L. Tang, R. D. Todd, A. Heller and K. L. O'Malley: Pharmacological and functional characterization of D2, D3 and D4 dopamine receptors in fibroblast and dopaminergic cell lines. J. Pharmacol. Exp. Ther. 268(1): 495-502, 1994.
The affinity constants of antagonists and agonists for transfected D2, D3 and D4 dopamine receptors in "Pharmacological and functional characterization of D2, D3 and D4 dopamine receptors in fibroblast and dopaminergic cell lines" by Tang et al., Vol. 268(1): 495-502 were incorrectly reported. Table 1 presents corrected values for D2, D3 and D4 receptor expressing cell lines. The latter were determined from newly transfected D4 receptor cell lines expressing 3-fold higher binding sites. The Ki of the high affinity state of the new D4 cell lines for quinpirole is 84.0 ± 12.3 nM (mean ± S.E.M., n = 3). As in the original publication, treatment of MN9D-D4 expressing cells with 10 µM quinpirole resulted in a 26.7 ± 4.4% (mean ± S.E.M., n = 3) decrease in cyclic AMP accumulation. We apologize for any inconvenience the errors in our manuscript may have caused. We note, however, that the conclusions of the paper remain unchanged. [SEE TABLE 1 IN SOURCE PDF].
- 1994 by The American Society for Pharmacology and Experimental Therapeutics