Table of Contents

July 1992; 262 (1)
    • C A Paronis and
    • S G Holtzman

    Development of tolerance to the analgesic activity of mu agonists after continuous infusion of morphine, meperidine or fentanyl in rats.

    J Pharmacol Exp Ther July 1992 262:1-9
    • S P Welch and
    • D L Stevens

    Antinociceptive activity of intrathecally administered cannabinoids alone, and in combination with morphine, in mice.

    J Pharmacol Exp Ther July 1992 262:10-18
    • C C Chao,
    • S Hu,
    • T W Molitor,
    • Y Zhou,
    • M P Murtaugh,
    • M Tsang,
    • and P K Peterson

    Morphine potentiates transforming growth factor-beta release from human peripheral blood mononuclear cell cultures.

    J Pharmacol Exp Ther July 1992 262:19-24
    • B Frances,
    • R Gout,
    • B Monsarrat,
    • J Cros,
    • and J M Zajac

    Further evidence that morphine-6 beta-glucuronide is a more potent opioid agonist than morphine.

    J Pharmacol Exp Ther July 1992 262:25-31
    • W D Bowen,
    • J M Walker,
    • B R de Costa,
    • R Wu,
    • P J Tolentino,
    • D Finn,
    • R B Rothman,
    • and K C Rice

    Characterization of the enantiomers of cis-N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1- pyrrolidinyl)cyclohexylamine (BD737 and BD738): novel compounds with high affinity, selectivity and biological efficacy at sigma receptors.

    J Pharmacol Exp Ther July 1992 262:32-40
    • J Lundström,
    • J E Lindgren,
    • S Ahlenius,
    • and V Hillegaart

    Relationship between brain levels of 3-(3-hydroxyphenyl)-N-n-propylpiperidine HCl enantiomers and effects on locomotor activity in rats.

    J Pharmacol Exp Ther July 1992 262:41-47
    • M P van der Weyde,
    • M R Wright,
    • S M Taylor,
    • J E Axelson,
    • and D W Rurak

    Metabolic effects of ritodrine in the fetal lamb.

    J Pharmacol Exp Ther July 1992 262:48-59
    • A A Seymour,
    • M M Asaad,
    • B E Abboa-Offei,
    • P L Rovnyak,
    • S Fennell,
    • and W L Rogers

    Potentiation of brain natriuretic peptides by SQ 28,603, an inhibitor of neutral endopeptidase 3.4.24.11, in monkeys and rats.

    J Pharmacol Exp Ther July 1992 262:60-70
    • I Findlay

    Effects of pH upon the inhibition by sulphonylurea drugs of ATP-sensitive K+ channels in cardiac muscle.

    J Pharmacol Exp Ther July 1992 262:71-79
    • R H Jackson,
    • M M Morrissey,
    • M A Sills,
    • and M F Jarvis

    Comparison of antagonist and agonist binding to the leukotriene B4 receptor intact human polymorphonuclear neutrophils (PMN).

    J Pharmacol Exp Ther July 1992 262:80-89
    • B Costall,
    • A M Domeney,
    • A J Farre,
    • M E Kelly,
    • L Martinez,
    • and R J Naylor

    Profile of action of a novel 5-hydroxytryptamine1A receptor ligand E-4424 to inhibit aversive behavior in the mouse, rat and marmoset.

    J Pharmacol Exp Ther July 1992 262:90-98
    • K S Lee

    Ibutilide, a new compound with potent class III antiarrhythmic activity, activates a slow inward Na+ current in guinea pig ventricular cells.

    J Pharmacol Exp Ther July 1992 262:99-108
    • S Ito,
    • G Koren,
    • and P A Harper

    Handling of digoxin and ouabain by renal tubular cells (LLC-PK1).

    J Pharmacol Exp Ther July 1992 262:109-113
    • G Bonanno and
    • M Raiteri

    Functional evidence for multiple gamma-aminobutyric acidB receptor subtypes in the rat cerebral cortex.

    J Pharmacol Exp Ther July 1992 262:114-118
    • L B Fernandes,
    • A D Fryer,
    • and C A Hirshman

    M2 muscarinic receptors inhibit isoproterenol-induced relaxation of canine airway smooth muscle.

    J Pharmacol Exp Ther July 1992 262:119-126
    • Q Wang,
    • M A Hollinger,
    • and S N Giri

    Attenuation of amiodarone-induced lung fibrosis and phospholipidosis in hamsters by taurine and/or niacin treatment.

    J Pharmacol Exp Ther July 1992 262:127-132
    • R S Chang,
    • P K Siegl,
    • B V Clineschmidt,
    • N B Mantlo,
    • P K Chakravarty,
    • W J Greenlee,
    • A A Patchett,
    • and V J Lotti

    In vitro pharmacology of L-158,809, a new highly potent and selective angiotensin II receptor antagonist.

    J Pharmacol Exp Ther July 1992 262:133-138
    • P K Siegl,
    • R S Chang,
    • N B Mantlo,
    • P K Chakravarty,
    • D L Ondeyka,
    • W J Greenlee,
    • A A Patchett,
    • C S Sweet,
    • and V J Lotti

    In vivo pharmacology of L-158,809, a new highly potent and selective nonpeptide angiotensin II receptor antagonist.

    J Pharmacol Exp Ther July 1992 262:139-144
    • J Nagakawa,
    • I Hishinuma,
    • K Miyamoto,
    • K Hirota,
    • S Abe,
    • T Yamanaka,
    • K Katayama,
    • and I Yamatsu

    Protective effects of (2E)-3-[5-(2,3-dimethoxy-6-methyl-1,4- benzoquinoyl)]-2-nonyl-2-propenoic acid on endotoxin-mediated hepatitis in mice.

    J Pharmacol Exp Ther July 1992 262:145-150
    • W C Elliott and
    • D S Patchin

    Aminoglycoside-mediated calciuresis.

    J Pharmacol Exp Ther July 1992 262:151-156
    • M M el-Mas and
    • A A Abdel-Rahman

    Role of aortic baroreceptors in ethanol-induced impairment of baroreflex control of heart rate in conscious rats.

    J Pharmacol Exp Ther July 1992 262:157-165
    • B C Abels,
    • J T Callis,
    • R A Branch,
    • and R Sabra

    Influence of the adenosine receptor antagonist, CGS 15943A, on renal function after reconstruction of chronic renal artery stenosis in the dog.

    J Pharmacol Exp Ther July 1992 262:166-172
    • J Lai,
    • L Nunan,
    • S L Waite,
    • S W Ma,
    • J W Bloom,
    • W R Roeske,
    • and H I Yamamura

    Chimeric M1/M2 muscarinic receptors: correlation of ligand selectivity and functional coupling with structural modifications.

    J Pharmacol Exp Ther July 1992 262:173-180
    • A Lecci,
    • S Giuliani,
    • P Santicioli,
    • and C A Maggi

    Involvement of 5-hydroxytryptamine1A receptors in the modulation of micturition reflexes in the anesthetized rat.

    J Pharmacol Exp Ther July 1992 262:181-189
    • T W Vanderah,
    • K D Wild,
    • A E Takemori,
    • M Sultana,
    • P S Portoghese,
    • W D Bowen,
    • H I Mosberg,
    • and F Porreca

    Mediation of swim-stress antinociception by the opioid delta 2 receptor in the mouse.

    J Pharmacol Exp Ther July 1992 262:190-197
    • B A Prins,
    • M A Weber,
    • and R E Purdy

    Norepinephrine amplifies angiotensin II-induced vasoconstriction in rabbit femoral artery.

    J Pharmacol Exp Ther July 1992 262:198-203
    • X H Xie and
    • E I Tietz

    Reduction in potency of selective gamma-aminobutyric acidA agonists and diazepam in CA1 region of in vitro hippocampal slices from chronic flurazepam-treated rats.

    J Pharmacol Exp Ther July 1992 262:204-211
    • C N Gillis,
    • X Chen,
    • and M M Merker

    Lisinopril and ramiprilat protection of the vascular endothelium against free radical-induced functional injury.

    J Pharmacol Exp Ther July 1992 262:212-216
    • J D Port,
    • C C Debellis,
    • J Klein,
    • G A Peeters,
    • W H Barry,
    • and M R Bristow

    Pharmacological characterization of chick and frog beta adrenergic receptors in primary cultures of myocardial cells.

    J Pharmacol Exp Ther July 1992 262:217-224
    • E Y Wu,
    • J W Langston,
    • and D A Di Monte

    Toxicity of the 1-methyl-4-phenyl-2,3-dihydropyridinium and 1-methyl-4-phenylpyridinium species in primary cultures of mouse astrocytes.

    J Pharmacol Exp Ther July 1992 262:225-230
    • O A Nedergaard,
    • A K Cho,
    • and L A Waggaman

    Effects of xylamine on vascular neuroeffector transmission.

    J Pharmacol Exp Ther July 1992 262:231-237
    • A K Okwu,
    • M E Ullian,
    • and P V Halushka

    Homologous desensitization of human platelet thromboxane A2/prostaglandin H2 receptors.

    J Pharmacol Exp Ther July 1992 262:238-245
    • P M Ormond,
    • M A Basinger,
    • M M Jones,
    • and K R Hande

    Association between increased atrial natriuretic peptide and reduced cisplatin nephrotoxicity in rats.

    J Pharmacol Exp Ther July 1992 262:246-251
    • C T Stier, Jr,
    • C P Quilley,
    • and J C McGiff

    Endothelin-3 effects on renal function and prostanoid release in the rat isolated kidney.

    J Pharmacol Exp Ther July 1992 262:252-256
    • R A Rabin,
    • A M Edelman,
    • and J A Wagner

    Activation of protein kinase A is necessary but not sufficient for ethanol-induced desensitization of cyclic AMP production.

    J Pharmacol Exp Ther July 1992 262:257-262
    • M Hamaguchi,
    • T Ishibashi,
    • and S Imai

    Involvement of charybdotoxin-sensitive K+ channel in the relaxation of bovine tracheal smooth muscle by glyceryl trinitrate and sodium nitroprusside.

    J Pharmacol Exp Ther July 1992 262:263-270
    • L E Rikans and
    • Y Cai

    Age-associated enhancement of diquat-induced lipid peroxidation and cytotoxicity in isolated rat hepatocytes.

    J Pharmacol Exp Ther July 1992 262:271-278
    • K L Preston,
    • J T Sullivan,
    • E C Strain,
    • and G E Bigelow

    Effects of cocaine alone and in combination with bromocriptine in human cocaine abusers.

    J Pharmacol Exp Ther July 1992 262:279-291
    • V J Aloyo

    Identification and characterization of delta opioid binding sites in the bovine pineal.

    J Pharmacol Exp Ther July 1992 262:292-297
    • H Schröder

    Cytochrome P-450 mediates bioactivation of organic nitrates.

    J Pharmacol Exp Ther July 1992 262:298-302
    • M van den Buuse

    Central effects of quinpirole on blood pressure of spontaneously hypertensive rats.

    J Pharmacol Exp Ther July 1992 262:303-311
    • N H Lee,
    • J Hu,
    • and E E el-Fakahany

    Modulation by certain conserved aspartate residues of the allosteric interaction of gallamine at the m1 muscarinic receptor.

    J Pharmacol Exp Ther July 1992 262:312-316
    • C S Wong,
    • Y F Su,
    • W D Watkins,
    • and K J Chang

    Continuous intrathecal opioid treatment abolishes the regulatory effects of magnesium and guanine nucleotides on mu opioid receptor binding in rat spinal membranes.

    J Pharmacol Exp Ther July 1992 262:317-326
    • E A Stein and
    • S A Fuller

    Selective effects of cocaine on regional cerebral blood flow in the rat.

    J Pharmacol Exp Ther July 1992 262:327-334
    • S F De Boer,
    • J L Katz,
    • and R J Valentino

    Common mechanisms underlying the proconflict effects of corticotropin-releasing factor, a benzodiazepine inverse agonist and electric foot-shock.

    J Pharmacol Exp Ther July 1992 262:335-342
    • H Togashi,
    • I Sakuma,
    • M Yoshioka,
    • T Kobayashi,
    • H Yasuda,
    • A Kitabatake,
    • H Saito,
    • S S Gross,
    • and R Levi

    A central nervous system action of nitric oxide in blood pressure regulation.

    J Pharmacol Exp Ther July 1992 262:343-347
    • B Levant and
    • C B Nemeroff

    Further studies on the modulation of regional brain neurotensin concentrations by antipsychotic drugs: focus on haloperidol and BMY 14802.

    J Pharmacol Exp Ther July 1992 262:348-355
    • H M Jacocks, 3rd and
    • B M Cox

    Serotonin-stimulated release of [3H]dopamine via reversal of the dopamine transporter in rat striatum and nucleus accumbens: a comparison with release elicited by potassium, N-methyl-D-aspartic acid, glutamic acid and D-amphetamine.

    J Pharmacol Exp Ther July 1992 262:356-364
    • S C Roerig,
    • S Lei,
    • K Kitto,
    • J K Hylden,
    • and G L Wilcox

    Spinal interactions between opioid and noradrenergic agonists in mice: multiplicativity involves delta and alpha-2 receptors.

    J Pharmacol Exp Ther July 1992 262:365-374
    • E Patterson,
    • B J Scherlag,
    • and R Lazzara

    Electrophysiologic actions of clofilium and lidocaine in ischemically injured canine epicardium.

    J Pharmacol Exp Ther July 1992 262:375-382
    • D M Mottola,
    • W K Brewster,
    • L L Cook,
    • D E Nichols,
    • and R B Mailman

    Dihydrexidine, a novel full efficacy D1 dopamine receptor agonist.

    J Pharmacol Exp Ther July 1992 262:383-393
    • Y Katz,
    • R Weizman,
    • A Weizman,
    • and M Gavish

    Disulfiram and diethyldithiocarbamate are competitive inhibitors at the peripheral benzodiazepine receptor.

    J Pharmacol Exp Ther July 1992 262:394-397
    • H Morimoto,
    • M Murai,
    • Y Maeda,
    • M Yamaoka,
    • M Nishikawa,
    • S Kiyotoh,
    • and T Fujii

    FK 224, a novel cyclopeptide substance P antagonist with NK1 and NK2 receptor selectivity.

    J Pharmacol Exp Ther July 1992 262:398-402
    • M Murai,
    • H Morimoto,
    • Y Maeda,
    • S Kiyotoh,
    • M Nishikawa,
    • and T Fujii

    Effects of FK224, a novel compound NK1 and NK2 receptor antagonist, on airway constriction and airway edema induced by neurokinins and sensory nerve stimulation in guinea pigs.

    J Pharmacol Exp Ther July 1992 262:403-408
    • C Moummi,
    • Y Xie,
    • J F Kachur,
    • and T S Gaginella

    Endothelin-1 stimulates contraction and ion transport in the rat colon: different mechanisms of action.

    J Pharmacol Exp Ther July 1992 262:409-414
    • A Ableitner and
    • R Schulz

    Neuroanatomical sites mediating the central actions of beta-endorphin as mapped by changes in glucose utilization: involvement of mu opioid receptors.

    J Pharmacol Exp Ther July 1992 262:415-423
    • B K Kishore,
    • S Ibrahim,
    • P Lambricht,
    • G Laurent,
    • P Maldague,
    • and P M Tulkens

    Comparative assessment of poly-L-aspartic and poly-L-glutamic acids as protectants against gentamicin-induced renal lysosomal phospholipidosis, phospholipiduria and cell proliferation in rats.

    J Pharmacol Exp Ther July 1992 262:424-432
    • R M Laethem,
    • C L Laethem,
    • X Ding,
    • and D R Koop

    P-450-dependent arachidonic acid metabolism in rabbit olfactory microsomes.

    J Pharmacol Exp Ther July 1992 262:433-438
    • H Tanaka and
    • T Kaneko

    Pharmacokinetic and pharmacodynamic comparisons between human granulocyte colony-stimulating factor purified from human bladder carcinoma cell line 5637 culture medium and recombinant human granulocyte colony-stimulating factor produced in Escherichia coli.

    J Pharmacol Exp Ther July 1992 262:439-444
    • T Grady,
    • A K Saluja,
    • M L Steer,
    • M M Lerch,
    • I M Modlin,
    • and R E Powers

    In vivo and in vitro effects of the azidothymidine analog dideoxyinosine on the exocrine pancreas of the rat.

    J Pharmacol Exp Ther July 1992 262:445-449

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