Table of Contents

May 1996; 277 (2)

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- B McAdam,
- R M Keimowitz,
- M Maher,
- and D J Fitzgerald
Transdermal modification of platelet function: an aspirin patch system results in marked suppression of platelet cyclooxygenase.
J Pharmacol Exp Ther May 1996 277:559-564
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- A Hara and
- Y Abiko
Protective effects of dilazep and its novel derivative, K-7259, on mechanical and metabolic derangements induced by hydrogen peroxide in the isolated perfused rat heart.
J Pharmacol Exp Ther May 1996 277:565-571
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- T Kawata,
- S Hashimoto,
- and T Koike
The angiotensin receptor antagonist 2-ethoxy-1-[[2'-(1H- tetrazol-5-yl) biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV11974) attenuates the tubuloglomerular feedback response during NO synthase blockade in rats.
J Pharmacol Exp Ther May 1996 277:572-577
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- L J Bristow,
- K L Flatman,
- P H Hutson,
- J J Kulagowski,
- P D Leeson,
- L Young,
- and M D Tricklebank
The atypical neuroleptic profile of the glycine/N-methyl-D-aspartate receptor antagonist, L-701,324, in rodents.
J Pharmacol Exp Ther May 1996 277:578-585
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- D R Compton,
- M D Aceto,
- J Lowe,
- and B R Martin
In vivo characterization of a specific cannabinoid receptor antagonist (SR141716A): inhibition of delta 9-tetrahydrocannabinol-induced responses and apparent agonist activity.
J Pharmacol Exp Ther May 1996 277:586-594
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- L Y Lin,
- M Fujimoto,
- E W Distefano,
- D A Schmitz,
- A Jayasinghe,
- and A K Cho
Selective mechanism-based inactivation of rat CYP2D by 4-allyloxymethamphetamine.
J Pharmacol Exp Ther May 1996 277:595-603
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- E J Gallaher,
- G E Jones,
- J K Belknap,
- and J C Crabbe
Identification of genetic markers for initial sensitivity and rapid tolerance to ethanol-induced ataxia using quantitative trait locus analysis in BXD recombinant inbred mice.
J Pharmacol Exp Ther May 1996 277:604-612
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- T J Phillips,
- C N Lessov,
- R D Harland,
- and S R Mitchell
Evaluation of potential genetic associations between ethanol tolerance and sensitization in BXD/Ty recombinant inbred mice.
J Pharmacol Exp Ther May 1996 277:613-623
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- J C Crabbe,
- T J Phillips,
- E J Gallaher,
- L I Crawshaw,
- and S R Mitchell
Common genetic determinants of the ataxic and hypothermic effects of ethanol in BXD/Ty recombinant inbred mice: genetic correlations and quantitative trait loci.
J Pharmacol Exp Ther May 1996 277:624-632
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- K Fecho,
- K A Maslonek,
- L A Dykstra,
- and D T Lysle
Evidence for sympathetic and adrenal involvement in the immunomodulatory effects of acute morphine treatment in rats.
J Pharmacol Exp Ther May 1996 277:633-645
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- J Sawynok and
- A Reid
Neurotoxin-induced lesions to central serotonergic, noradrenergic and dopaminergic systems modify caffeine-induced antinociception in the formalin test and locomotor stimulation in rats.
J Pharmacol Exp Ther May 1996 277:646-653
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- X H Chen,
- E B Geller,
- and M W Adler
Electrical stimulation at traditional acupuncture sites in periphery produces brain opioid-receptor-mediated antinociception in rats.
J Pharmacol Exp Ther May 1996 277:654-660
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- R J Thielen,
- N B Fangon,
- and A Frazer
4-(2'-Methoxyphenyl)-1-[2'-[N-(2"-pyridinyl)-p-iodobenzamido]ethyl] piperazine and 4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridinyl)-p- fluorobenzamido]ethyl]piperazine, two new antagonists at pre- and postsynaptic serotonin-1A receptors.
J Pharmacol Exp Ther May 1996 277:661-670
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- J J Lynch, Jr,
- A A Wallace,
- G L Stump,
- R F Stupienski, 3rd,
- T Kothstein,
- and J R Gehret
Differential efficacy of the class III agent MK-499 against programmed stimulation-induced and ischemic-induced ventricular arrhythmias in a canine model of previous myocardial infarction.
J Pharmacol Exp Ther May 1996 277:671-678
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- K T Lin,
- A Dudhane,
- H P Godfrey,
- and P Y Wong
Identification and characterization of a high-affinity leukotriene B4 receptor on guinea pig T lymphocytes and its regulation by lipoxin A4.
J Pharmacol Exp Ther May 1996 277:679-684
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- T Coleman,
- S W Ellis,
- I J Martin,
- M S Lennard,
- and G T Tucker
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is N-demethylated by cytochromes P450 2D6, 1A2 and 3A4--implications for susceptibility to Parkinson's disease.
J Pharmacol Exp Ther May 1996 277:685-690
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- J F McAnulty and
- X Q Huang
The effects of administering quinacrine during ultraprofound hypothermia on warm ischemic kidney cortex tissue.
J Pharmacol Exp Ther May 1996 277:691-699
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- S Palea,
- M Corsi,
- W Artibani,
- E Ostardo,
- and C Pietra
Pharmacological characterization of tachykinin NK2 receptors on isolated human urinary bladder, prostatic urethra and prostate.
J Pharmacol Exp Ther May 1996 277:700-705
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- D M Fehr,
- D R Larach,
- K A Zangari,
- and H G Schuler
Halothane constricts bovine pulmonary arteries by release of intracellular calcium.
J Pharmacol Exp Ther May 1996 277:706-713
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- Y Wang,
- W R Mathews,
- D M Guido,
- and H Jaeschke
The 21-aminosteroid tirilazad mesylate protects against liver injury via membrane stabilization not inhibition of lipid peroxidation.
J Pharmacol Exp Ther May 1996 277:714-720
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- S Yamada,
- S Uchida,
- T Ohkura,
- R Kimura,
- M Yamaguchi,
- M Suzuki,
- and M Yamamoto
Alterations in calcium antagonist receptors and calcium content in senescent brain and attenuation by nimodipine and nicardipine.
J Pharmacol Exp Ther May 1996 277:721-727
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- G M Bores,
- F P Huger,
- W Petko,
- A E Mutlib,
- F Camacho,
- D K Rush,
- D E Selk,
- V Wolf,
- R W Kosley, Jr,
- L Davis,
- and H M Vargas
Pharmacological evaluation of novel Alzheimer's disease therapeutics: acetylcholinesterase inhibitors related to galanthamine.
J Pharmacol Exp Ther May 1996 277:728-738
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- S G Holtzman
Discriminative effects of CGS 15943, a competitive adenosine receptor antagonist, in monkeys: comparison to methylxanthines.
J Pharmacol Exp Ther May 1996 277:739-746
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- T Katsuragi,
- K Matsuo,
- C Sato,
- K Honda,
- H Kamiya,
- and T Furukawa
Non-neuronal release of ATP and inositol 1,4,5-trisphosphate accumulation evoked by P2- and M-receptor stimulation in guinea pig ileal segments.
J Pharmacol Exp Ther May 1996 277:747-752
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- L C Nuttle and
- J M Farley
Frequency modulation of acetylcholine-induced oscillations in Ca++ and Ca(++)-activated Cl- current by cAMP in tracheal smooth muscle.
J Pharmacol Exp Ther May 1996 277:753-760
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- P Svensson,
- G Hesslow,
- and R Winton
Effect of ethanol on the excitability of the inferior olive in decerebrate ferret.
J Pharmacol Exp Ther May 1996 277:761-767
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- K Nunoya,
- Y Yokoi,
- K Kimura,
- T Kodama,
- M Funayama,
- K Inoue,
- K Nagashima,
- Y Funae,
- N Shimada,
- C Green,
- and T Kamataki
(+)-cis-3,5-dimethyl-2-(3-pyridyl) thiazolidin-4-one hydrochloride (SM-12502) as a novel substrate for cytochrome P450 2A6 in human liver microsomes.
J Pharmacol Exp Ther May 1996 277:768-774
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- P DeBoer and
- E D Abercrombie
Physiological release of striatal acetylcholine in vivo: modulation by D1 and D2 dopamine receptor subtypes.
J Pharmacol Exp Ther May 1996 277:775-783
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- M H Ossipov,
- C J Kovelowski,
- H Wheeler-Aceto,
- A Cowan,
- J C Hunter,
- J Lai,
- T P Malan, Jr,
- and F Porreca
Opioid antagonists and antisera to endogenous opioids increase the nociceptive response to formalin: demonstration of an opioid kappa and delta inhibitory tone.
J Pharmacol Exp Ther May 1996 277:784-788
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- X Liu and
- J M Farley
Depletion and refilling of acetylcholine- and caffeine-sensitive Ca++ stores in tracheal myocytes.
J Pharmacol Exp Ther May 1996 277:789-795
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- X Liu and
- J M Farley
Acetylcholine-induced Ca++-dependent chloride current oscillations are mediated by inositol 1,4,5-trisphosphate in tracheal myocytes.
J Pharmacol Exp Ther May 1996 277:796-804
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- R E Pearce,
- A D Rodrigues,
- J A Goldstein,
- and A Parkinson
Identification of the human P450 enzymes involved in lansoprazole metabolism.
J Pharmacol Exp Ther May 1996 277:805-816
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- S McKinzie,
- G M Tyce,
- and S Brimijoin
Lowered norepinephrine turnover as a sign of impaired ganglionic transmission after preganglionic lesioning by acetylcholinesterase antibodies.
J Pharmacol Exp Ther May 1996 277:817-822
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- S Consolo,
- S Arnaboldi,
- S Ramponi,
- L Nannini,
- H Ladinsky,
- and G Baldi
Endogenous serotonin facilitates in vivo acetylcholine release in rat frontal cortex through 5-HT 1B receptors.
J Pharmacol Exp Ther May 1996 277:823-830
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- U Wenzel,
- I Gebert,
- H Weintraut,
- W M Weber,
- W Clauss,
- and H Daniel
Transport characteristics of differently charged cephalosporin antibiotics in oocytes expressing the cloned intestinal peptide transporter PepT1 and in human intestinal Caco-2 cells.
J Pharmacol Exp Ther May 1996 277:831-839
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- E M Kudlacz,
- S A Shatzer,
- R W Knippenberg,
- D E Logan,
- M Poirot,
- P L van Giersbergen,
- and T P Burkholder
In vitro and in vivo characterization of MDL 105,212A, a nonpeptide NK-1/NK-2 tachykinin receptor antagonist.
J Pharmacol Exp Ther May 1996 277:840-851
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- T H de Boer,
- F Nefkens,
- A van Helvoirt,
- and A M van Delft
Differences in modulation of noradrenergic and serotonergic transmission by the alpha-2 adrenoceptor antagonists, mirtazapine, mianserin and idazoxan.
J Pharmacol Exp Ther May 1996 277:852-860
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- N Haddjeri,
- P Blier,
- and C de Montigny
Effect of the alpha-2 adrenoceptor antagonist mirtazapine on the 5-hydroxytryptamine system in the rat brain.
J Pharmacol Exp Ther May 1996 277:861-871
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- E G Silva,
- T Feres,
- L M Vianna,
- P Okuyama,
- and T B Paiva
Dual effect of clonidine on mesenteric artery adrenoceptors: agonistic (alpha-2) and antagonistic (alpha-1).
J Pharmacol Exp Ther May 1996 277:872-876
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- C C Taylor,
- D Wu,
- Y Soong,
- J S Yee,
- and H H Szeto
kappa-Opioid agonist, U50,488H, stimulates ovine fetal pituitary-adrenal function via hypothalamic arginine-vasopressin and corticotrophin-releasing factor.
J Pharmacol Exp Ther May 1996 277:877-884
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- J A Gibbons,
- A A Hancock,
- C R Vitt,
- S Knepper,
- S A Buckner,
- M E Brune,
- I Milicic,
- J F Kerwin, Jr,
- L S Richter,
- E W Taylor,
- K L Spear,
- R N Zuckermann,
- D C Spellmeyer,
- R A Braeckman,
- and W H Moos
Pharmacologic characterization of CHIR 2279, an N-substituted glycine peptoid with high-affinity binding for alpha 1-adrenoceptors.
J Pharmacol Exp Ther May 1996 277:885-899
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- S McLean,
- A Ganong,
- P A Seymour,
- D K Bryce,
- R T Crawford,
- J Morrone,
- L S Reynolds,
- A W Schmidt,
- S Zorn,
- J Watson,
- A Fossa,
- M DePasquale,
- T Rosen,
- A Nagahisa,
- M Tsuchiya,
- and J Heym
Characterization of CP-122,721; a nonpeptide antagonist of the neurokinin NK1 receptor.
J Pharmacol Exp Ther May 1996 277:900-908
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- M I Walton,
- W Gibson,
- G W Aherne,
- N Lawrence,
- T C Stephens,
- M N Smith,
- and A L Jackman
Preclinical pharmacology of CB30900, a novel dipeptide inhibitor of thymidylate synthase, in mice.
J Pharmacol Exp Ther May 1996 277:909-916
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- U Warpman,
- X Zhang,
- and A Nordberg
Effect of tacrine on in vivo release of dopamine and its metabolites in the striatum of freely moving rats.
J Pharmacol Exp Ther May 1996 277:917-922
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- S T Crooke,
- M J Graham,
- J E Zuckerman,
- D Brooks,
- B S Conklin,
- L L Cummins,
- M J Greig,
- C J Guinosso,
- D Kornbrust,
- M Manoharan,
- H M Sasmor,
- T Schleich,
- K L Tivel,
- and R H Griffey
Pharmacokinetic properties of several novel oligonucleotide analogs in mice.
J Pharmacol Exp Ther May 1996 277:923-937
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- R M Maiorino,
- D Gonzalez-Ramirez,
- M Zuniga-Charles,
- Z Xu,
- K M Hurlbut,
- M M Aposhian,
- R C Dart,
- J S Woods,
- P Ostrosky-Wegman,
- M E Gonsebatt,
- and H V Aposhian
Sodium 2,3-dimercaptopropane-1-sulfonate challenge test for mercury in humans. III. Urinary mercury after exposure to mercurous chloride.
J Pharmacol Exp Ther May 1996 277:938-944
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- T R Ozolins,
- D L Siksay,
- and P G Wells
Modulation of embryonic glutathione peroxidase activity and phenytoin teratogenicity by dietary deprivation of selenium in CD-1 mice.
J Pharmacol Exp Ther May 1996 277:945-953
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- D A Cox,
- S W Watts,
- and M L Cohen
Neomycin selectively inhibits 5-hydroxytryptamine-induced contraction in the guinea pig trachea.
J Pharmacol Exp Ther May 1996 277:954-959
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- M R Brandt and
- C P France
Discriminative stimulus effects on enadoline in pigeons.
J Pharmacol Exp Ther May 1996 277:960-967
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- J H Kehne,
- B M Baron,
- A A Carr,
- S F Chaney,
- J Elands,
- D J Feldman,
- R A Frank,
- P L van Giersbergen,
- T C McCloskey,
- M P Johnson,
- D R McCarty,
- M Poirot,
- Y Senyah,
- B W Siegel,
- and C Widmaier
Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile.
J Pharmacol Exp Ther May 1996 277:968-981
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- L C Wienkers,
- R C Steenwyk,
- P E Sanders,
- and P G Pearson
Biotransformation of tirilazad in human: 1. Cytochrome P450 3A-mediated hydroxylation of tirilazad mesylate in human liver microsomes.
J Pharmacol Exp Ther May 1996 277:982-990
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- J C Fleishaker,
- P G Pearson,
- L C Wienkers,
- L K Pearson,
- and G R Peters
Biotransformation of tirilazad in human: 2. Effect of ketoconazole on tirilazad clearance and oral bioavailability.
J Pharmacol Exp Ther May 1996 277:991-998
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- W Y Chan,
- N C Wo,
- L L Cheng,
- and M Manning
Isosteric substitution of Asn5 in antagonists of oxytocin and vasopressin leads to highly selective and potent oxytocin and V1a receptor antagonists: new approaches for the design of potential tocolytics for preterm labor.
J Pharmacol Exp Ther May 1996 277:999-1003
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- H Asai,
- S Imaoka,
- T Kuroki,
- T Monna,
- and Y Funae
Microsomal ethanol oxidizing system activity by human hepatic cytochrome P450s.
J Pharmacol Exp Ther May 1996 277:1004-1009
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- M Nakajima,
- T Yamamoto,
- K Nunoya,
- T Yokoi,
- K Nagashima,
- K Inoue,
- Y Funae,
- N Shimada,
- T Kamataki,
- and Y Kuroiwa
Characterization of CYP2A6 involved in 3'-hydroxylation of cotinine in human liver microsomes.
J Pharmacol Exp Ther May 1996 277:1010-1015
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- S Kanes,
- K Dains,
- L Cipp,
- J Gatley,
- B Hitzemann,
- E Rasmussen,
- S Sanderson,
- M Silverman,
- and R Hitzemann
Mapping the genes for haloperidol-induced catalepsy.
J Pharmacol Exp Ther May 1996 277:1016-1025
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- M P Waalkes,
- B A Diwan,
- S Rehm,
- J M Ward,
- M Moussa,
- M G Cherian,
- and R A Goyer
Down-regulation of metallothionein expression in human and murine hepatocellular tumors: association with the tumor-necrotizing and antineoplastic effects of cadmium in mice.
J Pharmacol Exp Ther May 1996 277:1026-1033
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- R Mosqueda-Garcia,
- R Fernandez-Violante,
- T Hamakubo,
- and R Stainback
Vasopressin mediates the pressor effects of endothelin in the subfornical organ of the rat.
J Pharmacol Exp Ther May 1996 277:1034-1042
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- M Ohkura,
- Y Miyashita,
- T Nikai,
- J Suzuki,
- Y Komori,
- H Sugihara,
- and Y Ohizumi
Properties of Ca++ release induced by puff adder lectin, a novel lectin from the snake Bitis arietans, in sarcoplasmic reticulum.
J Pharmacol Exp Ther May 1996 277:1043-1048
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- K M Laughlin,
- S M Evans,
- W T Jenkins,
- M Tracy,
- C Y Chan,
- E M Lord,
- and C J Koch
Biodistribution of the nitroimidazole EF5 (2-[2-nitro-1H-imidazol-1-yl]-N-(2,2,3,3,3-pentafluoropropyl) acetamide) in mice bearing subcutaneous EMT6 tumors.
J Pharmacol Exp Ther May 1996 277:1049-1057
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- S G Kim,
- H C Chung,
- and J Y Cho
Molecular mechanism for alkyl sulfide-modulated carbon tetrachloride-induced hepatotoxicity: the role of cytochrome P450 2E1, P450 2B and glutathione S-transferase expression.
J Pharmacol Exp Ther May 1996 277:1058-1066
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- L R Walus,
- W M Pardridge,
- R M Starzyk,
- and P M Friden
Enhanced uptake of rsCD4 across the rodent and primate blood-brain barrier after conjugation to anti-transferrin receptor antibodies.
J Pharmacol Exp Ther May 1996 277:1067-1075
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- G E Duncan,
- D J Knapp,
- K B Johnson,
- and G R Breese
Functional classification of antidepressants based on antagonism of swim stress-induced fos-like immunoreactivity.
J Pharmacol Exp Ther May 1996 277:1076-1089
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- S A Masten,
- W J Millard,
- J L Karlix,
- and K T Shiverick
Evaluation of immune parameters and lymphocyte production of prolactin-immunoreactive proteins after chronic administration of cocaine to pregnant rats.
J Pharmacol Exp Ther May 1996 277:1090-1096
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- N Makkonen,
- M R Hirvonen,
- T Teräväinen,
- K Savolainen,
- and J Mönkkönen
Different effects of three bisphosphonates on nitric oxide production by RAW 264 macrophage-like cells in vitro.
J Pharmacol Exp Ther May 1996 277:1097-1102
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- S W Watts,
- M Baez,
- and R C Webb
The 5-hydroxytryptamine2B receptor and 5-HT receptor signal transduction in mesenteric arteries from deoxycorticosterone acetate-salt hypertensive rats.
J Pharmacol Exp Ther May 1996 277:1103-1113
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- Y M Hernandez,
- V F Raczkowski,
- K L Dretchen,
- and R A Gillis
Cocaine inhibits sympathetic neural activity by acting in the central nervous system and at the sympathetic ganglion.
J Pharmacol Exp Ther May 1996 277:1114-1121
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- K Johnson,
- L Churchill,
- M A Klitenick,
- M S Hooks,
- and P W Kalivas
Involvement of the ventral tegmental area in locomotion elicited from the nucleus accumbens or ventral pallidum.
J Pharmacol Exp Ther May 1996 277:1122-1131
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- C J Allan,
- K Higashiura,
- M Martin,
- T A Morinelli,
- D T Kurtz,
- O Geoffroy,
- G P Meier,
- T W Gettys,
- and P V Halushka
Characterization of the cloned HEL cell thromboxane A2 receptor: evidence that the affinity state can be altered by G alpha 13 and G alpha q.
J Pharmacol Exp Ther May 1996 277:1132-1139
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- L R Williams,
- G Inouye,
- V Cummins,
- and M A Pelleymounter
Glial cell line-derived neurotrophic factor sustains axotomized basal forebrain cholinergic neurons in vivo: dose-response comparison to nerve growth factor and brain-derived neurotrophic factor.
J Pharmacol Exp Ther May 1996 277:1140-1151
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- G Gurujeyalakshmi,
- S N Iyer,
- M A Hollinger,
- and S N Giri
Procollagen gene expression is down-regulated by taurine and niacin at the transcriptional level in the bleomycin hamster model of lung fibrosis.
J Pharmacol Exp Ther May 1996 277:1152-1157
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- T L Hartsell,
- L M Hinman,
- P R Hamann,
- and N F Schor
Determinants of the response of neuroblastoma cells to DNA damage: the roles of pre-treatment cell morphology and chemical nature of the damage.
J Pharmacol Exp Ther May 1996 277:1158-1166
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- M E Morgan,
- D Singhal,
- and B D Anderson
Quantitative assessment of blood-brain barrier damage during microdialysis.
J Pharmacol Exp Ther May 1996 277:1167-1176
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- Y Bjijou,
- L Stinus,
- M Le Moal,
- and M Cador
Evidence for selective involvement of dopamine D1 receptors of the ventral tegmental area in the behavioral sensitization induced by intra-ventral tegmental area injections of D-amphetamine.
J Pharmacol Exp Ther May 1996 277:1177-1187
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Current Issue

November 2009, 331 (2)

Transdermal modification of platelet function: an aspirin patch system results in marked suppression of platelet cyclooxygenase.

Protective effects of dilazep and its novel derivative, K-7259, on mechanical and metabolic derangements induced by hydrogen peroxide in the isolated perfused rat heart.

The angiotensin receptor antagonist 2-ethoxy-1-[[2'-(1H- tetrazol-5-yl) biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV11974) attenuates the tubuloglomerular feedback response during NO synthase blockade in rats.

The atypical neuroleptic profile of the glycine/N-methyl-D-aspartate receptor antagonist, L-701,324, in rodents.

In vivo characterization of a specific cannabinoid receptor antagonist (SR141716A): inhibition of delta 9-tetrahydrocannabinol-induced responses and apparent agonist activity.

Selective mechanism-based inactivation of rat CYP2D by 4-allyloxymethamphetamine.

Identification of genetic markers for initial sensitivity and rapid tolerance to ethanol-induced ataxia using quantitative trait locus analysis in BXD recombinant inbred mice.

Evaluation of potential genetic associations between ethanol tolerance and sensitization in BXD/Ty recombinant inbred mice.

Common genetic determinants of the ataxic and hypothermic effects of ethanol in BXD/Ty recombinant inbred mice: genetic correlations and quantitative trait loci.

Evidence for sympathetic and adrenal involvement in the immunomodulatory effects of acute morphine treatment in rats.

Neurotoxin-induced lesions to central serotonergic, noradrenergic and dopaminergic systems modify caffeine-induced antinociception in the formalin test and locomotor stimulation in rats.

Electrical stimulation at traditional acupuncture sites in periphery produces brain opioid-receptor-mediated antinociception in rats.

4-(2'-Methoxyphenyl)-1-[2'-[N-(2"-pyridinyl)-p-iodobenzamido]ethyl] piperazine and 4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridinyl)-p- fluorobenzamido]ethyl]piperazine, two new antagonists at pre- and postsynaptic serotonin-1A receptors.

Differential efficacy of the class III agent MK-499 against programmed stimulation-induced and ischemic-induced ventricular arrhythmias in a canine model of previous myocardial infarction.

Identification and characterization of a high-affinity leukotriene B4 receptor on guinea pig T lymphocytes and its regulation by lipoxin A4.

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is N-demethylated by cytochromes P450 2D6, 1A2 and 3A4--implications for susceptibility to Parkinson's disease.

The effects of administering quinacrine during ultraprofound hypothermia on warm ischemic kidney cortex tissue.

Pharmacological characterization of tachykinin NK2 receptors on isolated human urinary bladder, prostatic urethra and prostate.

Halothane constricts bovine pulmonary arteries by release of intracellular calcium.

The 21-aminosteroid tirilazad mesylate protects against liver injury via membrane stabilization not inhibition of lipid peroxidation.

Alterations in calcium antagonist receptors and calcium content in senescent brain and attenuation by nimodipine and nicardipine.

Pharmacological evaluation of novel Alzheimer's disease therapeutics: acetylcholinesterase inhibitors related to galanthamine.

Discriminative effects of CGS 15943, a competitive adenosine receptor antagonist, in monkeys: comparison to methylxanthines.

Non-neuronal release of ATP and inositol 1,4,5-trisphosphate accumulation evoked by P2- and M-receptor stimulation in guinea pig ileal segments.

Frequency modulation of acetylcholine-induced oscillations in Ca++ and Ca(++)-activated Cl- current by cAMP in tracheal smooth muscle.

Effect of ethanol on the excitability of the inferior olive in decerebrate ferret.

(+)-cis-3,5-dimethyl-2-(3-pyridyl) thiazolidin-4-one hydrochloride (SM-12502) as a novel substrate for cytochrome P450 2A6 in human liver microsomes.

Physiological release of striatal acetylcholine in vivo: modulation by D1 and D2 dopamine receptor subtypes.

Opioid antagonists and antisera to endogenous opioids increase the nociceptive response to formalin: demonstration of an opioid kappa and delta inhibitory tone.

Depletion and refilling of acetylcholine- and caffeine-sensitive Ca++ stores in tracheal myocytes.

Acetylcholine-induced Ca++-dependent chloride current oscillations are mediated by inositol 1,4,5-trisphosphate in tracheal myocytes.

Identification of the human P450 enzymes involved in lansoprazole metabolism.

Lowered norepinephrine turnover as a sign of impaired ganglionic transmission after preganglionic lesioning by acetylcholinesterase antibodies.

Endogenous serotonin facilitates in vivo acetylcholine release in rat frontal cortex through 5-HT 1B receptors.

Transport characteristics of differently charged cephalosporin antibiotics in oocytes expressing the cloned intestinal peptide transporter PepT1 and in human intestinal Caco-2 cells.

In vitro and in vivo characterization of MDL 105,212A, a nonpeptide NK-1/NK-2 tachykinin receptor antagonist.

Differences in modulation of noradrenergic and serotonergic transmission by the alpha-2 adrenoceptor antagonists, mirtazapine, mianserin and idazoxan.

Effect of the alpha-2 adrenoceptor antagonist mirtazapine on the 5-hydroxytryptamine system in the rat brain.

Dual effect of clonidine on mesenteric artery adrenoceptors: agonistic (alpha-2) and antagonistic (alpha-1).

kappa-Opioid agonist, U50,488H, stimulates ovine fetal pituitary-adrenal function via hypothalamic arginine-vasopressin and corticotrophin-releasing factor.

Pharmacologic characterization of CHIR 2279, an N-substituted glycine peptoid with high-affinity binding for alpha 1-adrenoceptors.

Characterization of CP-122,721; a nonpeptide antagonist of the neurokinin NK1 receptor.

Preclinical pharmacology of CB30900, a novel dipeptide inhibitor of thymidylate synthase, in mice.

Effect of tacrine on in vivo release of dopamine and its metabolites in the striatum of freely moving rats.

Pharmacokinetic properties of several novel oligonucleotide analogs in mice.

Sodium 2,3-dimercaptopropane-1-sulfonate challenge test for mercury in humans. III. Urinary mercury after exposure to mercurous chloride.

Modulation of embryonic glutathione peroxidase activity and phenytoin teratogenicity by dietary deprivation of selenium in CD-1 mice.

Neomycin selectively inhibits 5-hydroxytryptamine-induced contraction in the guinea pig trachea.

Discriminative stimulus effects on enadoline in pigeons.

Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile.

Biotransformation of tirilazad in human: 1. Cytochrome P450 3A-mediated hydroxylation of tirilazad mesylate in human liver microsomes.

Biotransformation of tirilazad in human: 2. Effect of ketoconazole on tirilazad clearance and oral bioavailability.

Isosteric substitution of Asn5 in antagonists of oxytocin and vasopressin leads to highly selective and potent oxytocin and V1a receptor antagonists: new approaches for the design of potential tocolytics for preterm labor.

Microsomal ethanol oxidizing system activity by human hepatic cytochrome P450s.

Characterization of CYP2A6 involved in 3'-hydroxylation of cotinine in human liver microsomes.

Mapping the genes for haloperidol-induced catalepsy.

Down-regulation of metallothionein expression in human and murine hepatocellular tumors: association with the tumor-necrotizing and antineoplastic effects of cadmium in mice.

Vasopressin mediates the pressor effects of endothelin in the subfornical organ of the rat.

Properties of Ca++ release induced by puff adder lectin, a novel lectin from the snake Bitis arietans, in sarcoplasmic reticulum.

Biodistribution of the nitroimidazole EF5 (2-[2-nitro-1H-imidazol-1-yl]-N-(2,2,3,3,3-pentafluoropropyl) acetamide) in mice bearing subcutaneous EMT6 tumors.

Molecular mechanism for alkyl sulfide-modulated carbon tetrachloride-induced hepatotoxicity: the role of cytochrome P450 2E1, P450 2B and glutathione S-transferase expression.

Enhanced uptake of rsCD4 across the rodent and primate blood-brain barrier after conjugation to anti-transferrin receptor antibodies.

Functional classification of antidepressants based on antagonism of swim stress-induced fos-like immunoreactivity.

Evaluation of immune parameters and lymphocyte production of prolactin-immunoreactive proteins after chronic administration of cocaine to pregnant rats.

Different effects of three bisphosphonates on nitric oxide production by RAW 264 macrophage-like cells in vitro.

The 5-hydroxytryptamine2B receptor and 5-HT receptor signal transduction in mesenteric arteries from deoxycorticosterone acetate-salt hypertensive rats.

Cocaine inhibits sympathetic neural activity by acting in the central nervous system and at the sympathetic ganglion.

Involvement of the ventral tegmental area in locomotion elicited from the nucleus accumbens or ventral pallidum.

Characterization of the cloned HEL cell thromboxane A2 receptor: evidence that the affinity state can be altered by G alpha 13 and G alpha q.

Glial cell line-derived neurotrophic factor sustains axotomized basal forebrain cholinergic neurons in vivo: dose-response comparison to nerve growth factor and brain-derived neurotrophic factor.

Procollagen gene expression is down-regulated by taurine and niacin at the transcriptional level in the bleomycin hamster model of lung fibrosis.

Determinants of the response of neuroblastoma cells to DNA damage: the roles of pre-treatment cell morphology and chemical nature of the damage.

Quantitative assessment of blood-brain barrier damage during microdialysis.

Evidence for selective involvement of dopamine D1 receptors of the ventral tegmental area in the behavioral sensitization induced by intra-ventral tegmental area injections of D-amphetamine.

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