Journal of Pharmacology and Experimental Therapeutics: 277 (3)

June 01, 1996; Volume 277,Issue 3

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Use of digitalis glycosides to identify the mechanisms of amantadine transport by renal tubules.
M R Escobar and D S Sitar

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1189-1194;
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Possible contribution of platelet cyclooxygenase to the renal vascular action of 5,6-epoxyeicosatrienoic acid.
D Fulton, M Balazy, J C McGiff and J Quilley

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1195-1199;
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The zinc pool is involved in the immune-reconstituting effect of melatonin in pinealectomized mice.
E Mocchegiani, D Bulian, L Santarelli, A Tibaldi, M Muzzioli, V Lesnikov, W Pierpaoli and N Fabris

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1200-1208;
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Catecholamine secretion induced by nicotine is due to Ca++ channel but not Na+ channel activation in porcine adrenal chromaffin cells.
Q Li and E J Forsberg

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1209-1214;
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ATP-sensitive potassium channel modulators: both pinacidil and glibenclamide produce antiarrhythmic activity during acute myocardial infarction in conscious rats.
I Leprán, I Baczkó, A Varró and J G Papp

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1215-1220;
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Zwitterionic phospholipids enhance aspirin's therapeutic activity, as demonstrated in rodent model systems.
L M Lichtenberger, C Ulloa, A L Vanous, J J Romero, E J Dial, P A Illich and E T Walters

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1221-1227;
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Comparative clinical pharmacology of short-acting mu opioids in drug abusers.
M K Greenwald, H L June, M L Stitzer and A P Marco

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1228-1236;
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Functional antagonistic activity of Rec 15/2739, a novel alpha-1 antagonist selective for the lower urinary tract, on noradrenaline-induced contraction of human prostate and mesenteric artery.
R Testa, L Guarneri, C Taddei, E Poggesi, P Angelico, A Sartani, A Leonardi, O N Gofrit, S Meretyk and M Caine

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1237-1246;
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The effects of eticlopride and naltrexone on responding maintained by food, cocaine, heroin and cocaine/heroin combinations in rats.
S E Hemby, J E Smith and S I Dworkin

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1247-1258;
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Lack of 5-hydroxytryptamine1A-mediated inhibition of adenylyl cyclase in dorsal raphe of male and female rats.
W P Clarke, F D Yocca and S Maayani

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1259-1266;
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Effect of nicotine and nicotinic receptor agonists on latent inhibition in the rat.
J Rochford, A P Sen and R Quirion

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1267-1275;
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Inogatran, a novel direct low molecular weight thrombin inhibitor, given with, but not after, tissue-plasminogen activator, improves thrombolysis.
L Chen, W W Nichols, C Mattsson, A C Teger-Nilsson, T G Saldeen and J L Mehta

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1276-1283;
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Structure-activity relationships for SNC80 and related compounds at cloned human delta and mu opioid receptors.
R J Knapp, G Santoro, I A De Leon, K B Lee, S A Edsall, S Waite, E Malatynska, E Varga, S N Calderon, K C Rice, R B Rothman, F Porreca, W R Roeske and H I Yamamura

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1284-1291;
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Effects of 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1 -H-1-benzazepin-8-yl)-1-propanone fumarate (TAK-147), a novel acetylcholinesterase inhibitor, on impaired learning and memory in animal models.
M Miyamoto, H Takahashi, K Kato, K Hirai, Y Ishihara and G Goto

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1292-1304;
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A comparison of the effects of valproate and its major active metabolite E-2-en-valproate on single unit activity of substantia nigra pars reticulata neurons in rats.
A Rohlfs, C Rundfeldt, R Koch and W Löscher

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1305-1314;
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delta 9-Tetrahydrocannabinol selectively inhibits macrophage costimulatory activity and down-regulates heat-stable antigen expression.
D J Clements, G A Cabral and K L McCoy

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1315-1321;
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Buprenorphine differentially alters opioid receptor adaptation in rat brain regions.
M M Belcheva, M T Ho, E G Ignatova, L B Jefcoat, J Barg, Z Vogel, R J McHale, F E Johnson and C J Coscia

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1322-1327;
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Regional vascular effects of MPC-1304, a novel dihydropyridine derivative, in conscious normotensive and spontaneously hypertensive rats.
K Miyoshi, A Kanda, Y Nozawa, M Nakano and H Miyake

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1328-1336;
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Evidence of a bradykinin B1 receptor in human ileum: pharmacological comparison to the rabbit aorta B1 receptor.
J S Zuzack, M R Burkard, D K Cuadrado, R A Greer, W M Selig and E T Whalley

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1337-1343;
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Perinatal methadone exposure produces physical dependence and altered behavioral development in the rat.
P M Kunko, J A Smith, M J Wallace, J R Maher, J J Saady and S E Robinson

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1344-1351;
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A-4, a tertiary amine analog of HC-3, lowers arterial pressure in spontaneously hypertensive rats.
U Ozkutlu, R A Shaffer, S J Lewis and J P Long

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1352-1358;
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Mechanisms by which octreotide ameliorates symptoms in the dumping syndrome.
W L Hasler, H C Soudah and C Owyang

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1359-1365;
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Enkephalin analog prodrugs: assessment of in vitro conversion, enzyme cleavage characterization and blood-brain barrier permeability.
D L Greene, V S Hau, T J Abbruscato, H Bartosz, A Misicka, A W Lipkowski, S Hom, T J Gillespie, V J Hruby and T P Davis

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1366-1375;
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Heme oxygenase inhibitor zinc protoporphyrin IX causes an activation of nitric oxide synthase in the rabbit internal anal sphincter.
S Chakder, S Rathi, X L Ma and S Rattan

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1376-1382;
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Nicotinic agonists differ in activation and desensitization of 86Rb+ efflux from mouse thalamic synaptosomes.
M J Marks, S F Robinson and A C Collins

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1383-1396;
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Effects of iodotubercidin on adenosine kinase activity and nucleoside transport in DDT1 MF-2 smooth muscle cells.
F E Parkinson and J D Geiger

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1397-1401;
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Rates of glutathione synthesis in lung subcompartments of mice and monkeys: possible role in species and site selective injury.
X Duan, C Plopper, P Brennan and A Buckpitt

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1402-1409;
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L-deprenyl (selegiline) exerts anticonvulsant effects against different seizure types in mice.
W Löscher and H Lehmann

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1410-1417;
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Effect of endotoxin on permeability of bovine cerebral endothelial cell layers in vitro.
H E de Vries, M C Blom-Roosemalen, A G de Boer, T J van Berkel, D D Breimer and J Kuiper

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1418-1423;
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NG-nitro-L-arginine methyl ester attenuates the maintenance and expression of methamphetamine-induced behavioral sensitization and enhancement of striatal dopamine release.
H Inoue, I Arai, S Shibata and S Watanabe

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1424-1430;
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Electrically evoked acetylcholine release from hippocampal slices is inhibited by the cannabinoid receptor agonist, WIN 55212-2, and is potentiated by the cannabinoid antagonist, SR 141716A.
A N Gifford and C R Ashby

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1431-1436;
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Catecholamine transporters and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity: studies comparing the cloned human noradrenaline and human dopamine transporter.
C Pifl, O Hornykiewicz, B Giros and M G Caron

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1437-1443;
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Tamoxifen (estrogen antagonist) inhibits voltage-gated calcium current and contractility in vascular smooth muscle from rats.
J Song, P R Standley, F Zhang, D Joshi, S Gappy, J R Sowers and J L Ram

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1444-1453;
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Electrophysiological effects of a novel, short-acting and potent ester derivative of amiodarone, ATI-2001, in guinea pig isolated heart.
M J Raatikainen, C A Napolitano, P Druzgala and D M Dennis

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1454-1463;
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Nonsteroidal anti-inflammatory drugs activate carbonic anhydrase by a direct mechanism of action.
I Puscas, M Coltau and R Pasca

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1464-1466;
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Alterations in locomotor activity after microinjections of GBR-12909, selective dopamine antagonists or neurotensin into the medial prefrontal cortex.
R A Radcliffe and V G Erwin

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1467-1476;
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Alternations in splenocyte and thymocyte subpopulations in B6C3F1 mice exposed to cocaine plus diazinon.
D F Kump, R A Matulka, G F Burton, S D Jordan and M P Holsapple

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1477-1485;
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Nitric oxide mediates the inhibitory action of platelet-activating factor on angiotensin II-induced renal vasoconstriction, in vivo.
R K Handa and J W Strandhoy

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1486-1491;
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Regional hemodynamic effects of purinergic P2 receptor subtype agonists in rats.
B F Cox and G J Smits

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1492-1500;
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Mechanisms of [Ca++]i elevation induced by erythrocyte components in endothelial cells.
H Zhang, B K Weir, R L Macdonald, L S Marton, N J Solenski, A L Kwan and K S Lee

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1501-1509;
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Neural and endocrine circuits mediating inhibition of bradykinin-induced plasma extravasation by subcutaneous and spinal-intrathecal nicotine.
F J Miao, N Benowitz and J D Levine

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1510-1516;
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The effects of mibefradil, a novel calcium channel antagonist on ventricular arrhythmias induced by myocardial ischemia and programmed electrical stimulation.
G E Billman and R L Hamlin

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1517-1526;
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Protein kinase C activators decrease dopamine uptake into striatal synaptosomes.
B J Copeland, V Vogelsberg, N H Neff and M Hadjiconstantinou

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1527-1532;
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Evidence for the involvement of the caudal region of the periaqueductal gray in a subset of morphine-induced alterations of immune status.
D T Lysle, K E Hoffman and L A Dykstra

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1533-1540;
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Regional effects of MK-801 on dopamine release: effects of competitive NMDA or 5-HT2A receptor blockade.
C J Schmidt and G M Fadayel

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1541-1549;
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Brain efflux index as a novel method of analyzing efflux transport at the blood-brain barrier.
A Kakee, T Terasaki and Y Sugiyama

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1550-1559;
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LY215840, a high-affinity 5-HT7 receptor ligand, blocks serotonin-induced relaxation in canine coronary artery.
D J Cushing, J M Zgombick, D L Nelson and M L Cohen

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1560-1566;
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Nonpeptide endothelin receptor antagonists. VII: Binding characteristics of [3H]SB 209670, a novel nonpeptide antagonist of endothelin receptors.
P Nambi, M Pullen, H L Wu, D Lee, D Saunders, R Heys, N Aiyar, J Leber, J Elliott, D Brooks, E Ohlstein and R Ruffolo

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1567-1571;
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Positive inotropic effects of the calcium sensitizer CGP 48506 in guinea pig myocardium.
N Zimmermann, P Bokník, E Gams, J W Herzig, J Neumann, W Schmitz, H Scholz and H Wenzlaff

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1572-1578;
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Positive inotropic effects of the calcium sensitizer CGP 48506 in failing human myocardium.
J Neumann, T Eschenhagen, I L Grupp, A Haverich, J W Herzig, S Hirt, P Kalmár, W Schmitz, H Scholz, B Stein, H Wenzlaff and N Zimmermann

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1579-1585;
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Differential effects of unique profile antipsychotic drugs on extracellular amino acids in the ventral pallidum and globus pallidus of rats.
M A Chapman and R E See

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1586-1594;
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Properties of ABT-299, a prodrug of A-85783, a highly potent platelet activating factor receptor antagonist.
D H Albert, R G Conway, T J Magoc, P Tapang, D A Rhein, G Luo, J H Holms, S K Davidsen, J B Summers and G W Carter

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1595-1606;
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Platelet-activating factor production in stimulated macrophages is down-regulated by concurrently produced prostaglandin E2.
M Yamada, M Watanabe, S Mue and K Ohuchi

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1607-1614;
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Active transport of cimetidine and ranitidine into the milk of Sprague Dawley rats.
P J McNamara, J A Meece and E Paxton

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1615-1621;
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Involvement of endothelins in immediate and late asthmatic responses of guinea pigs.
Y Uchida, T Jun, H Ninomiya, H Ohse, S Hasegawa, A Nomura, T Sakamoto, M S Sardessai and F Hirata

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1622-1629;
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Prediction of the human pharmacokinetics of troglitazone, a new and extensively metabolized antidiabetic agent, after oral administration, with an animal scale-up approach.
T Izumi, S Enomoto, K Hosiyama, K Sasahara, A Shibukawa, T Nakagawa and Y Sugiyama

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1630-1641;
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Pharmacology of the spinal adenosine receptor which mediates the antiallodynic action of intrathecal adenosine agonists.
Y W Lee and T L Yaksh

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1642-1648;
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Inhibition of thalidomide teratogenicity by acetylsalicylic acid: evidence for prostaglandin H synthase-catalyzed bioactivation of thalidomide to a teratogenic reactive intermediate.
R R Arlen and P G Wells

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1649-1658;
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The biotransformation of clomipramine in vitro, identification of the cytochrome P450s responsible for the separate metabolic pathways.
K K Nielsen, J P Flinois, P Beaune and K Brøsen

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1659-1664;
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Protection from 1,1-dichloroethylene-induced Clara cell injury by diallyl sulfone, a derivative of garlic.
P G Forkert, R P Lee, T F Dowsley, J Y Hong and J B Ulreich

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1665-1671;
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Hyaluronic acid increases proteoglycan synthesis in bovine articular cartilage in the presence of interleukin-1.
K Fukuda, H Dan, M Takayama, F Kumano, M Saitoh and S Tanaka

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1672-1675;
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Suppressed expression of phenobarbital-inducible hepatic cytochrome P-450s in Eisai-hyperbilirubinuria rats (EHBR/Eis).
T Oguro, E Kaneko, Y Kaneko, S Numazawa, S Imaoka, Y Funae, T Mikami and T Yoshida

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1676-1684;
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Effects of nicotine on dopaminergic nigrostriatal axons requires stimulation of presynaptic glutamatergic receptors.
M Garcia-Munoz, P Patino, S J Young and P M Groves

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1685-1693;
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Medium chain triglycerides and vitamin E reduce the severity of established experimental alcoholic liver disease.
A A Nanji, E K Yang, F Fogt, S M Sadrzadeh and A J Dannenberg

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1694-1700;
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Angiotensin-converting enzyme inhibition attenuates arterial constrictor responses in experimental hypertension.
M Kähönen, H Mäkynen, X Wu, P Arvola, A Pekki and I Pörsti

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1701-1709;
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Selective suppression of rat hepatic microsomal activity during chronic cyclosporine nephrotoxicity.
L J Brunner, W M Bennett and D R Koop

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1710-1718;
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Hydrogen peroxide mediates the killing of U937 tumor cells elicited by pharmacologically attainable concentrations of ascorbic acid: cell death prevention by extracellular catalase or catalase from cocultured erythrocytes or fibroblasts.
P Sestili, G Brandi, L Brambilla, F Cattabeni and O Cantoni

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1719-1725;
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Inorganic mercury chloride-induced apoptosis in the cultured porcine renal cell line LLC-PK1.
K B Duncan-Achanzar, J T Jones, M F Burke, D E Carter and H E Laird

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1726-1732;
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The membrane hyperpolarization of rat dorsolateral septal nucleus neurons is mediated by a novel nicotinic receptor.
E M Sorenson and J P Gallagher

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1733-1743;
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In vivo effects of angiotensin II on vascular smooth muscle contraction and blood pressure are mediated through a protein tyrosine-kinase-dependent mechanism.
M D Sauro, R Sudakow and S Burns

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1744-1750;
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Adrenergic regulation of the heat shock response in brown adipose tissue.
J M Matz, K P LaVoi and M J Blake

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1751-1758;
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Effects of felbamate on muscarinic and metabotropic-glutamate agonist-mediated responses and magnesium-free or 4-aminopyridine-induced epileptiform activity in guinea pig olfactory cortex neurons in vitro.
V Libri, A Constanti, M Zibetti and S Nisticó

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1759-1769;
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Characterization and localization of [125I]RTI-55-labeled cocaine binding sites in fetal and adult rat brain.
L P Shearman, L M Collins and J S Meyer

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1770-1783;
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Felbamate inhibits [3H]t-butylbicycloorthobenzoate (TBOB) binding and enhances Cl- current at the gamma-aminobutyric AcidA (GABAA) receptor.
A Kume, L J Greenfield, R L Macdonald and R L Albin

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1784-1792;
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Prostaglandin E2 induces apoptosis in resting immature and mature human lymphocytes: a c-Myc-dependent and Bcl-2-independent associated pathway.
F Pica, O Franzese, C D'Onofrio, E Bonmassar, C Favalli and E Garaci

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1793-1800;
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Type II collagen-induced arthritis in the diabetic-resistant biobreeding rat: inflammatory and histopathological features of joint pathology and effects of antiinflammatory and antirheumatic drugs on this chronic arthritic process.
R J Smith and L M Sly

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1801-1813;
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Renal ischemia/reperfusion up-regulates heme oxygenase-1 (HSP32) expression and increases cGMP in rat heart.
V S Raju and M D Maines

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1814-1822;
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Regional distribution and characterization of [3H]dextrorphan binding sites in rat brain determined by quantitative autoradiography.
J E Roth, T F Murray and P H Franklin

Journal of Pharmacology and Experimental Therapeutics June 1996, 277 (3) 1823-1836;

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