Table of Contents

June 1996; 277 (3)

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- M R Escobar and
- D S Sitar
Use of digitalis glycosides to identify the mechanisms of amantadine transport by renal tubules.
J Pharmacol Exp Ther June 1996 277:1189-1194
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- D Fulton,
- M Balazy,
- J C McGiff,
- and J Quilley
Possible contribution of platelet cyclooxygenase to the renal vascular action of 5,6-epoxyeicosatrienoic acid.
J Pharmacol Exp Ther June 1996 277:1195-1199
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- E Mocchegiani,
- D Bulian,
- L Santarelli,
- A Tibaldi,
- M Muzzioli,
- V Lesnikov,
- W Pierpaoli,
- and N Fabris
The zinc pool is involved in the immune-reconstituting effect of melatonin in pinealectomized mice.
J Pharmacol Exp Ther June 1996 277:1200-1208
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- Q Li and
- E J Forsberg
Catecholamine secretion induced by nicotine is due to Ca++ channel but not Na+ channel activation in porcine adrenal chromaffin cells.
J Pharmacol Exp Ther June 1996 277:1209-1214
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- I Leprán,
- I Baczkó,
- A Varró,
- and J G Papp
ATP-sensitive potassium channel modulators: both pinacidil and glibenclamide produce antiarrhythmic activity during acute myocardial infarction in conscious rats.
J Pharmacol Exp Ther June 1996 277:1215-1220
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- L M Lichtenberger,
- C Ulloa,
- A L Vanous,
- J J Romero,
- E J Dial,
- P A Illich,
- and E T Walters
Zwitterionic phospholipids enhance aspirin's therapeutic activity, as demonstrated in rodent model systems.
J Pharmacol Exp Ther June 1996 277:1221-1227
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- M K Greenwald,
- H L June,
- M L Stitzer,
- and A P Marco
Comparative clinical pharmacology of short-acting mu opioids in drug abusers.
J Pharmacol Exp Ther June 1996 277:1228-1236
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- R Testa,
- L Guarneri,
- C Taddei,
- E Poggesi,
- P Angelico,
- A Sartani,
- A Leonardi,
- O N Gofrit,
- S Meretyk,
- and M Caine
Functional antagonistic activity of Rec 15/2739, a novel alpha-1 antagonist selective for the lower urinary tract, on noradrenaline-induced contraction of human prostate and mesenteric artery.
J Pharmacol Exp Ther June 1996 277:1237-1246
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- S E Hemby,
- J E Smith,
- and S I Dworkin
The effects of eticlopride and naltrexone on responding maintained by food, cocaine, heroin and cocaine/heroin combinations in rats.
J Pharmacol Exp Ther June 1996 277:1247-1258
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- W P Clarke,
- F D Yocca,
- and S Maayani
Lack of 5-hydroxytryptamine1A-mediated inhibition of adenylyl cyclase in dorsal raphe of male and female rats.
J Pharmacol Exp Ther June 1996 277:1259-1266
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- J Rochford,
- A P Sen,
- and R Quirion
Effect of nicotine and nicotinic receptor agonists on latent inhibition in the rat.
J Pharmacol Exp Ther June 1996 277:1267-1275
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- L Chen,
- W W Nichols,
- C Mattsson,
- A C Teger-Nilsson,
- T G Saldeen,
- and J L Mehta
Inogatran, a novel direct low molecular weight thrombin inhibitor, given with, but not after, tissue-plasminogen activator, improves thrombolysis.
J Pharmacol Exp Ther June 1996 277:1276-1283
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- R J Knapp,
- G Santoro,
- I A De Leon,
- K B Lee,
- S A Edsall,
- S Waite,
- E Malatynska,
- E Varga,
- S N Calderon,
- K C Rice,
- R B Rothman,
- F Porreca,
- W R Roeske,
- and H I Yamamura
Structure-activity relationships for SNC80 and related compounds at cloned human delta and mu opioid receptors.
J Pharmacol Exp Ther June 1996 277:1284-1291
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- M Miyamoto,
- H Takahashi,
- K Kato,
- K Hirai,
- Y Ishihara,
- and G Goto
Effects of 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1 -H-1-benzazepin-8-yl)-1-propanone fumarate (TAK-147), a novel acetylcholinesterase inhibitor, on impaired learning and memory in animal models.
J Pharmacol Exp Ther June 1996 277:1292-1304
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- A Rohlfs,
- C Rundfeldt,
- R Koch,
- and W Löscher
A comparison of the effects of valproate and its major active metabolite E-2-en-valproate on single unit activity of substantia nigra pars reticulata neurons in rats.
J Pharmacol Exp Ther June 1996 277:1305-1314
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- D J Clements,
- G A Cabral,
- and K L McCoy
delta 9-Tetrahydrocannabinol selectively inhibits macrophage costimulatory activity and down-regulates heat-stable antigen expression.
J Pharmacol Exp Ther June 1996 277:1315-1321
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- M M Belcheva,
- M T Ho,
- E G Ignatova,
- L B Jefcoat,
- J Barg,
- Z Vogel,
- R J McHale,
- F E Johnson,
- and C J Coscia
Buprenorphine differentially alters opioid receptor adaptation in rat brain regions.
J Pharmacol Exp Ther June 1996 277:1322-1327
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- K Miyoshi,
- A Kanda,
- Y Nozawa,
- M Nakano,
- and H Miyake
Regional vascular effects of MPC-1304, a novel dihydropyridine derivative, in conscious normotensive and spontaneously hypertensive rats.
J Pharmacol Exp Ther June 1996 277:1328-1336
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- J S Zuzack,
- M R Burkard,
- D K Cuadrado,
- R A Greer,
- W M Selig,
- and E T Whalley
Evidence of a bradykinin B1 receptor in human ileum: pharmacological comparison to the rabbit aorta B1 receptor.
J Pharmacol Exp Ther June 1996 277:1337-1343
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- P M Kunko,
- J A Smith,
- M J Wallace,
- J R Maher,
- J J Saady,
- and S E Robinson
Perinatal methadone exposure produces physical dependence and altered behavioral development in the rat.
J Pharmacol Exp Ther June 1996 277:1344-1351
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- U Ozkutlu,
- R A Shaffer,
- S J Lewis,
- and J P Long
A-4, a tertiary amine analog of HC-3, lowers arterial pressure in spontaneously hypertensive rats.
J Pharmacol Exp Ther June 1996 277:1352-1358
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- W L Hasler,
- H C Soudah,
- and C Owyang
Mechanisms by which octreotide ameliorates symptoms in the dumping syndrome.
J Pharmacol Exp Ther June 1996 277:1359-1365
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- D L Greene,
- V S Hau,
- T J Abbruscato,
- H Bartosz,
- A Misicka,
- A W Lipkowski,
- S Hom,
- T J Gillespie,
- V J Hruby,
- and T P Davis
Enkephalin analog prodrugs: assessment of in vitro conversion, enzyme cleavage characterization and blood-brain barrier permeability.
J Pharmacol Exp Ther June 1996 277:1366-1375
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- S Chakder,
- S Rathi,
- X L Ma,
- and S Rattan
Heme oxygenase inhibitor zinc protoporphyrin IX causes an activation of nitric oxide synthase in the rabbit internal anal sphincter.
J Pharmacol Exp Ther June 1996 277:1376-1382
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- M J Marks,
- S F Robinson,
- and A C Collins
Nicotinic agonists differ in activation and desensitization of 86Rb+ efflux from mouse thalamic synaptosomes.
J Pharmacol Exp Ther June 1996 277:1383-1396
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- F E Parkinson and
- J D Geiger
Effects of iodotubercidin on adenosine kinase activity and nucleoside transport in DDT1 MF-2 smooth muscle cells.
J Pharmacol Exp Ther June 1996 277:1397-1401
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- X Duan,
- C Plopper,
- P Brennan,
- and A Buckpitt
Rates of glutathione synthesis in lung subcompartments of mice and monkeys: possible role in species and site selective injury.
J Pharmacol Exp Ther June 1996 277:1402-1409
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- W Löscher and
- H Lehmann
L-deprenyl (selegiline) exerts anticonvulsant effects against different seizure types in mice.
J Pharmacol Exp Ther June 1996 277:1410-1417
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- H E de Vries,
- M C Blom-Roosemalen,
- A G de Boer,
- T J van Berkel,
- D D Breimer,
- and J Kuiper
Effect of endotoxin on permeability of bovine cerebral endothelial cell layers in vitro.
J Pharmacol Exp Ther June 1996 277:1418-1423
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- H Inoue,
- I Arai,
- S Shibata,
- and S Watanabe
NG-nitro-L-arginine methyl ester attenuates the maintenance and expression of methamphetamine-induced behavioral sensitization and enhancement of striatal dopamine release.
J Pharmacol Exp Ther June 1996 277:1424-1430
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- A N Gifford and
- C R Ashby, Jr
Electrically evoked acetylcholine release from hippocampal slices is inhibited by the cannabinoid receptor agonist, WIN 55212-2, and is potentiated by the cannabinoid antagonist, SR 141716A.
J Pharmacol Exp Ther June 1996 277:1431-1436
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- C Pifl,
- O Hornykiewicz,
- B Giros,
- and M G Caron
Catecholamine transporters and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity: studies comparing the cloned human noradrenaline and human dopamine transporter.
J Pharmacol Exp Ther June 1996 277:1437-1443
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- J Song,
- P R Standley,
- F Zhang,
- D Joshi,
- S Gappy,
- J R Sowers,
- and J L Ram
Tamoxifen (estrogen antagonist) inhibits voltage-gated calcium current and contractility in vascular smooth muscle from rats.
J Pharmacol Exp Ther June 1996 277:1444-1453
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- M J Raatikainen,
- C A Napolitano,
- P Druzgala,
- and D M Dennis
Electrophysiological effects of a novel, short-acting and potent ester derivative of amiodarone, ATI-2001, in guinea pig isolated heart.
J Pharmacol Exp Ther June 1996 277:1454-1463
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- I Puscas,
- M Coltau,
- and R Pasca
Nonsteroidal anti-inflammatory drugs activate carbonic anhydrase by a direct mechanism of action.
J Pharmacol Exp Ther June 1996 277:1464-1466
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- R A Radcliffe and
- V G Erwin
Alterations in locomotor activity after microinjections of GBR-12909, selective dopamine antagonists or neurotensin into the medial prefrontal cortex.
J Pharmacol Exp Ther June 1996 277:1467-1476
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- D F Kump,
- R A Matulka,
- G F Burton,
- S D Jordan,
- and M P Holsapple
Alternations in splenocyte and thymocyte subpopulations in B6C3F1 mice exposed to cocaine plus diazinon.
J Pharmacol Exp Ther June 1996 277:1477-1485
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- R K Handa and
- J W Strandhoy
Nitric oxide mediates the inhibitory action of platelet-activating factor on angiotensin II-induced renal vasoconstriction, in vivo.
J Pharmacol Exp Ther June 1996 277:1486-1491
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- B F Cox and
- G J Smits
Regional hemodynamic effects of purinergic P2 receptor subtype agonists in rats.
J Pharmacol Exp Ther June 1996 277:1492-1500
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- H Zhang,
- B K Weir,
- R L Macdonald,
- L S Marton,
- N J Solenski,
- A L Kwan,
- and K S Lee
Mechanisms of [Ca++]i elevation induced by erythrocyte components in endothelial cells.
J Pharmacol Exp Ther June 1996 277:1501-1509
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- F J Miao,
- N Benowitz,
- and J D Levine
Neural and endocrine circuits mediating inhibition of bradykinin-induced plasma extravasation by subcutaneous and spinal-intrathecal nicotine.
J Pharmacol Exp Ther June 1996 277:1510-1516
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- G E Billman and
- R L Hamlin
The effects of mibefradil, a novel calcium channel antagonist on ventricular arrhythmias induced by myocardial ischemia and programmed electrical stimulation.
J Pharmacol Exp Ther June 1996 277:1517-1526
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- B J Copeland,
- V Vogelsberg,
- N H Neff,
- and M Hadjiconstantinou
Protein kinase C activators decrease dopamine uptake into striatal synaptosomes.
J Pharmacol Exp Ther June 1996 277:1527-1532
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- D T Lysle,
- K E Hoffman,
- and L A Dykstra
Evidence for the involvement of the caudal region of the periaqueductal gray in a subset of morphine-induced alterations of immune status.
J Pharmacol Exp Ther June 1996 277:1533-1540
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- C J Schmidt and
- G M Fadayel
Regional effects of MK-801 on dopamine release: effects of competitive NMDA or 5-HT2A receptor blockade.
J Pharmacol Exp Ther June 1996 277:1541-1549
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- A Kakee,
- T Terasaki,
- and Y Sugiyama
Brain efflux index as a novel method of analyzing efflux transport at the blood-brain barrier.
J Pharmacol Exp Ther June 1996 277:1550-1559
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- D J Cushing,
- J M Zgombick,
- D L Nelson,
- and M L Cohen
LY215840, a high-affinity 5-HT7 receptor ligand, blocks serotonin-induced relaxation in canine coronary artery.
J Pharmacol Exp Ther June 1996 277:1560-1566
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- P Nambi,
- M Pullen,
- H L Wu,
- D Lee,
- D Saunders,
- R Heys,
- N Aiyar,
- J Leber,
- J Elliott,
- D Brooks,
- E Ohlstein,
- and R Ruffolo
Nonpeptide endothelin receptor antagonists. VII: Binding characteristics of [3H]SB 209670, a novel nonpeptide antagonist of endothelin receptors.
J Pharmacol Exp Ther June 1996 277:1567-1571
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- N Zimmermann,
- P Bokník,
- E Gams,
- J W Herzig,
- J Neumann,
- W Schmitz,
- H Scholz,
- and H Wenzlaff
Positive inotropic effects of the calcium sensitizer CGP 48506 in guinea pig myocardium.
J Pharmacol Exp Ther June 1996 277:1572-1578
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- J Neumann,
- T Eschenhagen,
- I L Grupp,
- A Haverich,
- J W Herzig,
- S Hirt,
- P Kalmár,
- W Schmitz,
- H Scholz,
- B Stein,
- H Wenzlaff,
- and N Zimmermann
Positive inotropic effects of the calcium sensitizer CGP 48506 in failing human myocardium.
J Pharmacol Exp Ther June 1996 277:1579-1585
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- M A Chapman and
- R E See
Differential effects of unique profile antipsychotic drugs on extracellular amino acids in the ventral pallidum and globus pallidus of rats.
J Pharmacol Exp Ther June 1996 277:1586-1594
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- D H Albert,
- R G Conway,
- T J Magoc,
- P Tapang,
- D A Rhein,
- G Luo,
- J H Holms,
- S K Davidsen,
- J B Summers,
- and G W Carter
Properties of ABT-299, a prodrug of A-85783, a highly potent platelet activating factor receptor antagonist.
J Pharmacol Exp Ther June 1996 277:1595-1606
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- M Yamada,
- M Watanabe,
- S Mue,
- and K Ohuchi
Platelet-activating factor production in stimulated macrophages is down-regulated by concurrently produced prostaglandin E2.
J Pharmacol Exp Ther June 1996 277:1607-1614
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- P J McNamara,
- J A Meece,
- and E Paxton
Active transport of cimetidine and ranitidine into the milk of Sprague Dawley rats.
J Pharmacol Exp Ther June 1996 277:1615-1621
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- Y Uchida,
- T Jun,
- H Ninomiya,
- H Ohse,
- S Hasegawa,
- A Nomura,
- T Sakamoto,
- M S Sardessai,
- and F Hirata
Involvement of endothelins in immediate and late asthmatic responses of guinea pigs.
J Pharmacol Exp Ther June 1996 277:1622-1629
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- T Izumi,
- S Enomoto,
- K Hosiyama,
- K Sasahara,
- A Shibukawa,
- T Nakagawa,
- and Y Sugiyama
Prediction of the human pharmacokinetics of troglitazone, a new and extensively metabolized antidiabetic agent, after oral administration, with an animal scale-up approach.
J Pharmacol Exp Ther June 1996 277:1630-1641
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- Y W Lee and
- T L Yaksh
Pharmacology of the spinal adenosine receptor which mediates the antiallodynic action of intrathecal adenosine agonists.
J Pharmacol Exp Ther June 1996 277:1642-1648
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- R R Arlen and
- P G Wells
Inhibition of thalidomide teratogenicity by acetylsalicylic acid: evidence for prostaglandin H synthase-catalyzed bioactivation of thalidomide to a teratogenic reactive intermediate.
J Pharmacol Exp Ther June 1996 277:1649-1658
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- K K Nielsen,
- J P Flinois,
- P Beaune,
- and K Brøsen
The biotransformation of clomipramine in vitro, identification of the cytochrome P450s responsible for the separate metabolic pathways.
J Pharmacol Exp Ther June 1996 277:1659-1664
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- P G Forkert,
- R P Lee,
- T F Dowsley,
- J Y Hong,
- and J B Ulreich
Protection from 1,1-dichloroethylene-induced Clara cell injury by diallyl sulfone, a derivative of garlic.
J Pharmacol Exp Ther June 1996 277:1665-1671
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- K Fukuda,
- H Dan,
- M Takayama,
- F Kumano,
- M Saitoh,
- and S Tanaka
Hyaluronic acid increases proteoglycan synthesis in bovine articular cartilage in the presence of interleukin-1.
J Pharmacol Exp Ther June 1996 277:1672-1675
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- T Oguro,
- E Kaneko,
- Y Kaneko,
- S Numazawa,
- S Imaoka,
- Y Funae,
- T Mikami,
- and T Yoshida
Suppressed expression of phenobarbital-inducible hepatic cytochrome P-450s in Eisai-hyperbilirubinuria rats (EHBR/Eis).
J Pharmacol Exp Ther June 1996 277:1676-1684
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- M Garcia-Munoz,
- P Patino,
- S J Young,
- and P M Groves
Effects of nicotine on dopaminergic nigrostriatal axons requires stimulation of presynaptic glutamatergic receptors.
J Pharmacol Exp Ther June 1996 277:1685-1693
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- A A Nanji,
- E K Yang,
- F Fogt,
- S M Sadrzadeh,
- and A J Dannenberg
Medium chain triglycerides and vitamin E reduce the severity of established experimental alcoholic liver disease.
J Pharmacol Exp Ther June 1996 277:1694-1700
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- M Kähönen,
- H Mäkynen,
- X Wu,
- P Arvola,
- A Pekki,
- and I Pörsti
Angiotensin-converting enzyme inhibition attenuates arterial constrictor responses in experimental hypertension.
J Pharmacol Exp Ther June 1996 277:1701-1709
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- L J Brunner,
- W M Bennett,
- and D R Koop
Selective suppression of rat hepatic microsomal activity during chronic cyclosporine nephrotoxicity.
J Pharmacol Exp Ther June 1996 277:1710-1718
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- P Sestili,
- G Brandi,
- L Brambilla,
- F Cattabeni,
- and O Cantoni
Hydrogen peroxide mediates the killing of U937 tumor cells elicited by pharmacologically attainable concentrations of ascorbic acid: cell death prevention by extracellular catalase or catalase from cocultured erythrocytes or fibroblasts.
J Pharmacol Exp Ther June 1996 277:1719-1725
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- K B Duncan-Achanzar,
- J T Jones,
- M F Burke,
- D E Carter,
- and H E Laird, 2nd
Inorganic mercury chloride-induced apoptosis in the cultured porcine renal cell line LLC-PK1.
J Pharmacol Exp Ther June 1996 277:1726-1732
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- E M Sorenson and
- J P Gallagher
The membrane hyperpolarization of rat dorsolateral septal nucleus neurons is mediated by a novel nicotinic receptor.
J Pharmacol Exp Ther June 1996 277:1733-1743
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- M D Sauro,
- R Sudakow,
- and S Burns
In vivo effects of angiotensin II on vascular smooth muscle contraction and blood pressure are mediated through a protein tyrosine-kinase-dependent mechanism.
J Pharmacol Exp Ther June 1996 277:1744-1750
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- J M Matz,
- K P LaVoi,
- and M J Blake
Adrenergic regulation of the heat shock response in brown adipose tissue.
J Pharmacol Exp Ther June 1996 277:1751-1758
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- V Libri,
- A Constanti,
- M Zibetti,
- and S Nisticó
Effects of felbamate on muscarinic and metabotropic-glutamate agonist-mediated responses and magnesium-free or 4-aminopyridine-induced epileptiform activity in guinea pig olfactory cortex neurons in vitro.
J Pharmacol Exp Ther June 1996 277:1759-1769
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- L P Shearman,
- L M Collins,
- and J S Meyer
Characterization and localization of [125I]RTI-55-labeled cocaine binding sites in fetal and adult rat brain.
J Pharmacol Exp Ther June 1996 277:1770-1783
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- A Kume,
- L J Greenfield, Jr,
- R L Macdonald,
- and R L Albin
Felbamate inhibits [3H]t-butylbicycloorthobenzoate (TBOB) binding and enhances Cl- current at the gamma-aminobutyric AcidA (GABAA) receptor.
J Pharmacol Exp Ther June 1996 277:1784-1792
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- F Pica,
- O Franzese,
- C D'Onofrio,
- E Bonmassar,
- C Favalli,
- and E Garaci
Prostaglandin E2 induces apoptosis in resting immature and mature human lymphocytes: a c-Myc-dependent and Bcl-2-independent associated pathway.
J Pharmacol Exp Ther June 1996 277:1793-1800
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- R J Smith and
- L M Sly
Type II collagen-induced arthritis in the diabetic-resistant biobreeding rat: inflammatory and histopathological features of joint pathology and effects of antiinflammatory and antirheumatic drugs on this chronic arthritic process.
J Pharmacol Exp Ther June 1996 277:1801-1813
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- V S Raju and
- M D Maines
Renal ischemia/reperfusion up-regulates heme oxygenase-1 (HSP32) expression and increases cGMP in rat heart.
J Pharmacol Exp Ther June 1996 277:1814-1822
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- J E Roth,
- T F Murray,
- and P H Franklin
Regional distribution and characterization of [3H]dextrorphan binding sites in rat brain determined by quantitative autoradiography.
J Pharmacol Exp Ther June 1996 277:1823-1836
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Current Issue

November 2009, 331 (2)

Use of digitalis glycosides to identify the mechanisms of amantadine transport by renal tubules.

Possible contribution of platelet cyclooxygenase to the renal vascular action of 5,6-epoxyeicosatrienoic acid.

The zinc pool is involved in the immune-reconstituting effect of melatonin in pinealectomized mice.

Catecholamine secretion induced by nicotine is due to Ca++ channel but not Na+ channel activation in porcine adrenal chromaffin cells.

ATP-sensitive potassium channel modulators: both pinacidil and glibenclamide produce antiarrhythmic activity during acute myocardial infarction in conscious rats.

Zwitterionic phospholipids enhance aspirin's therapeutic activity, as demonstrated in rodent model systems.

Comparative clinical pharmacology of short-acting mu opioids in drug abusers.

Functional antagonistic activity of Rec 15/2739, a novel alpha-1 antagonist selective for the lower urinary tract, on noradrenaline-induced contraction of human prostate and mesenteric artery.

The effects of eticlopride and naltrexone on responding maintained by food, cocaine, heroin and cocaine/heroin combinations in rats.

Lack of 5-hydroxytryptamine1A-mediated inhibition of adenylyl cyclase in dorsal raphe of male and female rats.

Effect of nicotine and nicotinic receptor agonists on latent inhibition in the rat.

Inogatran, a novel direct low molecular weight thrombin inhibitor, given with, but not after, tissue-plasminogen activator, improves thrombolysis.

Structure-activity relationships for SNC80 and related compounds at cloned human delta and mu opioid receptors.

Effects of 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1 -H-1-benzazepin-8-yl)-1-propanone fumarate (TAK-147), a novel acetylcholinesterase inhibitor, on impaired learning and memory in animal models.

A comparison of the effects of valproate and its major active metabolite E-2-en-valproate on single unit activity of substantia nigra pars reticulata neurons in rats.

delta 9-Tetrahydrocannabinol selectively inhibits macrophage costimulatory activity and down-regulates heat-stable antigen expression.

Buprenorphine differentially alters opioid receptor adaptation in rat brain regions.

Regional vascular effects of MPC-1304, a novel dihydropyridine derivative, in conscious normotensive and spontaneously hypertensive rats.

Evidence of a bradykinin B1 receptor in human ileum: pharmacological comparison to the rabbit aorta B1 receptor.

Perinatal methadone exposure produces physical dependence and altered behavioral development in the rat.

A-4, a tertiary amine analog of HC-3, lowers arterial pressure in spontaneously hypertensive rats.

Mechanisms by which octreotide ameliorates symptoms in the dumping syndrome.

Enkephalin analog prodrugs: assessment of in vitro conversion, enzyme cleavage characterization and blood-brain barrier permeability.

Heme oxygenase inhibitor zinc protoporphyrin IX causes an activation of nitric oxide synthase in the rabbit internal anal sphincter.

Nicotinic agonists differ in activation and desensitization of 86Rb+ efflux from mouse thalamic synaptosomes.

Effects of iodotubercidin on adenosine kinase activity and nucleoside transport in DDT1 MF-2 smooth muscle cells.

Rates of glutathione synthesis in lung subcompartments of mice and monkeys: possible role in species and site selective injury.

L-deprenyl (selegiline) exerts anticonvulsant effects against different seizure types in mice.

Effect of endotoxin on permeability of bovine cerebral endothelial cell layers in vitro.

NG-nitro-L-arginine methyl ester attenuates the maintenance and expression of methamphetamine-induced behavioral sensitization and enhancement of striatal dopamine release.

Electrically evoked acetylcholine release from hippocampal slices is inhibited by the cannabinoid receptor agonist, WIN 55212-2, and is potentiated by the cannabinoid antagonist, SR 141716A.

Catecholamine transporters and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity: studies comparing the cloned human noradrenaline and human dopamine transporter.

Tamoxifen (estrogen antagonist) inhibits voltage-gated calcium current and contractility in vascular smooth muscle from rats.

Electrophysiological effects of a novel, short-acting and potent ester derivative of amiodarone, ATI-2001, in guinea pig isolated heart.

Nonsteroidal anti-inflammatory drugs activate carbonic anhydrase by a direct mechanism of action.

Alterations in locomotor activity after microinjections of GBR-12909, selective dopamine antagonists or neurotensin into the medial prefrontal cortex.

Alternations in splenocyte and thymocyte subpopulations in B6C3F1 mice exposed to cocaine plus diazinon.

Nitric oxide mediates the inhibitory action of platelet-activating factor on angiotensin II-induced renal vasoconstriction, in vivo.

Regional hemodynamic effects of purinergic P2 receptor subtype agonists in rats.

Mechanisms of [Ca++]i elevation induced by erythrocyte components in endothelial cells.

Neural and endocrine circuits mediating inhibition of bradykinin-induced plasma extravasation by subcutaneous and spinal-intrathecal nicotine.

The effects of mibefradil, a novel calcium channel antagonist on ventricular arrhythmias induced by myocardial ischemia and programmed electrical stimulation.

Protein kinase C activators decrease dopamine uptake into striatal synaptosomes.

Evidence for the involvement of the caudal region of the periaqueductal gray in a subset of morphine-induced alterations of immune status.

Regional effects of MK-801 on dopamine release: effects of competitive NMDA or 5-HT2A receptor blockade.

Brain efflux index as a novel method of analyzing efflux transport at the blood-brain barrier.

LY215840, a high-affinity 5-HT7 receptor ligand, blocks serotonin-induced relaxation in canine coronary artery.

Nonpeptide endothelin receptor antagonists. VII: Binding characteristics of [3H]SB 209670, a novel nonpeptide antagonist of endothelin receptors.

Positive inotropic effects of the calcium sensitizer CGP 48506 in guinea pig myocardium.

Positive inotropic effects of the calcium sensitizer CGP 48506 in failing human myocardium.

Differential effects of unique profile antipsychotic drugs on extracellular amino acids in the ventral pallidum and globus pallidus of rats.

Properties of ABT-299, a prodrug of A-85783, a highly potent platelet activating factor receptor antagonist.

Platelet-activating factor production in stimulated macrophages is down-regulated by concurrently produced prostaglandin E2.

Active transport of cimetidine and ranitidine into the milk of Sprague Dawley rats.

Involvement of endothelins in immediate and late asthmatic responses of guinea pigs.

Prediction of the human pharmacokinetics of troglitazone, a new and extensively metabolized antidiabetic agent, after oral administration, with an animal scale-up approach.

Pharmacology of the spinal adenosine receptor which mediates the antiallodynic action of intrathecal adenosine agonists.

Inhibition of thalidomide teratogenicity by acetylsalicylic acid: evidence for prostaglandin H synthase-catalyzed bioactivation of thalidomide to a teratogenic reactive intermediate.

The biotransformation of clomipramine in vitro, identification of the cytochrome P450s responsible for the separate metabolic pathways.

Protection from 1,1-dichloroethylene-induced Clara cell injury by diallyl sulfone, a derivative of garlic.

Hyaluronic acid increases proteoglycan synthesis in bovine articular cartilage in the presence of interleukin-1.

Suppressed expression of phenobarbital-inducible hepatic cytochrome P-450s in Eisai-hyperbilirubinuria rats (EHBR/Eis).

Effects of nicotine on dopaminergic nigrostriatal axons requires stimulation of presynaptic glutamatergic receptors.

Medium chain triglycerides and vitamin E reduce the severity of established experimental alcoholic liver disease.

Angiotensin-converting enzyme inhibition attenuates arterial constrictor responses in experimental hypertension.

Selective suppression of rat hepatic microsomal activity during chronic cyclosporine nephrotoxicity.

Hydrogen peroxide mediates the killing of U937 tumor cells elicited by pharmacologically attainable concentrations of ascorbic acid: cell death prevention by extracellular catalase or catalase from cocultured erythrocytes or fibroblasts.

Inorganic mercury chloride-induced apoptosis in the cultured porcine renal cell line LLC-PK1.

The membrane hyperpolarization of rat dorsolateral septal nucleus neurons is mediated by a novel nicotinic receptor.

In vivo effects of angiotensin II on vascular smooth muscle contraction and blood pressure are mediated through a protein tyrosine-kinase-dependent mechanism.

Adrenergic regulation of the heat shock response in brown adipose tissue.

Effects of felbamate on muscarinic and metabotropic-glutamate agonist-mediated responses and magnesium-free or 4-aminopyridine-induced epileptiform activity in guinea pig olfactory cortex neurons in vitro.

Characterization and localization of [125I]RTI-55-labeled cocaine binding sites in fetal and adult rat brain.

Felbamate inhibits [3H]t-butylbicycloorthobenzoate (TBOB) binding and enhances Cl- current at the gamma-aminobutyric AcidA (GABAA) receptor.

Prostaglandin E2 induces apoptosis in resting immature and mature human lymphocytes: a c-Myc-dependent and Bcl-2-independent associated pathway.

Type II collagen-induced arthritis in the diabetic-resistant biobreeding rat: inflammatory and histopathological features of joint pathology and effects of antiinflammatory and antirheumatic drugs on this chronic arthritic process.

Renal ischemia/reperfusion up-regulates heme oxygenase-1 (HSP32) expression and increases cGMP in rat heart.

Regional distribution and characterization of [3H]dextrorphan binding sites in rat brain determined by quantitative autoradiography.

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