Table of Contents

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- K D Meisheri,
- L A Cipkus,
- and C J Taylor
Mechanism of action of minoxidil sulfate-induced vasodilation: a role for increased K+ permeability.
J Pharmacol Exp Ther June 1988 245:751-760
- Abstract
- Full Text (PDF)
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- I S Hoffmann,
- R K Talmaciu,
- C P Ferro,
- and L X Cubeddu
Sustained high release at rapid stimulation rates and reduced functional autoreceptors characterize prefrontal cortex dopamine terminals.
J Pharmacol Exp Ther June 1988 245:761-772
- Abstract
- Full Text (PDF)
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- G Scholtysik,
- Y Imoto,
- A Yatani,
- and A M Brown
5-Hydroxytryptamine antagonist ICS 205-930 blocks cardiac potassium, sodium and calcium currents.
J Pharmacol Exp Ther June 1988 245:773-778
- Abstract
- Full Text (PDF)
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- K P Patel and
- P G Schmid
Vasopressin inhibits sympathetic ganglionic transmission but potentiates sympathetic neuroeffector responses in hindlimb vasculature of rabbits.
J Pharmacol Exp Ther June 1988 245:779-785
- Abstract
- Full Text (PDF)
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- A Hedberg,
- S E Hall,
- M L Ogletree,
- D N Harris,
- and E C Liu
Characterization of [5,6-3H]SQ 29,548 as a high affinity radioligand, binding to thromboxane A2/prostaglandin H2-receptors in human platelets.
J Pharmacol Exp Ther June 1988 245:786-792
- Abstract
- Full Text (PDF)
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- V K Lamba-Kanwal,
- A Hamada,
- A Adejare,
- M T Clark,
- D D Miller,
- and P N Patil
Activation of alpha-1 adrenoreceptors of rat aorta by analogs of imidazoline.
J Pharmacol Exp Ther June 1988 245:793-797
- Abstract
- Full Text (PDF)
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- R N Daly,
- P B Goldberg,
- and J Roberts
Effects of age on neurotransmission at the cardiac sympathetic neuroeffector junction.
J Pharmacol Exp Ther June 1988 245:798-803
- Abstract
- Full Text (PDF)
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- T D Bjornsson,
- D E Schneider,
- and A R Hecht
Effects of N-deacetylation and N-desulfation of heparin on its anticoagulant activity and in vivo disposition.
J Pharmacol Exp Ther June 1988 245:804-808
- Abstract
- Full Text (PDF)
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- M G Wientjes and
- G Levy
Nonlinear pharmacokinetics of aspirin in rats.
J Pharmacol Exp Ther June 1988 245:809-815
- Abstract
- Full Text (PDF)
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- D R Jones,
- S D Hall,
- E K Jackson,
- R A Branch,
- and G R Wilkinson
Brain uptake of benzodiazepines: effects of lipophilicity and plasma protein binding.
J Pharmacol Exp Ther June 1988 245:816-822
- Abstract
- Full Text (PDF)
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- Y Miyamoto,
- D F Balkovetz,
- V Ganapathy,
- T Iwatsubo,
- M Hanano,
- and F H Leibach
Effects of phenothiazines on the Na+-H+ exchanger of the brush-border membrane from the proximal small intestine of the rabbit.
J Pharmacol Exp Ther June 1988 245:823-828
- Abstract
- Full Text (PDF)
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- R E Chipkin,
- J G Berger,
- W Billard,
- L C Iorio,
- R Chapman,
- and A Barnett
Pharmacology of SCH 34826, an orally active enkephalinase inhibitor analgesic.
J Pharmacol Exp Ther June 1988 245:829-838
- Abstract
- Full Text (PDF)
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- F A Fitzpatrick and
- C F Lawson
Myotropic activity of leukotriene B4 on lung parenchyma strips is not necessarily attributable to thromboxane A2 release.
J Pharmacol Exp Ther June 1988 245:839-844
- Abstract
- Full Text (PDF)
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- R G Knodell,
- R K Dubey,
- G R Wilkinson,
- and F P Guengerich
Oxidative metabolism of hexobarbital in human liver: relationship to polymorphic S-mephenytoin 4-hydroxylation.
J Pharmacol Exp Ther June 1988 245:845-849
- Abstract
- Full Text (PDF)
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- B A Berkowitz,
- A J Arleth,
- C P Sung,
- L I Kruse,
- W E DeWolf, Jr,
- and E H Ohlstein
Effects of the novel dopamine beta-hydroxylase inhibitor SK&F 102698 on catecholamines and blood pressure in spontaneously hypertensive rats.
J Pharmacol Exp Ther June 1988 245:850-857
- Abstract
- Full Text (PDF)
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- H Rollema,
- W G Kuhr,
- G Kranenborg,
- J De Vries,
- and C Van den Berg
MPP+-induced efflux of dopamine and lactate from rat striatum have similar time courses as shown by in vivo brain dialysis.
J Pharmacol Exp Ther June 1988 245:858-866
- Abstract
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- L L Simpson
Use of pharmacologic antagonists to deduce commonalities of biologic activity among clostridial neurotoxins.
J Pharmacol Exp Ther June 1988 245:867-872
- Abstract
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- J F Nash, Jr,
- H Y Meltzer,
- and G A Gudelsky
Elevation of serum prolactin and corticosterone concentrations in the rat after the administration of 3,4-methylenedioxymethamphetamine.
J Pharmacol Exp Ther June 1988 245:873-879
- Abstract
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- P D Suzdak,
- S M Paul,
- and J N Crawley
Effects of Ro15-4513 and other benzodiazepine receptor inverse agonists on alcohol-induced intoxication in the rat.
J Pharmacol Exp Ther June 1988 245:880-886
- Abstract
- Full Text (PDF)
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- S A Rogers,
- K C Gale,
- J F Newton,
- J G Dent,
- and T B Leonard
Inhibition by ranitidine of acetaminophen conjugation and its possible role in ranitidine potentiation of acetaminophen-induced hepatotoxicity.
J Pharmacol Exp Ther June 1988 245:887-894
- Abstract
- Full Text (PDF)
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- N K Mello,
- J H Mendelson,
- M P Bree,
- and A Skupny
Alcohol effects on naloxone-stimulated luteinizing hormone, follicle-stimulating hormone and prolactin plasma levels in female rhesus monkeys.
J Pharmacol Exp Ther June 1988 245:895-904
- Abstract
- Full Text (PDF)
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- R E Solomon and
- G F Gebhart
Mechanisms of effects of intrathecal serotonin on nociception and blood pressure in rats.
J Pharmacol Exp Ther June 1988 245:905-912
- Abstract
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- H U Bryant,
- E W Bernton,
- and J W Holaday
Morphine pellet-induced immunomodulation in mice: temporal relationships.
J Pharmacol Exp Ther June 1988 245:913-920
- Abstract
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- J A Near,
- J C Bigelow,
- and R M Wightman
Comparison of uptake of dopamine in rat striatal chopped tissue and synaptosomes.
J Pharmacol Exp Ther June 1988 245:921-927
- Abstract
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- S D Provan and
- R A Yokel
Aluminum uptake by the in situ rat gut preparation.
J Pharmacol Exp Ther June 1988 245:928-931
- Abstract
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- B R Lindgren,
- N Grundström,
- and R G Andersson
Effects of an alpha-2 adrenoceptor agonist on angiotensin converting enzyme inhibitor-induced hypotension and potentiated allergen-evoked inflammatory skin responses.
J Pharmacol Exp Ther June 1988 245:932-935
- Abstract
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- T Nakane,
- G Tsujimoto,
- K Hashimoto,
- and S Chiba
Beta adrenoceptors in the canine large coronary arteries: beta-1 adrenoceptors predominate in vasodilation.
J Pharmacol Exp Ther June 1988 245:936-943
- Abstract
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- B Valenta,
- H Drobny,
- and E A Singer
Presynaptic autoinhibition of central noradrenaline release in vitro: operational characteristics and effects of drugs acting at alpha-2 adrenoceptors in the presence of uptake inhibition.
J Pharmacol Exp Ther June 1988 245:944-949
- Abstract
- Full Text (PDF)
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- B Jackson,
- R B Cubela,
- and C I Johnston
Inhibition of tissue angiotensin converting enzyme by perindopril: in vivo assessment in the rat using radioinhibitor binding displacement.
J Pharmacol Exp Ther June 1988 245:950-955
- Abstract
- Full Text (PDF)
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- J S Leeder,
- M Cannon,
- A Nakhooda,
- and S P Spielberg
Drug metabolite toxicity assessed in human lymphocytes with a purified, reconstituted cytochrome P-450 system.
J Pharmacol Exp Ther June 1988 245:956-962
- Abstract
- Full Text (PDF)
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- A Eschalier,
- J Fialip,
- O Varoquaux,
- M C Makambila,
- H Marty,
- and P Bastide
Pharmacokinetic patterns of repeated administration of antidepressants in animals. I. Implications for antinociceptive action of clomipramine in mice.
J Pharmacol Exp Ther June 1988 245:963-968
- Abstract
- Full Text (PDF)
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- W Koek,
- J H Woods,
- and G D Winger
MK-801, a proposed noncompetitive antagonist of excitatory amino acid neurotransmission, produces phencyclidine-like behavioral effects in pigeons, rats and rhesus monkeys.
J Pharmacol Exp Ther June 1988 245:969-974
- Abstract
- Full Text (PDF)
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- M Gascon-Barré,
- P M Huet,
- G St-Onge-Brault,
- A Brault,
- and I Kassissia
Liver extraction of vitamin D3 is independent of its hepatic venous or arterial route of delivery. Studies in isolated-perfused rat liver preparations.
J Pharmacol Exp Ther June 1988 245:975-981
- Abstract
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- H Mitsushio,
- M Takashima,
- N Mataga,
- and M Toru
Effects of chronic treatment with trihexyphenidyl and carbamazepine alone or in combination with haloperidol on substance P content in rat brain: a possible implication of substance P in affective disorders.
J Pharmacol Exp Ther June 1988 245:982-989
- Abstract
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- T Okamoto,
- K Kurahashi,
- and M Fujiwara
Cholinergic transmission in the superior cervical ganglion reinnervated by peripheral vagal stump cut below the nodose ganglion in cats.
J Pharmacol Exp Ther June 1988 245:990-994
- Abstract
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- J E Gairin,
- R Gout,
- J C Meunier,
- and J Cros
[D-Pro10]-dynorphin(1-11) is a kappa-selective opioid analgesic in mice.
J Pharmacol Exp Ther June 1988 245:995-1001
- Abstract
- Full Text (PDF)
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- E E Daniel,
- F Kostolanska,
- H D Allescher,
- S Ahmad,
- and J E Fox
Local actions of trimebutine maleate in canine small intestine.
J Pharmacol Exp Ther June 1988 245:1002-1009
- Abstract
- Full Text (PDF)
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- A J Kaumann and
- M Frenken
ICI 169,369 is both a competitive antagonist and an allosteric activator of the arterial 5-hydroxytryptamine2 receptor system.
J Pharmacol Exp Ther June 1988 245:1010-1015
- Abstract
- Full Text (PDF)
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- J C Wanstall and
- S R O'Donnell
Inhibition of norepinephrine contractions by diltiazem on aorta and pulmonary artery from young and aged rats: influence of alpha-adrenoceptor reserve.
J Pharmacol Exp Ther June 1988 245:1016-1020
- Abstract
- Full Text (PDF)
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- S C Mah,
- J R Opperman,
- H P Baum,
- and K G Hofbauer
Biologic response to chronic blockade of vasopressin receptors in Sprague-Dawley rats.
J Pharmacol Exp Ther June 1988 245:1021-1027
- Abstract
- Full Text (PDF)
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- S C Mah and
- K G Hofbauer
Evaluation of the pharmacologic properties of a vasopressin antagonist in Brattleboro rats.
J Pharmacol Exp Ther June 1988 245:1028-1032
- Abstract
- Full Text (PDF)
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- J Benavides,
- B Peny,
- A Dubois,
- G Perrault,
- E Morel,
- B Zivkovic,
- and B Scatton
In vivo interaction of zolpidem with central benzodiazepine (BZD) binding sites (as labeled by [3H]Ro 15-1788) in the mouse brain. Preferential affinity of zolpidem for the omega 1 (BZD1) subtype.
J Pharmacol Exp Ther June 1988 245:1033-1041
- Abstract
- Full Text (PDF)
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- S Phaneuf,
- P Berta,
- L P Peuch,
- J Haiech,
- and J C Cavadore
Phorbol ester modulation of cyclic AMP accumulation in a primary culture of rat aortic smooth muscle cells.
J Pharmacol Exp Ther June 1988 245:1042-1047
- Abstract
- Full Text (PDF)
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- S G Gilbert,
- D C Rice,
- K R Reuhl,
- and B Stavric
Adverse pregnancy outcome in the monkey (Macaca fascicularis) after chronic caffeine exposure.
J Pharmacol Exp Ther June 1988 245:1048-1053
- Abstract
- Full Text (PDF)
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- B M Tune,
- R K Sibley,
- and C Y Hsu
The mitochondrial respiratory toxicity of cephalosporin antibiotics. An inhibitory effect on substrate uptake.
J Pharmacol Exp Ther June 1988 245:1054-1059
- Abstract
- Full Text (PDF)
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- S M Shreeve
Classification of bovine aortic alpha-1 adrenoceptors by the criteria of ligand affinity and molecular mass.
J Pharmacol Exp Ther June 1988 245:1060-1067
- Abstract
- Full Text (PDF)
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- J G Granneman and
- R G MacKenzie
Neural modulation of the stimulatory regulatory protein of adenylate cyclase in rat brown adipose tissue.
J Pharmacol Exp Ther June 1988 245:1068-1074
- Abstract
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- J G Granneman
Norepinephrine infusions increase adenylate cyclase responsiveness in brown adipose tissue.
J Pharmacol Exp Ther June 1988 245:1075-1080
- Abstract
- Full Text (PDF)
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- M P Goldberg,
- V Viseskul,
- and D W Choi
Phencyclidine receptor ligands attenuate cortical neuronal injury after N-methyl-D-aspartate exposure or hypoxia.
J Pharmacol Exp Ther June 1988 245:1081-1087
- Abstract
- Full Text (PDF)
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- S M Spaethe,
- M S Freed,
- K De Schryver-Kecskemeti,
- J B Lefkowith,
- and P Needleman
Essential fatty acid deficiency reduces the inflammatory cell invasion in rabbit hydronephrosis resulting in suppression of the exaggerated eicosanoid production.
J Pharmacol Exp Ther June 1988 245:1088-1094
- Abstract
- Full Text (PDF)
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- P W Kalivas and
- B Weber
Amphetamine injection into the ventral mesencephalon sensitizes rats to peripheral amphetamine and cocaine.
J Pharmacol Exp Ther June 1988 245:1095-1102
- Abstract
- Full Text (PDF)
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- J G Kenna,
- H Satoh,
- D D Christ,
- and L R Pohl
Metabolic basis for a drug hypersensitivity: antibodies in sera from patients with halothane hepatitis recognize liver neoantigens that contain the trifluoroacetyl group derived from halothane.
J Pharmacol Exp Ther June 1988 245:1103-1109
- Abstract
- Full Text (PDF)

Mechanism of action of minoxidil sulfate-induced vasodilation: a role for increased K+ permeability.

Sustained high release at rapid stimulation rates and reduced functional autoreceptors characterize prefrontal cortex dopamine terminals.

5-Hydroxytryptamine antagonist ICS 205-930 blocks cardiac potassium, sodium and calcium currents.

Vasopressin inhibits sympathetic ganglionic transmission but potentiates sympathetic neuroeffector responses in hindlimb vasculature of rabbits.

Characterization of [5,6-3H]SQ 29,548 as a high affinity radioligand, binding to thromboxane A2/prostaglandin H2-receptors in human platelets.

Activation of alpha-1 adrenoreceptors of rat aorta by analogs of imidazoline.

Effects of age on neurotransmission at the cardiac sympathetic neuroeffector junction.

Effects of N-deacetylation and N-desulfation of heparin on its anticoagulant activity and in vivo disposition.

Nonlinear pharmacokinetics of aspirin in rats.

Brain uptake of benzodiazepines: effects of lipophilicity and plasma protein binding.

Effects of phenothiazines on the Na+-H+ exchanger of the brush-border membrane from the proximal small intestine of the rabbit.

Pharmacology of SCH 34826, an orally active enkephalinase inhibitor analgesic.

Myotropic activity of leukotriene B4 on lung parenchyma strips is not necessarily attributable to thromboxane A2 release.

Oxidative metabolism of hexobarbital in human liver: relationship to polymorphic S-mephenytoin 4-hydroxylation.

Effects of the novel dopamine beta-hydroxylase inhibitor SK&F 102698 on catecholamines and blood pressure in spontaneously hypertensive rats.

MPP+-induced efflux of dopamine and lactate from rat striatum have similar time courses as shown by in vivo brain dialysis.

Use of pharmacologic antagonists to deduce commonalities of biologic activity among clostridial neurotoxins.

Elevation of serum prolactin and corticosterone concentrations in the rat after the administration of 3,4-methylenedioxymethamphetamine.

Effects of Ro15-4513 and other benzodiazepine receptor inverse agonists on alcohol-induced intoxication in the rat.

Inhibition by ranitidine of acetaminophen conjugation and its possible role in ranitidine potentiation of acetaminophen-induced hepatotoxicity.

Alcohol effects on naloxone-stimulated luteinizing hormone, follicle-stimulating hormone and prolactin plasma levels in female rhesus monkeys.

Mechanisms of effects of intrathecal serotonin on nociception and blood pressure in rats.

Morphine pellet-induced immunomodulation in mice: temporal relationships.

Comparison of uptake of dopamine in rat striatal chopped tissue and synaptosomes.

Aluminum uptake by the in situ rat gut preparation.

Effects of an alpha-2 adrenoceptor agonist on angiotensin converting enzyme inhibitor-induced hypotension and potentiated allergen-evoked inflammatory skin responses.

Beta adrenoceptors in the canine large coronary arteries: beta-1 adrenoceptors predominate in vasodilation.

Presynaptic autoinhibition of central noradrenaline release in vitro: operational characteristics and effects of drugs acting at alpha-2 adrenoceptors in the presence of uptake inhibition.

Inhibition of tissue angiotensin converting enzyme by perindopril: in vivo assessment in the rat using radioinhibitor binding displacement.

Drug metabolite toxicity assessed in human lymphocytes with a purified, reconstituted cytochrome P-450 system.

Pharmacokinetic patterns of repeated administration of antidepressants in animals. I. Implications for antinociceptive action of clomipramine in mice.

MK-801, a proposed noncompetitive antagonist of excitatory amino acid neurotransmission, produces phencyclidine-like behavioral effects in pigeons, rats and rhesus monkeys.

Liver extraction of vitamin D3 is independent of its hepatic venous or arterial route of delivery. Studies in isolated-perfused rat liver preparations.

Effects of chronic treatment with trihexyphenidyl and carbamazepine alone or in combination with haloperidol on substance P content in rat brain: a possible implication of substance P in affective disorders.

Cholinergic transmission in the superior cervical ganglion reinnervated by peripheral vagal stump cut below the nodose ganglion in cats.

[D-Pro10]-dynorphin(1-11) is a kappa-selective opioid analgesic in mice.

Local actions of trimebutine maleate in canine small intestine.

ICI 169,369 is both a competitive antagonist and an allosteric activator of the arterial 5-hydroxytryptamine2 receptor system.

Inhibition of norepinephrine contractions by diltiazem on aorta and pulmonary artery from young and aged rats: influence of alpha-adrenoceptor reserve.

Biologic response to chronic blockade of vasopressin receptors in Sprague-Dawley rats.

Evaluation of the pharmacologic properties of a vasopressin antagonist in Brattleboro rats.

In vivo interaction of zolpidem with central benzodiazepine (BZD) binding sites (as labeled by [3H]Ro 15-1788) in the mouse brain. Preferential affinity of zolpidem for the omega 1 (BZD1) subtype.

Phorbol ester modulation of cyclic AMP accumulation in a primary culture of rat aortic smooth muscle cells.

Adverse pregnancy outcome in the monkey (Macaca fascicularis) after chronic caffeine exposure.

The mitochondrial respiratory toxicity of cephalosporin antibiotics. An inhibitory effect on substrate uptake.

Classification of bovine aortic alpha-1 adrenoceptors by the criteria of ligand affinity and molecular mass.

Neural modulation of the stimulatory regulatory protein of adenylate cyclase in rat brown adipose tissue.

Norepinephrine infusions increase adenylate cyclase responsiveness in brown adipose tissue.

Phencyclidine receptor ligands attenuate cortical neuronal injury after N-methyl-D-aspartate exposure or hypoxia.

Essential fatty acid deficiency reduces the inflammatory cell invasion in rabbit hydronephrosis resulting in suppression of the exaggerated eicosanoid production.

Amphetamine injection into the ventral mesencephalon sensitizes rats to peripheral amphetamine and cocaine.

Metabolic basis for a drug hypersensitivity: antibodies in sera from patients with halothane hepatitis recognize liver neoantigens that contain the trifluoroacetyl group derived from halothane.

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