History on [3H]Nicotine Binding in Human Postmortem Brain

Pharmacological Comparison of Transient and Persistent [3H]Dopamine Release from Mouse Striatal Synaptosomes and Response to Chronic l-Nicotine Treatment

In Vitro and In Vivo Characterization of the Dopamine D4 Receptor, Serotonin 5-HT2AReceptor and Alpha-1 Adrenoceptor Antagonist (R)-(+)-2-Amino-4-(4-Fluorophenyl)- 5-[1-[4-(4-Fluorophenyl)-4-Oxobutyl]Pyrrolidin-3-yl]Thiazole (NRA0045)

Transport of Clonidine Across Cultured Brain Microvessel Endothelial Cells

S 15535, A Novel Benzodioxopiperazine Ligand of Serotonin (5-HT)1A Receptors: I. Interaction with Cloned Human (h)5-HT1A, Dopamine hD2/hD3 and hα2A-Adrenergic Receptors in Relation to Modulation of Cortical Monoamine Release and Activity in Models of Potential Antidepressant Activity

S 15535, A Novel Benzodioxopiperazine Ligand of Serotonin (5-HT)1A Receptors: II. Modulation of Hippocampal Serotonin Release in Relation to Potential Anxiolytic Properties

[35S]Guanosine-5′-O-(3-thio)triphosphate Binding as a Measure of Efficacy at Human Recombinant Dopamine D4.4Receptors: Actions of Antiparkinsonian and Antipsychotic Agents

The Potassium Channel Blockers 4-Aminopyridine and Tetraethylammonium Increase the Spontaneous Basal Release of [3H]5-Hydroxytryptamine in Rat Hippocampal Slices

Antagonism of N-Methyl-d-Aspartate Receptors by ς Site Ligands: Potency, Subtype-Selectivity and Mechanisms of Inhibition

Pharmacology of Lobeline, A Nicotinic Receptor Ligand

N-(3-Iodoprop-2E-enyl)-2β-carbomethoxy-3β-(3′,4′-dichlorophenyl)nortropane (β-CDIT), a Tropane Derivative: Pharmacological Characterization as a Specific Ligand for the Dopamine Transporter in the Rodent Brain

GASTROINTESTINAL PHARMACOLOGY

Opposing Effects of Vasoactive Intestinal Polypeptide on Gastric Motor Function in the Dorsal Vagal Complex and the Nucleus Raphe Obscurus of the Rat

l-Arginine Deficiency Causes Suppression of Nonadrenergic Noncholinergic Nerve-Mediated Smooth Muscle Relaxation: Role of l-Citrulline Recycling

Contractile Action of Ethanol in Guinea Pig Gastric Smooth Muscle: Inhibition by Tyrosine Kinase Inhibitors and Comparison with the Contractile Action of Epidermal Growth Factor-Urogastrone

CARDIOVASCULAR PHARMACOLOGY

The Cardiac Effects of Pimobendan (But Not Amrinone) Are Preserved at Rest and During Exercise in Conscious Dogs with Pacing-Induced Heart Failure

Electrophysiological Characterization of the Prokinetic Agents Cisapride and Mosapride in Vivo and in Vitro: Implications for Proarrhythmic Potential?

Structure-Activity Relationships of Spontaneous Nitric Oxide Releasers, FK409 and its Derivatives

Extracellular Mg++ Manipulation Prevents the Proarrhythmic Activity of Cromakalim in Ischemic/Reperfused Diabetic Hearts

Carvedilol Retards Sudden Loss of Contraction during Early Regional Myocardial Ischemia in Feline Hearts

Basic Fibroblast Growth Factor in a Porcine Model of Chronic Myocardial Ischemia: A Comparison of Angiographic, Echocardiographic and Coronary Flow Parameters

BEHAVIORAL PHARMACOLOGY

Effects of Kappa Opioids on Cocaine Self-Administration by Rhesus Monkeys

Ultrasonic Vocalizations In Rat Pups: Modulation at the γ-Aminobutyric AcidA Receptor Complex and the Neurosteroid Recognition Site ,

Ventilation in Morphine-Maintained Rhesus Monkeys. I: Effects of Naltrexone and Abstinence-Associated Withdrawal ,

Ventilation in Morphine-Maintained Rhesus Monkeys. II: Tolerance to the Antinociceptive But Not the Ventilatory Effects of Morphine ,

CCD-3693: An Orally Bioavailable Analog of the Endogenous Neuroactive Steroid, Pregnanolone, Demonstrates Potent Sedative Hypnotic Actions in the Rat

CELLULAR AND MOLECULAR PHARMACOLOGY

Action of Methylmercury on GABAA Receptor-Mediated Inhibitory Synaptic Transmission Is Primarily Responsible for Its Early Stimulatory Effects on Hippocampal CA1 Excitatory Synaptic Transmission

Waglerin-1 Modulates γ-Aminobutyric Acid Activated Current of Murine Hypothalamic Neurons

Evaluation of the Antimyotonic Activity of Mexiletine and Some New Analogs on Sodium Currents of Single Muscle Fibers and on the Abnormal Excitability of the Myotonic ADR Mouse

Full Reversal of Pb++ Block of L-Type Ca++ Channels Requires Treatment with Heavy Metal Antidotes

Pharmacological Profile of YM087, A Novel Potent Nonpeptide Vasopressin V1A and V2 Receptor Antagonist,in Vitro and in Vivo

[125I]IPH, an Epibatidine Analog, Binds with High Affinity to Neuronal Nicotinic Cholinergic Receptors

ANALGESIA AND DRUGS OF ABUSE

Enhancement of Analgesia from Systemic Opioid in Humans by Spinal Cholinesterase Inhibition

Antagonistic Modulation Between the Delta Opioid Agonist BW373U86 and the Mu Opioid Agonist Fentanyl in Mice

EEG Spectral Analysis of the Neuroprotective KappaOpioids Enadoline and PD117302

Antinociceptive Profile of 3-α-tropanyl-(2-Cl)-acid phenoxybutyrate (SM-21): A Novel Analgesic with a Presynaptic Cholinergic Mechanism of Action

PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS

Analysis of Eicosanoid Mediation of the Renal Functional Effects of Hyperchloremia ,

Signal Transduction Mechanism(s) Involved in Prostacyclin Production Elicited by Acetylcholine in Coronary Endothelial Cells of Rabbit Heart

Variabilin: A Dual Inhibitor of Human Secretory and Cytosolic Phospholipase A2 With Anti-inflammatory Activity

The Biodisposition and Metabolism of Anandamide in Mice

Potencies of Leflunomide and HR325 as Inhibitors of Prostaglandin Endoperoxide H Synthase-1 and -2: Comparison with Nonsteroidal Anti-Inflammatory Drugs

Induction of Prostaglandin Endoperoxide Synthase-2 by Serine-Threonine Phosphatase Inhibition

Involvement of Phospholipase C-γ2 in Activation of Mitogen-Activated Protein Kinase and Phospholipase A2 by Zooxanthellatoxin-A in Rabbit Platelets

CHEMOTHERAPY/GENE THERAPY

Heme Polymerase Activity and the Stage Specificity of Antimalarial Action of Chloroquine

DRUG METABOLISM AND DISPOSITION

Carrier-Mediated Hepatic Uptake of Quinolone Antibiotics in the Rat

Role of CYP3A4 in Human Hepatic Diltiazem N-Demethylation: Inhibition of CYP3A4 Activity by Oxidized Diltiazem Metabolites

Effect of Albumin on the Estimation, In Vitro, of Phenytoin Vmax and K m Values: Implications for Clinical Correlation

TOXICOLOGY

DMPS-Arsenic Challenge Test. I: Increased Urinary Excretion of Monomethylarsonic Acid in Humans Given Dimercaptopropane Sulfonate

Protection from Gentamicin Ototoxicity by Iron Chelators in Guinea Pig In Vivo ,

AUTONOMIC PHARMACOLOGY

An Analysis of the Mechanisms Involved in the Okadaic Acid-Induced Contraction of the Estrogen-Primed Rat Uterus

Comparative Alpha-1 Adrenoceptor Subtype Selectivity and Functional Uroselectivity of Alpha-1 Adrenoceptor Antagonists

Activation of Alpha-2 Adrenergic Receptors Inhibits Norepinephrine Release by a Pertussis Toxin-Insensitive Pathway Independent of Changes in Cytosolic Calcium in Cultured Rat Sympathetic Neurons

Three Allosteric Modulators Act at a Common Site, Distinct from that of Competitive Antagonists, at Muscarinic Acetylcholine M2 Receptors

Adenosine 3′,5′-Cyclic Monophosphate-Stimulated Ca++Efflux and Acetylcholine Release in Ileal Myenteric Plexus Are Mediated by N-Type Ca++ Channels: Inhibition by theKappa Opioid Receptor Agonist

Impaired Contractile Response to Beta Adrenoceptor Stimulation in Diabetic Rat Hearts: Alterations in BetaAdrenoceptors-G Protein-Adenylate Cyclase System and Phospholamban Phosphorylation

PULMONARY PHARMACOLOGY

Selective O-Desulfation Produces Nonanticoagulant Heparin that Retains Pharmacological Activity in the Lung ,

IMMUNOPHARMACOLOGY

Ethodin: Pharmacological Evidence of the Interaction between Smooth Muscle and Mast Cells in the Myometrium

MK-801 Limits Neurovascular Dysfunction during Experimental Allergic Encephalomyelitis

The Natural Product Hymenialdisine Inhibits Interleukin-8 Production in U937 Cells by Inhibition of Nuclear Factor-κB

Differential Regulation of Human Antigen-Specific Th1 and Th2 Lymphocyte Responses by Isozyme Selective Cyclic Nucleotide Phosphodiesterase Inhibitors

RENAL PHARMACOLOGY

p-Glycoprotein-Mediated Transport of a Fluorescent Rapamycin Derivative in Renal Proximal Tubule

This Issue

Current Issue

Effect of Smoking History on [³H]Nicotine Binding in Human Postmortem Brain

Pharmacological Comparison of Transient and Persistent [³H]Dopamine Release from Mouse Striatal Synaptosomes and Response to Chronic l-Nicotine Treatment

In Vitro and In Vivo Characterization of the Dopamine D₄ Receptor, Serotonin 5-HT_2AReceptor and Alpha-1 Adrenoceptor Antagonist (R)-(+)-2-Amino-4-(4-Fluorophenyl)- 5-[1-[4-(4-Fluorophenyl)-4-Oxobutyl]Pyrrolidin-3-yl]Thiazole (NRA0045)

S 15535, A Novel Benzodioxopiperazine Ligand of Serotonin (5-HT)_1A Receptors: I. Interaction with Cloned Human (h)5-HT_1A, Dopamine hD₂/hD₃ and hα_2A-Adrenergic Receptors in Relation to Modulation of Cortical Monoamine Release and Activity in Models of Potential Antidepressant Activity

S 15535, A Novel Benzodioxopiperazine Ligand of Serotonin (5-HT)_1A Receptors: II. Modulation of Hippocampal Serotonin Release in Relation to Potential Anxiolytic Properties

[³⁵S]Guanosine-5′-O-(3-thio)triphosphate Binding as a Measure of Efficacy at Human Recombinant Dopamine D_4.4Receptors: Actions of Antiparkinsonian and Antipsychotic Agents

The Potassium Channel Blockers 4-Aminopyridine and Tetraethylammonium Increase the Spontaneous Basal Release of [³H]5-Hydroxytryptamine in Rat Hippocampal Slices

Extracellular Mg⁺⁺ Manipulation Prevents the Proarrhythmic Activity of Cromakalim in Ischemic/Reperfused Diabetic Hearts

Ultrasonic Vocalizations In Rat Pups: Modulation at the γ-Aminobutyric Acid_A Receptor Complex and the Neurosteroid Recognition Site ^,

Ventilation in Morphine-Maintained Rhesus Monkeys. I: Effects of Naltrexone and Abstinence-Associated Withdrawal ^,

Ventilation in Morphine-Maintained Rhesus Monkeys. II: Tolerance to the Antinociceptive But Not the Ventilatory Effects of Morphine ^,

Action of Methylmercury on GABA_A Receptor-Mediated Inhibitory Synaptic Transmission Is Primarily Responsible for Its Early Stimulatory Effects on Hippocampal CA1 Excitatory Synaptic Transmission

Full Reversal of Pb⁺⁺ Block of L-Type Ca⁺⁺ Channels Requires Treatment with Heavy Metal Antidotes

Pharmacological Profile of YM087, A Novel Potent Nonpeptide Vasopressin V_1A and V₂ Receptor Antagonist,in Vitro and in Vivo

[¹²⁵I]IPH, an Epibatidine Analog, Binds with High Affinity to Neuronal Nicotinic Cholinergic Receptors

Analysis of Eicosanoid Mediation of the Renal Functional Effects of Hyperchloremia ^,

Variabilin: A Dual Inhibitor of Human Secretory and Cytosolic Phospholipase A₂ With Anti-inflammatory Activity

Involvement of Phospholipase C-γ2 in Activation of Mitogen-Activated Protein Kinase and Phospholipase A₂ by Zooxanthellatoxin-A in Rabbit Platelets

Effect of Albumin on the Estimation, In Vitro, of Phenytoin V_max and K _m Values: Implications for Clinical Correlation

Protection from Gentamicin Ototoxicity by Iron Chelators in Guinea Pig In Vivo ^,

Three Allosteric Modulators Act at a Common Site, Distinct from that of Competitive Antagonists, at Muscarinic Acetylcholine M₂ Receptors

Adenosine 3′,5′-Cyclic Monophosphate-Stimulated Ca⁺⁺Efflux and Acetylcholine Release in Ileal Myenteric Plexus Are Mediated by N-Type Ca⁺⁺ Channels: Inhibition by theKappa Opioid Receptor Agonist

Selective O-Desulfation Produces Nonanticoagulant Heparin that Retains Pharmacological Activity in the Lung ^,