Table of Contents

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- S L Abrahams,
- R J Hazen,
- A G Batson,
- and A P Phillips
Trifenagrel: a chemically novel platelet aggregation inhibitor.
J Pharmacol Exp Ther May 1989 249:359-365
- Abstract
- Full Text (PDF)
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- C R Albrightson-Winslow,
- N Caldwell,
- D P Brooks,
- W F Huffman,
- F L Stassen,
- and L B Kinter
Cyclooxygenase inhibition unmasks the full antidiuretic agonist activity of the vasopressin antagonist, SK&F 101926, in dogs.
J Pharmacol Exp Ther May 1989 249:366-371
- Abstract
- Full Text (PDF)
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- M E Brier and
- G B Harding
Pharmacokinetics and pharmacodynamics of atrial natriuretic peptide after bolus and infusion administration in the isolated perfused rat kidney.
J Pharmacol Exp Ther May 1989 249:372-377
- Abstract
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- M P Knadler,
- D C Brater,
- and S D Hall
Plasma protein binding of flurbiprofen: enantioselectivity and influence of pathophysiological status.
J Pharmacol Exp Ther May 1989 249:378-385
- Abstract
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- R M Craft,
- M J Picker,
- and L A Dykstra
Differential cross-tolerance to opioid agonists in morphine-tolerant pigeons responding under a schedule of food presentation.
J Pharmacol Exp Ther May 1989 249:386-393
- Abstract
- Full Text (PDF)
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- A L Harris,
- B M Lemp,
- R G Bentley,
- M H Perrone,
- L T Hamel,
- and P J Silver
Phosphodiesterase isozyme inhibition and the potentiation by zaprinast of endothelium-derived relaxing factor and guanylate cyclase stimulating agents in vascular smooth muscle.
J Pharmacol Exp Ther May 1989 249:394-400
- Abstract
- Full Text (PDF)
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- R A Bond,
- A G Ornstein,
- and D E Clarke
Unsurmountable antagonism to 5-hydroxytryptamine in rat kidney results from pseudoirreversible inhibition rather than multiple receptors or allosteric receptor modulation.
J Pharmacol Exp Ther May 1989 249:401-410
- Abstract
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- P A Krieter,
- G M Olins,
- S P Verrett,
- and R C Durley
In vivo metabolism of atrial natriuretic peptide: identification of plasma metabolites and enzymes responsible for their generation.
J Pharmacol Exp Ther May 1989 249:411-417
- Abstract
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- A K Mehta and
- M K Ticku
Benzodiazepine and beta-carboline interactions with GABAA receptor-gated chloride channels in mammalian cultured spinal cord neurons.
J Pharmacol Exp Ther May 1989 249:418-423
- Abstract
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- H U Bryant,
- J W Holaday,
- and E W Bernton
Cysteamine produces dose-related bidirectional immunomodulatory effects in mice.
J Pharmacol Exp Ther May 1989 249:424-429
- Abstract
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- T J Torphy,
- J F Newton,
- M A Wasserman,
- L Vickery-Clark,
- R R Osborn,
- L S Bailey,
- L A Yodis,
- D C Underwood,
- and D W Hay
The bronchopulmonary pharmacology of SK&F 104353 in anesthetized guinea pigs: demonstration of potent and selective antagonism of responses to peptidoleukotrienes.
J Pharmacol Exp Ther May 1989 249:430-437
- Abstract
- Full Text (PDF)
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- J Willetts and
- R L Balster
Pentobarbital-like discriminative stimulus effects of N-methyl-D-aspartate antagonists.
J Pharmacol Exp Ther May 1989 249:438-443
- Abstract
- Full Text (PDF)
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- J E Shook and
- T F Burks
Psychoactive cannabinoids reduce gastrointestinal propulsion and motility in rodents.
J Pharmacol Exp Ther May 1989 249:444-449
- Abstract
- Full Text (PDF)
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- D Hoyt and
- R E Larson
Effect of 1,3-bis-(2-chloroethyl)-1-nitrosourea on cholephilic dye metabolism and excretion in anesthetized rats.
J Pharmacol Exp Ther May 1989 249:450-455
- Abstract
- Full Text (PDF)
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- J C Crabbe,
- D J Feller,
- and J S Dorow
Sensitivity and tolerance to ethanol-induced hypothermia in genetically selected mice.
J Pharmacol Exp Ther May 1989 249:456-461
- Abstract
- Full Text (PDF)
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- R J Sheldon,
- L Nunan,
- and F Porreca
Differential modulation by [D-Pen2, D-Pen5]enkephalin and dynorphin A-(1-17) of the inhibitory bladder motility effects of selected mu agonists in vivo.
J Pharmacol Exp Ther May 1989 249:462-469
- Abstract
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- G G Orce,
- O A Carretero,
- G Scicli,
- and A G Scicli
Kinins contribute to the contractile effects of rat glandular kallikrein on the isolated rat uterus.
J Pharmacol Exp Ther May 1989 249:470-475
- Abstract
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- E E Bagwell,
- J G Webb,
- T Walle,
- and T E Gaffney
Stereoselective uptake of atenolol into storage granules isolated from PC12 cells.
J Pharmacol Exp Ther May 1989 249:476-482
- Abstract
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- A S Kimes,
- K Kumor,
- K McCullough,
- D Holtzclaw,
- D Teller,
- D Dobyan,
- and D Spector
Effects of acute and chronic acyclovir on canine renal function.
J Pharmacol Exp Ther May 1989 249:483-491
- Abstract
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- K K Hui and
- J L Yu
Effects of protein kinase inhibitor, 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine, on beta-2 adrenergic receptor activation and desensitization in intact human lymphocytes.
J Pharmacol Exp Ther May 1989 249:492-498
- Abstract
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- J B Long,
- A Martinez-Arizala,
- S H Johnson,
- and J W Holaday
Arginine8-vasopressin reduces spinal cord blood flow after spinal subarachnoid injection in rats.
J Pharmacol Exp Ther May 1989 249:499-506
- Abstract
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- J D Winkler and
- B Weiss
Effect of continuous exposure to selective D1 and D2 dopaminergic agonists on rotational behavior in supersensitive mice.
J Pharmacol Exp Ther May 1989 249:507-516
- Abstract
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- T A Baillie,
- W J Adams,
- D G Kaiser,
- L S Olanoff,
- G W Halstead,
- H Harpootlian,
- and G J Van Giessen
Mechanistic studies of the metabolic chiral inversion of (R)-ibuprofen in humans.
J Pharmacol Exp Ther May 1989 249:517-523
- Abstract
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- M Barnette,
- T J Torphy,
- M Grous,
- C Fine,
- and H S Ormsbee, 3rd
Cyclic GMP: a potential mediator of neurally- and drug-induced relaxation of opossum lower esophageal sphincter.
J Pharmacol Exp Ther May 1989 249:524-528
- Abstract
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- F A Gesek and
- J W Strandhoy
Alpha adrenoceptor agonist stimulation of oxygen consumption in rat proximal and distal nephrons.
J Pharmacol Exp Ther May 1989 249:529-534
- Abstract
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- T J Murphy and
- D B Bylund
Characterization of serotonin-1B receptors negatively coupled to adenylate cyclase in OK cells, a renal epithelial cell line from the opossum.
J Pharmacol Exp Ther May 1989 249:535-543
- Abstract
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- T H Kramer,
- J E Shook,
- W Kazmierski,
- E A Ayres,
- W S Wire,
- V J Hruby,
- and T F Burks
Novel peptidic mu opioid antagonists: pharmacologic characterization in vitro and in vivo.
J Pharmacol Exp Ther May 1989 249:544-551
- Abstract
- Full Text (PDF)
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- W H Adams,
- R D Stoner,
- D G Adams,
- H Read,
- D N Slatkin,
- and H W Siegelman
Prophylaxis of cyanobacterial and mushroom cyclic peptide toxins.
J Pharmacol Exp Ther May 1989 249:552-556
- Abstract
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- M J Picker and
- L A Dykstra
Discriminative stimulus effects of mu and kappa opioids in the pigeon: analysis of the effects of full and partial mu and kappa agonists.
J Pharmacol Exp Ther May 1989 249:557-566
- Abstract
- Full Text (PDF)
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- K M Boje and
- H L Fung
Characterization of the pharmacokinetic interaction between nifedipine and ethanol in the rat.
J Pharmacol Exp Ther May 1989 249:567-571
- Abstract
- Full Text (PDF)
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- R J Sheldon,
- M E Malarchik,
- D A Fox,
- T F Burks,
- and F Porreca
Pharmacological characterization of neural mechanisms regulating mucosal ion transport in mouse jejunum.
J Pharmacol Exp Ther May 1989 249:572-582
- Abstract
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- J Galitzky,
- P Mauriege,
- M Berlan,
- and M Lafontan
Human fat cell alpha-2 adrenoceptors. I. Functional exploration and pharmacological definition with selected alpha-2 agonists and antagonists.
J Pharmacol Exp Ther May 1989 249:583-591
- Abstract
- Full Text (PDF)
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- J Galitzky,
- M Lafontan,
- H Paris,
- and M Berlan
Human fat cell alpha-2 adrenoceptors. II. Comparative study of partial and full agonist binding parameters using [3H]clonidine and [3H]UK-14,304.
J Pharmacol Exp Ther May 1989 249:592-600
- Abstract
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- J Dingemanse,
- J B van Bree,
- and M Danhof
Pharmacokinetic modeling of the anticonvulsant action of phenobarbital in rats.
J Pharmacol Exp Ther May 1989 249:601-608
- Abstract
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- P Gohlke,
- H Urbach,
- B Schölkens,
- and T Unger
Inhibition of converting enzyme in the cerebrospinal fluid of rats after oral treatment with converting enzyme inhibitors.
J Pharmacol Exp Ther May 1989 249:609-616
- Abstract
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- H J Duff
Mexiletine-quinidine combination: enhanced antiarrhythmic and electrophysiologic activity in the dog.
J Pharmacol Exp Ther May 1989 249:617-622
- Abstract
- Full Text (PDF)
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- M P Gupta,
- S L Lee,
- and N S Dhalla
Activation of heart sarcoplasmic reticulum Ca++-stimulated adenosine triphosphatase by insulin.
J Pharmacol Exp Ther May 1989 249:623-630
- Abstract
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- K R Gallant and
- M G Cherian
Metabolic changes in glutathione and metallothionein in newborn rat liver.
J Pharmacol Exp Ther May 1989 249:631-637
- Abstract
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- J H Schellens,
- J H van der Wart,
- M Brugman,
- and D D Breimer
Influence of enzyme induction and inhibition on the oxidation of nifedipine, sparteine, mephenytoin and antipyrine in humans as assessed by a "cocktail" study design.
J Pharmacol Exp Ther May 1989 249:638-645
- Abstract
- Full Text (PDF)
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- T Hisayama,
- I Takayanagi,
- N Kumagai,
- and H Kubo
Interaction of 8-(N,N-diethylamino)octyl 3,4,5-trimethoxybenzoate hydrochloride, ryanodine and procaine with muscarinic cholinergic M2 receptor sites in smooth muscle.
J Pharmacol Exp Ther May 1989 249:646-651
- Abstract
- Full Text (PDF)
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- H D Allescher,
- S Ahmad,
- F Kostolanska,
- C Y Kwan,
- and E E Daniel
Modulation of pyloric motor activity via adrenergic receptors.
J Pharmacol Exp Ther May 1989 249:652-659
- Abstract
- Full Text (PDF)
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- D Bhaskaran and
- C R Freed
Catechol and indole metabolism in rostral ventrolateral medulla change synchronously with changing blood pressure.
J Pharmacol Exp Ther May 1989 249:660-666
- Abstract
- Full Text (PDF)
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- A J Sherratt,
- D E Banet,
- M W Linder,
- and R A Prough
Potentiation of 3-methylcholanthrene induction of rat hepatic cytochrome P450IA1 by dexamethasone in vivo.
J Pharmacol Exp Ther May 1989 249:667-672
- Abstract
- Full Text (PDF)

Trifenagrel: a chemically novel platelet aggregation inhibitor.

Cyclooxygenase inhibition unmasks the full antidiuretic agonist activity of the vasopressin antagonist, SK&F 101926, in dogs.

Pharmacokinetics and pharmacodynamics of atrial natriuretic peptide after bolus and infusion administration in the isolated perfused rat kidney.

Plasma protein binding of flurbiprofen: enantioselectivity and influence of pathophysiological status.

Differential cross-tolerance to opioid agonists in morphine-tolerant pigeons responding under a schedule of food presentation.

Phosphodiesterase isozyme inhibition and the potentiation by zaprinast of endothelium-derived relaxing factor and guanylate cyclase stimulating agents in vascular smooth muscle.

Unsurmountable antagonism to 5-hydroxytryptamine in rat kidney results from pseudoirreversible inhibition rather than multiple receptors or allosteric receptor modulation.

In vivo metabolism of atrial natriuretic peptide: identification of plasma metabolites and enzymes responsible for their generation.

Benzodiazepine and beta-carboline interactions with GABAA receptor-gated chloride channels in mammalian cultured spinal cord neurons.

Cysteamine produces dose-related bidirectional immunomodulatory effects in mice.

The bronchopulmonary pharmacology of SK&F 104353 in anesthetized guinea pigs: demonstration of potent and selective antagonism of responses to peptidoleukotrienes.

Pentobarbital-like discriminative stimulus effects of N-methyl-D-aspartate antagonists.

Psychoactive cannabinoids reduce gastrointestinal propulsion and motility in rodents.

Effect of 1,3-bis-(2-chloroethyl)-1-nitrosourea on cholephilic dye metabolism and excretion in anesthetized rats.

Sensitivity and tolerance to ethanol-induced hypothermia in genetically selected mice.

Differential modulation by [D-Pen2, D-Pen5]enkephalin and dynorphin A-(1-17) of the inhibitory bladder motility effects of selected mu agonists in vivo.

Kinins contribute to the contractile effects of rat glandular kallikrein on the isolated rat uterus.

Stereoselective uptake of atenolol into storage granules isolated from PC12 cells.

Effects of acute and chronic acyclovir on canine renal function.

Effects of protein kinase inhibitor, 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine, on beta-2 adrenergic receptor activation and desensitization in intact human lymphocytes.

Arginine8-vasopressin reduces spinal cord blood flow after spinal subarachnoid injection in rats.

Effect of continuous exposure to selective D1 and D2 dopaminergic agonists on rotational behavior in supersensitive mice.

Mechanistic studies of the metabolic chiral inversion of (R)-ibuprofen in humans.

Cyclic GMP: a potential mediator of neurally- and drug-induced relaxation of opossum lower esophageal sphincter.

Alpha adrenoceptor agonist stimulation of oxygen consumption in rat proximal and distal nephrons.

Characterization of serotonin-1B receptors negatively coupled to adenylate cyclase in OK cells, a renal epithelial cell line from the opossum.

Novel peptidic mu opioid antagonists: pharmacologic characterization in vitro and in vivo.

Prophylaxis of cyanobacterial and mushroom cyclic peptide toxins.

Discriminative stimulus effects of mu and kappa opioids in the pigeon: analysis of the effects of full and partial mu and kappa agonists.

Characterization of the pharmacokinetic interaction between nifedipine and ethanol in the rat.

Pharmacological characterization of neural mechanisms regulating mucosal ion transport in mouse jejunum.

Human fat cell alpha-2 adrenoceptors. I. Functional exploration and pharmacological definition with selected alpha-2 agonists and antagonists.

Human fat cell alpha-2 adrenoceptors. II. Comparative study of partial and full agonist binding parameters using [3H]clonidine and [3H]UK-14,304.

Pharmacokinetic modeling of the anticonvulsant action of phenobarbital in rats.

Inhibition of converting enzyme in the cerebrospinal fluid of rats after oral treatment with converting enzyme inhibitors.

Mexiletine-quinidine combination: enhanced antiarrhythmic and electrophysiologic activity in the dog.

Activation of heart sarcoplasmic reticulum Ca++-stimulated adenosine triphosphatase by insulin.

Metabolic changes in glutathione and metallothionein in newborn rat liver.

Influence of enzyme induction and inhibition on the oxidation of nifedipine, sparteine, mephenytoin and antipyrine in humans as assessed by a "cocktail" study design.

Interaction of 8-(N,N-diethylamino)octyl 3,4,5-trimethoxybenzoate hydrochloride, ryanodine and procaine with muscarinic cholinergic M2 receptor sites in smooth muscle.

Modulation of pyloric motor activity via adrenergic receptors.

Catechol and indole metabolism in rostral ventrolateral medulla change synchronously with changing blood pressure.

Potentiation of 3-methylcholanthrene induction of rat hepatic cytochrome P450IA1 by dexamethasone in vivo.

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