Table of Contents

September 1993; 266 (3)

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- D W Snyder,
- C D Sommers,
- J L Bobbitt,
- and E D Mihelich
Characterization of the contractile effects of human recombinant nonpancreatic secretory phospholipase A2 (PLA2) and other PLA2s on guinea pig lung pleural strips.
J Pharmacol Exp Ther September 1993 266:1147-1155
- Abstract
- Full Text (PDF)
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- J D Vickers
U73122 affects the equilibria between the phosphoinositides as well as phospholipase C activity in unstimulated and thrombin-stimulated human and rabbit platelets.
J Pharmacol Exp Ther September 1993 266:1156-1163
- Abstract
- Full Text (PDF)
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- W S Enochs,
- M J Nilges,
- and H M Swartz
The minocycline-induced thyroid pigment and several synthetic models: identification and characterization by electron paramagnetic resonance spectroscopy.
J Pharmacol Exp Ther September 1993 266:1164-1176
- Abstract
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- L T Meltzer,
- B W Caprathe,
- C L Christoffersen,
- A E Corbin,
- J C Jaen,
- F W Ninteman,
- T A Pugsley,
- K A Serpa,
- Y H Shih,
- and S Z Whetzel
Pharmacological profile of the dopamine partial agonist, (+/-)-PD 128483 and its enantiomers.
J Pharmacol Exp Ther September 1993 266:1177-1189
- Abstract
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- K Yokotani,
- Y Okuma,
- K Nakamura,
- and Y Osumi
Release of endogenous acetylcholine from a vascularly perfused rat stomach in vitro; inhibition by M3 muscarinic autoreceptors and alpha-2 adrenoceptors.
J Pharmacol Exp Ther September 1993 266:1190-1195
- Abstract
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- Z Abolfathi,
- C Fiset,
- M Gilbert,
- K Moerike,
- P M Bélanger,
- and J Turgeon
Role of polymorphic debrisoquin 4-hydroxylase activity in the stereoselective disposition of mexiletine in humans.
J Pharmacol Exp Ther September 1993 266:1196-1201
- Abstract
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- Y Hattori,
- H Nakaya,
- J Nishihira,
- and M Kanno
A dual-component positive inotropic effect of endothelin-1 in guinea pig left atria: a role of protein kinase C.
J Pharmacol Exp Ther September 1993 266:1202-1212
- Abstract
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- A Doble,
- T Canton,
- S Dreisler,
- O Piot,
- A Boireau,
- J M Stutzmann,
- M C Bardone,
- J Rataud,
- M Roux,
- and G Roussel
RP 59037 and RP 60503: anxiolytic cyclopyrrolone derivatives with low sedative potential. interaction with the gamma-aminobutyric acidA/benzodiazepine receptor complex and behavioral effects in the rodent.
J Pharmacol Exp Ther September 1993 266:1213-1226
- Abstract
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- L Zhang,
- J L Weiner,
- and P L Carlen
Potentiation of gamma-aminobutyric acid type A receptor-mediated synaptic currents by pentobarbital and diazepam in immature hippocampal CA1 neurons.
J Pharmacol Exp Ther September 1993 266:1227-1235
- Abstract
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- D P Devine,
- P Leone,
- D Pocock,
- and R A Wise
Differential involvement of ventral tegmental mu, delta and kappa opioid receptors in modulation of basal mesolimbic dopamine release: in vivo microdialysis studies.
J Pharmacol Exp Ther September 1993 266:1236-1246
- Abstract
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- J X Liu,
- K Tanonaka,
- Y Ohtsuka,
- Y Sakai,
- and S Takeo
Improvement of ischemia/reperfusion-induced contractile dysfunction of perfused hearts by class Ic antiarrhythmic agents.
J Pharmacol Exp Ther September 1993 266:1247-1254
- Abstract
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- J Fioramonti,
- C Dupuy,
- J Dupuy,
- and L Bueno
The mycotoxin, deoxynivalenol, delays gastric emptying through serotonin-3 receptors in rodents.
J Pharmacol Exp Ther September 1993 266:1255-1260
- Abstract
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- J U Adams,
- R J Tallarida,
- E B Geller,
- and M W Adler
Isobolographic superadditivity between delta and mu opioid agonists in the rat depends on the ratio of compounds, the mu agonist and the analgesic assay used.
J Pharmacol Exp Ther September 1993 266:1261-1267
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- M J Marks,
- S R Grady,
- and A C Collins
Downregulation of nicotinic receptor function after chronic nicotine infusion.
J Pharmacol Exp Ther September 1993 266:1268-1276
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- T Chikai,
- R Oishi,
- and K Saeki
Microdialysis study of the effects of sedative drugs on extracellular histamine in the striatum of freely moving rats.
J Pharmacol Exp Ther September 1993 266:1277-1281
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- E Dicker and
- A I Cederbaum
Requirement for iron for the production of hydroxyl radicals by rat liver quinone reductase.
J Pharmacol Exp Ther September 1993 266:1282-1290
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- R C Falcone,
- S J Hubbs,
- J D Vanderloo,
- J C Prosser,
- J Little,
- B Gomes,
- D Aharony,
- and R D Krell
Characterization of bradykinin receptors in guinea pig gall bladder.
J Pharmacol Exp Ther September 1993 266:1291-1299
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- T Kimura,
- T Miyaoka,
- P A Saunders,
- M L Baker,
- A S Hume,
- I Yamamoto,
- and I K Ho
Induction of tolerance to and physical dependence on pentobarbital continuous intracerebroventricular administration.
J Pharmacol Exp Ther September 1993 266:1300-1305
- Abstract
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- A Choquet,
- R Magous,
- and J P Bali
Gastric mucosal endogenous prostanoids are involved in the cellular regulation of acid secretion from isolated parietal cells.
J Pharmacol Exp Ther September 1993 266:1306-1311
- Abstract
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- J de Jong,
- P R Schoofs,
- A M Snabilié,
- A Bast,
- and W J van der Vijgh
The role of biotransformation in anthracycline-induced cardiotoxicity in mice.
J Pharmacol Exp Ther September 1993 266:1312-1320
- Abstract
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- W F Oellerich and
- K U Malik
Neuropeptide Y modulates the vascular response to periarterial nerve stimulation primarily by a postjunctional action in the isolated perfused rat kidney.
J Pharmacol Exp Ther September 1993 266:1321-1329
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- M I Damaj,
- S P Welch,
- and B R Martin
Involvement of calcium and L-type channels in nicotine-induced antinociception.
J Pharmacol Exp Ther September 1993 266:1330-1338
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- D C Yang,
- B Goldstin,
- A E Moormann,
- D L Flynn,
- and G W Gullikson
SC-53606, a potent and selective antagonist of 5-hydroxytryptamine4 receptors in isolated rat esophageal tunica muscularis mucosae.
J Pharmacol Exp Ther September 1993 266:1339-1347
- Abstract
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- G S Friedrichs,
- L Chi,
- S C Black,
- P J Manley,
- J Y Oh,
- and B R Lucchesi
Antifibrillatory effects of ibutilide in the rabbit isolated heart: mediation via ATP-dependent potassium channels.
J Pharmacol Exp Ther September 1993 266:1348-1354
- Abstract
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- S S Negus,
- E R Butelman,
- Y Al,
- and J H Woods
Prostaglandin E2-induced thermal hyperalgesia and its reversal by morphine in the warm-water tail-withdrawal procedure in rhesus monkeys.
J Pharmacol Exp Ther September 1993 266:1355-1363
- Abstract
- Full Text (PDF)
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- M Farré,
- R de la Torre,
- M Llorente,
- X Lamas,
- B Ugena,
- J Segura,
- and J Camí
Alcohol and cocaine interactions in humans.
J Pharmacol Exp Ther September 1993 266:1364-1373
- Abstract
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- C A Stockmeier,
- J J DiCarlo,
- Y Zhang,
- P Thompson,
- and H Y Meltzer
Characterization of typical and atypical antipsychotic drugs based on in vivo occupancy of serotonin2 and dopamine2 receptors.
J Pharmacol Exp Ther September 1993 266:1374-1384
- Abstract
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- C Alcaraz,
- M V Milanés,
- and M L Vargas
Chronic kappa opioid receptor antagonism produces supersensitivity to U-50,488H at the hypothalamo-pituitary-adrenocortical (HPA) axis level.
J Pharmacol Exp Ther September 1993 266:1385-1389
- Abstract
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- A C Collins,
- E Romm,
- S Selvaag,
- S Turner,
- and M J Marks
A comparison of the effects of chronic nicotine infusion on tolerance to nicotine and cross-tolerance to ethanol in long- and short-sleep mice.
J Pharmacol Exp Ther September 1993 266:1390-1397
- Abstract
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- C M de Fiebre and
- A C Collins
A comparison of the development of tolerance to ethanol and cross-tolerance to nicotine after chronic ethanol treatment in long- and short-sleep mice.
J Pharmacol Exp Ther September 1993 266:1398-1406
- Abstract
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- F L Smith,
- S P Welch,
- D S Dombrowski,
- and W L Dewey
The role of endogenous opioids as mediators of the hypothermic effects of intrathecally administered calcium and calcitonin gene-related peptide in mice.
J Pharmacol Exp Ther September 1993 266:1407-1415
- Abstract
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- T Okamura,
- M Enokibori,
- and N Toda
Neurogenic and non-neurogenic relaxations caused by nicotine in isolated dog superficial temporal artery.
J Pharmacol Exp Ther September 1993 266:1416-1421
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- C A Sargent,
- G J Grover,
- M J Antonaccio,
- and J R McCullough
The cardioprotective, vasorelaxant and electrophysiological profile of the large conductance calcium-activated potassium channel opener NS-004.
J Pharmacol Exp Ther September 1993 266:1422-1429
- Abstract
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- L F Tseng and
- K A Collins
Spinal involvement of both dynorphin A and Met-enkephalin in the antinociception induced by intracerebroventricularly administered bremazocine but not morphine in the mouse.
J Pharmacol Exp Ther September 1993 266:1430-1438
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- M B McClurkan,
- J L Valentine,
- L Arnold,
- and S M Owens
Disposition of a monoclonal anti-phencyclidine Fab fragment of immunoglobulin G in rats.
J Pharmacol Exp Ther September 1993 266:1439-1445
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- H J Carlisle and
- M J Stock
Thermoregulatory effects of beta adrenoceptors: effects of selective agonists and the interaction of antagonists with isoproterenol and BRL-35135 in the cold.
J Pharmacol Exp Ther September 1993 266:1446-1453
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- M D Meglasson,
- J M Wilson,
- J H Yu,
- D D Robinson,
- B M Wyse,
- and C J de Souza
Antihyperglycemic action of guanidinoalkanoic acids: 3-guanidinopropionic acid ameliorates hyperglycemia in diabetic KKAy and C57BL6Job/ob mice and increases glucose disappearance in rhesus monkeys.
J Pharmacol Exp Ther September 1993 266:1454-1462
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- V Casadó,
- G Allende,
- J Mallol,
- R Franco,
- C Lluis,
- and E I Canela
Thermodynamic analysis of agonist and antagonist binding to membrane-bound and solubilized A1 adenosine receptors.
J Pharmacol Exp Ther September 1993 266:1463-1474
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- M E Wylam,
- R W Samsel,
- P T Schumacker,
- and J G Umans
Extracellular calcium and intrinsic tone in the human umbilical artery.
J Pharmacol Exp Ther September 1993 266:1475-1481
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- C L Cowan,
- J J Palacino,
- S Najibi,
- and R A Cohen
Potassium channel-mediated relaxation to acetylcholine in rabbit arteries.
J Pharmacol Exp Ther September 1993 266:1482-1489
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- M Malcangio and
- N G Bowery
Gamma-aminobutyric acidB, but not gamma-aminobutyric acidA receptor activation, inhibits electrically evoked substance P-like immunoreactivity release from the rat spinal cord in vitro.
J Pharmacol Exp Ther September 1993 266:1490-1496
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- C M Venturini,
- R M Palmer,
- and S Moncada
Vascular smooth muscle contains a depletable store of a vasodilator which is light-activated and restored by donors of nitric oxide.
J Pharmacol Exp Ther September 1993 266:1497-1500
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- D R Ramjit,
- J J Lynch, Jr,
- G R Sitko,
- M J Mellott,
- M A Holahan,
- I I Stabilito,
- M T Stranieri,
- G Zhang,
- R J Lynch,
- and P D Manno
Antithrombotic effects of MK-0852, a platelet fibrinogen receptor antagonist, in canine models of thrombosis.
J Pharmacol Exp Ther September 1993 266:1501-1511
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- K Takeuchi,
- T Ohuchi,
- H Miyake,
- and S Okabe
Stimulation by nitric oxide synthase inhibitors of gastric and duodenal HCO3- secretion in rats.
J Pharmacol Exp Ther September 1993 266:1512-1519
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- P M Schiffers,
- H A van der Heijden,
- G E Fazzi,
- H A Boudier,
- and J G De Mey
Tonic tone in arteries exposed continuously to angiotensin II in vitro.
J Pharmacol Exp Ther September 1993 266:1520-1527
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- E Patterson
Coronary vascular injury following transient coronary artery occlusion: prevention by pretreatment with deferoxamine, dimethylthiourea and N-2-mercaptoproprionyl glycine.
J Pharmacol Exp Ther September 1993 266:1528-1535
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- R C Carneiro,
- E P Pereira,
- J Cipolla-Neto,
- and R P Markus
Age-related changes in melatonin modulation of sympathetic neurotransmission.
J Pharmacol Exp Ther September 1993 266:1536-1540
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- M Watanabe,
- D Rominger,
- S D Hurt,
- E B De Souza,
- and S W Tam
[3H]1-(cyclopropylmethyl)-4-(2-(4-fluorophenyl)-2-oxoethyl) piperidine HBr (DuP 734). A selective ligand for sigma receptors in mouse brain in vivo.
J Pharmacol Exp Ther September 1993 266:1541-1548
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- R Fern,
- B R Ransom,
- P K Stys,
- and S G Waxman
Pharmacological protection of CNS white matter during anoxia: actions of phenytoin, carbamazepine and diazepam.
J Pharmacol Exp Ther September 1993 266:1549-1555
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- R L Kline and
- D F Cechetto
Renal effects of rilmenidine in anesthetized rats: importance of renal nerves.
J Pharmacol Exp Ther September 1993 266:1556-1562
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- G B Kaplan,
- D J Greenblatt,
- M A Kent,
- and M M Cotreau-Bibbo
Caffeine treatment and withdrawal in mice: relationships between dosage, concentrations, locomotor activity and A1 adenosine receptor binding.
J Pharmacol Exp Ther September 1993 266:1563-1572
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- P T Brackley,
- D R Bell,
- S K Choi,
- K Nakanishi,
- and P N Usherwood
Selective antagonism of native and cloned kainate and NMDA receptors by polyamine-containing toxins.
J Pharmacol Exp Ther September 1993 266:1573-1580
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- K Yasoshima,
- F Yamasaki,
- T Shinkawa,
- K Yoshitomi,
- and M Imai
Effect of a novel diuretic, 7-chloro-2,3-dihydro-1-(2-methylbenzoyl)-4(IH)-quinolinone-4-oxime-o- sulfonic acid, potassium salt (M17055) on Na+ and K+ transport in the distal nephron segments.
J Pharmacol Exp Ther September 1993 266:1581-1588
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- F Yamasaki,
- K Yoshitomi,
- T Shinkawa,
- and M Imai
Effects of amiloride and a novel diuretic, 7-chloro-2,3-dihydro-1-(2-methylbenzoyl)-4(1H)-quinolinone-4-oxime-o-su lfonic acid, potassium salt (M17055), on calcium transport in the rabbit connecting tubule.
J Pharmacol Exp Ther September 1993 266:1589-1593
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- A Ray and
- K M MacLeod
A pharmacological investigation of the contribution of muscarinic receptor-linked potassium channels to the reversal by carbachol of positive inotropic responses of rabbit left atrium to cyclic AMP-generating agents.
J Pharmacol Exp Ther September 1993 266:1594-1601
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- C Alcaraz,
- M L Vargas,
- T Fuente,
- and M V Milanés
Chronic naloxone treatment induces supersensitivity to a mu but not to a kappa agonist at the hypothalamus-pituitary-adrenocortical axis level.
J Pharmacol Exp Ther September 1993 266:1602-1606
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- J Liu,
- Y Liu,
- C Madhu,
- and C D Klaassen
Protective effects of oleanolic acid on acetaminophen-induced hepatotoxicity in mice.
J Pharmacol Exp Ther September 1993 266:1607-1613
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- N Okamura,
- M Hirai,
- Y Tanigawara,
- K Tanaka,
- M Yasuhara,
- K Ueda,
- T Komano,
- and R Hori
Digoxin-cyclosporin A interaction: modulation of the multidrug transporter P-glycoprotein in the kidney.
J Pharmacol Exp Ther September 1993 266:1614-1619
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- R Hori,
- N Okamura,
- T Aiba,
- and Y Tanigawara
Role of P-glycoprotein in renal tubular secretion of digoxin in the isolated perfused rat kidney.
J Pharmacol Exp Ther September 1993 266:1620-1625
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- M F Hare,
- K M McGinnis,
- and W D Atchison
Methylmercury increases intracellular concentrations of Ca++ and heavy metals in NG108-15 cells.
J Pharmacol Exp Ther September 1993 266:1626-1635
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- N J Reynolds,
- G J Fisher,
- C E Griffiths,
- A Tavakkol,
- H S Talwar,
- P E Rowse,
- T A Hamilton,
- and J J Voorhees
Retinoic acid metabolites exhibit biological activity in human keratinocytes, mouse melanoma cells and hairless mouse skin in vivo.
J Pharmacol Exp Ther September 1993 266:1636-1642
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- M Samoszuk,
- D Ehrlich,
- and E Ramzi
Preclinical safety studies of glucose oxidase.
J Pharmacol Exp Ther September 1993 266:1643-1648
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- S J Weber,
- T J Abbruscato,
- E A Brownson,
- A W Lipkowski,
- R Polt,
- A Misicka,
- R C Haaseth,
- H Bartosz,
- V J Hruby,
- and T P Davis
Assessment of an in vitro blood-brain barrier model using several [Met5]enkephalin opioid analogs.
J Pharmacol Exp Ther September 1993 266:1649-1655
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- M P Waalkes,
- B A Diwan,
- C M Weghorst,
- J M Ward,
- J M Rice,
- M G Cherian,
- and R A Goyer
Further evidence of the tumor-suppressive effects of cadmium in the B6C3F1 mouse liver and lung: late stage vulnerability of tumors to cadmium and the role of metallothionein.
J Pharmacol Exp Ther September 1993 266:1656-1663
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- M Kawamura,
- Z Terashita,
- H Okuda,
- Y Imura,
- A Shino,
- M Nakao,
- and K Nishikawa
TCV-116, a novel angiotensin II receptor antagonist, prevents intimal thickening and impairment of vascular function after carotid injury in rats.
J Pharmacol Exp Ther September 1993 266:1664-1669
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- S A Elgebaly,
- M E Allam,
- S Houser,
- F Hashmi,
- F Forouhar,
- and D Miano
Cyclocreatine inhibits neutrophil accumulation in the myocardium of a canine model of coronary artery occlusion and reperfusion.
J Pharmacol Exp Ther September 1993 266:1670-1677
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- D M Lawrence and
- J M Bidlack
The kappa opioid receptor expressed on the mouse R1.1 thymoma cell line is coupled to adenylyl cyclase through a pertussis toxin-sensitive guanine nucleotide-binding regulatory protein.
J Pharmacol Exp Ther September 1993 266:1678-1683
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- M A Osinski and
- P Bass
Chronic denervation of rat jejunum results in cholinergic supersensitivity due to reduction of cholinesterase activity.
J Pharmacol Exp Ther September 1993 266:1684-1690
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- C J Dunn,
- L A Galinet,
- H Wu,
- R A Nugent,
- S T Schlachter,
- N D Staite,
- D G Aspar,
- G A Elliott,
- N A Essani,
- and N A Rohloff
Demonstration of novel anti-arthritic and anti-inflammatory effects of diphosphonates.
J Pharmacol Exp Ther September 1993 266:1691-1698
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- S Kojima,
- T Icho,
- M Hayashi,
- Y Kajiwara,
- K Kitabatake,
- and K Kubota
Inhibitory effect of 5,6,7,8-tetrahydroneopterin on adriamycin-induced cardiotoxicity.
J Pharmacol Exp Ther September 1993 266:1699-1704
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- Z Nie,
- X Yuan,
- S G Madamba,
- and G R Siggins
Ethanol decreases glutamatergic synaptic transmission in rat nucleus accumbens in vitro: naloxone reversal.
J Pharmacol Exp Ther September 1993 266:1705-1712
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- D J Cole,
- P M Patel,
- L Reynolds,
- J C Drummond,
- and S Marcantonio
Temporary focal cerebral ischemia in spontaneously hypertensive rats: the effect of ibuprofen on infarct volume.
J Pharmacol Exp Ther September 1993 266:1713-1717
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- A V Miller-Wing,
- J M Hanesworth,
- M F Sardinia,
- K L Hall,
- J W Wright,
- R C Speth,
- K L Grove,
- and J W Harding
Central angiotensin IV binding sites: distribution and specificity in guinea pig brain.
J Pharmacol Exp Ther September 1993 266:1718-1726
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Current Issue

November 2009, 331 (2)

Characterization of the contractile effects of human recombinant nonpancreatic secretory phospholipase A2 (PLA2) and other PLA2s on guinea pig lung pleural strips.

U73122 affects the equilibria between the phosphoinositides as well as phospholipase C activity in unstimulated and thrombin-stimulated human and rabbit platelets.

The minocycline-induced thyroid pigment and several synthetic models: identification and characterization by electron paramagnetic resonance spectroscopy.

Pharmacological profile of the dopamine partial agonist, (+/-)-PD 128483 and its enantiomers.

Release of endogenous acetylcholine from a vascularly perfused rat stomach in vitro; inhibition by M3 muscarinic autoreceptors and alpha-2 adrenoceptors.

Role of polymorphic debrisoquin 4-hydroxylase activity in the stereoselective disposition of mexiletine in humans.

A dual-component positive inotropic effect of endothelin-1 in guinea pig left atria: a role of protein kinase C.

RP 59037 and RP 60503: anxiolytic cyclopyrrolone derivatives with low sedative potential. interaction with the gamma-aminobutyric acidA/benzodiazepine receptor complex and behavioral effects in the rodent.

Potentiation of gamma-aminobutyric acid type A receptor-mediated synaptic currents by pentobarbital and diazepam in immature hippocampal CA1 neurons.

Differential involvement of ventral tegmental mu, delta and kappa opioid receptors in modulation of basal mesolimbic dopamine release: in vivo microdialysis studies.

Improvement of ischemia/reperfusion-induced contractile dysfunction of perfused hearts by class Ic antiarrhythmic agents.

The mycotoxin, deoxynivalenol, delays gastric emptying through serotonin-3 receptors in rodents.

Isobolographic superadditivity between delta and mu opioid agonists in the rat depends on the ratio of compounds, the mu agonist and the analgesic assay used.

Downregulation of nicotinic receptor function after chronic nicotine infusion.

Microdialysis study of the effects of sedative drugs on extracellular histamine in the striatum of freely moving rats.

Requirement for iron for the production of hydroxyl radicals by rat liver quinone reductase.

Characterization of bradykinin receptors in guinea pig gall bladder.

Induction of tolerance to and physical dependence on pentobarbital continuous intracerebroventricular administration.

Gastric mucosal endogenous prostanoids are involved in the cellular regulation of acid secretion from isolated parietal cells.

The role of biotransformation in anthracycline-induced cardiotoxicity in mice.

Neuropeptide Y modulates the vascular response to periarterial nerve stimulation primarily by a postjunctional action in the isolated perfused rat kidney.

Involvement of calcium and L-type channels in nicotine-induced antinociception.

SC-53606, a potent and selective antagonist of 5-hydroxytryptamine4 receptors in isolated rat esophageal tunica muscularis mucosae.

Antifibrillatory effects of ibutilide in the rabbit isolated heart: mediation via ATP-dependent potassium channels.

Prostaglandin E2-induced thermal hyperalgesia and its reversal by morphine in the warm-water tail-withdrawal procedure in rhesus monkeys.

Alcohol and cocaine interactions in humans.

Characterization of typical and atypical antipsychotic drugs based on in vivo occupancy of serotonin2 and dopamine2 receptors.

Chronic kappa opioid receptor antagonism produces supersensitivity to U-50,488H at the hypothalamo-pituitary-adrenocortical (HPA) axis level.

A comparison of the effects of chronic nicotine infusion on tolerance to nicotine and cross-tolerance to ethanol in long- and short-sleep mice.

A comparison of the development of tolerance to ethanol and cross-tolerance to nicotine after chronic ethanol treatment in long- and short-sleep mice.

The role of endogenous opioids as mediators of the hypothermic effects of intrathecally administered calcium and calcitonin gene-related peptide in mice.

Neurogenic and non-neurogenic relaxations caused by nicotine in isolated dog superficial temporal artery.

The cardioprotective, vasorelaxant and electrophysiological profile of the large conductance calcium-activated potassium channel opener NS-004.

Spinal involvement of both dynorphin A and Met-enkephalin in the antinociception induced by intracerebroventricularly administered bremazocine but not morphine in the mouse.

Disposition of a monoclonal anti-phencyclidine Fab fragment of immunoglobulin G in rats.

Thermoregulatory effects of beta adrenoceptors: effects of selective agonists and the interaction of antagonists with isoproterenol and BRL-35135 in the cold.

Antihyperglycemic action of guanidinoalkanoic acids: 3-guanidinopropionic acid ameliorates hyperglycemia in diabetic KKAy and C57BL6Job/ob mice and increases glucose disappearance in rhesus monkeys.

Thermodynamic analysis of agonist and antagonist binding to membrane-bound and solubilized A1 adenosine receptors.

Extracellular calcium and intrinsic tone in the human umbilical artery.

Potassium channel-mediated relaxation to acetylcholine in rabbit arteries.

Gamma-aminobutyric acidB, but not gamma-aminobutyric acidA receptor activation, inhibits electrically evoked substance P-like immunoreactivity release from the rat spinal cord in vitro.

Vascular smooth muscle contains a depletable store of a vasodilator which is light-activated and restored by donors of nitric oxide.

Antithrombotic effects of MK-0852, a platelet fibrinogen receptor antagonist, in canine models of thrombosis.

Stimulation by nitric oxide synthase inhibitors of gastric and duodenal HCO3- secretion in rats.

Tonic tone in arteries exposed continuously to angiotensin II in vitro.

Coronary vascular injury following transient coronary artery occlusion: prevention by pretreatment with deferoxamine, dimethylthiourea and N-2-mercaptoproprionyl glycine.

Age-related changes in melatonin modulation of sympathetic neurotransmission.

[3H]1-(cyclopropylmethyl)-4-(2-(4-fluorophenyl)-2-oxoethyl) piperidine HBr (DuP 734). A selective ligand for sigma receptors in mouse brain in vivo.

Pharmacological protection of CNS white matter during anoxia: actions of phenytoin, carbamazepine and diazepam.

Renal effects of rilmenidine in anesthetized rats: importance of renal nerves.

Caffeine treatment and withdrawal in mice: relationships between dosage, concentrations, locomotor activity and A1 adenosine receptor binding.

Selective antagonism of native and cloned kainate and NMDA receptors by polyamine-containing toxins.

Effect of a novel diuretic, 7-chloro-2,3-dihydro-1-(2-methylbenzoyl)-4(IH)-quinolinone-4-oxime-o- sulfonic acid, potassium salt (M17055) on Na+ and K+ transport in the distal nephron segments.

Effects of amiloride and a novel diuretic, 7-chloro-2,3-dihydro-1-(2-methylbenzoyl)-4(1H)-quinolinone-4-oxime-o-su lfonic acid, potassium salt (M17055), on calcium transport in the rabbit connecting tubule.

A pharmacological investigation of the contribution of muscarinic receptor-linked potassium channels to the reversal by carbachol of positive inotropic responses of rabbit left atrium to cyclic AMP-generating agents.

Chronic naloxone treatment induces supersensitivity to a mu but not to a kappa agonist at the hypothalamus-pituitary-adrenocortical axis level.

Protective effects of oleanolic acid on acetaminophen-induced hepatotoxicity in mice.

Digoxin-cyclosporin A interaction: modulation of the multidrug transporter P-glycoprotein in the kidney.

Role of P-glycoprotein in renal tubular secretion of digoxin in the isolated perfused rat kidney.

Methylmercury increases intracellular concentrations of Ca++ and heavy metals in NG108-15 cells.

Retinoic acid metabolites exhibit biological activity in human keratinocytes, mouse melanoma cells and hairless mouse skin in vivo.

Preclinical safety studies of glucose oxidase.

Assessment of an in vitro blood-brain barrier model using several [Met5]enkephalin opioid analogs.

Further evidence of the tumor-suppressive effects of cadmium in the B6C3F1 mouse liver and lung: late stage vulnerability of tumors to cadmium and the role of metallothionein.

TCV-116, a novel angiotensin II receptor antagonist, prevents intimal thickening and impairment of vascular function after carotid injury in rats.

Cyclocreatine inhibits neutrophil accumulation in the myocardium of a canine model of coronary artery occlusion and reperfusion.

The kappa opioid receptor expressed on the mouse R1.1 thymoma cell line is coupled to adenylyl cyclase through a pertussis toxin-sensitive guanine nucleotide-binding regulatory protein.

Chronic denervation of rat jejunum results in cholinergic supersensitivity due to reduction of cholinesterase activity.

Demonstration of novel anti-arthritic and anti-inflammatory effects of diphosphonates.

Inhibitory effect of 5,6,7,8-tetrahydroneopterin on adriamycin-induced cardiotoxicity.

Ethanol decreases glutamatergic synaptic transmission in rat nucleus accumbens in vitro: naloxone reversal.

Temporary focal cerebral ischemia in spontaneously hypertensive rats: the effect of ibuprofen on infarct volume.

Central angiotensin IV binding sites: distribution and specificity in guinea pig brain.

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