Table of Contents

February 1995; 272 (2)

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- K Fecho,
- K A Maslonek,
- L A Dykstra,
- and D T Lysle
Mechanisms whereby macrophage-derived nitric oxide is involved in morphine-induced suppression of splenic lymphocyte proliferation.
J Pharmacol Exp Ther February 1995 272:477-483
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- I Grattagliano,
- P Wieland,
- C Schranz,
- and B H Lauterburg
Disposition of glutathione monoethyl ester in the rat: glutathione ester is a slow release form of extracellular glutathione.
J Pharmacol Exp Ther February 1995 272:484-488
- Abstract
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- D Mullikin-Kilpatrick and
- S N Treistman
Inhibition of dihydropyridine-sensitive Ca++ channels by ethanol in undifferentiated and nerve growth factor-treated PC12 cells: interaction with the inactivated state.
J Pharmacol Exp Ther February 1995 272:489-497
- Abstract
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- M L Veyries,
- M Sinet,
- B Desforges,
- and B Rouveix
Effects of morphine on the pathogenesis of murine Friend retrovirus infection.
J Pharmacol Exp Ther February 1995 272:498-504
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- M Ohtani,
- H Kotaki,
- Y Sawada,
- and T Iga
Comparative analysis of buprenorphine- and norbuprenorphine-induced analgesic effects based on pharmacokinetic-pharmacodynamic modeling.
J Pharmacol Exp Ther February 1995 272:505-510
- Abstract
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- D R Luthin and
- J Linden
Comparison of A4 and A2a binding sites in striatum and COS cells transfected with adenosine A2a receptors.
J Pharmacol Exp Ther February 1995 272:511-518
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- S Apparsundaram and
- D C Eikenburg
Role of prejunctional beta adrenoceptors in rat cardiac sympathetic neurotransmission.
J Pharmacol Exp Ther February 1995 272:519-526
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- L Garofalo and
- A C Cuello
Pharmacological characterization of nerve growth factor and/or monosialoganglioside GM1 effects on cholinergic markers in the adult lesioned brain.
J Pharmacol Exp Ther February 1995 272:527-545
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- A Ohnishi,
- Y Orita,
- N Takagi,
- T Fujita,
- T Toyoki,
- Y Ihara,
- Y Yamamura,
- T Inoue,
- and T Tanaka
Aquaretic effect of a potent, orally active, nonpeptide V2 antagonist in men.
J Pharmacol Exp Ther February 1995 272:546-551
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- E D Pakarinen,
- J H Woods,
- and J M Moerschbaecher
Repeated acquisition of behavioral chains in squirrel monkeys: comparisons of a mu, kappa and delta opioid agonist.
J Pharmacol Exp Ther February 1995 272:552-559
- Abstract
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- J L Azorlosa,
- M K Greenwald,
- and M L Stitzer
Marijuana smoking: effects of varying puff volume and breathhold duration.
J Pharmacol Exp Ther February 1995 272:560-569
- Abstract
- Full Text (PDF)
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- G K Mumford,
- C R Rush,
- and R R Griffiths
Abecarnil and alprazolam in humans: behavioral, subjective and reinforcing effects.
J Pharmacol Exp Ther February 1995 272:570-580
- Abstract
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- J E Piletz,
- D N Chikkala,
- and P Ernsberger
Comparison of the properties of agmatine and endogenous clonidine-displacing substance at imidazoline and alpha-2 adrenergic receptors.
J Pharmacol Exp Ther February 1995 272:581-587
- Abstract
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- G Luo and
- T M Guenthner
Metabolism of allylbenzene 2',3'-oxide and estragole 2',3'-oxide in the isolated perfused rat liver.
J Pharmacol Exp Ther February 1995 272:588-596
- Abstract
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- G H Dillon,
- W B Im,
- J F Pregenzer,
- D B Carter,
- and B J Hamilton
[4-Dimethyl-3-t-butylcarboxyl-4,5-dihydro (1,5-a) quinoxaline] is a novel ligand to the picrotoxin site on GABAA receptors, and decreases single-channel open probability.
J Pharmacol Exp Ther February 1995 272:597-603
- Abstract
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- Z M Quezado,
- C Natanson,
- S M Banks,
- D W Alling,
- C A Koev,
- R L Danner,
- R J Elin,
- J M Hosseini,
- T S Parker,
- and D M Levine
Therapeutic trial of reconstituted human high-density lipoprotein in a canine model of gram-negative septic shock.
J Pharmacol Exp Ther February 1995 272:604-611
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- H T Beauchamp,
- R S Chang,
- P K Siegl,
- and R E Gibson
In vivo receptor occupancy of the angiotensin II receptor by nonpeptide antagonists: relationship to in vitro affinities and in vivo pharmacologic potency.
J Pharmacol Exp Ther February 1995 272:612-618
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- N C Trippodo,
- B C Panchal,
- and M Fox
Repression of angiotensin II and potentiation of bradykinin contribute to the synergistic effects of dual metalloprotease inhibition in heart failure.
J Pharmacol Exp Ther February 1995 272:619-627
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- E C Strain,
- K L Preston,
- I A Liebson,
- and G E Bigelow
Buprenorphine effects in methadone-maintained volunteers: effects at two hours after methadone.
J Pharmacol Exp Ther February 1995 272:628-638
- Abstract
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- M Murray and
- A M Butler
Identification of a reversible component in the in vitro inhibition of rat hepatic cytochrome P450 2B1 by parathion.
J Pharmacol Exp Ther February 1995 272:639-644
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- J M Spitsbergen and
- W D Atchison
The paralytic agent 2,4-dithiobiuret decreases open time of murine skeletal muscle acetylcholine receptor channels.
J Pharmacol Exp Ther February 1995 272:645-651
- Abstract
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- I M Maisonneuve,
- A Ho,
- and M J Kreek
Chronic administration of a cocaine "binge" alters basal extracellular levels in male rats: an in vivo microdialysis study.
J Pharmacol Exp Ther February 1995 272:652-657
- Abstract
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- J V Garaulet,
- M V Milanés,
- and M L Laorden
Cross-tolerance between kappa and mu opioid agonists in the guinea pig ileum myenteric plexus.
J Pharmacol Exp Ther February 1995 272:658-662
- Abstract
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- W H Dantzler,
- K K Evans,
- and S H Wright
Kinetics of interactions of para-aminohippurate, probenecid, cysteine conjugates and N-acetyl cysteine conjugates with basolateral organic anion transporter in isolated rabbit proximal renal tubules.
J Pharmacol Exp Ther February 1995 272:663-672
- Abstract
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- Y Dumont,
- A Fournier,
- S St-Pierre,
- and R Quirion
Characterization of neuropeptide Y binding sites in rat brain membrane preparations using [125I][Leu31,Pro34]peptide YY and [125I]peptide YY3-36 as selective Y1 and Y2 radioligands.
J Pharmacol Exp Ther February 1995 272:673-680
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- C Carpéné,
- P Collon,
- A Remaury,
- A Cordi,
- A Hudson,
- D Nutt,
- and M Lafontan
Inhibition of amine oxidase activity by derivatives that recognize imidazoline I2 sites.
J Pharmacol Exp Ther February 1995 272:681-688
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- C R Albrightson,
- P J Bugelski,
- T A Berkhout,
- B Jackson,
- W D Kerns,
- A J Organ,
- and A M Badger
Separation of immunomodulatory and cholesterol-lowering activities of heterocyclic azaspiranes.
J Pharmacol Exp Ther February 1995 272:689-698
- Abstract
- Full Text (PDF)
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- E Fride,
- J Barg,
- R Levy,
- D Saya,
- E Heldman,
- R Mechoulam,
- and Z Vogel
Low doses of anandamides inhibit pharmacological effects of delta 9-tetrahydrocannabinol.
J Pharmacol Exp Ther February 1995 272:699-707
- Abstract
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- D J Sanger and
- G Perrault
Effects of typical and atypical antipsychotic drugs on response decrement patterns in rats.
J Pharmacol Exp Ther February 1995 272:708-713
- Abstract
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- F G de Lorenzi,
- T R Bridal,
- and W Spinelli
Voltage-dependent inhibition of the ATP-sensitive K+ current by the class Ia agent disopyramide in cat ventricular myocytes.
J Pharmacol Exp Ther February 1995 272:714-723
- Abstract
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- R L Bell,
- J B Bouska,
- P E Malo,
- C Lanni,
- R R Harris,
- E R Otis,
- A O Stewart,
- D W Brooks,
- and G W Carter
Optimization of the potency and duration of action of N-hydroxyurea 5-lipoxygenase inhibitors.
J Pharmacol Exp Ther February 1995 272:724-731
- Abstract
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- H A Campos and
- J Domínguez
Interaction between noradrenergic and histamine-containing neurons in the rat vas deferens.
J Pharmacol Exp Ther February 1995 272:732-738
- Abstract
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- M Tomita,
- M Hayashi,
- and S Awazu
Absorption-enhancing mechanism of sodium caprate and decanoylcarnitine in Caco-2 cells.
J Pharmacol Exp Ther February 1995 272:739-743
- Abstract
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- Y Furukawa,
- H Nakano,
- T Oguchi,
- M Kasama,
- Y Hoyano,
- and S Chiba
Selective inhibition by zatebradine and discrete parasympathetic stimulation of the positive chronotropic response to sympathetic stimulation in anesthetized dogs.
J Pharmacol Exp Ther February 1995 272:744-749
- Abstract
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- A Hilditch,
- A A Hunt,
- A Travers,
- J Polley,
- G M Drew,
- D Middlemiss,
- D B Judd,
- B C Ross,
- and M J Robertson
Pharmacological effects of GR138950, a novel angiotensin AT1 receptor antagonist.
J Pharmacol Exp Ther February 1995 272:750-757
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- D F Woodward,
- A L Nieves,
- C S Spada,
- L S Williams,
- and R P Tuckett
Characterization of a behavioral model for peripherally evoked itch suggests platelet-activating factor as a potent pruritogen.
J Pharmacol Exp Ther February 1995 272:758-765
- Abstract
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- S M Russo,
- J A Pepe,
- S Donohue,
- E E Cable,
- R W Lambrecht,
- and H L Bonkovsky
Tissue distribution of zinc-mesoporphyrin in rats: relationship to inhibition of heme oxygenase.
J Pharmacol Exp Ther February 1995 272:766-774
- Abstract
- Full Text (PDF)
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- A Madan and
- M D Faiman
Characterization of diethyldithiocarbamate methyl ester sulfine as an intermediate in the bioactivation of disulfiram.
J Pharmacol Exp Ther February 1995 272:775-780
- Abstract
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- M Diana,
- M Pistis,
- A Muntoni,
- and G Gessa
Profound decrease of mesolimbic dopaminergic neuronal activity in morphine withdrawn rats.
J Pharmacol Exp Ther February 1995 272:781-785
- Abstract
- Full Text (PDF)
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- I G Johansson-Rydberg,
- N Grundström,
- and R G Andersson
Pertussis toxin attenuates presynaptic inhibition of cholinergic but not nonadrenergic noncholinergic contraction in guinea pig airways.
J Pharmacol Exp Ther February 1995 272:786-790
- Abstract
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- C W Schindler,
- S R Tella,
- J Prada,
- and S R Goldberg
Calcium channel blockers antagonize some of cocaine's cardiovascular effects, but fail to alter cocaine's behavioral effects.
J Pharmacol Exp Ther February 1995 272:791-798
- Abstract
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- G P Dubé,
- J A Jakubowski,
- K A Brune,
- K G Bemis,
- and W L Kurtz
In vivo effects of a novel thromboxane A2/prostaglandin H2 (TXA2/PGH2) partial agonist, (+)5(Z)-7-[3-endo-phenylsulfonylamino[2.2.1]- bicyclohept-2-exo-yl]-heptenoic acid [(+)-S-145], on vascular, platelet and cardiac function.
J Pharmacol Exp Ther February 1995 272:799-807
- Abstract
- Full Text (PDF)
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- M Watanabe,
- Y Kawase,
- J Tanabe,
- K R Min,
- S Mue,
- and K Ohuchi
Suppression of interleukin-1 alpha production by protein kinase C activators in human vascular endothelial cells.
J Pharmacol Exp Ther February 1995 272:808-814
- Abstract
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- J Raber,
- G F Koob,
- and F E Bloom
Interleukin-2 (IL-2) induces corticotropin-releasing factor (CRF) release from the amygdala and involves a nitric oxide-mediated signaling; comparison with the hypothalamic response.
J Pharmacol Exp Ther February 1995 272:815-824
- Abstract
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- T Saeki,
- H Adachi,
- Y Takase,
- S Yoshitake,
- S Souda,
- and I Saito
A selective type V phosphodiesterase inhibitor, E4021, dilates porcine large coronary artery.
J Pharmacol Exp Ther February 1995 272:825-831
- Abstract
- Full Text (PDF)
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- A J Farré,
- M Colombo,
- I Alvarez,
- and G B Glavin
Some novel 5-hydroxytryptamine1A (5-HT1A) receptor agonists reduce gastric acid and pepsin secretion, reduce experimental gastric mucosal injury and enhance gastric mucus in rats.
J Pharmacol Exp Ther February 1995 272:832-837
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- T Oguchi,
- Y Furukawa,
- S Sawaki,
- M Kasama,
- and S Chiba
Are negative chronotropic and inotropic responses to adenosine differentiated at the receptor or postreceptor levels in isolated dog hearts?
J Pharmacol Exp Ther February 1995 272:838-844
- Abstract
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- E R Butelman,
- G Winger,
- G Zernig,
- and J H Woods
Butorphanol: characterization of agonist and antagonist effects in rhesus monkeys.
J Pharmacol Exp Ther February 1995 272:845-853
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- P J Blanchet,
- F Calon,
- J C Martel,
- P J Bédard,
- T Di Paolo,
- R R Walters,
- and M F Piercey
Continuous administration decreases and pulsatile administration increases behavioral sensitivity to a novel dopamine D2 agonist (U-91356A) in MPTP-exposed monkeys.
J Pharmacol Exp Ther February 1995 272:854-859
- Abstract
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- G M Farfel and
- L S Seiden
Role of hypothermia in the mechanism of protection against serotonergic toxicity. I. Experiments using 3,4-methylenedioxymethamphetamine, dizocilpine, CGS 19755 and NBQX.
J Pharmacol Exp Ther February 1995 272:860-867
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- G M Farfel and
- L S Seiden
Role of hypothermia in the mechanism of protection against serotonergic toxicity. II. Experiments with methamphetamine, p-chloroamphetamine, fenfluramine, dizocilpine and dextromethorphan.
J Pharmacol Exp Ther February 1995 272:868-875
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- W P Watson and
- H J Little
Identification of distinct components, with different time courses, of the changes in response to convulsive stimuli during ethanol withdrawal.
J Pharmacol Exp Ther February 1995 272:876-884
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- B Desta,
- M Nakashima,
- M Kirchengast,
- P M Vanhoutte,
- and C M Boulanger
Previous exposure to bradykinin unmasks an endothelium-dependent relaxation to the converting enzyme inhibitor trandolaprilat in isolated canine coronary arteries.
J Pharmacol Exp Ther February 1995 272:885-891
- Abstract
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- F Orzi,
- Y Sun,
- K Pettigrew,
- L Sokoloff,
- and C B Smith
Effects of acute and delayed effects of prior chronic cocaine administration on regional rates of cerebral protein synthesis in rats.
J Pharmacol Exp Ther February 1995 272:892-900
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- L J Porrino,
- H M Davies,
- and S R Childers
Behavioral and local cerebral metabolic effects of the novel tropane analog, 2 beta-propanoyl-3 beta-(4-tolyl)-tropane.
J Pharmacol Exp Ther February 1995 272:901-910
- Abstract
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- H Shinyama,
- H Nagai,
- T Kawamura,
- Y Narita,
- T Uchida,
- M Watanabe,
- and Y Kagitani
Protective effects of AE0047, a novel calcium antagonist, on incidence of stroke and hemodynamic disturbances in stroke-prone spontaneously hypertensive rats.
J Pharmacol Exp Ther February 1995 272:911-919
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- T Jolas,
- R Schreiber,
- A M Laporte,
- M Chastanet,
- J De Vry,
- T Glaser,
- J Adrien,
- and M Hamon
Are postsynaptic 5-HT1A receptors involved in the anxiolytic effects of 5-HT1A receptor agonists and in their inhibitory effects on the firing of serotonergic neurons in the rat?
J Pharmacol Exp Ther February 1995 272:920-929
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- R Botla,
- J R Spivey,
- H Aguilar,
- S F Bronk,
- and G J Gores
Ursodeoxycholate (UDCA) inhibits the mitochondrial membrane permeability transition induced by glycochenodeoxycholate: a mechanism of UDCA cytoprotection.
J Pharmacol Exp Ther February 1995 272:930-938
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- T Hiroi,
- N Ohishi,
- S Imaoka,
- Y Yabusaki,
- H Fukui,
- and Y Funae
Mepyramine, a histamine H1 receptor antagonist, inhibits the metabolic activity of rat and human P450 2D forms.
J Pharmacol Exp Ther February 1995 272:939-944
- Abstract
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- M S Finkel,
- C V Oddis,
- O H Mayer,
- B G Hattler,
- and R L Simmons
Nitric oxide synthase inhibitor alters papillary muscle force-frequency relationship.
J Pharmacol Exp Ther February 1995 272:945-952
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- M J Potchoiba,
- T G Tensfeldt,
- M R Nocerini,
- and B M Silber
A novel quantitative method for determining the biodistribution of radiolabeled xenobiotics using whole-body cryosectioning and autoradioluminography.
J Pharmacol Exp Ther February 1995 272:953-962
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- Full Text (PDF)

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J Pharmacol Exp Ther February 1995 272:962
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Mechanisms whereby macrophage-derived nitric oxide is involved in morphine-induced suppression of splenic lymphocyte proliferation.

Disposition of glutathione monoethyl ester in the rat: glutathione ester is a slow release form of extracellular glutathione.

Inhibition of dihydropyridine-sensitive Ca++ channels by ethanol in undifferentiated and nerve growth factor-treated PC12 cells: interaction with the inactivated state.

Effects of morphine on the pathogenesis of murine Friend retrovirus infection.

Comparative analysis of buprenorphine- and norbuprenorphine-induced analgesic effects based on pharmacokinetic-pharmacodynamic modeling.

Comparison of A4 and A2a binding sites in striatum and COS cells transfected with adenosine A2a receptors.

Role of prejunctional beta adrenoceptors in rat cardiac sympathetic neurotransmission.

Pharmacological characterization of nerve growth factor and/or monosialoganglioside GM1 effects on cholinergic markers in the adult lesioned brain.

Aquaretic effect of a potent, orally active, nonpeptide V2 antagonist in men.

Repeated acquisition of behavioral chains in squirrel monkeys: comparisons of a mu, kappa and delta opioid agonist.

Marijuana smoking: effects of varying puff volume and breathhold duration.

Abecarnil and alprazolam in humans: behavioral, subjective and reinforcing effects.

Comparison of the properties of agmatine and endogenous clonidine-displacing substance at imidazoline and alpha-2 adrenergic receptors.

Metabolism of allylbenzene 2',3'-oxide and estragole 2',3'-oxide in the isolated perfused rat liver.

[4-Dimethyl-3-t-butylcarboxyl-4,5-dihydro (1,5-a) quinoxaline] is a novel ligand to the picrotoxin site on GABAA receptors, and decreases single-channel open probability.

Therapeutic trial of reconstituted human high-density lipoprotein in a canine model of gram-negative septic shock.

In vivo receptor occupancy of the angiotensin II receptor by nonpeptide antagonists: relationship to in vitro affinities and in vivo pharmacologic potency.

Repression of angiotensin II and potentiation of bradykinin contribute to the synergistic effects of dual metalloprotease inhibition in heart failure.

Buprenorphine effects in methadone-maintained volunteers: effects at two hours after methadone.

Identification of a reversible component in the in vitro inhibition of rat hepatic cytochrome P450 2B1 by parathion.

The paralytic agent 2,4-dithiobiuret decreases open time of murine skeletal muscle acetylcholine receptor channels.

Chronic administration of a cocaine "binge" alters basal extracellular levels in male rats: an in vivo microdialysis study.

Cross-tolerance between kappa and mu opioid agonists in the guinea pig ileum myenteric plexus.

Kinetics of interactions of para-aminohippurate, probenecid, cysteine conjugates and N-acetyl cysteine conjugates with basolateral organic anion transporter in isolated rabbit proximal renal tubules.

Characterization of neuropeptide Y binding sites in rat brain membrane preparations using [125I][Leu31,Pro34]peptide YY and [125I]peptide YY3-36 as selective Y1 and Y2 radioligands.

Inhibition of amine oxidase activity by derivatives that recognize imidazoline I2 sites.

Separation of immunomodulatory and cholesterol-lowering activities of heterocyclic azaspiranes.

Low doses of anandamides inhibit pharmacological effects of delta 9-tetrahydrocannabinol.

Effects of typical and atypical antipsychotic drugs on response decrement patterns in rats.

Voltage-dependent inhibition of the ATP-sensitive K+ current by the class Ia agent disopyramide in cat ventricular myocytes.

Optimization of the potency and duration of action of N-hydroxyurea 5-lipoxygenase inhibitors.

Interaction between noradrenergic and histamine-containing neurons in the rat vas deferens.

Absorption-enhancing mechanism of sodium caprate and decanoylcarnitine in Caco-2 cells.

Selective inhibition by zatebradine and discrete parasympathetic stimulation of the positive chronotropic response to sympathetic stimulation in anesthetized dogs.

Pharmacological effects of GR138950, a novel angiotensin AT1 receptor antagonist.

Characterization of a behavioral model for peripherally evoked itch suggests platelet-activating factor as a potent pruritogen.

Tissue distribution of zinc-mesoporphyrin in rats: relationship to inhibition of heme oxygenase.

Characterization of diethyldithiocarbamate methyl ester sulfine as an intermediate in the bioactivation of disulfiram.

Profound decrease of mesolimbic dopaminergic neuronal activity in morphine withdrawn rats.

Pertussis toxin attenuates presynaptic inhibition of cholinergic but not nonadrenergic noncholinergic contraction in guinea pig airways.

Calcium channel blockers antagonize some of cocaine's cardiovascular effects, but fail to alter cocaine's behavioral effects.

In vivo effects of a novel thromboxane A2/prostaglandin H2 (TXA2/PGH2) partial agonist, (+)5(Z)-7-[3-endo-phenylsulfonylamino[2.2.1]- bicyclohept-2-exo-yl]-heptenoic acid [(+)-S-145], on vascular, platelet and cardiac function.

Suppression of interleukin-1 alpha production by protein kinase C activators in human vascular endothelial cells.

Interleukin-2 (IL-2) induces corticotropin-releasing factor (CRF) release from the amygdala and involves a nitric oxide-mediated signaling; comparison with the hypothalamic response.

A selective type V phosphodiesterase inhibitor, E4021, dilates porcine large coronary artery.

Some novel 5-hydroxytryptamine1A (5-HT1A) receptor agonists reduce gastric acid and pepsin secretion, reduce experimental gastric mucosal injury and enhance gastric mucus in rats.

Are negative chronotropic and inotropic responses to adenosine differentiated at the receptor or postreceptor levels in isolated dog hearts?

Butorphanol: characterization of agonist and antagonist effects in rhesus monkeys.

Continuous administration decreases and pulsatile administration increases behavioral sensitivity to a novel dopamine D2 agonist (U-91356A) in MPTP-exposed monkeys.

Role of hypothermia in the mechanism of protection against serotonergic toxicity. I. Experiments using 3,4-methylenedioxymethamphetamine, dizocilpine, CGS 19755 and NBQX.

Role of hypothermia in the mechanism of protection against serotonergic toxicity. II. Experiments with methamphetamine, p-chloroamphetamine, fenfluramine, dizocilpine and dextromethorphan.

Identification of distinct components, with different time courses, of the changes in response to convulsive stimuli during ethanol withdrawal.

Previous exposure to bradykinin unmasks an endothelium-dependent relaxation to the converting enzyme inhibitor trandolaprilat in isolated canine coronary arteries.

Effects of acute and delayed effects of prior chronic cocaine administration on regional rates of cerebral protein synthesis in rats.

Behavioral and local cerebral metabolic effects of the novel tropane analog, 2 beta-propanoyl-3 beta-(4-tolyl)-tropane.

Protective effects of AE0047, a novel calcium antagonist, on incidence of stroke and hemodynamic disturbances in stroke-prone spontaneously hypertensive rats.

Are postsynaptic 5-HT1A receptors involved in the anxiolytic effects of 5-HT1A receptor agonists and in their inhibitory effects on the firing of serotonergic neurons in the rat?

Ursodeoxycholate (UDCA) inhibits the mitochondrial membrane permeability transition induced by glycochenodeoxycholate: a mechanism of UDCA cytoprotection.

Mepyramine, a histamine H1 receptor antagonist, inhibits the metabolic activity of rat and human P450 2D forms.

Nitric oxide synthase inhibitor alters papillary muscle force-frequency relationship.

A novel quantitative method for determining the biodistribution of radiolabeled xenobiotics using whole-body cryosectioning and autoradioluminography.

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