Table of Contents

November 1996; 279 (2)

Select this article
- L Mao and
- A A Abdel-Rahman
Synergistic behavioral interaction between ethanol and clonidine in rats: role of alpha-2 adrenoceptors.
J Pharmacol Exp Ther November 1996 279:443-449
- Abstract
- Full Text (PDF)
Select this article
- W B Pickworth,
- R V Fant,
- M F Butschky,
- and J E Henningfield
Effects of transdermal nicotine delivery on measures of acute nicotine withdrawal.
J Pharmacol Exp Ther November 1996 279:450-456
- Abstract
- Full Text (PDF)
Select this article
- Y N Wu and
- S W Johnson
Pharmacological characterization of inward current evoked by N-methyl-D-aspartate in dopamine neurons in the rat brain slice.
J Pharmacol Exp Ther November 1996 279:457-463
- Abstract
- Full Text (PDF)
Select this article
- T Joseph,
- C Coirault,
- L Ducros,
- and Y Lecarpentier
Mechanical and energetic effects of cromakalim on guinea pig left ventricular papillary muscle.
J Pharmacol Exp Ther November 1996 279:464-471
- Abstract
- Full Text (PDF)
Select this article
- C Blaya,
- J Crespo,
- A Crespo,
- and S F Aliño
Anti-interleukin 4 antibody and indomethacin synergistic effect on B16 melanoma tumor progression.
J Pharmacol Exp Ther November 1996 279:472-477
- Abstract
- Full Text (PDF)
Select this article
- T A Slotkin,
- L Thai,
- E C McCook,
- J L Saleh,
- J Zhang,
- and F J Seidler
Aging and glucocorticoids: effects on cell signaling mediated through adenylyl cyclase.
J Pharmacol Exp Ther November 1996 279:478-491
- Abstract
- Full Text (PDF)
Select this article
- L J Bristow,
- P H Hutson,
- J J Kulagowski,
- P D Leeson,
- S Matheson,
- F Murray,
- D Rathbone,
- K L Saywell,
- L Thorn,
- A P Watt,
- and M D Tricklebank
Anticonvulsant and behavioral profile of L-701,324, a potent, orally active antagonist at the glycine modulatory site on the N-methyl-D-aspartate receptor complex.
J Pharmacol Exp Ther November 1996 279:492-501
- Abstract
- Full Text (PDF)
Select this article
- Y A Kolesnikov,
- S Jain,
- R Wilson,
- and G W Pasternak
Peripheral morphine analgesia: synergy with central sites and a target of morphine tolerance.
J Pharmacol Exp Ther November 1996 279:502-506
- Abstract
- Full Text (PDF)
Select this article
- J Yu,
- E R Butelman,
- J H Woods,
- B T Chait,
- and M J Kreek
In vitro biotransformation of dynorphin A (1-17) is similar in human and rhesus monkey blood as studied by matrix-assisted laser desorption/ionization mass spectrometry.
J Pharmacol Exp Ther November 1996 279:507-514
- Abstract
- Full Text (PDF)
Select this article
- F A Boeckman and
- E Aizenman
Pharmacological properties of acquired excitotoxicity in Chinese hamster ovary cells transfected with N-methyl-D-aspartate receptor subunits.
J Pharmacol Exp Ther November 1996 279:515-523
- Abstract
- Full Text (PDF)
Select this article
- S L Walsh,
- J T Sullivan,
- K L Preston,
- J E Garner,
- and G E Bigelow
Effects of naltrexone on response to intravenous cocaine, hydromorphone and their combination in humans.
J Pharmacol Exp Ther November 1996 279:524-538
- Abstract
- Full Text (PDF)
Select this article
- J Y Xu,
- A Seyed-Mozaffari,
- S Archer,
- and J M Bidlack
N-cyclobutylmethyl analog of normorphinone, N-CBM-TAMO: a short-term opioid agonist and long-term Mu-selective irreversible opioid antagonist.
J Pharmacol Exp Ther November 1996 279:539-547
- Abstract
- Full Text (PDF)
Select this article
- L Trumper,
- L A Monasterolo,
- and M M Elías
Nephrotoxicity of acetaminophen in male Wistar rats: role of hepatically derived metabolites.
J Pharmacol Exp Ther November 1996 279:548-554
- Abstract
- Full Text (PDF)
Select this article
- M H Holtmann,
- E M Hadac,
- C D Ulrich,
- and L J Miller
Molecular basis and species specificity of high affinity binding of vasoactive intestinal polypeptide by the rat secretin receptor.
J Pharmacol Exp Ther November 1996 279:555-560
- Abstract
- Full Text (PDF)
Select this article
- W Löscher,
- C Rundfeldt,
- D Hönack,
- and U Ebert
Long-term studies on anticonvulsant tolerance and withdrawal characteristics of benzodiazepine receptor ligands in different seizure models in mice. I. Comparison of diazepam, clonazepam, clobazam and abecarnil.
J Pharmacol Exp Ther November 1996 279:561-572
- Abstract
- Full Text (PDF)
Select this article
- W Löscher,
- C Rundfeldt,
- D Hönack,
- and U Ebert
Long-term studies on anticonvulsant tolerance and withdrawal characteristics of benzodiazepine receptor ligands in different seizure models in mice. II. The novel imidazoquinazolines NNC 14-0185 and NNC 14-0189.
J Pharmacol Exp Ther November 1996 279:573-581
- Abstract
- Full Text (PDF)
Select this article
- B D Waterhouse,
- E M Gould,
- and I Bekavac
Monoaminergic substrates underlying cocaine-induced enhancement of somatosensory-evoked discharges in rat barrel field cortical neurons.
J Pharmacol Exp Ther November 1996 279:582-592
- Abstract
- Full Text (PDF)
Select this article
- J P Kukkonen,
- J Näsman,
- P Ojala,
- C Oker-Blom,
- and K E Akerman
Functional properties of muscarinic receptor subtypes Hm1, Hm3 and Hm5 expressed in Sf9 cells using the baculovirus expression system.
J Pharmacol Exp Ther November 1996 279:593-601
- Abstract
- Full Text (PDF)
Select this article
- L A Monasterolo,
- L Trumper,
- and M M Elías
Effects of gamma-aminobutyric acid agonists on the isolated perfused rat kidney.
J Pharmacol Exp Ther November 1996 279:602-607
- Abstract
- Full Text (PDF)
Select this article
- G Pugh, Jr,
- P B Smith,
- D S Dombrowski,
- and S P Welch
The role of endogenous opioids in enhancing the antinociception produced by the combination of delta 9-tetrahydrocannabinol and morphine in the spinal cord.
J Pharmacol Exp Ther November 1996 279:608-616
- Abstract
- Full Text (PDF)
Select this article
- Y Watanabe,
- Y Hara,
- M Tamagawa,
- and H Nakaya
Inhibitory effect of amiodarone on the muscarinic acetylcholine receptor-operated potassium current in guinea pig atrial cells.
J Pharmacol Exp Ther November 1996 279:617-624
- Abstract
- Full Text (PDF)
Select this article
- B S Chan,
- V A Lazzaro,
- J P Seale,
- and G G Duggin
Transport of paraquat in a renal epithelial cell line LLC-PK1.
J Pharmacol Exp Ther November 1996 279:625-632
- Abstract
- Full Text (PDF)
Select this article
- A M Mayer,
- S Brenic,
- and K B Glaser
Pharmacological targeting of signaling pathways in protein kinase C-stimulated superoxide generation in neutrophil-like HL-60 cells: effect of phorbol ester, arachidonic acid and inhibitors of kinase(s), phosphatase(s) and phospholipase A2.
J Pharmacol Exp Ther November 1996 279:633-644
- Abstract
- Full Text (PDF)
Select this article
- M J Currens,
- R J Gulakowski,
- J M Mariner,
- R A Moran,
- R W Buckheit, Jr,
- K R Gustafson,
- J B McMahon,
- and M R Boyd
Antiviral activity and mechanism of action of calanolide A against the human immunodeficiency virus type-1.
J Pharmacol Exp Ther November 1996 279:645-651
- Abstract
- Full Text (PDF)
Select this article
- M J Currens,
- J M Mariner,
- J B McMahon,
- and M R Boyd
Kinetic analysis of inhibition of human immunodeficiency virus type-1 reverse transcriptase by calanolide A.
J Pharmacol Exp Ther November 1996 279:652-661
- Abstract
- Full Text (PDF)
Select this article
- J S Kreeger and
- A A Larson
The substance P amino-terminal metabolite substance P(1-7), administered peripherally, prevents the development of acute morphine tolerance and attenuates the expression of withdrawal in mice.
J Pharmacol Exp Ther November 1996 279:662-667
- Abstract
- Full Text (PDF)
Select this article
- H Xie,
- I Laher,
- and J A Bevan
Protein kinase C modulates flow-initiated contraction.
J Pharmacol Exp Ther November 1996 279:668-674
- Abstract
- Full Text (PDF)
Select this article
- Y Masuda,
- T Sugo,
- T Kikuchi,
- A Kawata,
- M Satoh,
- Y Fujisawa,
- Y Itoh,
- M Wakimasu,
- and T Ohtaki
Receptor binding and antagonist properties of a novel endothelin receptor antagonist, TAK-044 [cyclo[D-alpha-aspartyl-3-[(4-phenylpiperazin-1-yl) carbonyl]-L-alanyl-L-alpha-aspartyl-D-2-(2-thienyl) glycyl-L-leucyl-D-tryptophyl]disodium salt], in human endothelinA and endothelinB receptors.
J Pharmacol Exp Ther November 1996 279:675-685
- Abstract
- Full Text (PDF)
Select this article
- A W Fox,
- B W Sullivan,
- J D Buffini,
- M L Neichin,
- R Nicora,
- F K Hoehler,
- R O'Rourke,
- and R R Stoltz
Reduction of serum lactate by sodium dichloroacetate, and human pharmacokinetic-pharmacodynamic relationships.
J Pharmacol Exp Ther November 1996 279:686-693
- Abstract
- Full Text (PDF)
Select this article
- J E Piletz,
- H Zhu,
- and D N Chikkala
Comparison of ligand binding affinities at human I1-imidazoline binding sites and the high affinity state of alpha-2 adrenoceptor subtypes.
J Pharmacol Exp Ther November 1996 279:694-702
- Abstract
- Full Text (PDF)
Select this article
- N J Brown,
- D Ryder,
- J V Gainer,
- J D Morrow,
- and J Nadeau
Differential effects of angiotensin converting enzyme inhibitors on the vasodepressor and prostacyclin responses to bradykinin.
J Pharmacol Exp Ther November 1996 279:703-712
- Abstract
- Full Text (PDF)
Select this article
- L M Kamendulis,
- M R Brzezinski,
- E V Pindel,
- W F Bosron,
- and R A Dean
Metabolism of cocaine and heroin is catalyzed by the same human liver carboxylesterases.
J Pharmacol Exp Ther November 1996 279:713-717
- Abstract
- Full Text (PDF)
Select this article
- J G Gerber and
- N A Payne
Secretin inhibits canine gastric acid secretion in response to pentagastrin by modulating gastric histamine release.
J Pharmacol Exp Ther November 1996 279:718-723
- Abstract
- Full Text (PDF)
Select this article
- Y Masubuchi,
- S Igarashi,
- T Suzuki,
- T Horie,
- and S Narimatsu
Imipramine-induced inactivation of a cytochrome P450 2D enzyme in rat liver microsomes: in relation to covalent binding of its reactive intermediate.
J Pharmacol Exp Ther November 1996 279:724-731
- Abstract
- Full Text (PDF)
Select this article
- E M Kudlacz,
- R W Knippenberg,
- D E Logan,
- and T P Burkholder
Effect of MDL 105,212, a nonpeptide NK-1/NK-2 receptor antagonist in an allergic guinea pig model.
J Pharmacol Exp Ther November 1996 279:732-739
- Abstract
- Full Text (PDF)
Select this article
- K S Hsu,
- C C Huang,
- M T Su,
- and J J Tsai
L-deprenyl (selegiline) decreases excitatory synaptic transmission in the rat hippocampus via a dopaminergic mechanism.
J Pharmacol Exp Ther November 1996 279:740-747
- Abstract
- Full Text (PDF)
Select this article
- M De Ryck,
- R Keersmaekers,
- H Duytschaever,
- C Claes,
- G Clincke,
- M Janssen,
- and G Van Reet
Lubeluzole protects sensorimotor function and reduces infarct size in a photochemical stroke model in rats.
J Pharmacol Exp Ther November 1996 279:748-758
- Abstract
- Full Text (PDF)
Select this article
- A S Lesage,
- L Peeters,
- and J E Leysen
Lubeluzole, a novel long-term neuroprotectant, inhibits the glutamate-activated nitric oxide synthase pathway.
J Pharmacol Exp Ther November 1996 279:759-766
- Abstract
- Full Text (PDF)
Select this article
- T J Cicero,
- B Nock,
- and E R Meyer
Gender-related differences in the antinociceptive properties of morphine.
J Pharmacol Exp Ther November 1996 279:767-773
- Abstract
- Full Text (PDF)
Select this article
- Y Kwon,
- R D Lee,
- and M E Morris
Hepatic uptake of choline in rat liver basolateral and canalicular membrane vesicle preparations.
J Pharmacol Exp Ther November 1996 279:774-781
- Abstract
- Full Text (PDF)
Select this article
- P Mazzola-Pomietto,
- C S Aulakh,
- S J Huang,
- and D L Murphy
Repeated administration of meta-chlorophenylpiperazine or 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane produces tolerance to its stimulatory effect on adrenocorticotropin hormone but not prolactin or corticosterone secretion in rats.
J Pharmacol Exp Ther November 1996 279:782-789
- Abstract
- Full Text (PDF)
Select this article
- M A Bowman,
- O G Simell,
- A B Peck,
- J Cornelius,
- R Luchetta,
- Z Look,
- N K Maclaren,
- and M A Atkinson
Pharmacokinetics of aminoguanidine administration and effects on the diabetes frequency in nonobese diabetic mice.
J Pharmacol Exp Ther November 1996 279:790-794
- Abstract
- Full Text (PDF)
Select this article
- C H Yang,
- M H Shyr,
- P P Tan,
- and S H Chan
Participation of AT1 and AT2 receptors in the differential interaction between angiotensin II or III and alpha-2 adrenoceptors in the nucleus reticularis gigantocellularis in cardiovascular regulation and antinociception in rats.
J Pharmacol Exp Ther November 1996 279:795-802
- Abstract
- Full Text (PDF)
Select this article
- A Hoogerkamp,
- R H Arends,
- A M Bomers,
- J W Mandema,
- R A Voskuyl,
- and M Danhof
Pharmacokinetic/pharmacodynamic relationship of benzodiazepines in the direct cortical stimulation model of anticonvulsant effect.
J Pharmacol Exp Ther November 1996 279:803-812
- Abstract
- Full Text (PDF)
Select this article
- L J Janssen and
- J Wattie
Non-neurogenic electrically evoked relaxation in canine airway muscle involves action of free radicals on K+ channels.
J Pharmacol Exp Ther November 1996 279:813-821
- Abstract
- Full Text (PDF)
Select this article
- M Mukai,
- K Kushiku,
- H Yamada,
- K Yamada,
- K Dan,
- and T Furukawa
The inhibition of ganglionic transmission via presynaptic dopamine DA1 and postsynaptic DA2 receptor activation in the canine cardiac sympathetic ganglia.
J Pharmacol Exp Ther November 1996 279:822-829
- Abstract
- Full Text (PDF)
Select this article
- Y Nomura,
- M Asano,
- K Ito,
- Y Uyama,
- Y Imaizumi,
- and M Watanabe
Superficial sarcoplasmic reticulum calcium buffering of resting, voltage-dependent Ca++ influx in rat femoral arterial smooth muscle.
J Pharmacol Exp Ther November 1996 279:830-837
- Abstract
- Full Text (PDF)
Select this article
- K Minami,
- N Yanagihara,
- K Segawa,
- T Sata,
- M Tsutsui,
- A Shigematsu,
- and F Izumi
Inhibition by protamine of catecholamine secretion and ion influxes in bovine adrenal medullary cells in culture.
J Pharmacol Exp Ther November 1996 279:838-843
- Abstract
- Full Text (PDF)
Select this article
- G N Tseng,
- B Zhu,
- S Ling,
- and J A Yao
Quinidine enhances and suppresses Kv1.2 from outside and inside the cell, respectively.
J Pharmacol Exp Ther November 1996 279:844-855
- Abstract
- Full Text (PDF)
Select this article
- J A Yao,
- E J Trybulski,
- and G N Tseng
Quinidine preferentially blocks the slow delayed rectifier potassium channel in the rested state.
J Pharmacol Exp Ther November 1996 279:856-864
- Abstract
- Full Text (PDF)
Select this article
- G N Tseng,
- M Jiang,
- and J A Yao
Reverse use dependence of Kv4.2 blockade by 4-aminopyridine.
J Pharmacol Exp Ther November 1996 279:865-876
- Abstract
- Full Text (PDF)
Select this article
- M Murakami,
- M Kinukawa,
- T Kanazawa,
- K Maruyama,
- M Miyagi,
- H Miyata,
- and A Ujiie
Effects of the new class I antiarrhythmic agent Ro 22-9194, (2R)-2-amino-N-(2,6-dimethylphenyl)-N-[3-(3-pyridyl)propyl]propionamide D-tartrate, on ischemia- and reperfusion-induced arrhythmias in dogs: involvement of thromboxane A2 synthase inhibitory activity.
J Pharmacol Exp Ther November 1996 279:877-883
- Abstract
- Full Text (PDF)
Select this article
- C Ghelardini,
- N Galeotti,
- M Figini,
- A Imperato,
- M Nicolodi,
- F Sicuteri,
- G L Gessa,
- and A Bartolini
The central cholinergic system has a role in the antinociception induced in rodents and guinea pigs by the antimigraine drug sumatriptan.
J Pharmacol Exp Ther November 1996 279:884-890
- Abstract
- Full Text (PDF)
Select this article
- H Wiegand,
- L J McIntosh,
- U Gotzsch,
- and U Krämer
Effects of tetrandrine on spontaneous and evoked release of acetylcholine at the mouse neuromuscular junction.
J Pharmacol Exp Ther November 1996 279:891-901
- Abstract
- Full Text (PDF)
Select this article
- M Lefebvre,
- G Caillé,
- and P du Souich
Organ-specific pattern of inhibition of diltiazem metabolism at steady state in rabbits.
J Pharmacol Exp Ther November 1996 279:902-907
- Abstract
- Full Text (PDF)
Select this article
- P Singh and
- M S Roberts
Local deep tissue penetration of compounds after dermal application: structure-tissue penetration relationships.
J Pharmacol Exp Ther November 1996 279:908-917
- Abstract
- Full Text (PDF)
Select this article
- T S Peters and
- S J Lewis
Lipopolysaccharide inhibits acetylcholine- and nitric oxide-mediated vasodilation in vivo.
J Pharmacol Exp Ther November 1996 279:918-925
- Abstract
- Full Text (PDF)
Select this article
- C Tränkle,
- E Kostenis,
- U Burgmer,
- and K Mohr
Search for lead structures to develop new allosteric modulators of muscarinic receptors.
J Pharmacol Exp Ther November 1996 279:926-933
- Abstract
- Full Text (PDF)
Select this article
- E R Butelman,
- J W Lewis,
- and J H Woods
Methoclocinnamox: agonist and antagonist effects of a novel long-lasting opioid in rhesus monkeys.
J Pharmacol Exp Ther November 1996 279:934-938
- Abstract
- Full Text (PDF)
Select this article
- A J Fischman,
- A A Bonab,
- J W Babich,
- N M Alpert,
- S L Rauch,
- D R Elmaleh,
- T M Shoup,
- S A Williams,
- and R H Rubin
Positron emission tomographic analysis of central 5-hydroxytryptamine2 receptor occupancy in healthy volunteers treated with the novel antipsychotic agent, ziprasidone.
J Pharmacol Exp Ther November 1996 279:939-947
- Abstract
- Full Text (PDF)
Select this article
- F C Barone,
- A H Nelson,
- E H Ohlstein,
- R N Willette,
- J E Sealey,
- J H Laragh,
- W G Campbell, Jr,
- and G Z Feuerstein
Chronic carvedilol reduces mortality and renal damage in hypertensive stroke-prone rats.
J Pharmacol Exp Ther November 1996 279:948-955
- Abstract
- Full Text (PDF)
Select this article
- J D Winkler,
- T Eris,
- C M Sung,
- M Chabot-Fletcher,
- R J Mayer,
- M E Surette,
- and F H Chilton
Inhibitors of coenzyme A-independent transacylase induce apoptosis in human HL-60 cells.
J Pharmacol Exp Ther November 1996 279:956-966
- Abstract
- Full Text (PDF)
Select this article
- T P Abrahams,
- W Liu,
- and K J Varner
Blockade of alpha-2 adrenergic receptors in the rostral ventrolateral medulla attenuates the sympathoinhibitory response to cocaine.
J Pharmacol Exp Ther November 1996 279:967-974
- Abstract
- Full Text (PDF)
Select this article
- S Takahashi and
- S Okabe
The cytoprotective effect of leminoprazole on indomethacin-induced damage to rabbit gastric mucosal cells.
J Pharmacol Exp Ther November 1996 279:975-982
- Abstract
- Full Text (PDF)
Select this article
- S Kim,
- A Hamaguchi,
- T Shinkawa,
- Y Kato,
- N Tsuchiya,
- K Miura,
- K Ohta,
- and H Iwao
Molecular effects of M17055, furosemide and thiazide on cardiac hypertrophy of spontaneously hypertensive rats.
J Pharmacol Exp Ther November 1996 279:983-990
- Abstract
- Full Text (PDF)
Select this article
- A K Agrawal and
- B H Shapiro
Imprinted overinduction of hepatic CYP2B1 and 2B2 in adult rats neonatally exposed to phenobarbital.
J Pharmacol Exp Ther November 1996 279:991-999
- Abstract
- Full Text (PDF)
Select this article
- J A Fox,
- T E Hotaling,
- C Struble,
- J Ruppel,
- D J Bates,
- and M B Schoenhoff
Tissue distribution and complex formation with IgE of an anti-IgE antibody after intravenous administration in cynomolgus monkeys.
J Pharmacol Exp Ther November 1996 279:1000-1008
- Abstract
- Full Text (PDF)
Select this article
- P Harvie,
- R F Omar,
- N Dusserre,
- N Lansac,
- A Désormeaux,
- P Gourde,
- M Simard,
- M Tremblay,
- D Beauchamp,
- and M G Bergeron
Ribavirin potentiates the efficacy and toxicity of 2',3'- dideoxyinosine in the murine acquired immunodeficiency syndrome model.
J Pharmacol Exp Ther November 1996 279:1009-1017
- Abstract
- Full Text (PDF)
Select this article
- D T Vistica,
- S Kenney,
- M Hursey,
- and M R Boyd
Role of membrane potential in the accumulation of quaternized ellipticines by human tumor cell lines.
J Pharmacol Exp Ther November 1996 279:1018-1025
- Abstract
- Full Text (PDF)
Select this article
- V R Muzykantov,
- E S Barnathan,
- E N Atochina,
- A Kuo,
- S M Danilov,
- and A B Fisher
Targeting of antibody-conjugated plasminogen activators to the pulmonary vasculature.
J Pharmacol Exp Ther November 1996 279:1026-1034
- Abstract
- Full Text (PDF)
Select this article
- Q Li,
- N A Muma,
- and L D van de Kar
Chronic fluoxetine induces a gradual desensitization of 5-HT1A receptors: reductions in hypothalamic and midbrain Gi and G(o) proteins and in neuroendocrine responses to a 5-HT1A agonist.
J Pharmacol Exp Ther November 1996 279:1035-1042
- Abstract
- Full Text (PDF)
Select this article
- M Sparago,
- J Wlos,
- J Yuan,
- G Hatzidimitriou,
- J Tolliver,
- T A Dal Cason,
- J Katz,
- and G Ricaurte
Neurotoxic and pharmacologic studies on enantiomers of the N-methylated analog of cathinone (methcathinone): a new drug of abuse.
J Pharmacol Exp Ther November 1996 279:1043-1052
- Abstract
- Full Text (PDF)
Select this article
- K J Salter and
- R Z Kozlowski
Endothelin receptor coupling to potassium and chloride channels in isolated rat pulmonary arterial myocytes.
J Pharmacol Exp Ther November 1996 279:1053-1062
- Abstract
- Full Text (PDF)

Article

Select this article

IN MEMORIAM
J Pharmacol Exp Ther November 1996 279:443-S
- Abstract
- Full Text (PDF)

Current Issue

November 2009, 331 (2)

Synergistic behavioral interaction between ethanol and clonidine in rats: role of alpha-2 adrenoceptors.

Effects of transdermal nicotine delivery on measures of acute nicotine withdrawal.

Pharmacological characterization of inward current evoked by N-methyl-D-aspartate in dopamine neurons in the rat brain slice.

Mechanical and energetic effects of cromakalim on guinea pig left ventricular papillary muscle.

Anti-interleukin 4 antibody and indomethacin synergistic effect on B16 melanoma tumor progression.

Aging and glucocorticoids: effects on cell signaling mediated through adenylyl cyclase.

Anticonvulsant and behavioral profile of L-701,324, a potent, orally active antagonist at the glycine modulatory site on the N-methyl-D-aspartate receptor complex.

Peripheral morphine analgesia: synergy with central sites and a target of morphine tolerance.

In vitro biotransformation of dynorphin A (1-17) is similar in human and rhesus monkey blood as studied by matrix-assisted laser desorption/ionization mass spectrometry.

Pharmacological properties of acquired excitotoxicity in Chinese hamster ovary cells transfected with N-methyl-D-aspartate receptor subunits.

Effects of naltrexone on response to intravenous cocaine, hydromorphone and their combination in humans.

N-cyclobutylmethyl analog of normorphinone, N-CBM-TAMO: a short-term opioid agonist and long-term Mu-selective irreversible opioid antagonist.

Nephrotoxicity of acetaminophen in male Wistar rats: role of hepatically derived metabolites.

Molecular basis and species specificity of high affinity binding of vasoactive intestinal polypeptide by the rat secretin receptor.

Long-term studies on anticonvulsant tolerance and withdrawal characteristics of benzodiazepine receptor ligands in different seizure models in mice. I. Comparison of diazepam, clonazepam, clobazam and abecarnil.

Long-term studies on anticonvulsant tolerance and withdrawal characteristics of benzodiazepine receptor ligands in different seizure models in mice. II. The novel imidazoquinazolines NNC 14-0185 and NNC 14-0189.

Monoaminergic substrates underlying cocaine-induced enhancement of somatosensory-evoked discharges in rat barrel field cortical neurons.

Functional properties of muscarinic receptor subtypes Hm1, Hm3 and Hm5 expressed in Sf9 cells using the baculovirus expression system.

Effects of gamma-aminobutyric acid agonists on the isolated perfused rat kidney.

The role of endogenous opioids in enhancing the antinociception produced by the combination of delta 9-tetrahydrocannabinol and morphine in the spinal cord.

Inhibitory effect of amiodarone on the muscarinic acetylcholine receptor-operated potassium current in guinea pig atrial cells.

Transport of paraquat in a renal epithelial cell line LLC-PK1.

Pharmacological targeting of signaling pathways in protein kinase C-stimulated superoxide generation in neutrophil-like HL-60 cells: effect of phorbol ester, arachidonic acid and inhibitors of kinase(s), phosphatase(s) and phospholipase A2.

Antiviral activity and mechanism of action of calanolide A against the human immunodeficiency virus type-1.

Kinetic analysis of inhibition of human immunodeficiency virus type-1 reverse transcriptase by calanolide A.

The substance P amino-terminal metabolite substance P(1-7), administered peripherally, prevents the development of acute morphine tolerance and attenuates the expression of withdrawal in mice.

Protein kinase C modulates flow-initiated contraction.

Receptor binding and antagonist properties of a novel endothelin receptor antagonist, TAK-044 [cyclo[D-alpha-aspartyl-3-[(4-phenylpiperazin-1-yl) carbonyl]-L-alanyl-L-alpha-aspartyl-D-2-(2-thienyl) glycyl-L-leucyl-D-tryptophyl]disodium salt], in human endothelinA and endothelinB receptors.

Reduction of serum lactate by sodium dichloroacetate, and human pharmacokinetic-pharmacodynamic relationships.

Comparison of ligand binding affinities at human I1-imidazoline binding sites and the high affinity state of alpha-2 adrenoceptor subtypes.

Differential effects of angiotensin converting enzyme inhibitors on the vasodepressor and prostacyclin responses to bradykinin.

Metabolism of cocaine and heroin is catalyzed by the same human liver carboxylesterases.

Secretin inhibits canine gastric acid secretion in response to pentagastrin by modulating gastric histamine release.

Imipramine-induced inactivation of a cytochrome P450 2D enzyme in rat liver microsomes: in relation to covalent binding of its reactive intermediate.

Effect of MDL 105,212, a nonpeptide NK-1/NK-2 receptor antagonist in an allergic guinea pig model.

L-deprenyl (selegiline) decreases excitatory synaptic transmission in the rat hippocampus via a dopaminergic mechanism.

Lubeluzole protects sensorimotor function and reduces infarct size in a photochemical stroke model in rats.

Lubeluzole, a novel long-term neuroprotectant, inhibits the glutamate-activated nitric oxide synthase pathway.

Gender-related differences in the antinociceptive properties of morphine.

Hepatic uptake of choline in rat liver basolateral and canalicular membrane vesicle preparations.

Repeated administration of meta-chlorophenylpiperazine or 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane produces tolerance to its stimulatory effect on adrenocorticotropin hormone but not prolactin or corticosterone secretion in rats.

Pharmacokinetics of aminoguanidine administration and effects on the diabetes frequency in nonobese diabetic mice.

Participation of AT1 and AT2 receptors in the differential interaction between angiotensin II or III and alpha-2 adrenoceptors in the nucleus reticularis gigantocellularis in cardiovascular regulation and antinociception in rats.

Pharmacokinetic/pharmacodynamic relationship of benzodiazepines in the direct cortical stimulation model of anticonvulsant effect.

Non-neurogenic electrically evoked relaxation in canine airway muscle involves action of free radicals on K+ channels.

The inhibition of ganglionic transmission via presynaptic dopamine DA1 and postsynaptic DA2 receptor activation in the canine cardiac sympathetic ganglia.

Superficial sarcoplasmic reticulum calcium buffering of resting, voltage-dependent Ca++ influx in rat femoral arterial smooth muscle.

Inhibition by protamine of catecholamine secretion and ion influxes in bovine adrenal medullary cells in culture.

Quinidine enhances and suppresses Kv1.2 from outside and inside the cell, respectively.

Quinidine preferentially blocks the slow delayed rectifier potassium channel in the rested state.

Reverse use dependence of Kv4.2 blockade by 4-aminopyridine.

Effects of the new class I antiarrhythmic agent Ro 22-9194, (2R)-2-amino-N-(2,6-dimethylphenyl)-N-[3-(3-pyridyl)propyl]propionamide D-tartrate, on ischemia- and reperfusion-induced arrhythmias in dogs: involvement of thromboxane A2 synthase inhibitory activity.

The central cholinergic system has a role in the antinociception induced in rodents and guinea pigs by the antimigraine drug sumatriptan.

Effects of tetrandrine on spontaneous and evoked release of acetylcholine at the mouse neuromuscular junction.

Organ-specific pattern of inhibition of diltiazem metabolism at steady state in rabbits.

Local deep tissue penetration of compounds after dermal application: structure-tissue penetration relationships.

Lipopolysaccharide inhibits acetylcholine- and nitric oxide-mediated vasodilation in vivo.

Search for lead structures to develop new allosteric modulators of muscarinic receptors.

Methoclocinnamox: agonist and antagonist effects of a novel long-lasting opioid in rhesus monkeys.

Positron emission tomographic analysis of central 5-hydroxytryptamine2 receptor occupancy in healthy volunteers treated with the novel antipsychotic agent, ziprasidone.

Chronic carvedilol reduces mortality and renal damage in hypertensive stroke-prone rats.

Inhibitors of coenzyme A-independent transacylase induce apoptosis in human HL-60 cells.

Blockade of alpha-2 adrenergic receptors in the rostral ventrolateral medulla attenuates the sympathoinhibitory response to cocaine.

The cytoprotective effect of leminoprazole on indomethacin-induced damage to rabbit gastric mucosal cells.

Molecular effects of M17055, furosemide and thiazide on cardiac hypertrophy of spontaneously hypertensive rats.

Imprinted overinduction of hepatic CYP2B1 and 2B2 in adult rats neonatally exposed to phenobarbital.

Tissue distribution and complex formation with IgE of an anti-IgE antibody after intravenous administration in cynomolgus monkeys.

Ribavirin potentiates the efficacy and toxicity of 2',3'- dideoxyinosine in the murine acquired immunodeficiency syndrome model.

Role of membrane potential in the accumulation of quaternized ellipticines by human tumor cell lines.

Targeting of antibody-conjugated plasminogen activators to the pulmonary vasculature.

Chronic fluoxetine induces a gradual desensitization of 5-HT1A receptors: reductions in hypothalamic and midbrain Gi and G(o) proteins and in neuroendocrine responses to a 5-HT1A agonist.

Neurotoxic and pharmacologic studies on enantiomers of the N-methylated analog of cathinone (methcathinone): a new drug of abuse.

Endothelin receptor coupling to potassium and chloride channels in isolated rat pulmonary arterial myocytes.

Article

IN MEMORIAM

This Issue

Current Issue