Abstract
Sodium arsenite intravenously administered in doses considerably below lethal causes a distinct but variable hyperglycemia in the rabbit.
Accompanying this hyperglycemia there is a reduction in the blood alkaline reserve; there is no significant alteration in blood concentration as indicated by determinations of corpuscle volume or per cent of hemoglobin.
The hyperglycemia still appears after bilateral splanchnotomy or right splanchnotomy and left adrenalectomy. Sodium arsenite therefore acts peripherally in all probability by increasing hepatic glycogenolysis.
The hyperglycemia may be checked or prevented by insulin. Intravenous injections of sodium arsenite in the dog cause a reduction in whole blood alkaline reserve often with a slight hyperglycemia.
Footnotes
- Received April 22, 1925.
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