Table of Contents

Select this article
- R W Van Dyke,
- E D Faber,
- and D K Meijer
Sequestration of organic cations by acidified hepatic endocytic vesicles and implications for biliary excretion.
J Pharmacol Exp Ther April 1992 261:1-11
- Abstract
- Full Text (PDF)
Select this article
- M J Alonso,
- M Salaices,
- C F Sanchez-Ferrer,
- and J Marin
Predominant role for nitric oxide in the relaxation induced by acetylcholine in cat cerebral arteries.
J Pharmacol Exp Ther April 1992 261:12-20
- Abstract
- Full Text (PDF)
Select this article
- L T Wong,
- D D Smyth,
- and D S Sitar
Interference with renal organic cation transport by (-)- and (+)-nicotine at concentrations documented in plasma of habitual tobacco smokers.
J Pharmacol Exp Ther April 1992 261:21-25
- Abstract
- Full Text (PDF)
Select this article
- M E Carroll,
- G N Carmona,
- S A May,
- S Buzalsky,
- and C Larson
Buprenorphine's effects on self-administration of smoked cocaine base and orally delivered phencyclidine, ethanol and saccharin in rhesus monkeys.
J Pharmacol Exp Ther April 1992 261:26-37
- Abstract
- Full Text (PDF)
Select this article
- J E Foster,
- E S Harpur,
- and H O Garland
An investigation of the acute effect of gentamicin on the renal handling of electrolytes in the rat.
J Pharmacol Exp Ther April 1992 261:38-43
- Abstract
- Full Text (PDF)
Select this article
- D A Di Monte,
- E Y Wu,
- L E Delanney,
- I Irwin,
- and J W Langston
Toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in primary cultures of mouse astrocytes.
J Pharmacol Exp Ther April 1992 261:44-49
- Abstract
- Full Text (PDF)
Select this article
- K V Speeg,
- A L Maldonado,
- J Liaci,
- and D Muirhead
Effect of cyclosporine on colchicine secretion by the kidney multidrug transporter studied in vivo.
J Pharmacol Exp Ther April 1992 261:50-55
- Abstract
- Full Text (PDF)
Select this article
- J W Mandema,
- M T Kuck,
- and M Danhof
In vivo modeling of the pharmacodynamic interaction between benzodiazepines which differ in intrinsic efficacy.
J Pharmacol Exp Ther April 1992 261:56-61
- Abstract
- Full Text (PDF)
Select this article
- K L Preston,
- I A Liebson,
- and G E Bigelow
Discrimination of agonist-antagonist opioids in humans trained on a two-choice saline-hydromorphone discrimination.
J Pharmacol Exp Ther April 1992 261:62-71
- Abstract
- Full Text (PDF)
Select this article
- J F Bowyer,
- G D Newport,
- G W Lipe,
- and L T Frame
A further evaluation of the effects of K+ depolarization on glutamate-evoked [3H]dopamine release from striatal slices.
J Pharmacol Exp Ther April 1992 261:72-80
- Abstract
- Full Text (PDF)
Select this article
- A M Stijnen,
- M Danhof,
- and C F Van Bezooijen
Increased sensitivity to the anesthetic effect of phenobarbital in aging BN/BiRij rats.
J Pharmacol Exp Ther April 1992 261:81-87
- Abstract
- Full Text (PDF)
Select this article
- J W Mandema,
- C D Heijligers-Feijen,
- E Tukker,
- A G De Boer,
- and M Danhof
Modeling of the effect site equilibration kinetics and pharmacodynamics of racemic baclofen and its enantiomers using quantitative EEG effect measures.
J Pharmacol Exp Ther April 1992 261:88-95
- Abstract
- Full Text (PDF)
Select this article
- Y X Wang and
- D P Brooks
Renin-angiotensin system inhibition reduces glycine-induced glomerular hyperfiltration in conscious rats.
J Pharmacol Exp Ther April 1992 261:96-100
- Abstract
- Full Text (PDF)
Select this article
- D J Cook,
- P R Housmans,
- and D K Rorie
Effect of ketamine HCl on norepinephrine disposition in isolated ferret ventricular myocardium.
J Pharmacol Exp Ther April 1992 261:101-107
- Abstract
- Full Text (PDF)
Select this article
- S J Mihic,
- H Kalant,
- J F Liu,
- and P H Wu
Role of the gamma-aminobutyric acid receptor/chloride channel complex in tolerance to ethanol and cross-tolerance to diazepam and pentobarbital.
J Pharmacol Exp Ther April 1992 261:108-113
- Abstract
- Full Text (PDF)
Select this article
- J L Azorlosa,
- S J Heishman,
- M L Stitzer,
- and J M Mahaffey
Marijuana smoking: effect of varying delta 9-tetrahydrocannabinol content and number of puffs.
J Pharmacol Exp Ther April 1992 261:114-122
- Abstract
- Full Text (PDF)
Select this article
- F P Monnet,
- G Debonnel,
- and C de Montigny
In vivo electrophysiological evidence for a selective modulation of N-methyl-D-aspartate-induced neuronal activation in rat CA3 dorsal hippocampus by sigma ligands.
J Pharmacol Exp Ther April 1992 261:123-130
- Abstract
- Full Text (PDF)
Select this article
- D N Harris,
- I M Michel,
- H J Goldenberg,
- K S Hartl,
- G T Allen,
- T E Steinbacher,
- W A Schumacher,
- W C Han,
- S E Hall,
- and D M Floyd
Pharmacological characterization of potent, long-acting thromboxane receptor antagonists, SQ 33,261 and SQ 33,552.
J Pharmacol Exp Ther April 1992 261:131-137
- Abstract
- Full Text (PDF)
Select this article
- K Takada,
- J E Barrett,
- M S Allen,
- J M Cook,
- and J L Katz
Punishment of schedule-controlled behavior with beta-carboline injections: antagonism and comparisons with other compounds.
J Pharmacol Exp Ther April 1992 261:138-145
- Abstract
- Full Text (PDF)
Select this article
- B B Holmes and
- J M Fujimoto
Naloxone and norbinaltorphimine administered intracerebroventricularly antagonize spinal morphine-induced antinociception in mice through the antianalgesic action of spinal dynorphin A (1-17).
J Pharmacol Exp Ther April 1992 261:146-153
- Abstract
- Full Text (PDF)
Select this article
- A Jansen,
- J Drazen,
- J A Osborne,
- R Brown,
- J Loscalzo,
- and J S Stamler
The relaxant properties in guinea pig airways of S-nitrosothiols.
J Pharmacol Exp Ther April 1992 261:154-160
- Abstract
- Full Text (PDF)
Select this article
- M R Pranzatelli,
- J N Murthy,
- and R S Pluchino
Identification of spinal 5-HT1C binding sites in the rat: characterization of [3H]mesulergine binding.
J Pharmacol Exp Ther April 1992 261:161-165
- Abstract
- Full Text (PDF)
Select this article
- M F Hare and
- W D Atchison
Comparative action of methylmercury and divalent inorganic mercury on nerve terminal and intraterminal mitochondrial membrane potentials.
J Pharmacol Exp Ther April 1992 261:166-172
- Abstract
- Full Text (PDF)
Select this article
- C M de Fiebre and
- A C Collins
Classical genetic analyses of responses to nicotine and ethanol in crosses derived from long- and short-sleep mice.
J Pharmacol Exp Ther April 1992 261:173-180
- Abstract
- Full Text (PDF)
Select this article
- F Noble,
- J M Soleilhac,
- E Soroca-Lucas,
- S Turcaud,
- M C Fournie-Zaluski,
- and B P Roques
Inhibition of the enkephalin-metabolizing enzymes by the first systemically active mixed inhibitor prodrug RB 101 induces potent analgesic responses in mice and rats.
J Pharmacol Exp Ther April 1992 261:181-190
- Abstract
- Full Text (PDF)
Select this article
- R Patacchini and
- C A Maggi
Effect of newly developed tachykinin agonist and antagonists on the guinea pig isolated gallbladder.
J Pharmacol Exp Ther April 1992 261:191-194
- Abstract
- Full Text (PDF)
Select this article
- K Inui,
- M Yamamoto,
- and H Saito
Transepithelial transport of oral cephalosporins by monolayers of intestinal epithelial cell line Caco-2: specific transport systems in apical and basolateral membranes.
J Pharmacol Exp Ther April 1992 261:195-201
- Abstract
- Full Text (PDF)
Select this article
- M L Cohen,
- D W Robertson,
- W E Bloomquist,
- and H C Wilson
LY215840, a potent 5-hydroxytryptamine (5-HT)2 receptor antagonist, blocks vascular and platelet 5-HT2 receptors and delays occlusion in a rabbit model of thrombosis.
J Pharmacol Exp Ther April 1992 261:202-208
- Abstract
- Full Text (PDF)
Select this article
- S Kalsner
Activation of a relaxation cascade in isolated coronary arteries by brief electrical pulses.
J Pharmacol Exp Ther April 1992 261:209-224
- Abstract
- Full Text (PDF)
Select this article
- H Itoh,
- R H Alper,
- and R D Buñag
Baroreflex changes produced by serotonergic or catecholaminergic lesions in the rat nucleus tractus solitarius.
J Pharmacol Exp Ther April 1992 261:225-233
- Abstract
- Full Text (PDF)
Select this article
- N Toda and
- T Okamura
Different susceptibility of vasodilator nerve, endothelium and smooth muscle functions to Ca++ antagonists in cerebral arteries.
J Pharmacol Exp Ther April 1992 261:234-239
- Abstract
- Full Text (PDF)
Select this article
- M L Pucci,
- L Lin,
- and A Nasjletti
Pressor and renal vasoconstrictor effects of NG-nitro-L-arginine as affected by blockade of pressor mechanisms mediated by the sympathetic nervous system, angiotensin, prostanoids and vasopressin.
J Pharmacol Exp Ther April 1992 261:240-245
- Abstract
- Full Text (PDF)
Select this article
- A M Young,
- M A Masaki,
- and C Geula
Discriminative stimulus effects of morphine: effects of training dose on agonist and antagonist effects of mu opioids.
J Pharmacol Exp Ther April 1992 261:246-257
- Abstract
- Full Text (PDF)
Select this article
- H Lemoine and
- C Overlack
Highly potent beta-2 sympathomimetics convert to less potent partial agonists as relaxants of guinea pig tracheae maximally contracted by carbachol. Comparison of relaxation with receptor binding and adenylate cyclase stimulation.
J Pharmacol Exp Ther April 1992 261:258-270
- Abstract
- Full Text (PDF)
Select this article
- R C Pleus and
- D B Bylund
Desensitization and down-regulation of the 5-hydroxytryptamine1B receptor in the opossum kidney cell line.
J Pharmacol Exp Ther April 1992 261:271-277
- Abstract
- Full Text (PDF)
Select this article
- A J Bertalmio,
- F Medzihradsky,
- G Winger,
- and J H Woods
Differential influence of N-dealkylation on the stimulus properties of some opioid agonists.
J Pharmacol Exp Ther April 1992 261:278-284
- Abstract
- Full Text (PDF)
Select this article
- L G Miller,
- W R Galpern,
- J J Byrnes,
- D J Greenblatt,
- and R I Shader
Chronic benzodiazepine administration. X. Concurrent administration of the peripheral-type benzodiazepine ligand PK11195 attenuates chronic effects of lorazepam.
J Pharmacol Exp Ther April 1992 261:285-289
- Abstract
- Full Text (PDF)
Select this article
- H N Bhargava and
- V M Villar
Pharmacodynamics and pharmacokinetics of intravenously administered morphine in spontaneously hypertensive and normotensive Wistar-Kyoto rats.
J Pharmacol Exp Ther April 1992 261:290-296
- Abstract
- Full Text (PDF)
Select this article
- K Miyata,
- T Kamato,
- A Nishida,
- H Ito,
- H Yuki,
- M Yamano,
- R Tsutsumi,
- Y Katsuyama,
- and K Honda
Role of the serotonin3 receptor in stress-induced defecation.
J Pharmacol Exp Ther April 1992 261:297-303
- Abstract
- Full Text (PDF)
Select this article
- L C Daniell
Alteration of general anesthetic potency by agonists and antagonists of the polyamine binding site of the N-methyl-D-aspartate receptor.
J Pharmacol Exp Ther April 1992 261:304-310
- Abstract
- Full Text (PDF)
Select this article
- G Winger,
- P Skjoldager,
- and J H Woods
Effects of buprenorphine and other opioid agonists and antagonists on alfentanil- and cocaine-reinforced responding in rhesus monkeys.
J Pharmacol Exp Ther April 1992 261:311-317
- Abstract
- Full Text (PDF)
Select this article
- S Bova,
- R Padrini,
- W F Goldman,
- D M Berman,
- and G Cargnelli
On the mechanism of vasodilating action of berberine: possible role of inositol lipid signaling system.
J Pharmacol Exp Ther April 1992 261:318-323
- Abstract
- Full Text (PDF)
Select this article
- M L Perrier,
- B Scatton,
- and J Benavides
Dihydropyridine- and omega-conotoxin-resistant, neomycin-sensitive calcium channels mediate the depolarization-induced increase in internal calcium levels in cortical slices from immature rat brain.
J Pharmacol Exp Ther April 1992 261:324-330
- Abstract
- Full Text (PDF)
Select this article
- E F Pereira,
- Y Aracava,
- R S Aronstam,
- E J Barreiro,
- and E X Albuquerque
Pyrazole, an alcohol dehydrogenase inhibitor, has dual effects on N-methyl-D-aspartate receptors of hippocampal pyramidal cells: agonist and noncompetitive antagonist.
J Pharmacol Exp Ther April 1992 261:331-340
- Abstract
- Full Text (PDF)
Select this article
- Y Qian,
- B Hitzemann,
- and R Hitzemann
D1 and D2 dopamine receptor distribution in the neuroleptic nonresponsive and neuroleptic responsive lines of mice, a quantitative receptor autoradiographic study.
J Pharmacol Exp Ther April 1992 261:341-348
- Abstract
- Full Text (PDF)
Select this article
- H Ishimaru,
- A Katoh,
- H Suzuki,
- T Fukuta,
- T Kameyama,
- and T Nabeshima
Effects of N-methyl-D-aspartate receptor antagonists on carbon monoxide-induced brain damage in mice.
J Pharmacol Exp Ther April 1992 261:349-352
- Abstract
- Full Text (PDF)
Select this article
- C G Plopper,
- C Suverkropp,
- D Morin,
- S Nishio,
- and A Buckpitt
Relationship of cytochrome P-450 activity to Clara cell cytotoxicity. I. Histopathologic comparison of the respiratory tract of mice, rats and hamsters after parenteral administration of naphthalene.
J Pharmacol Exp Ther April 1992 261:353-363
- Abstract
- Full Text (PDF)
Select this article
- A Buckpitt,
- M Buonarati,
- L B Avey,
- A M Chang,
- D Morin,
- and C G Plopper
Relationship of cytochrome P450 activity to Clara cell cytotoxicity. II. Comparison of stereoselectivity of naphthalene epoxidation in lung and nasal mucosa of mouse, hamster, rat and rhesus monkey.
J Pharmacol Exp Ther April 1992 261:364-372
- Abstract
- Full Text (PDF)
Select this article
- M Murray,
- E Cantrill,
- I Mehta,
- and G C Farrell
Impaired expression of microsomal cytochrome P450 2C11 in choline-deficient rat liver during the development of cirrhosis.
J Pharmacol Exp Ther April 1992 261:373-380
- Abstract
- Full Text (PDF)
Select this article
- J P Flinois,
- M Chabin,
- F Egros,
- A Dufour,
- I de Waziers,
- C Mas-Chamberlin,
- and P H Beaune
Metabolism rate of oxodipine in rats and humans: comparison of in vivo and in vitro data.
J Pharmacol Exp Ther April 1992 261:381-386
- Abstract
- Full Text (PDF)

Sequestration of organic cations by acidified hepatic endocytic vesicles and implications for biliary excretion.

Predominant role for nitric oxide in the relaxation induced by acetylcholine in cat cerebral arteries.

Interference with renal organic cation transport by (-)- and (+)-nicotine at concentrations documented in plasma of habitual tobacco smokers.

Buprenorphine's effects on self-administration of smoked cocaine base and orally delivered phencyclidine, ethanol and saccharin in rhesus monkeys.

An investigation of the acute effect of gentamicin on the renal handling of electrolytes in the rat.

Toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in primary cultures of mouse astrocytes.

Effect of cyclosporine on colchicine secretion by the kidney multidrug transporter studied in vivo.

In vivo modeling of the pharmacodynamic interaction between benzodiazepines which differ in intrinsic efficacy.

Discrimination of agonist-antagonist opioids in humans trained on a two-choice saline-hydromorphone discrimination.

A further evaluation of the effects of K+ depolarization on glutamate-evoked [3H]dopamine release from striatal slices.

Increased sensitivity to the anesthetic effect of phenobarbital in aging BN/BiRij rats.

Modeling of the effect site equilibration kinetics and pharmacodynamics of racemic baclofen and its enantiomers using quantitative EEG effect measures.

Renin-angiotensin system inhibition reduces glycine-induced glomerular hyperfiltration in conscious rats.

Effect of ketamine HCl on norepinephrine disposition in isolated ferret ventricular myocardium.

Role of the gamma-aminobutyric acid receptor/chloride channel complex in tolerance to ethanol and cross-tolerance to diazepam and pentobarbital.

Marijuana smoking: effect of varying delta 9-tetrahydrocannabinol content and number of puffs.

In vivo electrophysiological evidence for a selective modulation of N-methyl-D-aspartate-induced neuronal activation in rat CA3 dorsal hippocampus by sigma ligands.

Pharmacological characterization of potent, long-acting thromboxane receptor antagonists, SQ 33,261 and SQ 33,552.

Punishment of schedule-controlled behavior with beta-carboline injections: antagonism and comparisons with other compounds.

Naloxone and norbinaltorphimine administered intracerebroventricularly antagonize spinal morphine-induced antinociception in mice through the antianalgesic action of spinal dynorphin A (1-17).

The relaxant properties in guinea pig airways of S-nitrosothiols.

Identification of spinal 5-HT1C binding sites in the rat: characterization of [3H]mesulergine binding.

Comparative action of methylmercury and divalent inorganic mercury on nerve terminal and intraterminal mitochondrial membrane potentials.

Classical genetic analyses of responses to nicotine and ethanol in crosses derived from long- and short-sleep mice.

Inhibition of the enkephalin-metabolizing enzymes by the first systemically active mixed inhibitor prodrug RB 101 induces potent analgesic responses in mice and rats.

Effect of newly developed tachykinin agonist and antagonists on the guinea pig isolated gallbladder.

Transepithelial transport of oral cephalosporins by monolayers of intestinal epithelial cell line Caco-2: specific transport systems in apical and basolateral membranes.

LY215840, a potent 5-hydroxytryptamine (5-HT)2 receptor antagonist, blocks vascular and platelet 5-HT2 receptors and delays occlusion in a rabbit model of thrombosis.

Activation of a relaxation cascade in isolated coronary arteries by brief electrical pulses.

Baroreflex changes produced by serotonergic or catecholaminergic lesions in the rat nucleus tractus solitarius.

Different susceptibility of vasodilator nerve, endothelium and smooth muscle functions to Ca++ antagonists in cerebral arteries.

Pressor and renal vasoconstrictor effects of NG-nitro-L-arginine as affected by blockade of pressor mechanisms mediated by the sympathetic nervous system, angiotensin, prostanoids and vasopressin.

Discriminative stimulus effects of morphine: effects of training dose on agonist and antagonist effects of mu opioids.

Highly potent beta-2 sympathomimetics convert to less potent partial agonists as relaxants of guinea pig tracheae maximally contracted by carbachol. Comparison of relaxation with receptor binding and adenylate cyclase stimulation.

Desensitization and down-regulation of the 5-hydroxytryptamine1B receptor in the opossum kidney cell line.

Differential influence of N-dealkylation on the stimulus properties of some opioid agonists.

Chronic benzodiazepine administration. X. Concurrent administration of the peripheral-type benzodiazepine ligand PK11195 attenuates chronic effects of lorazepam.

Pharmacodynamics and pharmacokinetics of intravenously administered morphine in spontaneously hypertensive and normotensive Wistar-Kyoto rats.

Role of the serotonin3 receptor in stress-induced defecation.

Alteration of general anesthetic potency by agonists and antagonists of the polyamine binding site of the N-methyl-D-aspartate receptor.

Effects of buprenorphine and other opioid agonists and antagonists on alfentanil- and cocaine-reinforced responding in rhesus monkeys.

On the mechanism of vasodilating action of berberine: possible role of inositol lipid signaling system.

Dihydropyridine- and omega-conotoxin-resistant, neomycin-sensitive calcium channels mediate the depolarization-induced increase in internal calcium levels in cortical slices from immature rat brain.

Pyrazole, an alcohol dehydrogenase inhibitor, has dual effects on N-methyl-D-aspartate receptors of hippocampal pyramidal cells: agonist and noncompetitive antagonist.

D1 and D2 dopamine receptor distribution in the neuroleptic nonresponsive and neuroleptic responsive lines of mice, a quantitative receptor autoradiographic study.

Effects of N-methyl-D-aspartate receptor antagonists on carbon monoxide-induced brain damage in mice.

Relationship of cytochrome P-450 activity to Clara cell cytotoxicity. I. Histopathologic comparison of the respiratory tract of mice, rats and hamsters after parenteral administration of naphthalene.

Relationship of cytochrome P450 activity to Clara cell cytotoxicity. II. Comparison of stereoselectivity of naphthalene epoxidation in lung and nasal mucosa of mouse, hamster, rat and rhesus monkey.

Impaired expression of microsomal cytochrome P450 2C11 in choline-deficient rat liver during the development of cirrhosis.

Metabolism rate of oxodipine in rats and humans: comparison of in vivo and in vitro data.

This Issue

Current Issue