Table of Contents

December 1995; 275 (3)

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- R Zhuge and
- W H Hsu
The caffeine- and ryanodine-sensitive Ca++ store in porcine myometrial cells: its heterogeneity of all-or-none Ca++ release.
J Pharmacol Exp Ther December 1995 275:1077-1083
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- T Yoneyama,
- M Hori,
- T Tanaka,
- Y Matsuda,
- and H Karaki
Endothelin ETA and ETB receptors facilitating parasympathetic neurotransmission in the rabbit trachea.
J Pharmacol Exp Ther December 1995 275:1084-1089
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- B J Brockel and
- S C Fowler
Effects of chronic haloperidol on reaction time and errors in a sustained attention task: partial reversal by anticholinergics and by amphetamine.
J Pharmacol Exp Ther December 1995 275:1090-1098
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- A Bado,
- J P Laigneau,
- L Moizo,
- Y Cherifi,
- and M J Lewin
H3-receptor activation inhibits cholinergic stimulation of acid secretion in isolated rabbit fundic glands.
J Pharmacol Exp Ther December 1995 275:1099-1103
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- D S Albers and
- P K Sonsalla
Methamphetamine-induced hyperthermia and dopaminergic neurotoxicity in mice: pharmacological profile of protective and nonprotective agents.
J Pharmacol Exp Ther December 1995 275:1104-1114
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- A Tosaki,
- D T Engelman,
- R M Engelman,
- and D K Das
Diabetes and ATP-sensitive potassium channel openers and blockers in isolated ischemic/reperfused hearts.
J Pharmacol Exp Ther December 1995 275:1115-1123
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- G D Zeevalk,
- E Derr-Yellin,
- and W J Nicklas
Relative vulnerability of dopamine and GABA neurons in mesencephalic culture to inhibition of succinate dehydrogenase by malonate and 3-nitropropionic acid and protection by NMDA receptor blockade.
J Pharmacol Exp Ther December 1995 275:1124-1130
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- B J Ring,
- S N Binkley,
- L Roskos,
- and S A Wrighton
Effect of fluoxetine, norfluoxetine, sertraline and desmethyl sertraline on human CYP3A catalyzed 1'-hydroxy midazolam formation in vitro.
J Pharmacol Exp Ther December 1995 275:1131-1135
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- M M Prechel,
- A T Orawski,
- L L Maggiora,
- and W H Simmons
Effect of a new aminopeptidase P inhibitor, apstatin, on bradykinin degradation in the rat lung.
J Pharmacol Exp Ther December 1995 275:1136-1142
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- C Millar,
- J F Poyer,
- B T Gabelt,
- and P L Kaufman
Endothelin subtypes: effect on isolated rhesus monkey ciliary muscle.
J Pharmacol Exp Ther December 1995 275:1143-1147
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- A Boutros and
- J Wang
Ischemic preconditioning, adenosine and bethanechol protect spontaneously hypertensive isolated rat hearts.
J Pharmacol Exp Ther December 1995 275:1148-1156
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- M Magnon,
- P Gallix,
- and I Cavero
Intervessel (arteries and veins) and heart/vessel selectivities of therapeutically used calcium entry blockers: variable, vessel-dependent indexes.
J Pharmacol Exp Ther December 1995 275:1157-1166
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- L Belardinelli,
- J C Shryock,
- Y Zhang,
- P J Scammells,
- R Olsson,
- D Dennis,
- P Milner,
- J Pfister,
- and S P Baker
1,3-Dipropyl-8-[2-(5,6-epoxy)norbornyl]xanthine, a potent, specific and selective A1 adenosine receptor antagonist in the guinea pig heart and brain and in DDT1MF-2 cells.
J Pharmacol Exp Ther December 1995 275:1167-1176
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- S A Longman,
- P G Tardi,
- M J Parr,
- L Choi,
- P R Cullis,
- and M B Bally
Accumulation of protein-coated liposomes in an extravascular site: influence of increasing carrier circulation lifetimes.
J Pharmacol Exp Ther December 1995 275:1177-1184
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- J W Mandema and
- D R Wada
Pharmacodynamic model for acute tolerance development to the electroencephalographic effects of alfentanil in the rat.
J Pharmacol Exp Ther December 1995 275:1185-1194
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- T May,
- U Wolf,
- and J Wolffgramm
Striatal dopamine receptors and adenylyl cyclase activity in a rat model of alcohol addiction: effects of ethanol and lisuride treatment.
J Pharmacol Exp Ther December 1995 275:1195-1203
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- E B Fraser-Smith,
- J D Rosete,
- and R C Schatzman
Suppression by mycophenolate mofetil of the neointimal thickening caused by vascular injury in a rat arterial stenosis model.
J Pharmacol Exp Ther December 1995 275:1204-1208
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- R M Woodward,
- J E Huettner,
- M Tran,
- J Guastella,
- J F Keana,
- and E Weber
Pharmacology of 5-chloro-7-trifluoromethyl-1,4-dihydro-2,3-quinoxalinedione: a novel systemically active ionotropic glutamate receptor antagonist.
J Pharmacol Exp Ther December 1995 275:1209-1218
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- S Kalsner
Hypoxic relaxation in functionally intact cattle coronary artery segments involves K+ ATP channels.
J Pharmacol Exp Ther December 1995 275:1219-1226
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- B J Day,
- S Shawen,
- S I Liochev,
- and J D Crapo
A metalloporphyrin superoxide dismutase mimetic protects against paraquat-induced endothelial cell injury, in vitro.
J Pharmacol Exp Ther December 1995 275:1227-1232
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- M J Janusz,
- S L Durham,
- C M Hare,
- J L Geary,
- A K Mandagere,
- J C Poole,
- T N Thompson,
- D Xu,
- M R Anagelastro,
- and J P Burkhart
Pharmacological evaluation of selected, orally active, peptidyl inhibitors of human neutrophil elastase.
J Pharmacol Exp Ther December 1995 275:1233-1238
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- F Sautel,
- N Griffon,
- P Sokoloff,
- J C Schwartz,
- C Launay,
- P Simon,
- J Costentin,
- A Schoenfelder,
- F Garrido,
- and A Mann
Nafadotride, a potent preferential dopamine D3 receptor antagonist, activates locomotion in rodents.
J Pharmacol Exp Ther December 1995 275:1239-1246
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- T Matsumoto,
- M Takahashi,
- I Nakae,
- and M Kinoshita
Vasorelaxing effect of S-nitrosocaptopril on dog coronary arteries: no cross-tolerance with nitroglycerin.
J Pharmacol Exp Ther December 1995 275:1247-1253
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- M G Bischof,
- K Redlich,
- C Schiller,
- M V Chirayath,
- M Uskokovic,
- M Peterlik,
- and H S Cross
Growth inhibitory effects on human colon adenocarcinoma-derived Caco-2 cells and calcemic potential of 1 alpha,25-dihydroxyvitamin D3 analogs: structure-function relationships.
J Pharmacol Exp Ther December 1995 275:1254-1260
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- S S Hegde,
- D W Bonhaus,
- W Stanley,
- R M Eglen,
- T M Moy,
- M Loeb,
- S G Shetty,
- A DeSouza,
- and J Krstenansky
Pharmacological evaluation of 1229U91, a novel high-affinity and selective neuropeptide Y-Y1 receptor antagonist.
J Pharmacol Exp Ther December 1995 275:1261-1266
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- J M Witkin,
- S Brave,
- D French,
- and B Geter-Douglass
Discriminative stimulus effects of R-(+)-3-amino-1-hydroxypyrrolid-2-one, [(+)-HA-966], a partial agonist of the strychnine-insensitive modulatory site of the N-methyl-D-aspartate receptor.
J Pharmacol Exp Ther December 1995 275:1267-1273
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- T A Spalding,
- E S Burstein,
- H Brauner-Osborne,
- D Hill-Eubanks,
- and M R Brann
Pharmacology of a constitutively active muscarinic receptor generated by random mutagenesis.
J Pharmacol Exp Ther December 1995 275:1274-1279
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- S Y Yousufzai,
- Z Ye,
- and A A Abdel-Latif
Prostaglandins mediate the stimulatory effects of endothelin-1 on cAMP accumulation and inositol-1,4,5-trisphosphate production and contraction in cat iris sphincter.
J Pharmacol Exp Ther December 1995 275:1280-1287
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- E Tagaya,
- J Tamaoki,
- A Chiyotani,
- and K Konno
Stimulation of opioid mu-receptors potentiates beta adrenoceptor-mediated relaxation of canine airway smooth muscle.
J Pharmacol Exp Ther December 1995 275:1288-1292
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- N J Liu,
- T Xu,
- C Xu,
- C Q Li,
- Y X Yu,
- H G Kang,
- and J S Han
Cholecystokinin octapeptide reverses mu-opioid-receptor-mediated inhibition of calcium current in rat dorsal root ganglion neurons.
J Pharmacol Exp Ther December 1995 275:1293-1299
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- H Barelli,
- Z Woskowska,
- S Cipris,
- J E Fox-Threlkeld,
- E E Daniel,
- J P Vincent,
- and F Checler
Pharmacological role and degradation processes of neuromedin N in the gastrointestinal tract: an in vitro and in vivo study.
J Pharmacol Exp Ther December 1995 275:1300-1307
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- Y Yuan and
- W D Atchison
Methylmercury acts at multiple sites to block hippocampal synaptic transmission.
J Pharmacol Exp Ther December 1995 275:1308-1316
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- M R Escobar,
- K Goralski,
- and D S Sitar
L(+)- and D(-)-lactate modulate rat renal tubular accumulation of amantadine in the presence and absence of bicarbonate.
J Pharmacol Exp Ther December 1995 275:1317-1323
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- C Marie,
- C Mossiat,
- J M Lecomte,
- J C Schwartz,
- and J Bralet
Hemodynamic effects of acute and chronic treatment with aladotril, a mixed inhibitor of neutral endopeptidase and angiotensin I-converting enzyme, in conscious rats with myocardial infarction.
J Pharmacol Exp Ther December 1995 275:1324-1331
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- W G Smith,
- A F Shaffer,
- J L Currie,
- J M Thompson,
- S Kim,
- T Rao,
- and P C Isakson
Characterization of 5-lipoxygenase inhibitors in biochemical and functional in vivo assays.
J Pharmacol Exp Ther December 1995 275:1332-1338
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- M L Nichols,
- D Bian,
- M H Ossipov,
- J Lai,
- and F Porreca
Regulation of morphine antiallodynic efficacy by cholecystokinin in a model of neuropathic pain in rats.
J Pharmacol Exp Ther December 1995 275:1339-1345
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- M B Gatch,
- S S Negus,
- E R Butelman,
- and N K Mello
Antinociceptive effects of cocaine/opioid combinations in rhesus monkeys.
J Pharmacol Exp Ther December 1995 275:1346-1354
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- T A Pugsley,
- M D Davis,
- H C Akunne,
- R G MacKenzie,
- Y H Shih,
- G Damsma,
- H Wikstrom,
- S Z Whetzel,
- L M Georgic,
- and L W Cooke
Neurochemical and functional characterization of the preferentially selective dopamine D3 agonist PD 128907.
J Pharmacol Exp Ther December 1995 275:1355-1366
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- M R Weed and
- W L Woolverton
The reinforcing effects of dopamine D1 receptor agonists in rhesus monkeys.
J Pharmacol Exp Ther December 1995 275:1367-1374
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- M Wolzt,
- L Schmetterer,
- J Kastner,
- K Krejcy,
- G Zanaschka,
- C Unfried,
- and H G Eichler
Short-term drug effects on the signal-averaged electrocardiogram in healthy men: assessment of intra- and interindividual variability of spectral temporal mapping and time-domain analysis.
J Pharmacol Exp Ther December 1995 275:1375-1381
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- A J Carter,
- W D Bechtel,
- M Grauert,
- P Harrison,
- H Merz,
- and W Stransky
BIII 277 CL is a potent and specific ion-channel blocker of the NMDA receptor-channel complex.
J Pharmacol Exp Ther December 1995 275:1382-1389
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- H K Im,
- W B Im,
- J F Pregenzer,
- D B Carter,
- and B J Hamilton
U-89843A is a novel allosteric modulator of gamma-aminobutyric acidA receptors.
J Pharmacol Exp Ther December 1995 275:1390-1395
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- S Takahashi,
- E Nakamura,
- and S Okabe
Stimulatory effect of leminoprazole on secretion and synthesis of mucus by rabbit gastric mucosal cells.
J Pharmacol Exp Ther December 1995 275:1396-1401
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- J H Song and
- T Narahashi
Selective block of tetramethrin-modified sodium channels by (+/-)-alpha-tocopherol (vitamin E).
J Pharmacol Exp Ther December 1995 275:1402-1411
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- L D McCauley and
- K W Gee
Influence of the estrus cycle on the discrimination of apparent neuroactive steroid site subtypes on the gamma-aminobutyric acidA receptor complex in the rat.
J Pharmacol Exp Ther December 1995 275:1412-1417
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- M Bencherif,
- C M Eisenhour,
- R J Prince,
- P M Lippiello,
- and R J Lukas
The "calcium antagonist" TMB-8 [3,4,5-trimethoxybenzoic acid 8-(diethylamino)octyl ester] is a potent, non-competitive, functional antagonist at diverse nicotinic acetylcholine receptor subtypes.
J Pharmacol Exp Ther December 1995 275:1418-1426
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- R Schleiffer,
- M Galluser,
- and F Raul
Intestinal absorption of calcium in vivo is dependent on endogenous nitric oxide.
J Pharmacol Exp Ther December 1995 275:1427-1432
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- B Korbmacher,
- U Sunderdiek,
- H D Schulte,
- G Arnold,
- and J D Schipke
Comparison between the effects of a novel Ca++ sensitizer and a phosphodiesterase inhibitor on stunned myocardium.
J Pharmacol Exp Ther December 1995 275:1433-1441
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- R Yu and
- M K Ticku
Effects of chronic pentobarbital treatment on the GABAA receptor complex in mammalian cortical neurons.
J Pharmacol Exp Ther December 1995 275:1442-1446
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- A Fujii,
- H Matsumoto,
- T Hashimoto,
- and Y Akimoto
Tenidap, an anti-inflammatory agent, discharges intracellular Ca++ store and inhibits Ca++ influx in cultured human gingival fibroblasts.
J Pharmacol Exp Ther December 1995 275:1447-1452
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- L M Ireland,
- C H Yan,
- L M Nelson,
- and W D Atchison
Differential effects of 2,4-dithiobiuret on the synthesis and release of acetylcholine and dopamine from rat pheochromocytoma (PC12) cells.
J Pharmacol Exp Ther December 1995 275:1453-1462
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- J L Maggs,
- D Williams,
- M Pirmohamed,
- and B K Park
The metabolic formation of reactive intermediates from clozapine, a drug associated with agranulocytosis in man.
J Pharmacol Exp Ther December 1995 275:1463-1475
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- Z C Liu and
- J P Uetrecht
Clozapine is oxidized by activated human neutrophils to a reactive nitrenium ion that irreversibly binds to the cells.
J Pharmacol Exp Ther December 1995 275:1476-1483
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- T K Eisenstein,
- J J Meissler, Jr,
- T J Rogers,
- E B Geller,
- and M W Adler
Mouse strain differences in immunosuppression by opioids in vitro.
J Pharmacol Exp Ther December 1995 275:1484-1489
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- S Pierno,
- A De Luca,
- D Tricarico,
- A Roselli,
- F Natuzzi,
- E Ferrannini,
- M Laico,
- and D C Camerino
Potential risk of myopathy by HMG-CoA reductase inhibitors: a comparison of pravastatin and simvastatin effects on membrane electrical properties of rat skeletal muscle fibers.
J Pharmacol Exp Ther December 1995 275:1490-1496
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- R Vezza,
- G G Nenci,
- and P Gresele
Thromboxane synthase inhibitors suppress more effectively the aggregation of thromboxane receptor-desensitized than that of normal platelets: role of adenylylcyclase up-regulation.
J Pharmacol Exp Ther December 1995 275:1497-1505
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- H J Kim,
- P Rozman,
- and C D Klaassen
Acetaminophen does not decrease hepatic 3'-phosphoadenosine 5'-phosphosulfate in mice.
J Pharmacol Exp Ther December 1995 275:1506-1511
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- Z Zhong,
- H D Connor,
- R P Mason,
- W Qu,
- W Gao,
- J J Lemasters,
- and R G Thurman
Role of Kupffer cells in reperfusion injury in fat-loaded livers from ethanol-treated rats.
J Pharmacol Exp Ther December 1995 275:1512-1517
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- D L Williams, Jr,
- K L Murphy,
- N A Nolan,
- J A O'Brien,
- D J Pettibone,
- S D Kivlighn,
- S M Krause,
- E V Lis, Jr,
- G J Zingaro,
- and R A Gabel
Pharmacology of L-754,142, a highly potent, orally active, nonpeptidyl endothelin antagonist.
J Pharmacol Exp Ther December 1995 275:1518-1526
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- M Chiba,
- J A Nishime,
- and J H Lin
Potent and selective inactivation of human liver microsomal cytochrome P-450 isoforms by L-754,394, an investigational human immune deficiency virus protease inhibitor.
J Pharmacol Exp Ther December 1995 275:1527-1534
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- R M Craft,
- S R Henley,
- R C Haaseth,
- V J Hruby,
- and F Porreca
Opioid antinociception in a rat model of visceral pain: systemic versus local drug administration.
J Pharmacol Exp Ther December 1995 275:1535-1542
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- C A Kanashiro,
- T B Paiva,
- A C Paiva,
- R N Prioste,
- J Aboulafia,
- and S I Shimuta
Angiotensin II tachyphylaxis in the guinea pig ileum and its prevention: a pharmacological and biochemical study.
J Pharmacol Exp Ther December 1995 275:1543-1550
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- L L Howell and
- L D Byrd
Serotonergic modulation of the behavioral effects of cocaine in the squirrel monkey.
J Pharmacol Exp Ther December 1995 275:1551-1559
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- M C Olianas and
- P Onali
Participation of delta opioid receptor subtypes in the stimulation of adenylyl cyclase activity in rat olfactory bulb.
J Pharmacol Exp Ther December 1995 275:1560-1567
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- C H Yang,
- M H Shyr,
- T B Kuo,
- P P Tan,
- and S H Chan
Effects of propofol on nociceptive response and power spectra of electroencephalographic and systemic arterial pressure signals in the rat: correlation with plasma concentration.
J Pharmacol Exp Ther December 1995 275:1568-1574
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- A Guidarelli,
- P Sestili,
- A Cossarizza,
- C Franceschi,
- F Cattabeni,
- and O Cantoni
Evidence for dissimilar mechanisms of enhancement of inorganic and organic hydroperoxide cytotoxicity by L-histidine.
J Pharmacol Exp Ther December 1995 275:1575-1582
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- M T Piascik,
- R D Guarino,
- M S Smith,
- E E Soltis,
- D L Saussy, Jr,
- and D M Perez
The specific contribution of the novel alpha-1D adrenoceptor to the contraction of vascular smooth muscle.
J Pharmacol Exp Ther December 1995 275:1583-1589
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- P Sánchez-Blázquez,
- A García-España,
- and J Garzón
In vivo injection of antisense oligodeoxynucleotides to G alpha subunits and supraspinal analgesia evoked by mu and delta opioid agonists.
J Pharmacol Exp Ther December 1995 275:1590-1596
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- I Kitchen,
- F M Leslie,
- M Kelly,
- R Barnes,
- T J Crook,
- R G Hill,
- A Borsodi,
- G Toth,
- P Melchiorri,
- and L Negri
Development of delta-opioid receptor subtypes and the regulatory role of weaning: radioligand binding, autoradiography and in situ hybridization studies.
J Pharmacol Exp Ther December 1995 275:1597-1607
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- J P Desjardins and
- P L Iversen
Inhibition of the rat cytochrome P450 3A2 by an antisense phosphorothioate oligodeoxynucleotide in vivo.
J Pharmacol Exp Ther December 1995 275:1608-1613
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- Y Dai and
- A I Cederbaum
Inactivation and degradation of human cytochrome P4502E1 by CCl4 in a transfected HepG2 cell line.
J Pharmacol Exp Ther December 1995 275:1614-1622
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- D R Bachvarov,
- E Saint-Jacques,
- J F Larrivée,
- L Levesque,
- F Rioux,
- G Drapeau,
- and F Marceau
Cloning and pharmacological characterization of the rabbit bradykinin B2 receptor.
J Pharmacol Exp Ther December 1995 275:1623-1630
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- H Saito,
- M Okuda,
- T Terada,
- S Sasaki,
- and K Inui
Cloning and characterization of a rat H+/peptide cotransporter mediating absorption of beta-lactam antibiotics in the intestine and kidney.
J Pharmacol Exp Ther December 1995 275:1631-1637
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- B L Roth,
- E P Palvimaki,
- S Berry,
- N Khan,
- N Sachs,
- A Uluer,
- and M S Choudhary
5-Hydroxytryptamine2A (5-HT2A) receptor desensitization can occur without down-regulation.
J Pharmacol Exp Ther December 1995 275:1638-1646
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- J F Strasser,
- L K Fung,
- S Eller,
- S A Grossman,
- and W M Saltzman
Distribution of 1,3-bis(2-chloroethyl)-1-nitrosourea and tracers in the rabbit brain after interstitial delivery by biodegradable polymer implants.
J Pharmacol Exp Ther December 1995 275:1647-1655
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- H Gurdal,
- N Tilakaratne,
- R D Brown,
- M Fonseca,
- E Friedman,
- and M D Johnson
The expression of alpha 1 adrenoceptor subtypes changes with age in the rat aorta.
J Pharmacol Exp Ther December 1995 275:1656-1662
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- H W Suh,
- P M Hudson,
- M K McMillian,
- K P Das,
- B C Wilson,
- G C Wu,
- and J S Hong
Long-term stimulation of nicotinic receptors is required to increase proenkephalin A mRNA levels and the delayed secretion of [Met5]-enkephalin in bovine adrenal medullary chromaffin cells.
J Pharmacol Exp Ther December 1995 275:1663-1670
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- H E Nye,
- B T Hope,
- M B Kelz,
- M Iadarola,
- and E J Nestler
Pharmacological studies of the regulation of chronic FOS-related antigen induction by cocaine in the striatum and nucleus accumbens.
J Pharmacol Exp Ther December 1995 275:1671-1680
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- J Koropatnick,
- D M Kloth,
- S Kadhim,
- J L Chin,
- and M G Cherian
Metallothionein expression and resistance to cisplatin in a human germ cell tumor cell line.
J Pharmacol Exp Ther December 1995 275:1681-1687
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Current Issue

November 2009, 331 (2)

The caffeine- and ryanodine-sensitive Ca++ store in porcine myometrial cells: its heterogeneity of all-or-none Ca++ release.

Endothelin ETA and ETB receptors facilitating parasympathetic neurotransmission in the rabbit trachea.

Effects of chronic haloperidol on reaction time and errors in a sustained attention task: partial reversal by anticholinergics and by amphetamine.

H3-receptor activation inhibits cholinergic stimulation of acid secretion in isolated rabbit fundic glands.

Methamphetamine-induced hyperthermia and dopaminergic neurotoxicity in mice: pharmacological profile of protective and nonprotective agents.

Diabetes and ATP-sensitive potassium channel openers and blockers in isolated ischemic/reperfused hearts.

Relative vulnerability of dopamine and GABA neurons in mesencephalic culture to inhibition of succinate dehydrogenase by malonate and 3-nitropropionic acid and protection by NMDA receptor blockade.

Effect of fluoxetine, norfluoxetine, sertraline and desmethyl sertraline on human CYP3A catalyzed 1'-hydroxy midazolam formation in vitro.

Effect of a new aminopeptidase P inhibitor, apstatin, on bradykinin degradation in the rat lung.

Endothelin subtypes: effect on isolated rhesus monkey ciliary muscle.

Ischemic preconditioning, adenosine and bethanechol protect spontaneously hypertensive isolated rat hearts.

Intervessel (arteries and veins) and heart/vessel selectivities of therapeutically used calcium entry blockers: variable, vessel-dependent indexes.

1,3-Dipropyl-8-[2-(5,6-epoxy)norbornyl]xanthine, a potent, specific and selective A1 adenosine receptor antagonist in the guinea pig heart and brain and in DDT1MF-2 cells.

Accumulation of protein-coated liposomes in an extravascular site: influence of increasing carrier circulation lifetimes.

Pharmacodynamic model for acute tolerance development to the electroencephalographic effects of alfentanil in the rat.

Striatal dopamine receptors and adenylyl cyclase activity in a rat model of alcohol addiction: effects of ethanol and lisuride treatment.

Suppression by mycophenolate mofetil of the neointimal thickening caused by vascular injury in a rat arterial stenosis model.

Pharmacology of 5-chloro-7-trifluoromethyl-1,4-dihydro-2,3-quinoxalinedione: a novel systemically active ionotropic glutamate receptor antagonist.

Hypoxic relaxation in functionally intact cattle coronary artery segments involves K+ ATP channels.

A metalloporphyrin superoxide dismutase mimetic protects against paraquat-induced endothelial cell injury, in vitro.

Pharmacological evaluation of selected, orally active, peptidyl inhibitors of human neutrophil elastase.

Nafadotride, a potent preferential dopamine D3 receptor antagonist, activates locomotion in rodents.

Vasorelaxing effect of S-nitrosocaptopril on dog coronary arteries: no cross-tolerance with nitroglycerin.

Growth inhibitory effects on human colon adenocarcinoma-derived Caco-2 cells and calcemic potential of 1 alpha,25-dihydroxyvitamin D3 analogs: structure-function relationships.

Pharmacological evaluation of 1229U91, a novel high-affinity and selective neuropeptide Y-Y1 receptor antagonist.

Discriminative stimulus effects of R-(+)-3-amino-1-hydroxypyrrolid-2-one, [(+)-HA-966], a partial agonist of the strychnine-insensitive modulatory site of the N-methyl-D-aspartate receptor.

Pharmacology of a constitutively active muscarinic receptor generated by random mutagenesis.

Prostaglandins mediate the stimulatory effects of endothelin-1 on cAMP accumulation and inositol-1,4,5-trisphosphate production and contraction in cat iris sphincter.

Stimulation of opioid mu-receptors potentiates beta adrenoceptor-mediated relaxation of canine airway smooth muscle.

Cholecystokinin octapeptide reverses mu-opioid-receptor-mediated inhibition of calcium current in rat dorsal root ganglion neurons.

Pharmacological role and degradation processes of neuromedin N in the gastrointestinal tract: an in vitro and in vivo study.

Methylmercury acts at multiple sites to block hippocampal synaptic transmission.

L(+)- and D(-)-lactate modulate rat renal tubular accumulation of amantadine in the presence and absence of bicarbonate.

Hemodynamic effects of acute and chronic treatment with aladotril, a mixed inhibitor of neutral endopeptidase and angiotensin I-converting enzyme, in conscious rats with myocardial infarction.

Characterization of 5-lipoxygenase inhibitors in biochemical and functional in vivo assays.

Regulation of morphine antiallodynic efficacy by cholecystokinin in a model of neuropathic pain in rats.

Antinociceptive effects of cocaine/opioid combinations in rhesus monkeys.

Neurochemical and functional characterization of the preferentially selective dopamine D3 agonist PD 128907.

The reinforcing effects of dopamine D1 receptor agonists in rhesus monkeys.

Short-term drug effects on the signal-averaged electrocardiogram in healthy men: assessment of intra- and interindividual variability of spectral temporal mapping and time-domain analysis.

BIII 277 CL is a potent and specific ion-channel blocker of the NMDA receptor-channel complex.

U-89843A is a novel allosteric modulator of gamma-aminobutyric acidA receptors.

Stimulatory effect of leminoprazole on secretion and synthesis of mucus by rabbit gastric mucosal cells.

Selective block of tetramethrin-modified sodium channels by (+/-)-alpha-tocopherol (vitamin E).

Influence of the estrus cycle on the discrimination of apparent neuroactive steroid site subtypes on the gamma-aminobutyric acidA receptor complex in the rat.

The "calcium antagonist" TMB-8 [3,4,5-trimethoxybenzoic acid 8-(diethylamino)octyl ester] is a potent, non-competitive, functional antagonist at diverse nicotinic acetylcholine receptor subtypes.

Intestinal absorption of calcium in vivo is dependent on endogenous nitric oxide.

Comparison between the effects of a novel Ca++ sensitizer and a phosphodiesterase inhibitor on stunned myocardium.

Effects of chronic pentobarbital treatment on the GABAA receptor complex in mammalian cortical neurons.

Tenidap, an anti-inflammatory agent, discharges intracellular Ca++ store and inhibits Ca++ influx in cultured human gingival fibroblasts.

Differential effects of 2,4-dithiobiuret on the synthesis and release of acetylcholine and dopamine from rat pheochromocytoma (PC12) cells.

The metabolic formation of reactive intermediates from clozapine, a drug associated with agranulocytosis in man.

Clozapine is oxidized by activated human neutrophils to a reactive nitrenium ion that irreversibly binds to the cells.

Mouse strain differences in immunosuppression by opioids in vitro.

Potential risk of myopathy by HMG-CoA reductase inhibitors: a comparison of pravastatin and simvastatin effects on membrane electrical properties of rat skeletal muscle fibers.

Thromboxane synthase inhibitors suppress more effectively the aggregation of thromboxane receptor-desensitized than that of normal platelets: role of adenylylcyclase up-regulation.

Acetaminophen does not decrease hepatic 3'-phosphoadenosine 5'-phosphosulfate in mice.

Role of Kupffer cells in reperfusion injury in fat-loaded livers from ethanol-treated rats.

Pharmacology of L-754,142, a highly potent, orally active, nonpeptidyl endothelin antagonist.

Potent and selective inactivation of human liver microsomal cytochrome P-450 isoforms by L-754,394, an investigational human immune deficiency virus protease inhibitor.

Opioid antinociception in a rat model of visceral pain: systemic versus local drug administration.

Angiotensin II tachyphylaxis in the guinea pig ileum and its prevention: a pharmacological and biochemical study.

Serotonergic modulation of the behavioral effects of cocaine in the squirrel monkey.

Participation of delta opioid receptor subtypes in the stimulation of adenylyl cyclase activity in rat olfactory bulb.

Effects of propofol on nociceptive response and power spectra of electroencephalographic and systemic arterial pressure signals in the rat: correlation with plasma concentration.

Evidence for dissimilar mechanisms of enhancement of inorganic and organic hydroperoxide cytotoxicity by L-histidine.

The specific contribution of the novel alpha-1D adrenoceptor to the contraction of vascular smooth muscle.

In vivo injection of antisense oligodeoxynucleotides to G alpha subunits and supraspinal analgesia evoked by mu and delta opioid agonists.

Development of delta-opioid receptor subtypes and the regulatory role of weaning: radioligand binding, autoradiography and in situ hybridization studies.

Inhibition of the rat cytochrome P450 3A2 by an antisense phosphorothioate oligodeoxynucleotide in vivo.

Inactivation and degradation of human cytochrome P4502E1 by CCl4 in a transfected HepG2 cell line.

Cloning and pharmacological characterization of the rabbit bradykinin B2 receptor.

Cloning and characterization of a rat H+/peptide cotransporter mediating absorption of beta-lactam antibiotics in the intestine and kidney.

5-Hydroxytryptamine2A (5-HT2A) receptor desensitization can occur without down-regulation.

Distribution of 1,3-bis(2-chloroethyl)-1-nitrosourea and tracers in the rabbit brain after interstitial delivery by biodegradable polymer implants.

The expression of alpha 1 adrenoceptor subtypes changes with age in the rat aorta.

Long-term stimulation of nicotinic receptors is required to increase proenkephalin A mRNA levels and the delayed secretion of [Met5]-enkephalin in bovine adrenal medullary chromaffin cells.

Pharmacological studies of the regulation of chronic FOS-related antigen induction by cocaine in the striatum and nucleus accumbens.

Metallothionein expression and resistance to cisplatin in a human germ cell tumor cell line.