Table of Contents

September 1996; 278 (3)

Select this article
- V M Showalter,
- D R Compton,
- B R Martin,
- and M E Abood
Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands.
J Pharmacol Exp Ther September 1996 278:989-999
- Abstract
- Full Text (PDF)
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- L C Trost and
- J J Lemasters
The mitochondrial permeability transition: a new pathophysiological mechanism for Reye's syndrome and toxic liver injury.
J Pharmacol Exp Ther September 1996 278:1000-1005
- Abstract
- Full Text (PDF)
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- Y Tsutsumi,
- T Kihira,
- S Tsunoda,
- H Kamada,
- S Nakagawa,
- Y Kaneda,
- T Kanamori,
- and T Mayumi
Molecular design of hybrid tumor necrosis factor-alpha III: polyethylene glycol-modified tumor necrosis factor-alpha has markedly enhanced antitumor potency due to longer plasma half-life and higher tumor accumulation.
J Pharmacol Exp Ther September 1996 278:1006-1011
- Abstract
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- S L Waters and
- R G Schnellmann
Extracellular acidosis and chloride channel inhibitors act in the late phase of cellular injury to prevent death.
J Pharmacol Exp Ther September 1996 278:1012-1017
- Abstract
- Full Text (PDF)
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- N R Kitteringham,
- C Davis,
- N Howard,
- M Pirmohamed,
- and B K Park
Interindividual and interspecies variation in hepatic microsomal epoxide hydrolase activity: studies with cis-stilbene oxide, carbamazepine 10, 11-epoxide and naphthalene.
J Pharmacol Exp Ther September 1996 278:1018-1027
- Abstract
- Full Text (PDF)
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- T Takahashi,
- K Takahashi,
- S Kishi-Tanikawa,
- K Tsuchida,
- H Araki,
- and S Higuchi
Effects of a new calcium antagonist, CD-832, on isoproterenol-induced myocardial ischemia in dogs with partial coronary stenosis.
J Pharmacol Exp Ther September 1996 278:1028-1033
- Abstract
- Full Text (PDF)
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- J A Schriefer,
- E P Broudy,
- and A H Hassen
Endopeptidase inhibitors decrease myocardial ischemia/reperfusion injury in an in vivo rabbit model.
J Pharmacol Exp Ther September 1996 278:1034-1039
- Abstract
- Full Text (PDF)
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- M J Owens,
- C A Ballenger,
- D L Knight,
- and C B Nemeroff
Platelet 5-hydroxytryptamine (5-HT) transporter and 5-HT2A receptor binding after chronic hypercorticosteronemia, (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane administration or neurotoxin-induced depletion of central nervous system 5-HT in the rat.
J Pharmacol Exp Ther September 1996 278:1040-1049
- Abstract
- Full Text (PDF)
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- T C Krejcie,
- T K Henthorn,
- C U Niemann,
- C Klein,
- D K Gupta,
- W B Gentry,
- C A Shanks,
- and M J Avram
Recirculatory pharmacokinetic models of markers of blood, extracellular fluid and total body water administered concomitantly.
J Pharmacol Exp Ther September 1996 278:1050-1057
- Abstract
- Full Text (PDF)
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- M Tominaga,
- H Tsukada,
- M Hosokawa,
- H Nakamura,
- T Taniguchi,
- S Ueda,
- M Sakai,
- and M Okuma
ONO-1078 antagonizes diarrhea-causing changes in ion transport and smooth muscle contraction induced by peptidoleukotrienes in rat and human colon in vitro.
J Pharmacol Exp Ther September 1996 278:1058-1063
- Abstract
- Full Text (PDF)
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- N Bel and
- F Artigas
In vivo effects of the simultaneous blockade of serotonin and norepinephrine transporters on serotonergic function. Microdialysis studies.
J Pharmacol Exp Ther September 1996 278:1064-1072
- Abstract
- Full Text (PDF)
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- M A Wilson,
- R Biscardi,
- M D Smith,
- and S P Wilson
Effects of benzodiazepine agonist exposure on corticotropin-releasing factor content and hormonal stress responses: divergent responses in male and ovariectomized female rats.
J Pharmacol Exp Ther September 1996 278:1073-1082
- Abstract
- Full Text (PDF)
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- E Malatynska,
- Y Wang,
- R J Knapp,
- S Waite,
- S Calderon,
- K Rice,
- V J Hruby,
- H I Yamamura,
- and W R Roeske
Human delta opioid receptor: functional studies on stably transfected Chinese hamster ovary cells after acute and chronic treatment with the selective nonpeptidic agonist SNC-80.
J Pharmacol Exp Ther September 1996 278:1083-1089
- Abstract
- Full Text (PDF)
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- G P Thomas,
- G R Ferrier,
- and S E Howlett
Losartan exerts antiarrhythmic activity independent of angiotensin II receptor blockade in simulated ventricular ischemia and reperfusion.
J Pharmacol Exp Ther September 1996 278:1090-1097
- Abstract
- Full Text (PDF)
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- R B Raffa,
- M L Haslego,
- C A Maryanoff,
- F J Villani,
- E E Codd,
- C D Connelly,
- R P Martinez,
- J J Schupsky,
- J A Buben,
- W N Wu,
- A N Takacs,
- and L A Mckown
Unexpected antinociceptive effect of the N-oxide (RWJ 38705) of tramadol hydrochloride.
J Pharmacol Exp Ther September 1996 278:1098-1104
- Abstract
- Full Text (PDF)
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- M Weiss,
- E M Schneider,
- J Tarnow,
- S Mettler,
- M Krone,
- A Teschemacher,
- and H Lemoine
Is inhibition of oxygen radical production of neutrophils by sympathomimetics mediated via beta-2 adrenoceptors?
J Pharmacol Exp Ther September 1996 278:1105-1113
- Abstract
- Full Text (PDF)
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- O Massó,
- S F Aliño,
- M Lejarreta,
- F Blasco,
- and J Piulats
Specific serological response by active immunization with GD3-bearing liposomes.
J Pharmacol Exp Ther September 1996 278:1114-1120
- Abstract
- Full Text (PDF)
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- P J Emmerson,
- M J Clark,
- A Mansour,
- H Akil,
- J H Woods,
- and F Medzihradsky
Characterization of opioid agonist efficacy in a C6 glioma cell line expressing the mu opioid receptor.
J Pharmacol Exp Ther September 1996 278:1121-1127
- Abstract
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- R D Spealman
Dopamine D3 receptor agonists partially reproduce the discriminative stimulus effects of cocaine in squirrel monkeys.
J Pharmacol Exp Ther September 1996 278:1128-1137
- Abstract
- Full Text (PDF)
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- J G Hensler,
- L S Cervera,
- H A Miller,
- and J Corbitt
Expression and modulation of 5-hydroxytryptamine1A receptors in P11 cells.
J Pharmacol Exp Ther September 1996 278:1138-1145
- Abstract
- Full Text (PDF)
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- T Minami,
- E Okuda-Ashitaka,
- H Mori,
- S Ito,
- and O Hayaishi
Prostaglandin D2 inhibits prostaglandin E2-induced allodynia in conscious mice.
J Pharmacol Exp Ther September 1996 278:1146-1152
- Abstract
- Full Text (PDF)
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- R W Foltin and
- M W Fischman
Effects of methadone or buprenorphine maintenance on the subjective and reinforcing effects of intravenous cocaine in humans.
J Pharmacol Exp Ther September 1996 278:1153-1164
- Abstract
- Full Text (PDF)
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- Y Caraco,
- J Sheller,
- and A J Wood
Pharmacogenetic determination of the effects of codeine and prediction of drug interactions.
J Pharmacol Exp Ther September 1996 278:1165-1174
- Abstract
- Full Text (PDF)
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- E S Rocha,
- K L Swanson,
- Y Aracava,
- J E Goolsby,
- A Maelicke,
- and E X Albuquerque
Paraoxon: cholinesterase-independent stimulation of transmitter release and selective block of ligand-gated ion channels in cultured hippocampal neurons.
J Pharmacol Exp Ther September 1996 278:1175-1187
- Abstract
- Full Text (PDF)
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- G P McCallum,
- A C Weedon,
- P Krug,
- and J R Bend
Microsomal cytochrome P450 peroxygenase metabolism of arachidonic acid in guinea pig liver.
J Pharmacol Exp Ther September 1996 278:1188-1194
- Abstract
- Full Text (PDF)
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- C M Heesch,
- B H Negus,
- J E Bost,
- J H Keffer,
- R W Snyder, 2nd,
- and E J Eichhorn
Effects of cocaine on anterior pituitary and gonadal hormones.
J Pharmacol Exp Ther September 1996 278:1195-1200
- Abstract
- Full Text (PDF)
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- E J Barbarito,
- C E Lau,
- and J L Falk
Tolerance to the anxiolytic effects of the triazolobenzodiazepines triazolam and alprazolam, as measured by the ingestion of a hypertonic sodium chloride solution in rats.
J Pharmacol Exp Ther September 1996 278:1201-1208
- Abstract
- Full Text (PDF)
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- S Dionisotti,
- S Ferrara,
- C Molta,
- C Zocchi,
- and E Ongini
Labeling of A2A adenosine receptors in human platelets by use of the new nonxanthine antagonist radioligand [3H]SCH 58261.
J Pharmacol Exp Ther September 1996 278:1209-1214
- Abstract
- Full Text (PDF)
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- J D Deupree,
- K A Hinton,
- D R Cerutis,
- and D B Bylund
Buffers differentially alter the binding of [3H]rauwolscine and [3H]RX821002 to the alpha-2 adrenergic receptor subtypes.
J Pharmacol Exp Ther September 1996 278:1215-1227
- Abstract
- Full Text (PDF)
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- M E Beyer,
- G Slesak,
- and H M Hoffmeister
Significance of endothelinB receptors for myocardial contractility and myocardial energy metabolism.
J Pharmacol Exp Ther September 1996 278:1228-1234
- Abstract
- Full Text (PDF)
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- C S Bockman,
- I Gonzalez-Cabrera,
- and P W Abel
Alpha-2 adrenoceptor subtype causing nitric oxide-mediated vascular relaxation in rats.
J Pharmacol Exp Ther September 1996 278:1235-1243
- Abstract
- Full Text (PDF)
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- T A Lewis,
- A E Munson,
- and K L McCoy
Gallium arsenide selectively suppresses antigen processing by splenic macrophages for CD4+ T cell activation.
J Pharmacol Exp Ther September 1996 278:1244-1251
- Abstract
- Full Text (PDF)
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- N A Sharif,
- S X Xu,
- S T Miller,
- D A Gamache,
- and J M Yanni
Characterization of the ocular antiallergic and antihistaminic effects of olopatadine (AL-4943A), a novel drug for treating ocular allergic diseases.
J Pharmacol Exp Ther September 1996 278:1252-1261
- Abstract
- Full Text (PDF)
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- N E Cameron and
- M A Cotter
Effects of a nonpeptide endothelin-1 ETA antagonist on neurovascular function in diabetic rats: interaction with the renin-angiotensin system.
J Pharmacol Exp Ther September 1996 278:1262-1268
- Abstract
- Full Text (PDF)
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- A Hirasaki,
- K A Jones,
- W J Perkins,
- and D O Warner
Use of nitric oxide-nucleophile adducts as biological sources of nitric oxide: effects on airway smooth muscle.
J Pharmacol Exp Ther September 1996 278:1269-1275
- Abstract
- Full Text (PDF)
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- K J Scheidegger,
- J M Wood,
- H van Essen,
- and H A Struijker-Boudier
Effects of prolonged blockade of the renin angiotensin system on striated muscle microcirculation of spontaneously hypertensive rats.
J Pharmacol Exp Ther September 1996 278:1276-1281
- Abstract
- Full Text (PDF)
Select this article
- M B Gatch,
- S S Negus,
- N K Mello,
- S Archer,
- and J M Bidlack
Effects of the structurally novel opioid 14 alpha, 14' beta-[dithiobis [(2-oxo-2,1-ethanediyl)imino]]bis(7,8-dihydromorphinone) on schedule-controlled behavior and thermal nociception in rhesus monkeys.
J Pharmacol Exp Ther September 1996 278:1282-1289
- Abstract
- Full Text (PDF)
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- M D Aceto,
- S M Scates,
- J A Lowe,
- and B R Martin
Dependence on delta 9-tetrahydrocannabinol: studies on precipitated and abrupt withdrawal.
J Pharmacol Exp Ther September 1996 278:1290-1295
- Abstract
- Full Text (PDF)
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- A I Haj-Yehia and
- L Z Benet
In vivo depletion of free thiols does not account for nitroglycerin-induced tolerance: a thiol-nitrate interaction hypothesis as an alternative explanation for nitroglycerin activity and tolerance.
J Pharmacol Exp Ther September 1996 278:1296-1305
- Abstract
- Full Text (PDF)
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- T L Wallace,
- S A Bazemore,
- D J Kornbrust,
- and P A Cossum
Single-dose hemodynamic toxicity and pharmacokinetics of a partial phosphorothioate anti-HIV oligonucleotide (AR177) after intravenous infusion to cynomolgus monkeys.
J Pharmacol Exp Ther September 1996 278:1306-1312
- Abstract
- Full Text (PDF)
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- T L Wallace,
- S A Bazemore,
- D J Kornbrust,
- and P A Cossum
Repeat-dose toxicity and pharmacokinetics of a partial phosphorothioate anti-HIV oligonucleotide (AR177) after bolus intravenous administration to cynomolgus monkeys.
J Pharmacol Exp Ther September 1996 278:1313-1317
- Abstract
- Full Text (PDF)
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- P C Endresen,
- T Loennechen,
- H Kildalsen,
- and J Aarbakke
Apoptosis and transmethylation metabolites in HL-60 cells.
J Pharmacol Exp Ther September 1996 278:1318-1324
- Abstract
- Full Text (PDF)
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- W J Wu and
- S B Pruett
Suppression of splenic natural killer cell activity in a mouse model for binge drinking. I. Direct effects of ethanol and its major metabolites are not primarily responsible for decreased natural killer cell activity.
J Pharmacol Exp Ther September 1996 278:1325-1330
- Abstract
- Full Text (PDF)
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- W J Wu and
- S B Pruett
Suppression of splenic natural killer cell activity in a mouse model for binge drinking. II. Role of the neuroendocrine system.
J Pharmacol Exp Ther September 1996 278:1331-1339
- Abstract
- Full Text (PDF)
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- C Xu and
- M E Reith
Modeling of the pH dependence of the binding of WIN 35,428 to the dopamine transporter in rat striatal membranes: is the bioactive form positively charged or neutral?
J Pharmacol Exp Ther September 1996 278:1340-1348
- Abstract
- Full Text (PDF)
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- C R Turner,
- V L Cohan,
- J B Cheng,
- H J Showell,
- C J Pazoles,
- and J W Watson
The in vivo pharmacology of CP-80, 633, a selective inhibitor of phosphodiesterase 4.
J Pharmacol Exp Ther September 1996 278:1349-1355
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- Full Text (PDF)
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- V L Cohan,
- H J Showell,
- D A Fisher,
- C J Pazoles,
- J W Watson,
- C R Turner,
- and J B Cheng
In vitro pharmacology of the novel phosphodiesterase type 4 inhibitor, CP-80633.
J Pharmacol Exp Ther September 1996 278:1356-1361
- Abstract
- Full Text (PDF)
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- D Nakai,
- T Seita,
- T Terasaki,
- S Iwasa,
- Y Shoji,
- Y Mizushima,
- and Y Sugiyama
Cellular uptake mechanism for oligonucleotides: involvement of endocytosis in the uptake of phosphodiester oligonucleotides by a human colorectal adenocarcinoma cell line, HCT-15.
J Pharmacol Exp Ther September 1996 278:1362-1372
- Abstract
- Full Text (PDF)
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- G J Marek and
- G K Aghajanian
LSD and the phenethylamine hallucinogen DOI are potent partial agonists at 5-HT2A receptors on interneurons in rat piriform cortex.
J Pharmacol Exp Ther September 1996 278:1373-1382
- Abstract
- Full Text (PDF)
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- T K Chang and
- G D Bellward
Peripubertal androgen imprinting of rat hepatic cytochrome P450 2C11 and steroid 5 alpha-reductase: pretranslational regulation and impact on microsomal drug activation.
J Pharmacol Exp Ther September 1996 278:1383-1391
- Abstract
- Full Text (PDF)
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- Z Y Wei,
- F Karim,
- and S C Roerig
Spinal morphine/clonidine antinociceptive synergism: involvement of G proteins and N-type voltage-dependent calcium channels.
J Pharmacol Exp Ther September 1996 278:1392-1407
- Abstract
- Full Text (PDF)
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- J Lakritz,
- A Chang,
- A Weir,
- S Nishio,
- D Hyde,
- R Philpot,
- A Buckpitt,
- and C Plopper
Cellular and metabolic basis of Clara cell tolerance to multiple doses of cytochrome P450-activated cytotoxicants. I: Bronchiolar epithelial reorganization and expression of cytochrome P450 monooxygenases in mice exposed to multiple doses of naphthalene.
J Pharmacol Exp Ther September 1996 278:1408-1418
- Abstract
- Full Text (PDF)
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- J P Desjardins,
- B S Sproat,
- B Beijer,
- M Blaschke,
- M Dunkel,
- W Gerdes,
- J Ludwig,
- V Reither,
- T Rupp,
- and P L Iversen
Pharmacokinetics of a synthetic, chemically modified hammerhead ribozyme against the rat cytochrome P-450 3A2 mRNA after single intravenous injections.
J Pharmacol Exp Ther September 1996 278:1419-1427
- Abstract
- Full Text (PDF)
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- S Iwata,
- G H Hewlett,
- S T Ferrell,
- A J Czernik,
- K F Meiri,
- and M E Gnegy
Increased in vivo phosphorylation state of neuromodulin and synapsin I in striatum from rats treated with repeated amphetamine.
J Pharmacol Exp Ther September 1996 278:1428-1434
- Abstract
- Full Text (PDF)
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- Y T Shen,
- P Cervoni,
- T Claus,
- and S F Vatner
Differences in beta 3-adrenergic receptor cardiovascular regulation in conscious primates, rats and dogs.
J Pharmacol Exp Ther September 1996 278:1435-1443
- Abstract
- Full Text (PDF)
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- C May,
- R I James,
- R Gunther,
- and R S McIvor
Methotrexate dose-escalation studies in transgenic mice and marrow transplant recipients expressing drug-resistant dihydrofolate reductase activity.
J Pharmacol Exp Ther September 1996 278:1444-1451
- Abstract
- Full Text (PDF)
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- T R Wiernicki,
- J S Bean,
- C Dell,
- A Williams,
- D Wood,
- R F Kauffman,
- and J P Singh
Inhibition of vascular smooth muscle cell proliferation and arterial intimal thickening by a novel antiproliferative naphthopyran.
J Pharmacol Exp Ther September 1996 278:1452-1459
- Abstract
- Full Text (PDF)
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- M Alkondon,
- E S Rocha,
- A Maelicke,
- and E X Albuquerque
Diversity of nicotinic acetylcholine receptors in rat brain. V. alpha-Bungarotoxin-sensitive nicotinic receptors in olfactory bulb neurons and presynaptic modulation of glutamate release.
J Pharmacol Exp Ther September 1996 278:1460-1471
- Abstract
- Full Text (PDF)
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- E F Pereira,
- M Alkondon,
- J M McIntosh,
- and E X Albuquerque
Alpha-conotoxin-ImI: a competitive antagonist at alpha-bungarotoxin-sensitive neuronal nicotinic receptors in hippocampal neurons.
J Pharmacol Exp Ther September 1996 278:1472-1483
- Abstract
- Full Text (PDF)
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- L Foissier,
- M Lonchampt,
- F Cogé,
- and E Canet
In vitro down-regulation of antigen-induced IL-5 gene expression and protein production by cAMP-specific phosphodiesterase type 4 inhibitor.
J Pharmacol Exp Ther September 1996 278:1484-1490
- Abstract
- Full Text (PDF)
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- P M Friden,
- T S Olson,
- R Obar,
- L R Walus,
- and S D Putney
Characterization, receptor mapping and blood-brain barrier transcytosis of antibodies to the human transferrin receptor.
J Pharmacol Exp Ther September 1996 278:1491-1498
- Abstract
- Full Text (PDF)
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- A E Kelley,
- E P Bless,
- and C J Swanson
Investigation of the effects of opiate antagonists infused into the nucleus accumbens on feeding and sucrose drinking in rats.
J Pharmacol Exp Ther September 1996 278:1499-1507
- Abstract
- Full Text (PDF)

Current Issue

November 2009, 331 (2)

Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands.

The mitochondrial permeability transition: a new pathophysiological mechanism for Reye's syndrome and toxic liver injury.

Molecular design of hybrid tumor necrosis factor-alpha III: polyethylene glycol-modified tumor necrosis factor-alpha has markedly enhanced antitumor potency due to longer plasma half-life and higher tumor accumulation.

Extracellular acidosis and chloride channel inhibitors act in the late phase of cellular injury to prevent death.

Interindividual and interspecies variation in hepatic microsomal epoxide hydrolase activity: studies with cis-stilbene oxide, carbamazepine 10, 11-epoxide and naphthalene.

Effects of a new calcium antagonist, CD-832, on isoproterenol-induced myocardial ischemia in dogs with partial coronary stenosis.

Endopeptidase inhibitors decrease myocardial ischemia/reperfusion injury in an in vivo rabbit model.

Platelet 5-hydroxytryptamine (5-HT) transporter and 5-HT2A receptor binding after chronic hypercorticosteronemia, (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane administration or neurotoxin-induced depletion of central nervous system 5-HT in the rat.

Recirculatory pharmacokinetic models of markers of blood, extracellular fluid and total body water administered concomitantly.

ONO-1078 antagonizes diarrhea-causing changes in ion transport and smooth muscle contraction induced by peptidoleukotrienes in rat and human colon in vitro.

In vivo effects of the simultaneous blockade of serotonin and norepinephrine transporters on serotonergic function. Microdialysis studies.

Effects of benzodiazepine agonist exposure on corticotropin-releasing factor content and hormonal stress responses: divergent responses in male and ovariectomized female rats.

Human delta opioid receptor: functional studies on stably transfected Chinese hamster ovary cells after acute and chronic treatment with the selective nonpeptidic agonist SNC-80.

Losartan exerts antiarrhythmic activity independent of angiotensin II receptor blockade in simulated ventricular ischemia and reperfusion.

Unexpected antinociceptive effect of the N-oxide (RWJ 38705) of tramadol hydrochloride.

Is inhibition of oxygen radical production of neutrophils by sympathomimetics mediated via beta-2 adrenoceptors?

Specific serological response by active immunization with GD3-bearing liposomes.

Characterization of opioid agonist efficacy in a C6 glioma cell line expressing the mu opioid receptor.

Dopamine D3 receptor agonists partially reproduce the discriminative stimulus effects of cocaine in squirrel monkeys.

Expression and modulation of 5-hydroxytryptamine1A receptors in P11 cells.

Prostaglandin D2 inhibits prostaglandin E2-induced allodynia in conscious mice.

Effects of methadone or buprenorphine maintenance on the subjective and reinforcing effects of intravenous cocaine in humans.

Pharmacogenetic determination of the effects of codeine and prediction of drug interactions.

Paraoxon: cholinesterase-independent stimulation of transmitter release and selective block of ligand-gated ion channels in cultured hippocampal neurons.

Microsomal cytochrome P450 peroxygenase metabolism of arachidonic acid in guinea pig liver.

Effects of cocaine on anterior pituitary and gonadal hormones.

Tolerance to the anxiolytic effects of the triazolobenzodiazepines triazolam and alprazolam, as measured by the ingestion of a hypertonic sodium chloride solution in rats.

Labeling of A2A adenosine receptors in human platelets by use of the new nonxanthine antagonist radioligand [3H]SCH 58261.

Buffers differentially alter the binding of [3H]rauwolscine and [3H]RX821002 to the alpha-2 adrenergic receptor subtypes.

Significance of endothelinB receptors for myocardial contractility and myocardial energy metabolism.

Alpha-2 adrenoceptor subtype causing nitric oxide-mediated vascular relaxation in rats.

Gallium arsenide selectively suppresses antigen processing by splenic macrophages for CD4+ T cell activation.

Characterization of the ocular antiallergic and antihistaminic effects of olopatadine (AL-4943A), a novel drug for treating ocular allergic diseases.

Effects of a nonpeptide endothelin-1 ETA antagonist on neurovascular function in diabetic rats: interaction with the renin-angiotensin system.

Use of nitric oxide-nucleophile adducts as biological sources of nitric oxide: effects on airway smooth muscle.

Effects of prolonged blockade of the renin angiotensin system on striated muscle microcirculation of spontaneously hypertensive rats.

Effects of the structurally novel opioid 14 alpha, 14' beta-[dithiobis [(2-oxo-2,1-ethanediyl)imino]]bis(7,8-dihydromorphinone) on schedule-controlled behavior and thermal nociception in rhesus monkeys.

Dependence on delta 9-tetrahydrocannabinol: studies on precipitated and abrupt withdrawal.

In vivo depletion of free thiols does not account for nitroglycerin-induced tolerance: a thiol-nitrate interaction hypothesis as an alternative explanation for nitroglycerin activity and tolerance.

Single-dose hemodynamic toxicity and pharmacokinetics of a partial phosphorothioate anti-HIV oligonucleotide (AR177) after intravenous infusion to cynomolgus monkeys.

Repeat-dose toxicity and pharmacokinetics of a partial phosphorothioate anti-HIV oligonucleotide (AR177) after bolus intravenous administration to cynomolgus monkeys.

Apoptosis and transmethylation metabolites in HL-60 cells.

Suppression of splenic natural killer cell activity in a mouse model for binge drinking. I. Direct effects of ethanol and its major metabolites are not primarily responsible for decreased natural killer cell activity.

Suppression of splenic natural killer cell activity in a mouse model for binge drinking. II. Role of the neuroendocrine system.

Modeling of the pH dependence of the binding of WIN 35,428 to the dopamine transporter in rat striatal membranes: is the bioactive form positively charged or neutral?

The in vivo pharmacology of CP-80, 633, a selective inhibitor of phosphodiesterase 4.

In vitro pharmacology of the novel phosphodiesterase type 4 inhibitor, CP-80633.

Cellular uptake mechanism for oligonucleotides: involvement of endocytosis in the uptake of phosphodiester oligonucleotides by a human colorectal adenocarcinoma cell line, HCT-15.

LSD and the phenethylamine hallucinogen DOI are potent partial agonists at 5-HT2A receptors on interneurons in rat piriform cortex.

Peripubertal androgen imprinting of rat hepatic cytochrome P450 2C11 and steroid 5 alpha-reductase: pretranslational regulation and impact on microsomal drug activation.

Spinal morphine/clonidine antinociceptive synergism: involvement of G proteins and N-type voltage-dependent calcium channels.

Cellular and metabolic basis of Clara cell tolerance to multiple doses of cytochrome P450-activated cytotoxicants. I: Bronchiolar epithelial reorganization and expression of cytochrome P450 monooxygenases in mice exposed to multiple doses of naphthalene.

Pharmacokinetics of a synthetic, chemically modified hammerhead ribozyme against the rat cytochrome P-450 3A2 mRNA after single intravenous injections.

Increased in vivo phosphorylation state of neuromodulin and synapsin I in striatum from rats treated with repeated amphetamine.

Differences in beta 3-adrenergic receptor cardiovascular regulation in conscious primates, rats and dogs.

Methotrexate dose-escalation studies in transgenic mice and marrow transplant recipients expressing drug-resistant dihydrofolate reductase activity.

Inhibition of vascular smooth muscle cell proliferation and arterial intimal thickening by a novel antiproliferative naphthopyran.

Diversity of nicotinic acetylcholine receptors in rat brain. V. alpha-Bungarotoxin-sensitive nicotinic receptors in olfactory bulb neurons and presynaptic modulation of glutamate release.

Alpha-conotoxin-ImI: a competitive antagonist at alpha-bungarotoxin-sensitive neuronal nicotinic receptors in hippocampal neurons.

In vitro down-regulation of antigen-induced IL-5 gene expression and protein production by cAMP-specific phosphodiesterase type 4 inhibitor.

Characterization, receptor mapping and blood-brain barrier transcytosis of antibodies to the human transferrin receptor.

Investigation of the effects of opiate antagonists infused into the nucleus accumbens on feeding and sucrose drinking in rats.

This Issue

Current Issue