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Table of Contents
July 1993; 266 (1)
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C S Cook
,
C Hauswald
,
J A Oppermann
,
and
G L Schoenhard
Involvement of cytochrome P-450IIIA in metabolism of potassium canrenoate to an epoxide: mechanism of inhibition of the epoxide formation by spironolactone and its sulfur-containing metabolite.
J Pharmacol Exp Ther
July 1993
266
:
1
-
7
Abstract
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C B Baron
,
J Pompeo
,
D Blackman
,
and
R F Coburn
Common phosphatidylinositol 4,5-bisphosphate pools are involved in carbachol and serotonin activation of tracheal smooth muscle.
J Pharmacol Exp Ther
July 1993
266
:
8
-
15
Abstract
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R C Gupta
,
J Neumann
,
and
A M Watanabe
Comparison of adenosine and muscarinic receptor-mediated effects on protein phosphatase inhibitor-1 activity in the heart.
J Pharmacol Exp Ther
July 1993
266
:
16
-
22
Abstract
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T A Glauser
,
A N Nelson
,
D E Zembower
,
J J Lipsky
,
and
R M Weinshilboum
Diethyldithiocarbamate S-methylation: evidence for catalysis by human liver thiol methyltransferase and thiopurine methyltransferase.
J Pharmacol Exp Ther
July 1993
266
:
23
-
32
Abstract
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M Bak
,
M Shalmi
,
J S Petersen
,
L B Poulsen
,
and
S Christensen
Effects of angiotensin-converting enzyme inhibition on renal adaptations to acute furosemide administration in conscious rats.
J Pharmacol Exp Ther
July 1993
266
:
33
-
40
Abstract
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R G Carpentier
,
B R Coleman
,
and
D J Patel
Cocaine enhances postrest and paired-stimulation potentiation in rat papillary muscle.
J Pharmacol Exp Ther
July 1993
266
:
41
-
46
Abstract
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P R Mayeux
and
S V Shah
Intracellular calcium mediates the cytotoxicity of lipid A in LLC-PK1 cells.
J Pharmacol Exp Ther
July 1993
266
:
47
-
51
Abstract
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K Chiba
,
K Kobayashi
,
K Manabe
,
M Tani
,
T Kamataki
,
and
T Ishizaki
Oxidative metabolism of omeprazole in human liver microsomes: cosegregation with S-mephenytoin 4'-hydroxylation.
J Pharmacol Exp Ther
July 1993
266
:
52
-
59
Abstract
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H Ogura
and
T G Aigner
MK-801 impairs recognition memory in rhesus monkeys: comparison with cholinergic drugs.
J Pharmacol Exp Ther
July 1993
266
:
60
-
64
Abstract
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K U Petersen
,
P Cormann
,
H J Macherey
,
G Sprakties
,
and
J M Winterhager
Electrogenic and electroneutral HCO3-secretion by guinea pig gallbladder epithelium: discriminatory abilities of Cl- channel blockers.
J Pharmacol Exp Ther
July 1993
266
:
65
-
73
Abstract
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M Kadowaki
,
Y Nagakura
,
M Tomoi
,
J Mori
,
and
M Kohsaka
Effect of FK1052, a potent 5-hydroxytryptamine3 and 5-hydroxytryptamine4 receptor dual antagonist, on colonic function in vivo.
J Pharmacol Exp Ther
July 1993
266
:
74
-
80
Abstract
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V M Lakshmi
,
T V Zenser
,
M B Mattammal
,
and
B B Davis
Phenylbutazone peroxidatic metabolism and conjugation.
J Pharmacol Exp Ther
July 1993
266
:
81
-
88
Abstract
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M Elhamri
,
B Ferrier
,
M Martin
,
and
G Baverel
Effect of valproate, sodium 2-propyl-4-pentenoate and sodium 2-propyl-2-pentenoate on renal substrate uptake and ammoniagenesis in the rat.
J Pharmacol Exp Ther
July 1993
266
:
89
-
96
Abstract
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E Nisoli
,
C Tonello
,
R Imhof
,
R Scherschlicht
,
M da Prada
,
and
M O Carruba
Neurochemical and behavioral evidence that Ro 41-9067 is a selective presynaptic dopamine receptor agonist.
J Pharmacol Exp Ther
July 1993
266
:
97
-
105
Abstract
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K M Standifer
,
J A Clark
,
and
G W Pasternak
Modulation of Mu1 opioid binding by magnesium: evidence for multiple receptor conformations.
J Pharmacol Exp Ther
July 1993
266
:
106
-
113
Abstract
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Y Shibouta
,
Y Inada
,
M Ojima
,
T Wada
,
M Noda
,
T Sanada
,
K Kubo
,
Y Kohara
,
T Naka
,
and
K Nishikawa
Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4- yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (+/-)-1-(cyclohexyloxycarbonyloxy)-ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5- yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (TCV-116).
J Pharmacol Exp Ther
July 1993
266
:
114
-
120
Abstract
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A E Takemori
,
H H Loh
,
and
N M Lee
Suppression by dynorphin A and [des-Tyr1]dynorphin A peptides of the expression of opiate withdrawal and tolerance in morphine-dependent mice.
J Pharmacol Exp Ther
July 1993
266
:
121
-
124
Abstract
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M J Antonaccio
,
D Normandin
,
R Serafino
,
and
S Moreland
Effects of thrombin and thrombin receptor activating peptides on rat aortic vascular smooth muscle.
J Pharmacol Exp Ther
July 1993
266
:
125
-
132
Abstract
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E A Johnson
,
C E Tsai
,
Y H Shahan
,
and
A J Azzaro
Serotonin 5-HT1A receptors mediate inhibition of tyrosine hydroxylation in rat striatum.
J Pharmacol Exp Ther
July 1993
266
:
133
-
141
Abstract
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C Russo
,
M Marchi
,
G C Andrioli
,
P Cavazzani
,
and
M Raiteri
Enhancement of glycine release from human brain cortex synaptosomes by acetylcholine acting at M4 muscarinic receptors.
J Pharmacol Exp Ther
July 1993
266
:
142
-
146
Abstract
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M Nordström
,
T Abrahamsson
,
M Ervik
,
E Forshult
,
and
C G Regårdh
Central nervous and systemic kinetics of ramipril and ramiprilat in the conscious dog.
J Pharmacol Exp Ther
July 1993
266
:
147
-
152
Abstract
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B Longoni
,
G C Demontis
,
and
R W Olsen
Enhancement of gamma-aminobutyric acidA receptor function and binding by the volatile anesthetic halothane.
J Pharmacol Exp Ther
July 1993
266
:
153
-
159
Abstract
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P C Churchill
and
V R Ellis
Purinergic P2y receptors stimulate renin secretion by rat renal cortical slices.
J Pharmacol Exp Ther
July 1993
266
:
160
-
163
Abstract
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D P Brooks
,
G Giardina
,
M Gellai
,
G Dondio
,
R M Edwards
,
G Petrone
,
P D DePalma
,
M Sbacchi
,
M Jugus
,
and
P Misiano
Opiate receptors within the blood-brain barrier mediate kappa agonist-induced water diuresis.
J Pharmacol Exp Ther
July 1993
266
:
164
-
171
Abstract
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A J Barbier
and
R A Lefebvre
Involvement of the L-arginine: nitric oxide pathway in nonadrenergic noncholinergic relaxation of the cat gastric fundus.
J Pharmacol Exp Ther
July 1993
266
:
172
-
178
Abstract
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L Y Wing
,
C F Chan
,
and
M J Jiang
Acetylpolyamines decrease blood pressure, [Ca++]i and isometric force of vascular smooth muscle.
J Pharmacol Exp Ther
July 1993
266
:
179
-
183
Abstract
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K J Slavik
and
J E Szilagyi
Naloxone-induced potentiation of cardiac alpha-2 adrenoceptor-mediated depression of neurogenic tachycardia.
J Pharmacol Exp Ther
July 1993
266
:
184
-
191
Abstract
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G Drapeau
,
R Audet
,
L Levesque
,
D Godin
,
and
F Marceau
Development and in vivo evaluation of metabolically resistant antagonists of B1 receptors for kinins.
J Pharmacol Exp Ther
July 1993
266
:
192
-
199
Abstract
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H Mizumoto
,
A Karasawa
,
and
K Kubo
Diuretic and renal protective effects of 8-(noradamantan-3-yl)-1,3-dipropylxanthine (KW-3902), a novel adenosine A1-receptor antagonist, via pertussis toxin insensitive mechanism.
J Pharmacol Exp Ther
July 1993
266
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200
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206
Abstract
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J S Kahle
and
C W Cotman
L-2-amino-4-phosphonobutanoic acid and 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid reduce paired-pulse depression recorded from medial perforant path in the dentate gyrus of rat hippocampal slices.
J Pharmacol Exp Ther
July 1993
266
:
207
-
215
Abstract
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C Rundfeldt
and
W Löscher
Anticonvulsant efficacy and adverse effects of phenytoin during chronic treatment in amygdala-kindled rats.
J Pharmacol Exp Ther
July 1993
266
:
216
-
223
Abstract
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K T Wilson
,
Y Xie
,
M W Musch
,
and
E B Chang
Sodium nitroprusside stimulates anion secretion and inhibits sodium chloride absorption in rat colon.
J Pharmacol Exp Ther
July 1993
266
:
224
-
230
Abstract
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K Williams
Effects of Agelenopsis aperta toxins on the N-methyl-D-aspartate receptor: polyamine-like and high-affinity antagonist actions.
J Pharmacol Exp Ther
July 1993
266
:
231
-
236
Abstract
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S Z Wang
and
E E el-Fakahany
Application of transfected cell lines in studies of functional receptor subtype selectivity of muscarinic agonists.
J Pharmacol Exp Ther
July 1993
266
:
237
-
243
Abstract
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M Ekblom
,
M Hammarlund-Udenaes
,
and
L Paalzow
Modeling of tolerance development and rebound effect during different intravenous administrations of morphine to rats.
J Pharmacol Exp Ther
July 1993
266
:
244
-
252
Abstract
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D H Wolsing
and
J S Rosenbaum
The mechanism for the rapid desensitization in bradykinin-stimulated inositol monophosphate production in NG108-15 cells involves interaction of a single receptor with multiple signaling pathways.
J Pharmacol Exp Ther
July 1993
266
:
253
-
261
Abstract
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T A Deisher
,
H Narita
,
P Zera
,
R Ginsburg
,
M R Bristow
,
M E Billingham
,
M B Fowler
,
and
B B Hoffman
Protective effect of clentiazem against epinephrine-induced cardiac injury in rats.
J Pharmacol Exp Ther
July 1993
266
:
262
-
269
Abstract
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G Piedimonte
,
C Bertrand
,
P Geppetti
,
R M Snider
,
M C Desai
,
and
J A Nadel
A new NK1 receptor antagonist (CP-99,994) prevents the increase in tracheal vascular permeability produced by hypertonic saline.
J Pharmacol Exp Ther
July 1993
266
:
270
-
273
Abstract
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T Jones-Dombi
and
P Churchill
The baroreceptor mechanism for controlling renin secretion: effect of calcium channel blockers.
J Pharmacol Exp Ther
July 1993
266
:
274
-
278
Abstract
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D Mohuczy-Dominiak
and
L C Garg
Alpha-2 adrenoceptors in medullary thick ascending limbs of the rabbit kidney.
J Pharmacol Exp Ther
July 1993
266
:
279
-
287
Abstract
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J W Lenders
,
R Kvetnansky
,
K Pacak
,
D S Goldstein
,
I J Kopin
,
and
G Eisenhofer
Extraneuronal metabolism of endogenous and exogenous norepinephrine and epinephrine in rats.
J Pharmacol Exp Ther
July 1993
266
:
288
-
293
Abstract
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R B Marala
and
S J Mustafa
Direct evidence for the coupling of A2-adenosine receptor to stimulatory guanine nucleotide-binding-protein in bovine brain striatum.
J Pharmacol Exp Ther
July 1993
266
:
294
-
300
Abstract
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M T Griffin
,
E A Thomas
,
and
F J Ehlert
Kinetics of activation and in vivo muscarinic receptor binding of N-(2-bromoethyl)-4-piperidinyl diphenylacetate: an analog of 4-DAMP mustard.
J Pharmacol Exp Ther
July 1993
266
:
301
-
305
Abstract
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D C Underwood
,
R R Osborn
,
L B Novak
,
J K Matthews
,
S J Newsholme
,
B J Undem
,
J M Hand
,
and
T J Torphy
Inhibition of antigen-induced bronchoconstriction and eosinophil infiltration in the guinea pig by the cyclic AMP-specific phosphodiesterase inhibitor, rolipram.
J Pharmacol Exp Ther
July 1993
266
:
306
-
313
Abstract
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J J Buccafusco
,
C A Lapp
,
R S Aronstam
,
A C Hays
,
and
L C Shuster
Role of prostanoids in the regulation of central cholinergic receptor sensitivity.
J Pharmacol Exp Ther
July 1993
266
:
314
-
322
Abstract
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M L Adams
,
B Sewing
,
J B Forman
,
E R Meyer
,
and
T J Cicero
Opioid-induced suppression of rat testicular function.
J Pharmacol Exp Ther
July 1993
266
:
323
-
328
Abstract
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E T Iwamoto
and
L Marion
Characterization of the antinociception produced by intrathecally administered muscarinic agonists in rats.
J Pharmacol Exp Ther
July 1993
266
:
329
-
338
Abstract
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S B Penner
,
D D Smyth
,
and
G B Glavin
Effects of neuropeptide Y and [Leu31,Pro34] neuropeptide Y on experimental gastric lesion formation and gastric secretion in the rat.
J Pharmacol Exp Ther
July 1993
266
:
339
-
343
Abstract
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T Kanayama
,
Y Kimura
,
and
S Mizogami
A new prostacyclin analog, KP-10614, inhibits platelet-polymorphonuclear leukocyte interaction and limits experimental infarct size in rat heart.
J Pharmacol Exp Ther
July 1993
266
:
344
-
349
Abstract
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S Ofori
,
O Bugnon
,
and
M Schorderet
Agonist-induced desensitization of dopamine D-1 receptors in bovine retina and rat striatum.
J Pharmacol Exp Ther
July 1993
266
:
350
-
357
Abstract
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J Galitzky
,
M Reverte
,
C Carpene
,
M Lafontan
,
and
M Berlan
Beta 3-adrenoceptors in dog adipose tissue: studies on their involvement in the lipomobilizing effect of catecholamines.
J Pharmacol Exp Ther
July 1993
266
:
358
-
366
Abstract
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T Ishine
,
Y Miyauchi
,
and
M K Uchida
Ca(++)-independent relaxation mediated by beta adrenoceptor in Ca(++)-independent contraction of uterine smooth muscle.
J Pharmacol Exp Ther
July 1993
266
:
367
-
373
Abstract
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R E Kramer
Effects of diltiazem on calcium metabolism in cultured bovine glomerulosa cells: relationships to the actions of angiotensin II and potassium.
J Pharmacol Exp Ther
July 1993
266
:
374
-
384
Abstract
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F Knoflach
,
U Drescher
,
L Scheurer
,
P Malherbe
,
and
H Mohler
Full and partial agonism displayed by benzodiazepine receptor ligands at recombinant gamma-aminobutyric acidA receptor subtypes.
J Pharmacol Exp Ther
July 1993
266
:
385
-
391
Abstract
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S Chakder
and
S Rattan
The entire vasoactive intestinal polypeptide molecule is required for the activation of the vasoactive intestinal polypeptide receptor: functional and binding studies on opossum internal anal sphincter smooth muscle.
J Pharmacol Exp Ther
July 1993
266
:
392
-
399
Abstract
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Y Liu
,
H Kreppel
,
J Liu
,
S Choudhuri
,
and
C D Klaassen
Oleanolic acid protects against cadmium hepatotoxicity by inducing metallothionein.
J Pharmacol Exp Ther
July 1993
266
:
400
-
406
Abstract
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G E Billman
Effect of calcium channel antagonists on cocaine-induced malignant arrhythmias: protection against ventricular fibrillation.
J Pharmacol Exp Ther
July 1993
266
:
407
-
416
Abstract
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B A Fuchs
and
S B Pruett
Morphine induces apoptosis in murine thymocytes in vivo but not in vitro: involvement of both opiate and glucocorticoid receptors.
J Pharmacol Exp Ther
July 1993
266
:
417
-
423
Abstract
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B A Sorg
,
S Y Chen
,
and
P W Kalivas
Time course of tyrosine hydroxylase expression after behavioral sensitization to cocaine.
J Pharmacol Exp Ther
July 1993
266
:
424
-
430
Abstract
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R Hitzemann
,
Y Qian
,
and
B Hitzemann
Dopamine and acetylcholine cell density in the neuroleptic responsive (NR) and neuroleptic nonresponsive (NNR) lines of mice.
J Pharmacol Exp Ther
July 1993
266
:
431
-
438
Abstract
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C Legrand
,
S Mhaouty
,
C Rigolot
,
and
J P Maltier
Heterogeneity of alpha-2 adrenoceptors in pregnant rat uterus: identification of subtypes and autoradiographic distribution.
J Pharmacol Exp Ther
July 1993
266
:
439
-
449
Abstract
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R F Kauffman
,
J S Bean
,
W E Bloomquist
,
and
M L Cohen
Vascular serotonin 5-hydroxytryptamine2 receptor blockade by LY215840: lack of effect upon neointima formation in balloon-injured rat carotid arteries.
J Pharmacol Exp Ther
July 1993
266
:
450
-
455
Abstract
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I Findlay
Sulphonylurea drugs no longer inhibit ATP-sensitive K+ channels during metabolic stress in cardiac muscle.
J Pharmacol Exp Ther
July 1993
266
:
456
-
467
Abstract
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M J Miller
,
S Chotinaruemol
,
H Sadowska-Krowikca
,
X J Zhang
,
J A McIntyre
,
and
D A Clark
Guinea pig ileitis is attenuated by the leumedin N-(fluorenyl-9- methoxycarbonyl)-leucine (NPC 15199).
J Pharmacol Exp Ther
July 1993
266
:
468
-
472
Abstract
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