Table of Contents

July 1988; 246 (1)

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- T E Tenner, Jr,
- J Young,
- B J Riker,
- and S Ramanadham
Nonspecific supersensitivity induced by reserpine in guinea pig cardiac ventricle tissue.
J Pharmacol Exp Ther July 1988 246:1-6
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- D R Rutledge,
- J A Pieper,
- and D M Mirvis
Effects of chronic phenobarbital on verapamil disposition in humans.
J Pharmacol Exp Ther July 1988 246:7-13
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- T J Cicero,
- E R Meyer,
- B T Miller,
- and R D Bell
Age-related differences in the sensitivity of serum luteinizing hormone to prototypic mu, kappa and delta opiate agonists and antagonists.
J Pharmacol Exp Ther July 1988 246:14-20
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- R R Griffiths and
- P P Woodson
Reinforcing effects of caffeine in humans.
J Pharmacol Exp Ther July 1988 246:21-29
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- A A Alousi,
- A M Grant,
- P D Allen,
- and E D Pagani
Effects of milrinone on Ca++-sensitivity of myofibrillar Mg-adenosine triphosphatase isolated from normal human and canine hearts.
J Pharmacol Exp Ther July 1988 246:30-37
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- J M O'Donnell
Psychopharmacological consequences of activation of beta adrenergic receptors by SOM-1122.
J Pharmacol Exp Ther July 1988 246:38-46
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- B J Undem and
- G K Adams, 3rd
An analysis of the functional interactions of selected contractile agonists in the guinea pig isolated trachea.
J Pharmacol Exp Ther July 1988 246:47-53
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- S Connors and
- M Vore
Coregulation of C3-hydroxyl versus C17-hydroxyl glucuronidation of beta-estradiol in pregnancy and after treatment with phenobarbital or ethinyl-estradiol.
J Pharmacol Exp Ther July 1988 246:54-59
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- G M Rubanyi,
- U Hoeffner,
- A Schwartz,
- and P M Vanhoutte
Stereoselective effect of diltiazem on endothelium-dependent relaxations in canine femoral arteries.
J Pharmacol Exp Ther July 1988 246:60-64
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- J Lehmann,
- A J Hutchison,
- S E McPherson,
- C Mondadori,
- M Schmutz,
- C M Sinton,
- C Tsai,
- D E Murphy,
- D J Steel,
- and M Williams
CGS 19755, a selective and competitive N-methyl-D-aspartate-type excitatory amino acid receptor antagonist.
J Pharmacol Exp Ther July 1988 246:65-75
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- J L Katz
Effects of drugs on stimulus control of behavior. III. Analysis of effects of pentobarbital and d-amphetamine.
J Pharmacol Exp Ther July 1988 246:76-83
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- D A Cory-Slechta
Mobilization of lead over the course of DMSA chelation therapy and long-term efficacy.
J Pharmacol Exp Ther July 1988 246:84-91
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- R L Spencer,
- V J Hruby,
- and T F Burks
Body temperature response profiles for selective mu, delta and kappa opioid agonists in restrained and unrestrained rats.
J Pharmacol Exp Ther July 1988 246:92-101
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- C F Lundergan,
- T M Fitzpatrick,
- J C Rose,
- P W Ramwell,
- and P A Kot
Effect of cyclooxygenase inhibition on the pulmonary vasodilator response to furosemide.
J Pharmacol Exp Ther July 1988 246:102-106
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- O Yu,
- T H Chiu,
- and H C Rosenberg
Modulation of GABA-gated chloride ion flux in rat brain by acute and chronic benzodiazepine administration.
J Pharmacol Exp Ther July 1988 246:107-113
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- R S Mansbach,
- C Harrod,
- S M Hoffmann,
- M A Nader,
- Z Lei,
- J M Witkin,
- and J E Barrett
Behavioral studies with anxiolytic drugs. V. Behavioral and in vivo neurochemical analyses in pigeons of drugs that increase punished responding.
J Pharmacol Exp Ther July 1988 246:114-120
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- C N Nair
Proton gradient independent organic cation transport by HeLa cells.
J Pharmacol Exp Ther July 1988 246:121-124
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- R N Friedman,
- G D Bittner,
- and J A Blundon
Electrophysiological and behavioral effects of ethanol on crayfish.
J Pharmacol Exp Ther July 1988 246:125-131
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- D S Louie,
- H T Chen,
- and C Owyang
Inhibition of exocrine pancreatic secretion by opiates is mediated by suppression of cholinergic transmission: characterization of receptor subtypes.
J Pharmacol Exp Ther July 1988 246:132-136
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- S Rothman
Noncompetitive N-methyl-D-aspartate antagonists affect multiple ionic currents.
J Pharmacol Exp Ther July 1988 246:137-142
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- S A Chow,
- D E Rickert,
- and L J Fischer
Evidence that drug metabolites are involved in cyproheptadine-induced loss of pancreatic insulin.
J Pharmacol Exp Ther July 1988 246:143-149
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- U M Joshi,
- P R Kodavanti,
- B Coudert,
- T M Dwyer,
- and H M Mehendale
Types of interaction of amphiphilic drugs with phospholipid vesicles.
J Pharmacol Exp Ther July 1988 246:150-157
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- A L Morrow,
- P D Suzdak,
- J W Karanian,
- and S M Paul
Chronic ethanol administration alters gamma-aminobutyric acid, pentobarbital and ethanol-mediated 36Cl- uptake in cerebral cortical synaptoneurosomes.
J Pharmacol Exp Ther July 1988 246:158-164
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- M Yasuhara and
- G Levy
Kinetics of drug action in disease states. XXVII. Effect of experimental renal failure on the pharmacodynamics of zoxazolamine and chlorzoxazone.
J Pharmacol Exp Ther July 1988 246:165-169
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- L G Miller,
- D J Greenblatt,
- J G Barnhill,
- and R I Shader
Chronic benzodiazepine administration. I. Tolerance is associated with benzodiazepine receptor downregulation and decreased gamma-aminobutyric acidA receptor function.
J Pharmacol Exp Ther July 1988 246:170-176
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- L G Miller,
- D J Greenblatt,
- R B Roy,
- W R Summer,
- and R I Shader
Chronic benzodiazepine administration. II. Discontinuation syndrome is associated with upregulation of gamma-aminobutyric acidA receptor complex binding and function.
J Pharmacol Exp Ther July 1988 246:177-182
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- A F DeFelice and
- A Brousseau
Natriuretic and vasodilating activities of intrarenally administered atriopeptin II, substance P and bradykinin in the dog.
J Pharmacol Exp Ther July 1988 246:183-188
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- D A Twombly,
- M Yoshii,
- and T Narahashi
Mechanisms of calcium channel block by phenytoin.
J Pharmacol Exp Ther July 1988 246:189-195
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- R R Matsumoto,
- K H Brinsfield,
- R L Patrick,
- and J M Walker
Rotational behavior mediated by dopaminergic and nondopaminergic mechanisms after intranigral microinjection of specific mu, delta and kappa opioid agonists.
J Pharmacol Exp Ther July 1988 246:196-203
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- J D Winkler,
- H M Sarau,
- J J Foley,
- S Mong,
- and S T Crooke
Leukotriene B4-induced homologous desensitization of calcium mobilization and phosphoinositide metabolism in U-937 cells.
J Pharmacol Exp Ther July 1988 246:204-210
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- G J Trachte
Adrenergic nerves mediate angiotensin-induced prostaglandin release in the rabbit vas deferens.
J Pharmacol Exp Ther July 1988 246:211-217
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- L J Ignarro,
- G M Buga,
- R E Byrns,
- K S Wood,
- and G Chaudhuri
Endothelium-derived relaxing factor and nitric oxide possess identical pharmacologic properties as relaxants of bovine arterial and venous smooth muscle.
J Pharmacol Exp Ther July 1988 246:218-226
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- S H Pollock,
- H H Herman,
- L C Fowler,
- A S Edwards,
- C O Evans,
- and S W May
Demonstration of the antihypertensive activity of phenyl-2-aminoethyl selenide.
J Pharmacol Exp Ther July 1988 246:227-234
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- V Elharrar
Recovery from use-dependent block of Vmax and restitution of action potential duration in canine cardiac Purkinje fibers.
J Pharmacol Exp Ther July 1988 246:235-242
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- V H Sethy and
- J W Francis
Regulation of brain acetylcholine concentration by muscarinic receptors.
J Pharmacol Exp Ther July 1988 246:243-248
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- I C Medgett and
- R R Ruffolo, Jr
Alpha adrenoceptor-mediated vasoconstriction in rat hindlimb: innervated alpha-2 adrenoceptors in the saphenous arterial bed.
J Pharmacol Exp Ther July 1988 246:249-254
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- A E Takemori,
- B Y Ho,
- J S Naeseth,
- and P S Portoghese
Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays.
J Pharmacol Exp Ther July 1988 246:255-258
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- P F Vonvoigtlander and
- R A Lewis
Analgesic and mechanistic evaluation of spiradoline, a potent kappa opioid.
J Pharmacol Exp Ther July 1988 246:259-262
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- G J Grover,
- P G Sleph,
- and C S Parham
Effect of diltiazem on infarct size, reperfusion flow and flow reserve: the effect of timing of treatment.
J Pharmacol Exp Ther July 1988 246:263-269
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- G L Diamond,
- J M Klotzbach,
- and J R Stewart
Complexing activity of 2,3-dimercapto-1-propanesulfonate and its disulfide auto-oxidation product in rat kidney.
J Pharmacol Exp Ther July 1988 246:270-274
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- H E Shannon,
- T J Hagen,
- F Guzman,
- and J A Cook
Beta-carbolines as antagonists of the discriminative stimulus effects of diazepam in rats.
J Pharmacol Exp Ther July 1988 246:275-281
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- L L Werling,
- A Frattali,
- P S Portoghese,
- A E Takemori,
- and B M Cox
Kappa receptor regulation of dopamine release from striatum and cortex of rats and guinea pigs.
J Pharmacol Exp Ther July 1988 246:282-286
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- F Delaini,
- N Perico,
- M Tagliaferri,
- C Lupini,
- O Patino,
- G Remuzzi,
- and S Garattini
Tertatolol ameliorates renal function in rats with chronic renal failure.
J Pharmacol Exp Ther July 1988 246:287-293
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- K Sato,
- H Ozaki,
- and H Karaki
Changes in cytosolic calcium level in vascular smooth muscle strip measured simultaneously with contraction using fluorescent calcium indicator fura 2.
J Pharmacol Exp Ther July 1988 246:294-300
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- P Gresele,
- D Blockmans,
- H Deckmyn,
- and J Vermylen
Adenylate cyclase activation determines the effect of thromboxane synthase inhibitors on platelet aggregation in vitro. Comparison of platelets from responders and nonresponders.
J Pharmacol Exp Ther July 1988 246:301-307
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- C A Maggi,
- M Parlani,
- M Astolfi,
- P Santicioli,
- P Rovero,
- L Abelli,
- V Somma,
- S Giuliani,
- D Regoli,
- and R Patacchini
Neurokinin receptors in the rat lower urinary tract.
J Pharmacol Exp Ther July 1988 246:308-315
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- R A Bassani and
- S de Moraes
Effects of repeated footshock stress on the chronotropic responsiveness of the isolated pacemaker of the rat: role of beta-2 adrenoceptors.
J Pharmacol Exp Ther July 1988 246:316-321
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- S Giuliani,
- C A Maggi,
- P Rovero,
- and A Meli
Neurokinins induce a relaxation of the rat duodenum "in vivo" by activating postganglionic sympathetic elements in prevertebral ganglia: involvement of an NK-2 type of neurokinin receptor.
J Pharmacol Exp Ther July 1988 246:322-327
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- A Wellstein,
- G G Belz,
- and D Palm
Beta adrenoceptor subtype binding activity in plasma and beta blockade by propranolol and beta-1 selective bisoprolol in humans. Evaluation with Schild-plots.
J Pharmacol Exp Ther July 1988 246:328-337
- Abstract
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- I Tamai,
- A Tsuji,
- and Y Kin
Carrier-mediated transport of cefixime, a new cephalosporin antibiotic, via an organic anion transport system in the rat renal brush-border membrane.
J Pharmacol Exp Ther July 1988 246:338-344
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- J O Karlsson,
- H Elwing,
- N Grundström,
- and R G Andersson
Pronounced supersensitivity of postjunctional alpha adrenoceptors after denervation of fish melanophores.
J Pharmacol Exp Ther July 1988 246:345-351
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- J W Downie and
- G J Bialik
Evidence for a spinal site of action of clonidine on somatic and viscerosomatic reflex activity evoked on the pudendal nerve in cats.
J Pharmacol Exp Ther July 1988 246:352-358
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- Y Chaput and
- C de Montigny
Effects of the 5-hydroxytryptamine receptor antagonist, BMY 7378, on 5-hydroxytryptamine neurotransmission: electrophysiological studies in the rat central nervous system.
J Pharmacol Exp Ther July 1988 246:359-370
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- J Dingemanse,
- M Polhuijs,
- and M Danhof
Altered pharmacokinetic-pharmacodynamic relationship of heptabarbital in experimental renal failure in rats.
J Pharmacol Exp Ther July 1988 246:371-376
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- R C Levi and
- G Alloatti
Histamine modulates calcium current in guinea pig ventricular myocytes.
J Pharmacol Exp Ther July 1988 246:377-383
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- P Molenaar,
- C R Jones,
- L R McMartin,
- and R J Summers
Autoradiographic localization and densitometric analysis of beta-1 and beta-2 adrenoceptors in the canine left anterior descending coronary artery.
J Pharmacol Exp Ther July 1988 246:384-393
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- J P O'Callaghan and
- D B Miller
Acute exposure of the neonatal rat to tributyltin results in decreases in biochemical indicators of synaptogenesis and myelinogenesis.
J Pharmacol Exp Ther July 1988 246:394-402
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- S J Li,
- S P Sivam,
- J F McGinty,
- H K Jiang,
- J Douglass,
- L Calavetta,
- and J S Hong
Regulation of the metabolism of striatal dynorphin by the dopaminergic system.
J Pharmacol Exp Ther July 1988 246:403-408
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- P M Lippiello and
- K G Fernandes
Identification of putative high affinity nicotinic receptors on cultured cortical neurons.
J Pharmacol Exp Ther July 1988 246:409-416
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J Pharmacol Exp Ther July 1988 246:416-417
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Nonspecific supersensitivity induced by reserpine in guinea pig cardiac ventricle tissue.

Effects of chronic phenobarbital on verapamil disposition in humans.

Age-related differences in the sensitivity of serum luteinizing hormone to prototypic mu, kappa and delta opiate agonists and antagonists.

Reinforcing effects of caffeine in humans.

Effects of milrinone on Ca++-sensitivity of myofibrillar Mg-adenosine triphosphatase isolated from normal human and canine hearts.

Psychopharmacological consequences of activation of beta adrenergic receptors by SOM-1122.

An analysis of the functional interactions of selected contractile agonists in the guinea pig isolated trachea.

Coregulation of C3-hydroxyl versus C17-hydroxyl glucuronidation of beta-estradiol in pregnancy and after treatment with phenobarbital or ethinyl-estradiol.

Stereoselective effect of diltiazem on endothelium-dependent relaxations in canine femoral arteries.

CGS 19755, a selective and competitive N-methyl-D-aspartate-type excitatory amino acid receptor antagonist.

Effects of drugs on stimulus control of behavior. III. Analysis of effects of pentobarbital and d-amphetamine.

Mobilization of lead over the course of DMSA chelation therapy and long-term efficacy.

Body temperature response profiles for selective mu, delta and kappa opioid agonists in restrained and unrestrained rats.

Effect of cyclooxygenase inhibition on the pulmonary vasodilator response to furosemide.

Modulation of GABA-gated chloride ion flux in rat brain by acute and chronic benzodiazepine administration.

Behavioral studies with anxiolytic drugs. V. Behavioral and in vivo neurochemical analyses in pigeons of drugs that increase punished responding.

Proton gradient independent organic cation transport by HeLa cells.

Electrophysiological and behavioral effects of ethanol on crayfish.

Inhibition of exocrine pancreatic secretion by opiates is mediated by suppression of cholinergic transmission: characterization of receptor subtypes.

Noncompetitive N-methyl-D-aspartate antagonists affect multiple ionic currents.

Evidence that drug metabolites are involved in cyproheptadine-induced loss of pancreatic insulin.

Types of interaction of amphiphilic drugs with phospholipid vesicles.

Chronic ethanol administration alters gamma-aminobutyric acid, pentobarbital and ethanol-mediated 36Cl- uptake in cerebral cortical synaptoneurosomes.

Kinetics of drug action in disease states. XXVII. Effect of experimental renal failure on the pharmacodynamics of zoxazolamine and chlorzoxazone.

Chronic benzodiazepine administration. I. Tolerance is associated with benzodiazepine receptor downregulation and decreased gamma-aminobutyric acidA receptor function.

Chronic benzodiazepine administration. II. Discontinuation syndrome is associated with upregulation of gamma-aminobutyric acidA receptor complex binding and function.

Natriuretic and vasodilating activities of intrarenally administered atriopeptin II, substance P and bradykinin in the dog.

Mechanisms of calcium channel block by phenytoin.

Rotational behavior mediated by dopaminergic and nondopaminergic mechanisms after intranigral microinjection of specific mu, delta and kappa opioid agonists.

Leukotriene B4-induced homologous desensitization of calcium mobilization and phosphoinositide metabolism in U-937 cells.

Adrenergic nerves mediate angiotensin-induced prostaglandin release in the rabbit vas deferens.

Endothelium-derived relaxing factor and nitric oxide possess identical pharmacologic properties as relaxants of bovine arterial and venous smooth muscle.

Demonstration of the antihypertensive activity of phenyl-2-aminoethyl selenide.

Recovery from use-dependent block of Vmax and restitution of action potential duration in canine cardiac Purkinje fibers.

Regulation of brain acetylcholine concentration by muscarinic receptors.

Alpha adrenoceptor-mediated vasoconstriction in rat hindlimb: innervated alpha-2 adrenoceptors in the saphenous arterial bed.

Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays.

Analgesic and mechanistic evaluation of spiradoline, a potent kappa opioid.

Effect of diltiazem on infarct size, reperfusion flow and flow reserve: the effect of timing of treatment.

Complexing activity of 2,3-dimercapto-1-propanesulfonate and its disulfide auto-oxidation product in rat kidney.

Beta-carbolines as antagonists of the discriminative stimulus effects of diazepam in rats.

Kappa receptor regulation of dopamine release from striatum and cortex of rats and guinea pigs.

Tertatolol ameliorates renal function in rats with chronic renal failure.

Changes in cytosolic calcium level in vascular smooth muscle strip measured simultaneously with contraction using fluorescent calcium indicator fura 2.

Adenylate cyclase activation determines the effect of thromboxane synthase inhibitors on platelet aggregation in vitro. Comparison of platelets from responders and nonresponders.

Neurokinin receptors in the rat lower urinary tract.

Effects of repeated footshock stress on the chronotropic responsiveness of the isolated pacemaker of the rat: role of beta-2 adrenoceptors.

Neurokinins induce a relaxation of the rat duodenum "in vivo" by activating postganglionic sympathetic elements in prevertebral ganglia: involvement of an NK-2 type of neurokinin receptor.

Beta adrenoceptor subtype binding activity in plasma and beta blockade by propranolol and beta-1 selective bisoprolol in humans. Evaluation with Schild-plots.

Carrier-mediated transport of cefixime, a new cephalosporin antibiotic, via an organic anion transport system in the rat renal brush-border membrane.

Pronounced supersensitivity of postjunctional alpha adrenoceptors after denervation of fish melanophores.

Evidence for a spinal site of action of clonidine on somatic and viscerosomatic reflex activity evoked on the pudendal nerve in cats.

Effects of the 5-hydroxytryptamine receptor antagonist, BMY 7378, on 5-hydroxytryptamine neurotransmission: electrophysiological studies in the rat central nervous system.

Altered pharmacokinetic-pharmacodynamic relationship of heptabarbital in experimental renal failure in rats.

Histamine modulates calcium current in guinea pig ventricular myocytes.

Autoradiographic localization and densitometric analysis of beta-1 and beta-2 adrenoceptors in the canine left anterior descending coronary artery.

Acute exposure of the neonatal rat to tributyltin results in decreases in biochemical indicators of synaptogenesis and myelinogenesis.

Regulation of the metabolism of striatal dynorphin by the dopaminergic system.

Identification of putative high affinity nicotinic receptors on cultured cortical neurons.

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