Table of Contents

July 1996; 278 (1)

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- R B Raffa,
- J J Schupsky,
- D K Lee,
- and H I Jacoby
Characterization of endothelin-induced nociception in mice: evidence for a mechanistically distinct analgesic model.
J Pharmacol Exp Ther July 1996 278:1-7
- Abstract
- Full Text (PDF)
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- T Pelissier,
- A Alloui,
- F Caussade,
- C Dubray,
- A Cloarec,
- J Lavarenne,
- and A Eschalier
Paracetamol exerts a spinal antinociceptive effect involving an indirect interaction with 5-hydroxytryptamine3 receptors: in vivo and in vitro evidence.
J Pharmacol Exp Ther July 1996 278:8-14
- Abstract
- Full Text (PDF)
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- I A Omelchenko,
- C S Nelson,
- J L Marino,
- and C N Allen
The sensitivity of N-methyl-D-aspartate receptors to lead inhibition is dependent on the receptor subunit composition.
J Pharmacol Exp Ther July 1996 278:15-20
- Abstract
- Full Text (PDF)
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- E Koyama,
- K Chiba,
- M Tani,
- and T Ishizaki
Identification of human cytochrome P450 isoforms involved in the stereoselective metabolism of mianserin enantiomers.
J Pharmacol Exp Ther July 1996 278:21-30
- Abstract
- Full Text (PDF)
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- A A Somogyi,
- G Rumrich,
- G Fritzsch,
- and K J Ullrich
Stereospecificity in contraluminal and luminal transporters of organic cations in the rat renal proximal tubule.
J Pharmacol Exp Ther July 1996 278:31-36
- Abstract
- Full Text (PDF)
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- D P Begany,
- J A Carcillo,
- W A Herzer,
- Z Mi,
- and E K Jackson
Inhibition of type IV phosphodiesterase by Ro 20-1724 attenuates endotoxin-induced acute renal failure.
J Pharmacol Exp Ther July 1996 278:37-41
- Abstract
- Full Text (PDF)
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- T E Mertz,
- T B McClanahan,
- M A Flynn,
- P Juneau,
- E E Reynolds,
- H Hallak,
- L Bradford,
- and K P Gallagher
Endothelin A receptor antagonism by PD 156707 does not reduce infarct size after coronary artery occlusion/reperfusion in pigs.
J Pharmacol Exp Ther July 1996 278:42-49
- Abstract
- Full Text (PDF)
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- D E McMillan,
- W L Sun,
- and W C Hardwick
Effects of drug discrimination history on the generalization of pentobarbital to other drugs.
J Pharmacol Exp Ther July 1996 278:50-61
- Abstract
- Full Text (PDF)
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- J J Cook,
- M A Holahan,
- E A Lyle,
- D R Ramjit,
- G R Sitko,
- M T Stranieri,
- R F Stupienski, 3rd,
- A A Wallace,
- E L Hand,
- J R Gehret,
- T Kothstein,
- M D Drag,
- G Y McCormick,
- J J Perkins,
- N C Ihle,
- M E Duggan,
- G D Hartman,
- R J Gould,
- and J J Lynch, Jr
Nonpeptide glycoprotein IIb/IIIa inhibitors. 8. Antiplatelet activity and oral antithrombotic efficacy of L-734,217.
J Pharmacol Exp Ther July 1996 278:62-73
- Abstract
- Full Text (PDF)
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- S Ohdo,
- N Ogawa,
- S Nakano,
- and S Higuchi
Influence of feeding schedule on the chronopharmacological aspects of sodium valproate in mice.
J Pharmacol Exp Ther July 1996 278:74-81
- Abstract
- Full Text (PDF)
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- X Wang,
- F Rondu,
- A Lamouri,
- R Dokhan,
- S Marc,
- E Touboul,
- B Pfeiffer,
- D Manechez,
- P Renard,
- B Guardiola-Lemaitre,
- J J Godfroid,
- A Ktorza,
- and L Pénicaud
Effect of S-21663 (PMS 812), an imidazoline derivative, on glucose tolerance and insulin secretion in a rat model of type II diabetes.
J Pharmacol Exp Ther July 1996 278:82-89
- Abstract
- Full Text (PDF)
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- M O Urban,
- D J Smith,
- and G F Gebhart
Involvement of spinal cholecystokininB receptors in mediating neurotensin hyperalgesia from the medullary nucleus raphe magnus in the rat.
J Pharmacol Exp Ther July 1996 278:90-96
- Abstract
- Full Text (PDF)
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- I M Khan,
- M Marsala,
- M P Printz,
- P Taylor,
- and T L Yaksh
Intrathecal nicotinic agonist-elicited release of excitatory amino acids as measured by in vivo spinal microdialysis in rats.
J Pharmacol Exp Ther July 1996 278:97-106
- Abstract
- Full Text (PDF)
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- U Bickel,
- O P Schumacher,
- Y S Kang,
- and K Voigt
Poor permeability of morphine 3-glucuronide and morphine 6-glucuronide through the blood-brain barrier in the rat.
J Pharmacol Exp Ther July 1996 278:107-113
- Abstract
- Full Text (PDF)
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- X Yang,
- H E Criswell,
- P Simson,
- S Moy,
- and G R Breese
Evidence for a selective effect of ethanol on N-methyl-d-aspartate responses: ethanol affects a subtype of the ifenprodil-sensitive N-methyl-d-aspartate receptors.
J Pharmacol Exp Ther July 1996 278:114-124
- Abstract
- Full Text (PDF)
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- Y B Peng,
- Q Lin,
- and W D Willis
Involvement of alpha-2 adrenoceptors in the periaqueductal gray-induced inhibition of dorsal horn cell activity in rats.
J Pharmacol Exp Ther July 1996 278:125-135
- Abstract
- Full Text (PDF)
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- D L Saussy, Jr,
- A S Goetz,
- K L Queen,
- H K King,
- M W Lutz,
- and T J Rimele
Structure activity relationships of a series of buspirone analogs at alpha-1 adrenoceptors: further evidence that rat aorta alpha-1 adrenoceptors are of the alpha-1D-subtype.
J Pharmacol Exp Ther July 1996 278:136-144
- Abstract
- Full Text (PDF)
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- B Levant,
- J D Moehlenkamp,
- K A Morgan,
- N L Leonard,
- and C C Cheng
Modulation of [3H]quinpirole binding in brain by monoamine oxidase inhibitors: evidence for a potential novel binding site.
J Pharmacol Exp Ther July 1996 278:145-153
- Abstract
- Full Text (PDF)
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- C L Martin,
- M A Palomo,
- and E G Mcmahon
Comparison of bidisomide, flecainide and dofetilide on action potential duration in isolated canine atria: effect of isoproterenol.
J Pharmacol Exp Ther July 1996 278:154-162
- Abstract
- Full Text (PDF)
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- R Rosa,
- E Rodriguez-Farré,
- and C Sanfeliu
Cytotoxicity of hexachlorocyclohexane isomers and cyclodienes in primary cultures of cerebellar granule cells.
J Pharmacol Exp Ther July 1996 278:163-169
- Abstract
- Full Text (PDF)
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- E Robert,
- P Bruelle,
- J E de La Coussaye,
- J M Juan,
- J Brugada,
- P Peray,
- M Dauzat,
- and J J Eledjam
Electrophysiologic and proarrhythmogenic effects of therapeutic and toxic doses of imipramine: a study with high resolution ventricular epicardial mapping in rabbit hearts.
J Pharmacol Exp Ther July 1996 278:170-178
- Abstract
- Full Text (PDF)
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- J G Owens,
- S G Kamerling,
- S R Stanton,
- and M L Keowen
Evaluation of detomidine-induced analgesia in horses with chronic hoof pain.
J Pharmacol Exp Ther July 1996 278:179-184
- Abstract
- Full Text (PDF)
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- S M Aziz,
- M N Gillespie,
- P A Crooks,
- S F Tofiq,
- C P Tsuboi,
- J W Olson,
- and M P Gosland
The potential of a novel polyamine transport inhibitor in cancer chemotherapy.
J Pharmacol Exp Ther July 1996 278:185-192
- Abstract
- Full Text (PDF)
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- R K Rao,
- Y Lopez,
- P J Riviere,
- X Pascaud,
- J L Junien,
- and F Porreca
Nitric oxide modulates neuropeptide Y regulation of ion transport in mouse ileum.
J Pharmacol Exp Ther July 1996 278:193-198
- Abstract
- Full Text (PDF)
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- S Katsoulis,
- W E Schmidt,
- R Schwarzhoff,
- U R Folsch,
- J G Jin,
- J R Grider,
- and G M Makhlouf
Inhibitory transmission in guinea pig stomach mediated by distinct receptors for pituitary adenylate cyclase-activating peptide.
J Pharmacol Exp Ther July 1996 278:199-204
- Abstract
- Full Text (PDF)
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- H Saitoh,
- C Gerard,
- and B J Aungst
The secretory intestinal transport of some beta-lactam antibiotics and anionic compounds: a mechanism contributing to poor oral absorption.
J Pharmacol Exp Ther July 1996 278:205-211
- Abstract
- Full Text (PDF)
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- T W Vanderah,
- R N Bernstein,
- H I Yamamura,
- V J Hruby,
- and F Porreca
Enhancement of morphine antinociception by a CCKB antagonist in mice is mediated via opioid delta receptors.
J Pharmacol Exp Ther July 1996 278:212-219
- Abstract
- Full Text (PDF)
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- Y Fukuizumi,
- S Kobayashi,
- J Nishimura,
- and H Kanaide
The effects of calcitonin gene-related peptide on the cytosolic calcium concentration and force in the porcine coronary artery.
J Pharmacol Exp Ther July 1996 278:220-231
- Abstract
- Full Text (PDF)
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- E Bellissant,
- T Denolle,
- P Sinnassamy,
- D G Bichet,
- J F Giudicelli,
- F Lecoz,
- J M Gandon,
- and H Allain
Systemic and regional hemodynamic and biological effects of a new kappa-opioid agonist, niravoline, in healthy volunteers.
J Pharmacol Exp Ther July 1996 278:232-242
- Abstract
- Full Text (PDF)
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- T Kagaya,
- A Kajiwara,
- S Nagato,
- K Akasaka,
- and A Kubota
E2011 a novel, selective and reversible inhibitor of monoamine oxidase type A.
J Pharmacol Exp Ther July 1996 278:243-251
- Abstract
- Full Text (PDF)
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- J H Fleisch,
- C T Armstrong,
- C R Roman,
- E D Mihelich,
- S M Spaethe,
- W T Jackson,
- J L Bobbitt,
- S Draheim,
- N J Bach,
- R D Dillard,
- M Martinelli,
- R Fouts,
- and D W Snyder
Recombinant human secretory phospholipase A2 released thromboxane from guinea pig bronchoalveolar lavage cells: in vitro and ex vivo evaluation of a novel secretory phospholipase A2 inhibitor.
J Pharmacol Exp Ther July 1996 278:252-257
- Abstract
- Full Text (PDF)
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- J E Malberg,
- K E Sabol,
- and L S Seiden
Co-administration of MDMA with drugs that protect against MDMA neurotoxicity produces different effects on body temperature in the rat.
J Pharmacol Exp Ther July 1996 278:258-267
- Abstract
- Full Text (PDF)
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- I Kawikova,
- H Arakawa,
- B E Skoogh,
- C G Löfdahl,
- and J Lötvall
U46619 (a thromboxane A2 mimetic) induces airflow obstruction and airway plasma extravasation in the guinea pig: the role of histamine, cyclooxygenase metabolites, leukotrienes and PAF.
J Pharmacol Exp Ther July 1996 278:268-276
- Abstract
- Full Text (PDF)
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- J H Liu,
- R S Malone,
- H Stallings,
- and P C Smith
Influence of renal failure in rats on the disposition of salicyl acyl glucuronide and covalent binding of salicylate to plasma proteins.
J Pharmacol Exp Ther July 1996 278:277-283
- Abstract
- Full Text (PDF)
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- H Downes and
- P M Courogen
Contrasting effects of anesthetics in tadpole bioassays.
J Pharmacol Exp Ther July 1996 278:284-296
- Abstract
- Full Text (PDF)
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- M G Melaragno and
- G D Fink
Inhibition of the slow pressor effect of angiotensin II contributes to the antihypertensive effect of angiotensin-converting enzyme inhibitors in renovascular hypertension.
J Pharmacol Exp Ther July 1996 278:297-303
- Abstract
- Full Text (PDF)
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- Z R Vaz,
- V C Filho,
- R A Yunes,
- and J B Calixto
Antinociceptive action of 2-(4-bromobenzoyl)-3-methyl-4,6-dimethoxy benzofuran, a novel xanthoxyline derivative on chemical and thermal models of nociception in mice.
J Pharmacol Exp Ther July 1996 278:304-312
- Abstract
- Full Text (PDF)
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- C Larsson,
- P Simonsson,
- M Caron,
- and C Alling
Long-term exposure to ethanol increases the number and function of muscarinic M1 receptors in human neuroblastoma cells.
J Pharmacol Exp Ther July 1996 278:313-319
- Abstract
- Full Text (PDF)
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- R J Smith,
- J M Justen,
- A R McNab,
- C L Rosenbloom,
- A N Steele,
- P A Detmers,
- D C Anderson,
- and A M Manning
U-73122: a potent inhibitor of human polymorphonuclear neutrophil adhesion on biological surfaces and adhesion-related effector functions.
J Pharmacol Exp Ther July 1996 278:320-329
- Abstract
- Full Text (PDF)
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- D Boulay,
- D Duterte-Boucher,
- I Leroux-Nicollet,
- L Naudon,
- and J Costentin
Locomotor sensitization and decrease in [3H]mazindol binding to the dopamine transporter in the nucleus accumbens are delayed after chronic treatments by GBR12783 or cocaine.
J Pharmacol Exp Ther July 1996 278:330-337
- Abstract
- Full Text (PDF)
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- X Yang,
- A M Diehl,
- and G S Wand
Ethanol exposure alters the phosphorylation of cyclic AMP responsive element binding protein and cyclic AMP responsive element binding activity in rat cerebellum.
J Pharmacol Exp Ther July 1996 278:338-346
- Abstract
- Full Text (PDF)
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- W L Thomas, Jr,
- E S Cooke,
- and R P Hammer, Jr
Cocaine-induced sensitization of metabolic activity in extrapyramidal circuits involves prior dopamine D1-like receptor stimulation.
J Pharmacol Exp Ther July 1996 278:347-353
- Abstract
- Full Text (PDF)
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- C M O'Hara,
- L Tang,
- R Taussig,
- R D Todd,
- and K L O'Malley
Dopamine D2L receptor couples to G alpha i2 and G alpha i3 but not G alpha i1, leading to the inhibition of adenylate cyclase in transfected cell lines.
J Pharmacol Exp Ther July 1996 278:354-360
- Abstract
- Full Text (PDF)
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- J R Pauly,
- M J Marks,
- S F Robinson,
- J L van de Kamp,
- and A C Collins
Chronic nicotine and mecamylamine treatment increase brain nicotinic receptor binding without changing alpha 4 or beta 2 mRNA levels.
J Pharmacol Exp Ther July 1996 278:361-369
- Abstract
- Full Text (PDF)
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- D Y Li,
- D Abran,
- K G Peri,
- D R Varma,
- and S Chemtob
Inhibition of prostaglandin synthesis in newborn pigs increases cerebral microvessel prostaglandin F2 alpha and prostaglandin E2 receptors, their second messengers and vasoconstrictor response to adult levels.
J Pharmacol Exp Ther July 1996 278:370-377
- Abstract
- Full Text (PDF)
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- J M Pearson,
- A E Schultze,
- K A Schwartz,
- M A Scott,
- J M Davis,
- and R A Roth
The thrombin inhibitor, hirudin, attenuates lipopolysaccharide-induced liver injury in the rat.
J Pharmacol Exp Ther July 1996 278:378-383
- Abstract
- Full Text (PDF)
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- R C Pierce,
- B Born,
- M Adams,
- and P W Kalivas
Repeated intra-ventral tegmental area administration of SKF-38393 induces behavioral and neurochemical sensitization to a subsequent cocaine challenge.
J Pharmacol Exp Ther July 1996 278:384-392
- Abstract
- Full Text (PDF)
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- P Honoré,
- V Chapman,
- J Buritova,
- and J M Besson
To what extent do spinal interactions between an alpha-2 adrenoceptor agonist and a mu opioid agonist influence noxiously evoked c-Fos expression in the rat? A pharmacological study.
J Pharmacol Exp Ther July 1996 278:393-403
- Abstract
- Full Text (PDF)
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- W J Wojcik,
- P Swoveland,
- X Zhang,
- and P Vanguri
Chronic intrathecal infusion of phosphorothioate or phosphodiester antisense oligonucleotides against cytokine responsive gene-2/IP-10 in experimental allergic encephalomyelitis of lewis rat.
J Pharmacol Exp Ther July 1996 278:404-410
- Abstract
- Full Text (PDF)
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- B K Tolliver,
- L B Ho,
- M S Reid,
- and S P Berger
Evidence for involvement of ventral tegmental area cyclic AMP systems in behavioral sensitization to psychostimulants.
J Pharmacol Exp Ther July 1996 278:411-420
- Abstract
- Full Text (PDF)
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- S Jilg,
- J Barsig,
- M Leist,
- S Küsters,
- H D Volk,
- and A Wendel
Enhanced release of interleukin-10 and soluble tumor necrosis factor receptors as novel principles of methylxanthine action in murine models of endotoxic shock.
J Pharmacol Exp Ther July 1996 278:421-431
- Abstract
- Full Text (PDF)
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- R Kawatsu,
- S D Sanderson,
- I Blanco,
- N Kendall,
- A M Finch,
- S M Taylor,
- and D Colcher
Conformationally biased analogs of human C5a mediate changes in vascular permeability.
J Pharmacol Exp Ther July 1996 278:432-440
- Abstract
- Full Text (PDF)
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- E Aklillu,
- I Persson,
- L Bertilsson,
- I Johansson,
- F Rodrigues,
- and M Ingelman-Sundberg
Frequent distribution of ultrarapid metabolizers of debrisoquine in an ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles.
J Pharmacol Exp Ther July 1996 278:441-446
- Abstract
- Full Text (PDF)
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- R Ishitani,
- M Kimura,
- K Sunaga,
- N Katsube,
- M Tanaka,
- and D M Chuang
An antisense oligodeoxynucleotide to glyceraldehyde-3-phosphate dehydrogenase blocks age-induced apoptosis of mature cerebrocortical neurons in culture.
J Pharmacol Exp Ther July 1996 278:447-454
- Abstract
- Full Text (PDF)

Current Issue

November 2009, 331 (2)

Characterization of endothelin-induced nociception in mice: evidence for a mechanistically distinct analgesic model.

Paracetamol exerts a spinal antinociceptive effect involving an indirect interaction with 5-hydroxytryptamine3 receptors: in vivo and in vitro evidence.

The sensitivity of N-methyl-D-aspartate receptors to lead inhibition is dependent on the receptor subunit composition.

Identification of human cytochrome P450 isoforms involved in the stereoselective metabolism of mianserin enantiomers.

Stereospecificity in contraluminal and luminal transporters of organic cations in the rat renal proximal tubule.

Inhibition of type IV phosphodiesterase by Ro 20-1724 attenuates endotoxin-induced acute renal failure.

Endothelin A receptor antagonism by PD 156707 does not reduce infarct size after coronary artery occlusion/reperfusion in pigs.

Effects of drug discrimination history on the generalization of pentobarbital to other drugs.

Nonpeptide glycoprotein IIb/IIIa inhibitors. 8. Antiplatelet activity and oral antithrombotic efficacy of L-734,217.

Influence of feeding schedule on the chronopharmacological aspects of sodium valproate in mice.

Effect of S-21663 (PMS 812), an imidazoline derivative, on glucose tolerance and insulin secretion in a rat model of type II diabetes.

Involvement of spinal cholecystokininB receptors in mediating neurotensin hyperalgesia from the medullary nucleus raphe magnus in the rat.

Intrathecal nicotinic agonist-elicited release of excitatory amino acids as measured by in vivo spinal microdialysis in rats.

Poor permeability of morphine 3-glucuronide and morphine 6-glucuronide through the blood-brain barrier in the rat.

Evidence for a selective effect of ethanol on N-methyl-d-aspartate responses: ethanol affects a subtype of the ifenprodil-sensitive N-methyl-d-aspartate receptors.

Involvement of alpha-2 adrenoceptors in the periaqueductal gray-induced inhibition of dorsal horn cell activity in rats.

Structure activity relationships of a series of buspirone analogs at alpha-1 adrenoceptors: further evidence that rat aorta alpha-1 adrenoceptors are of the alpha-1D-subtype.

Modulation of [3H]quinpirole binding in brain by monoamine oxidase inhibitors: evidence for a potential novel binding site.

Comparison of bidisomide, flecainide and dofetilide on action potential duration in isolated canine atria: effect of isoproterenol.

Cytotoxicity of hexachlorocyclohexane isomers and cyclodienes in primary cultures of cerebellar granule cells.

Electrophysiologic and proarrhythmogenic effects of therapeutic and toxic doses of imipramine: a study with high resolution ventricular epicardial mapping in rabbit hearts.

Evaluation of detomidine-induced analgesia in horses with chronic hoof pain.

The potential of a novel polyamine transport inhibitor in cancer chemotherapy.

Nitric oxide modulates neuropeptide Y regulation of ion transport in mouse ileum.

Inhibitory transmission in guinea pig stomach mediated by distinct receptors for pituitary adenylate cyclase-activating peptide.

The secretory intestinal transport of some beta-lactam antibiotics and anionic compounds: a mechanism contributing to poor oral absorption.

Enhancement of morphine antinociception by a CCKB antagonist in mice is mediated via opioid delta receptors.

The effects of calcitonin gene-related peptide on the cytosolic calcium concentration and force in the porcine coronary artery.

Systemic and regional hemodynamic and biological effects of a new kappa-opioid agonist, niravoline, in healthy volunteers.

E2011 a novel, selective and reversible inhibitor of monoamine oxidase type A.

Recombinant human secretory phospholipase A2 released thromboxane from guinea pig bronchoalveolar lavage cells: in vitro and ex vivo evaluation of a novel secretory phospholipase A2 inhibitor.

Co-administration of MDMA with drugs that protect against MDMA neurotoxicity produces different effects on body temperature in the rat.

U46619 (a thromboxane A2 mimetic) induces airflow obstruction and airway plasma extravasation in the guinea pig: the role of histamine, cyclooxygenase metabolites, leukotrienes and PAF.

Influence of renal failure in rats on the disposition of salicyl acyl glucuronide and covalent binding of salicylate to plasma proteins.

Contrasting effects of anesthetics in tadpole bioassays.

Inhibition of the slow pressor effect of angiotensin II contributes to the antihypertensive effect of angiotensin-converting enzyme inhibitors in renovascular hypertension.

Antinociceptive action of 2-(4-bromobenzoyl)-3-methyl-4,6-dimethoxy benzofuran, a novel xanthoxyline derivative on chemical and thermal models of nociception in mice.

Long-term exposure to ethanol increases the number and function of muscarinic M1 receptors in human neuroblastoma cells.

U-73122: a potent inhibitor of human polymorphonuclear neutrophil adhesion on biological surfaces and adhesion-related effector functions.

Locomotor sensitization and decrease in [3H]mazindol binding to the dopamine transporter in the nucleus accumbens are delayed after chronic treatments by GBR12783 or cocaine.

Ethanol exposure alters the phosphorylation of cyclic AMP responsive element binding protein and cyclic AMP responsive element binding activity in rat cerebellum.

Cocaine-induced sensitization of metabolic activity in extrapyramidal circuits involves prior dopamine D1-like receptor stimulation.

Dopamine D2L receptor couples to G alpha i2 and G alpha i3 but not G alpha i1, leading to the inhibition of adenylate cyclase in transfected cell lines.

Chronic nicotine and mecamylamine treatment increase brain nicotinic receptor binding without changing alpha 4 or beta 2 mRNA levels.

Inhibition of prostaglandin synthesis in newborn pigs increases cerebral microvessel prostaglandin F2 alpha and prostaglandin E2 receptors, their second messengers and vasoconstrictor response to adult levels.

The thrombin inhibitor, hirudin, attenuates lipopolysaccharide-induced liver injury in the rat.

Repeated intra-ventral tegmental area administration of SKF-38393 induces behavioral and neurochemical sensitization to a subsequent cocaine challenge.

To what extent do spinal interactions between an alpha-2 adrenoceptor agonist and a mu opioid agonist influence noxiously evoked c-Fos expression in the rat? A pharmacological study.

Chronic intrathecal infusion of phosphorothioate or phosphodiester antisense oligonucleotides against cytokine responsive gene-2/IP-10 in experimental allergic encephalomyelitis of lewis rat.

Evidence for involvement of ventral tegmental area cyclic AMP systems in behavioral sensitization to psychostimulants.

Enhanced release of interleukin-10 and soluble tumor necrosis factor receptors as novel principles of methylxanthine action in murine models of endotoxic shock.

Conformationally biased analogs of human C5a mediate changes in vascular permeability.

Frequent distribution of ultrarapid metabolizers of debrisoquine in an ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles.

An antisense oligodeoxynucleotide to glyceraldehyde-3-phosphate dehydrogenase blocks age-induced apoptosis of mature cerebrocortical neurons in culture.

This Issue

Current Issue