Table of Contents

July 1994; 270 (1)

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- B F Pan,
- A Dutt,
- and J A Nelson
Enhanced transepithelial flux of cimetidine by Madin-Darby canine kidney cells overexpressing human P-glycoprotein.
J Pharmacol Exp Ther July 1994 270:1-7
- Abstract
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- J Bralet,
- C Marie,
- C Mossiat,
- J M Lecomte,
- C Gros,
- and J C Schwartz
Effects of alatriopril, a mixed inhibitor of atriopeptidase and angiotensin I-converting enzyme, on cardiac hypertrophy and hormonal responses in rats with myocardial infarction. Comparison with captopril.
J Pharmacol Exp Ther July 1994 270:8-14
- Abstract
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- P J Bushnell,
- K L Kelly,
- and T R Ward
Repeated inhibition of cholinesterase by chlorpyrifos in rats: behavioral, neurochemical and pharmacological indices of tolerance.
J Pharmacol Exp Ther July 1994 270:15-25
- Abstract
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- H L McLeod,
- L Fang,
- X Luo,
- E P Scott,
- and W E Evans
Ethnic differences in erythrocyte catechol-O-methyltransferase activity in black and white Americans.
J Pharmacol Exp Ther July 1994 270:26-29
- Abstract
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- A Delaunois,
- P Gustin,
- and M Ansay
Modulation of the acetylcholine- and substance P-induced pulmonary edema by calcitonin gene-related peptide in the rabbit.
J Pharmacol Exp Ther July 1994 270:30-36
- Abstract
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- Y Miyamoto,
- W D Bowen,
- P S Portoghese,
- and A E Takemori
Lack of involvement of delta-1 opioid receptors in the development of physical dependence on morphine in mice.
J Pharmacol Exp Ther July 1994 270:37-39
- Abstract
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- T Tang,
- J G Kiang,
- and B M Cox
Opioids acting through delta receptors elicit a transient increase in the intracellular free calcium concentration in dorsal root ganglion-neuroblastoma hybrid ND8-47 cells.
J Pharmacol Exp Ther July 1994 270:40-46
- Abstract
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- K Derakhchan,
- P Pagé,
- C Lambert,
- and T Kus
Effects of procainamide and propafenone on the composition of the excitable gap in canine atrial reentry tachycardia.
J Pharmacol Exp Ther July 1994 270:47-54
- Abstract
- Full Text (PDF)
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- M Domae,
- K Yamada,
- T Inoue,
- M Satoh,
- and T Furukawa
Endothelins stimulate cyclic AMP accumulation in the isolated rat anterior pituitary gland: possible involvement of ETA receptor activation and prostaglandin E2 production.
J Pharmacol Exp Ther July 1994 270:55-60
- Abstract
- Full Text (PDF)
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- L G Aguayo and
- F C Pancetti
Ethanol modulation of the gamma-aminobutyric acidA- and glycine-activated Cl- current in cultured mouse neurons.
J Pharmacol Exp Ther July 1994 270:61-69
- Abstract
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- J R Atack,
- A M Prior,
- S R Fletcher,
- K Quirk,
- R McKernan,
- and C I Ragan
Effects of L-690,488, a prodrug of the bisphosphonate inositol monophosphatase inhibitor L-690,330, on phosphatidylinositol cycle markers.
J Pharmacol Exp Ther July 1994 270:70-76
- Abstract
- Full Text (PDF)
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- O Valverde,
- R Maldonado,
- M C Fournie-Zaluski,
- and B P Roques
Cholecystokinin B antagonists strongly potentiate antinociception mediated by endogenous enkephalins.
J Pharmacol Exp Ther July 1994 270:77-88
- Abstract
- Full Text (PDF)
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- E Romeo,
- D L Cheney,
- I Zivkovic,
- E Costa,
- and A Guidotti
Mitochondrial diazepam-binding inhibitor receptor complex agonists antagonize dizocilpine amnesia: putative role for allopregnanolone.
J Pharmacol Exp Ther July 1994 270:89-96
- Abstract
- Full Text (PDF)
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- M Johnson,
- P K Sonsalla,
- A A Letter,
- G R Hanson,
- and J W Gibb
Role of the 5-HT2 receptor in the methamphetamine-induced neurochemical alterations.
J Pharmacol Exp Ther July 1994 270:97-103
- Abstract
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- M Isosaki,
- N Minami,
- and T Nakashima
Pharmacological evidence for regulation of Na(+)-Ca++ exchange by Ca++/calmodulin-dependent protein kinase in isolated bovine adrenal medullary cells.
J Pharmacol Exp Ther July 1994 270:104-110
- Abstract
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- J T Gordon,
- E E Tomlinson,
- J Greenberg,
- and M B Dratman
An acute dose of desmethylimipramine inhibits brain uptake of [125I]3,3',5-triiodothyronine (T3) in thyroxine-induced but not T3-induced hyperthyroid rats: implications for tricyclic antidepressant therapy.
J Pharmacol Exp Ther July 1994 270:111-117
- Abstract
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- R F Covert,
- M D Schreiber,
- I R Tebbett,
- and L J Torgerson
Hemodynamic and cerebral blood flow effects of cocaine, cocaethylene and benzoylecgonine in conscious and anesthetized fetal lambs.
J Pharmacol Exp Ther July 1994 270:118-126
- Abstract
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- C S Aulakh,
- P Mazzola-Pomietto,
- K M Wozniak,
- J L Hill,
- and D L Murphy
Evidence that 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane-induced hypophagia and hyperthermia in rats is mediated by serotonin-2A receptors.
J Pharmacol Exp Ther July 1994 270:127-132
- Abstract
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- J M Masserano,
- D Venable,
- and R J Wyatt
Effects of chronic cocaine administration on [3H]dopamine uptake in the nucleus accumbens, striatum and frontal cortex of rats.
J Pharmacol Exp Ther July 1994 270:133-141
- Abstract
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- P J Winsauer,
- J F Verrees,
- K P O'Halloran,
- M A Bixler,
- and P C Mele
Effects of chlordiazepoxide, 8-OH-DPAT and ondansetron on radiation-induced decreases in food intake in rats.
J Pharmacol Exp Ther July 1994 270:142-149
- Abstract
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- I M Khan,
- P Taylor,
- and T L Yaksh
Cardiovascular and behavioral responses to nicotinic agents administered intrathecally.
J Pharmacol Exp Ther July 1994 270:150-158
- Abstract
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- I M Khan,
- T L Yaksh,
- and P Taylor
Ligand specificity of nicotinic acetylcholine receptors in rat spinal cord: studies with nicotine and cytisine.
J Pharmacol Exp Ther July 1994 270:159-166
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- A Berson,
- L Schmets,
- C Fisch,
- D Fau,
- C Wolf,
- B Fromenty,
- D Deschamps,
- and D Pessayre
Inhibition by nilutamide of the mitochondrial respiratory chain and ATP formation. Possible contribution to the adverse effects of this antiandrogen.
J Pharmacol Exp Ther July 1994 270:167-176
- Abstract
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- P L Prather,
- A W Tsai,
- and P Y Law
Mu and delta opioid receptor desensitization in undifferentiated human neuroblastoma SHSY5Y cells.
J Pharmacol Exp Ther July 1994 270:177-184
- Abstract
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- S L Durham,
- C M Hare,
- M R Angelastro,
- J P Burkhart,
- J R Koehl,
- A L Marquart,
- S Mehdi,
- N P Peet,
- and M J Janusz
Pharmacology of N-[4-(4-morpholinylcarbonyl)benzoyl]-L-valyl-N- [3,3,4,4,4-pentafluoro-1-(1-methylethyl)-2-oxobutyl]-L-prolinamide (MDL 101,146): a potent orally active inhibitor of human neutrophil elastase.
J Pharmacol Exp Ther July 1994 270:185-191
- Abstract
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- S P Gygi,
- J W Gibb,
- and G R Hanson
Differential effects of antipsychotic and psychotomimetic drugs on neurotensin systems of discrete extrapyramidal and limbic regions.
J Pharmacol Exp Ther July 1994 270:192-197
- Abstract
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- P A Scott,
- J M Chou,
- H Tang,
- and A Frazer
Differential induction of 5-HT1A-mediated responses in vivo by three chemically dissimilar 5-HT1A agonists.
J Pharmacol Exp Ther July 1994 270:198-208
- Abstract
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- S B Caine and
- G F Koob
Effects of dopamine D-1 and D-2 antagonists on cocaine self-administration under different schedules of reinforcement in the rat.
J Pharmacol Exp Ther July 1994 270:209-218
- Abstract
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- P B Smith,
- D R Compton,
- S P Welch,
- R K Razdan,
- R Mechoulam,
- and B R Martin
The pharmacological activity of anandamide, a putative endogenous cannabinoid, in mice.
J Pharmacol Exp Ther July 1994 270:219-227
- Abstract
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- M Clozel,
- V Breu,
- G A Gray,
- B Kalina,
- B M Löffler,
- K Burri,
- J M Cassal,
- G Hirth,
- M Müller,
- and W Neidhart
Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist.
J Pharmacol Exp Ther July 1994 270:228-235
- Abstract
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- P M Hellstrom,
- K S Murthy,
- J R Grider,
- and G M Makhlouf
Coexistence of three tachykinin receptors coupled to Ca++ signaling pathways in intestinal muscle cells.
J Pharmacol Exp Ther July 1994 270:236-243
- Abstract
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- Y X Wang,
- G D Clarke,
- M Sbacchi,
- G Petrone,
- and D P Brooks
Contribution of alpha-2 adrenoceptors to kappa opioid agonist-induced water diuresis in the rat.
J Pharmacol Exp Ther July 1994 270:244-249
- Abstract
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- D C Underwood,
- C J Kotzer,
- S Bochnowicz,
- R R Osborn,
- M A Luttmann,
- D W Hay,
- and T J Torphy
Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea pigs.
J Pharmacol Exp Ther July 1994 270:250-259
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- J W Ryan,
- F A Valido,
- M J Sequeira,
- A Y Chung,
- P Berryer,
- X L Chen,
- and J D Catravas
Estimation of rate constants for reactions of pulmonary microvascular angiotensin converting enzyme with an inhibitor and a substrate in vivo.
J Pharmacol Exp Ther July 1994 270:260-268
- Abstract
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- R J Altiere,
- D C Travis,
- J Roberts,
- and D C Thompson
Pharmacological characterization of muscarinic receptors mediating acetylcholine-induced contraction and relaxation in rabbit intrapulmonary arteries.
J Pharmacol Exp Ther July 1994 270:269-276
- Abstract
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- G Cuadra,
- K Summers,
- and E Giacobini
Cholinesterase inhibitor effects on neurotransmitters in rat cortex in vivo.
J Pharmacol Exp Ther July 1994 270:277-284
- Abstract
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- K S Pang,
- F Barker, 3rd,
- A J Schwab,
- and C A Goresky
Demonstration of rapid entry and a cellular binding space for salicylamide in perfused rat liver: a multiple indicator dilution study.
J Pharmacol Exp Ther July 1994 270:285-295
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- R B Rothman,
- J L Cadet,
- H C Akunne,
- M L Silverthorn,
- M H Baumann,
- F I Carroll,
- K C Rice,
- B R de Costa,
- J S Partilla,
- and J B Wang
Studies of the biogenic amine transporters. IV. Demonstration of a multiplicity of binding sites in rat caudate membranes for the cocaine analog [125I]RTI-55.
J Pharmacol Exp Ther July 1994 270:296-309
- Abstract
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- S P Arneric,
- J P Sullivan,
- C A Briggs,
- D Donnelly-Roberts,
- D J Anderson,
- J L Raszkiewicz,
- M L Hughes,
- E D Cadman,
- P Adams,
- and D S Garvey
(S)-3-methyl-5-(1-methyl-2-pyrrolidinyl) isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: I. In vitro characterization.
J Pharmacol Exp Ther July 1994 270:310-318
- Abstract
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- M W Decker,
- J D Brioni,
- J P Sullivan,
- M J Buckley,
- R J Radek,
- J L Raszkiewicz,
- C H Kang,
- D J Kim,
- W J Giardina,
- and J T Wasicak
(S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: II. In vivo characterization.
J Pharmacol Exp Ther July 1994 270:319-328
- Abstract
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- K Higaki,
- K Kadono,
- S Goto,
- and M Nakano
Stereoselective renal tubular secretion of an organic anion in the isolated perfused rat kidney.
J Pharmacol Exp Ther July 1994 270:329-335
- Abstract
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- W K Kim,
- R G Johnson,
- L T Izu,
- and R A Rabin
Chronic ethanol exposure inhibits ATP-stimulated but not KCl-stimulated dopamine release in PC 12 cells.
J Pharmacol Exp Ther July 1994 270:336-341
- Abstract
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- A Ohnishi,
- M Mihara,
- S Yasuda,
- Y Tomono,
- J Hasegawa,
- and T Tanaka
Aquaretic effect of the stable dynorphin-A analog E2078 in the human.
J Pharmacol Exp Ther July 1994 270:342-347
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- R W Nims,
- R M McClain,
- P S Manchand,
- P S Belica,
- P E Thomas,
- D W Mellini,
- W E Utermahlen, Jr,
- and R A Lubet
Comparative pharmacodynamics of hepatic cytochrome P450 2B induction by 5,5-diphenyl- and 5,5-diethyl-substituted barbiturates and hydantoins in the male F344/NCr rat.
J Pharmacol Exp Ther July 1994 270:348-355
- Abstract
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- K K Burkhart,
- D Beard,
- and M L Billingsley
Enhanced elimination of biotinylated antibodies by avidin-based hemoperfusion in rats.
J Pharmacol Exp Ther July 1994 270:356-361
- Abstract
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- S Y Sakurai,
- A Kume,
- D E Burdette,
- and R L Albin
Quantitative autoradiography of [3H]t-butylbicycloorthobenzoate binding to the gamma-aminobutyric acid receptorA complex.
J Pharmacol Exp Ther July 1994 270:362-370
- Abstract
- Full Text (PDF)
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- R P Lee and
- P G Forkert
In vitro biotransformation of 1,1-dichloroethylene by hepatic cytochrome P-450 2E1 in mice.
J Pharmacol Exp Ther July 1994 270:371-376
- Abstract
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- L C Knickle,
- R M Philpot,
- and J R Bend
N-aralkylated derivatives of 1-aminobenzotriazole are potent isozyme- and lung-selective mechanism-based inhibitors of guinea pig cytochrome P-450 in vivo.
J Pharmacol Exp Ther July 1994 270:377-385
- Abstract
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- O Pol,
- I Ferrer,
- and M M Puig
Diarrhea associated with intestinal inflammation increases the potency of mu and delta opioids on the inhibition of gastrointestinal transit in mice.
J Pharmacol Exp Ther July 1994 270:386-391
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- A S Salhab,
- C L DeVane,
- T Medrano,
- W C Buhi,
- I R Tebbett,
- and K T Shiverick
Fetoplacental growth and placental protein synthesis in rats after chronic maternal cocaine administration.
J Pharmacol Exp Ther July 1994 270:392-398
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- K M Metters,
- Y Gareau,
- A Lord,
- C Rochette,
- and N Sawyer
Characterization of specific binding sites for cysteinyl leukotrienes in sheep lung.
J Pharmacol Exp Ther July 1994 270:399-406
- Abstract
- Full Text (PDF)
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- D Wu and
- A I Cederbaum
Characterization of pyrazole and 4-methylpyrazole induction of cytochrome P4502E1 in rat kidney.
J Pharmacol Exp Ther July 1994 270:407-413
- Abstract
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- T Shimada,
- H Yamazaki,
- M Mimura,
- Y Inui,
- and F P Guengerich
Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
J Pharmacol Exp Ther July 1994 270:414-423
- Abstract
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- T P Abrahams,
- P J Hornby,
- K Chen,
- A M Dasilva,
- and R A Gillis
The non-NMDA subtype of excitatory amino acid receptor plays the major role in control of cardiovascular function by the subretrofacial nucleus in cats.
J Pharmacol Exp Ther July 1994 270:424-432
- Abstract
- Full Text (PDF)

Current Issue

November 2009, 331 (2)

Enhanced transepithelial flux of cimetidine by Madin-Darby canine kidney cells overexpressing human P-glycoprotein.

Effects of alatriopril, a mixed inhibitor of atriopeptidase and angiotensin I-converting enzyme, on cardiac hypertrophy and hormonal responses in rats with myocardial infarction. Comparison with captopril.

Repeated inhibition of cholinesterase by chlorpyrifos in rats: behavioral, neurochemical and pharmacological indices of tolerance.

Ethnic differences in erythrocyte catechol-O-methyltransferase activity in black and white Americans.

Modulation of the acetylcholine- and substance P-induced pulmonary edema by calcitonin gene-related peptide in the rabbit.

Lack of involvement of delta-1 opioid receptors in the development of physical dependence on morphine in mice.

Opioids acting through delta receptors elicit a transient increase in the intracellular free calcium concentration in dorsal root ganglion-neuroblastoma hybrid ND8-47 cells.

Effects of procainamide and propafenone on the composition of the excitable gap in canine atrial reentry tachycardia.

Endothelins stimulate cyclic AMP accumulation in the isolated rat anterior pituitary gland: possible involvement of ETA receptor activation and prostaglandin E2 production.

Ethanol modulation of the gamma-aminobutyric acidA- and glycine-activated Cl- current in cultured mouse neurons.

Effects of L-690,488, a prodrug of the bisphosphonate inositol monophosphatase inhibitor L-690,330, on phosphatidylinositol cycle markers.

Cholecystokinin B antagonists strongly potentiate antinociception mediated by endogenous enkephalins.

Mitochondrial diazepam-binding inhibitor receptor complex agonists antagonize dizocilpine amnesia: putative role for allopregnanolone.

Role of the 5-HT2 receptor in the methamphetamine-induced neurochemical alterations.

Pharmacological evidence for regulation of Na(+)-Ca++ exchange by Ca++/calmodulin-dependent protein kinase in isolated bovine adrenal medullary cells.

An acute dose of desmethylimipramine inhibits brain uptake of [125I]3,3',5-triiodothyronine (T3) in thyroxine-induced but not T3-induced hyperthyroid rats: implications for tricyclic antidepressant therapy.

Hemodynamic and cerebral blood flow effects of cocaine, cocaethylene and benzoylecgonine in conscious and anesthetized fetal lambs.

Evidence that 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane-induced hypophagia and hyperthermia in rats is mediated by serotonin-2A receptors.

Effects of chronic cocaine administration on [3H]dopamine uptake in the nucleus accumbens, striatum and frontal cortex of rats.

Effects of chlordiazepoxide, 8-OH-DPAT and ondansetron on radiation-induced decreases in food intake in rats.

Cardiovascular and behavioral responses to nicotinic agents administered intrathecally.

Ligand specificity of nicotinic acetylcholine receptors in rat spinal cord: studies with nicotine and cytisine.

Inhibition by nilutamide of the mitochondrial respiratory chain and ATP formation. Possible contribution to the adverse effects of this antiandrogen.

Mu and delta opioid receptor desensitization in undifferentiated human neuroblastoma SHSY5Y cells.

Pharmacology of N-[4-(4-morpholinylcarbonyl)benzoyl]-L-valyl-N- [3,3,4,4,4-pentafluoro-1-(1-methylethyl)-2-oxobutyl]-L-prolinamide (MDL 101,146): a potent orally active inhibitor of human neutrophil elastase.

Differential effects of antipsychotic and psychotomimetic drugs on neurotensin systems of discrete extrapyramidal and limbic regions.

Differential induction of 5-HT1A-mediated responses in vivo by three chemically dissimilar 5-HT1A agonists.

Effects of dopamine D-1 and D-2 antagonists on cocaine self-administration under different schedules of reinforcement in the rat.

The pharmacological activity of anandamide, a putative endogenous cannabinoid, in mice.

Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist.

Coexistence of three tachykinin receptors coupled to Ca++ signaling pathways in intestinal muscle cells.

Contribution of alpha-2 adrenoceptors to kappa opioid agonist-induced water diuresis in the rat.

Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea pigs.

Estimation of rate constants for reactions of pulmonary microvascular angiotensin converting enzyme with an inhibitor and a substrate in vivo.

Pharmacological characterization of muscarinic receptors mediating acetylcholine-induced contraction and relaxation in rabbit intrapulmonary arteries.

Cholinesterase inhibitor effects on neurotransmitters in rat cortex in vivo.

Demonstration of rapid entry and a cellular binding space for salicylamide in perfused rat liver: a multiple indicator dilution study.

Studies of the biogenic amine transporters. IV. Demonstration of a multiplicity of binding sites in rat caudate membranes for the cocaine analog [125I]RTI-55.

(S)-3-methyl-5-(1-methyl-2-pyrrolidinyl) isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: I. In vitro characterization.

(S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: II. In vivo characterization.

Stereoselective renal tubular secretion of an organic anion in the isolated perfused rat kidney.

Chronic ethanol exposure inhibits ATP-stimulated but not KCl-stimulated dopamine release in PC 12 cells.

Aquaretic effect of the stable dynorphin-A analog E2078 in the human.

Comparative pharmacodynamics of hepatic cytochrome P450 2B induction by 5,5-diphenyl- and 5,5-diethyl-substituted barbiturates and hydantoins in the male F344/NCr rat.

Enhanced elimination of biotinylated antibodies by avidin-based hemoperfusion in rats.

Quantitative autoradiography of [3H]t-butylbicycloorthobenzoate binding to the gamma-aminobutyric acid receptorA complex.

In vitro biotransformation of 1,1-dichloroethylene by hepatic cytochrome P-450 2E1 in mice.

N-aralkylated derivatives of 1-aminobenzotriazole are potent isozyme- and lung-selective mechanism-based inhibitors of guinea pig cytochrome P-450 in vivo.

Diarrhea associated with intestinal inflammation increases the potency of mu and delta opioids on the inhibition of gastrointestinal transit in mice.

Fetoplacental growth and placental protein synthesis in rats after chronic maternal cocaine administration.

Characterization of specific binding sites for cysteinyl leukotrienes in sheep lung.

Characterization of pyrazole and 4-methylpyrazole induction of cytochrome P4502E1 in rat kidney.

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

The non-NMDA subtype of excitatory amino acid receptor plays the major role in control of cardiovascular function by the subretrofacial nucleus in cats.

This Issue

Current Issue