Table of Contents

January 1988; 244 (1)
    • D S Houston and
    • P M Vanhoutte

    Comparison of serotonergic receptor subtypes on the smooth muscle and endothelium of the canine coronary artery.

    J Pharmacol Exp Ther January 1988 244:1-10
    • D D Schwartz and
    • D C Eikenburg

    Enhanced endogenous neurotransmitter overflow in the isolated perfused rat kidney after chronic epinephrine administration: lack of a prejunctional beta adrenoceptor influence.

    J Pharmacol Exp Ther January 1988 244:11-18
    • V Gisclard,
    • V M Miller,
    • and P M Vanhoutte

    Effect of 17 beta-estradiol on endothelium-dependent responses in the rabbit.

    J Pharmacol Exp Ther January 1988 244:19-22
    • B J Aungst,
    • N J Rogers,
    • and E Shefter

    Comparison of nasal, rectal, buccal, sublingual and intramuscular insulin efficacy and the effects of a bile salt absorption promoter.

    J Pharmacol Exp Ther January 1988 244:23-27
    • S P Welch,
    • C W Cooper,
    • and W L Dewey

    An investigation of the antinociceptive activity of calcitonin gene-related peptide alone and in combination with morphine: correlation to 45Ca++ uptake by synaptosomes.

    J Pharmacol Exp Ther January 1988 244:28-33
    • P M Beardsley and
    • R L Balster

    Evaluation of antagonists of the discriminative stimulus and response rate effects of phencyclidine.

    J Pharmacol Exp Ther January 1988 244:34-40
    • W S Lai and
    • E E el-Fakahany

    Regulation of [3H]phorbol-12,13-dibutyrate binding sites in mouse neuroblastoma cells: simultaneous down-regulation by phorbol esters and desensitization of their inhibition of muscarinic receptor function.

    J Pharmacol Exp Ther January 1988 244:41-50
    • W D Winters,
    • A J Hance,
    • G G Cadd,
    • D D Quam,
    • and J L Benthuysen

    Ketamine- and morphine-induced analgesia and catalepsy. I. Tolerance, cross-tolerance, potentiation, residual morphine levels and naloxone action in the rat.

    J Pharmacol Exp Ther January 1988 244:51-57
    • P L Wood,
    • D J Steel,
    • H S Kim,
    • B Petrack,
    • and C A Altar

    Inhibition of climbing and mossy fiber input to mouse cerebellar Purkinje cells by cholecystokinin.

    J Pharmacol Exp Ther January 1988 244:58-62
    • C W Stevens,
    • M S Monasky,
    • and T L Yaksh

    Spinal infusion of opiate and alpha-2 agonists in rats: tolerance and cross-tolerance studies.

    J Pharmacol Exp Ther January 1988 244:63-70
    • D W Hay,
    • R M Muccitelli,
    • K A Wilson,
    • M A Wasserman,
    • and T J Torphy

    Functional antagonism by salbutamol suggests differences in the relative efficacies and dissociation constants of the peptidoleukotrienes in guinea pig trachea.

    J Pharmacol Exp Ther January 1988 244:71-78
    • S F Gonsalves and
    • D W Gallager

    Persistent reversal of tolerance to anticonvulsant effects and GABAergic subsensitivity by a single exposure to benzodiazepine antagonist during chronic benzodiazepine administration.

    J Pharmacol Exp Ther January 1988 244:79-83
    • P J Kadowitz,
    • W M Armstead,
    • P Y Roland,
    • A L Hyman,
    • and H L Lippton

    Inhibitory effects of diltiazem on vasoconstrictor responses in the cat.

    J Pharmacol Exp Ther January 1988 244:84-90
    • Z Gregus,
    • C Madhu,
    • and C D Klaassen

    Species variation in toxication and detoxication of acetaminophen in vivo: a comparative study of biliary and urinary excretion of acetaminophen metabolites.

    J Pharmacol Exp Ther January 1988 244:91-99
    • P J Gengo,
    • N Bowling,
    • V L Wyss,
    • and J S Hayes

    Effects of prolonged phenylephrine infusion on cardiac adrenoceptors and calcium channels.

    J Pharmacol Exp Ther January 1988 244:100-105
    • M L Cohen,
    • R W Fuller,
    • K D Kurz,
    • C J Parli,
    • N R Mason,
    • D B Meyers,
    • J K Smallwood,
    • and R E Toomey

    Preclinical pharmacology of a new serotonergic receptor antagonist, LY281067.

    J Pharmacol Exp Ther January 1988 244:106-112
    • G F Rush,
    • D Alberts,
    • S Lupo,
    • L A Yodis,
    • T H Brown,
    • and G J Durant

    Toxicity of H2-receptor antagonists to isolated rat hepatocytes: structure-activity relationships.

    J Pharmacol Exp Ther January 1988 244:113-117
    • S J Grossman and
    • D J Jollow

    Role of dapsone hydroxylamine in dapsone-induced hemolytic anemia.

    J Pharmacol Exp Ther January 1988 244:118-125
    • W K Bickel,
    • M L Stitzer,
    • I A Liebson,
    • and G E Bigelow

    Acute physical dependence in man: effects of naloxone after brief morphine exposure.

    J Pharmacol Exp Ther January 1988 244:126-132
    • G H Caughey,
    • F Leidig,
    • N F Viro,
    • and J A Nadel

    Substance P and vasoactive intestinal peptide degradation by mast cell tryptase and chymase.

    J Pharmacol Exp Ther January 1988 244:133-137
    • W M Armstead,
    • R Mirro,
    • C W Leffler,
    • and D W Busija

    The role of prostanoids in the mediation of responses to KC-404, a novel cerebrovasodilator.

    J Pharmacol Exp Ther January 1988 244:138-143
    • S J Offord,
    • G A Ordway,
    • and A Frazer

    Application of [125I]iodocyanopindolol to measure 5-hydroxytryptamine1B receptors in the brain of the rat.

    J Pharmacol Exp Ther January 1988 244:144-153
    • D D Gillespie,
    • D H Manier,
    • E Sanders-Bush,
    • and F Sulser

    The serotonin/norepinephrine-link in brain. II. Role of serotonin in the regulation of beta adrenoceptors in the low agonist affinity conformation.

    J Pharmacol Exp Ther January 1988 244:154-159
    • T M Reilly,
    • P C Wong,
    • W A Price,
    • and P B Timmermans

    Characterization of the functional antagonism and antihypertensive activity displayed by a monoclonal antibody to angiotensin II.

    J Pharmacol Exp Ther January 1988 244:160-165
    • T A Slotkin,
    • B Levant,
    • L Orband-Miller,
    • K L Queen,
    • and S Stasheff

    Do sympathetic neurons coordinate cellular development in the heart and kidney? Effects of neonatal central and peripheral catecholaminergic lesions on cardiac and renal nucleic acids and proteins.

    J Pharmacol Exp Ther January 1988 244:166-172
    • F Ruff,
    • J F Zander,
    • Y Edoute,
    • M C Santais,
    • N A Flavahan,
    • T J Verbeuren,
    • and P M Vanhoutte

    Beta-2 adrenergic responses to tulobuterol in airway smooth muscle, vascular smooth muscle and adrenergic nerves.

    J Pharmacol Exp Ther January 1988 244:173-180
    • L J Ignarro,
    • R E Byrns,
    • G M Buga,
    • K S Wood,
    • and G Chaudhuri

    Pharmacological evidence that endothelium-derived relaxing factor is nitric oxide: use of pyrogallol and superoxide dismutase to study endothelium-dependent and nitric oxide-elicited vascular smooth muscle relaxation.

    J Pharmacol Exp Ther January 1988 244:181-189
    • J G Gerber and
    • N A Payne

    Endogenous adenosine modulates gastric acid secretion to histamine in canine parietal cells.

    J Pharmacol Exp Ther January 1988 244:190-194
    • J W Simpkins,
    • M Smulkowski,
    • R Dixon,
    • and R Tuttle

    Evidence for the delivery of narcotic antagonists to the colon as their glucuronide conjugates.

    J Pharmacol Exp Ther January 1988 244:195-205
    • T P Kenakin and
    • P J Novak

    Classification of phenoxybenzamine/prazosin-resistant contractions of rat spleen to norepinephrine by Schild analysis: similarities and differences to postsynaptic alpha-2 adrenoceptors.

    J Pharmacol Exp Ther January 1988 244:206-212
    • R Pohorecki,
    • R Head,
    • and E F Domino

    Effects of selected muscarinic cholinergic antagonists on [3H]acetylcholine release from rat hippocampal slices.

    J Pharmacol Exp Ther January 1988 244:213-217
    • N M Porter,
    • M Radulovacki,
    • and R D Green

    Desensitization of adenosine and dopamine receptors in rat brain after treatment with adenosine analogs.

    J Pharmacol Exp Ther January 1988 244:218-225
    • K P Minneman,
    • G K Mumford,
    • and P W Abel

    High efficiency coupling of alpha-1 adrenergic receptors to inositol phospholipid metabolism revealed by denervation of rat vas deferens.

    J Pharmacol Exp Ther January 1988 244:226-230
    • H C Porchet,
    • N L Benowitz,
    • and L B Sheiner

    Pharmacodynamic model of tolerance: application to nicotine.

    J Pharmacol Exp Ther January 1988 244:231-236
    • J M Moerschbaecher,
    • C Devia,
    • and C Brocklehurst

    Differential antagonism by naltrexone of the effects of opioids on a fixed-ratio discrimination in rats.

    J Pharmacol Exp Ther January 1988 244:237-246
    • J C Eisenach

    Intravenous clonidine produces hypoxemia by a peripheral alpha-2 adrenergic mechanism.

    J Pharmacol Exp Ther January 1988 244:247-252
    • I J Weinstein,
    • L B Hough,
    • and K R Gogas

    Cross-tolerance and cross-sensitization between morphine analgesia and naloxone-sensitive and cimetidine-sensitive stress-induced analgesia.

    J Pharmacol Exp Ther January 1988 244:253-258
    • G Babany,
    • R E Morris,
    • I Babany,
    • and R E Kates

    Evaluation of the in vivo dose-response relationship of immunosuppressive drugs using a mouse heart transplant model: application to cyclosporine.

    J Pharmacol Exp Ther January 1988 244:259-262
    • F A Redegeld,
    • G A Hofman,
    • and J Noordhoek

    Conjugative clearance of 1-naphthol and disposition of its glucuronide and sulfate conjugates in the isolated perfused rat kidney.

    J Pharmacol Exp Ther January 1988 244:263-267
    • W E Mol,
    • G N Fokkema,
    • B Weert,
    • and D K Meijer

    Mechanisms for the hepatic uptake of organic cations. Studies with the muscle relaxant vecuronium in isolated rat hepatocytes.

    J Pharmacol Exp Ther January 1988 244:268-275
    • T J Verbeuren,
    • F H Jordaens,
    • H Bult,
    • and A G Herman

    The endothelium inhibits the penetration of serotonin and norepinephrine in the isolated canine saphenous vein.

    J Pharmacol Exp Ther January 1988 244:276-282
    • F Ballet,
    • Y Chretien,
    • C Rey,
    • and R Poupon

    Differential response of normal and cirrhotic liver to vasoactive agents. A study in the isolated perfused rat liver.

    J Pharmacol Exp Ther January 1988 244:283-289
    • A Ogbaghebriel and
    • P E Dresel

    Effects of cytochalasin-B and phloretin on digitalis inotropy.

    J Pharmacol Exp Ther January 1988 244:290-296
    • N Toda,
    • S Inoue,
    • K Bian,
    • and T Okamura

    Endothelium-dependent and independent responses to prostaglandin H2 and arachidonic acid in isolated dog cerebral arteries.

    J Pharmacol Exp Ther January 1988 244:297-302
    • T Nabeshima,
    • A Katoh,
    • and T Kameyama

    Inhibition of enkephalin degradation attenuated stress-induced motor suppression (conditioned suppression of motility).

    J Pharmacol Exp Ther January 1988 244:303-309
    • J E Leysen,
    • A Eens,
    • W Gommeren,
    • P van Gompel,
    • J Wynants,
    • and P A Janssen

    Identification of nonserotonergic [3H]ketanserin binding sites associated with nerve terminals in rat brain and with platelets; relation with release of biogenic amine metabolites induced by ketanserin- and tetrabenazine-like drugs.

    J Pharmacol Exp Ther January 1988 244:310-321
    • J F Brien,
    • B E McLaughlin,
    • S M Kobus,
    • J H Kawamoto,
    • K Nakatsu,
    • and G S Marks

    Mechanism of glyceryl trinitrate-induced vasodilation. I. Relationship between drug biotransformation, tissue cyclic GMP elevation and relaxation of rabbit aorta.

    J Pharmacol Exp Ther January 1988 244:322-327
    • J H Kawamoto,
    • J F Brien,
    • G S Marks,
    • and K Nakatsu

    Mechanism of glyceryl trinitrate-induced vasodilation. II. Lack of evidence for specific binding of GTN to bovine pulmonary vein.

    J Pharmacol Exp Ther January 1988 244:328-334
    • K Yokotani,
    • K Yokotani,
    • Y Okuma,
    • and Y Osumi

    Sympathoadrenomedullary system mediation of the prostaglandin E2-induced central inhibition of gastric acid output in rats.

    J Pharmacol Exp Ther January 1988 244:335-340
    • P L van Giersbergen and
    • W de Jong

    Antagonism by naltrexone of the hypotension and bradycardia induced by alpha-methyldopa in conscious normotensive rats.

    J Pharmacol Exp Ther January 1988 244:341-347
    • A Lukas and
    • G R Ferrier

    Electrophysiological effects of amrinone and milrinone in an isolated canine cardiac tissue model of ischemia and reperfusion.

    J Pharmacol Exp Ther January 1988 244:348-354
    • M Hagiwara,
    • M Inagaki,
    • K Kanamura,
    • H Ohta,
    • and H Hidaka

    Inhibitory effects of aminoglycosides on renal protein phosphorylation by protein kinase C.

    J Pharmacol Exp Ther January 1988 244:355-360
    • R N Mascardo and
    • G Eilon

    The cysteine protease inhibitor, E-64, stimulates the polarization and locomotor responses of endothelial cells to wounding.

    J Pharmacol Exp Ther January 1988 244:361-367
    • J P O'Callaghan and
    • D B Miller

    Acute exposure of the neonatal rat to triethyltin results in persistent changes in neurotypic and gliotypic proteins.

    J Pharmacol Exp Ther January 1988 244:368-378
    • K W Gee,
    • R E Brinton,
    • and B S McEwen

    Regional distribution of a Ro5 4864 binding site that is functionally coupled to the gamma-aminobutyric acid/benzodiazepine receptor complex in rat brain.

    J Pharmacol Exp Ther January 1988 244:379-383
    • M J Panzenbeck,
    • W Tan,
    • M A Hajdu,
    • and I H Zucker

    Prostaglandins mediate the increased sensitivity of left ventricular reflexes after captopril treatment in conscious dogs.

    J Pharmacol Exp Ther January 1988 244:384-390
    • E B De Souza,
    • W K Schmidt,
    • and M J Kuhar

    Nalbuphine: an autoradiographic opioid receptor binding profile in the central nervous system of an agonist/antagonist analgesic.

    J Pharmacol Exp Ther January 1988 244:391-402
    • R N Willette,
    • S Morrison,
    • H N Sapru,
    • and D J Reis

    Stimulation of opiate receptors in the dorsal pontine tegmentum inhibits reflex contraction of the urinary bladder.

    J Pharmacol Exp Ther January 1988 244:403-409
    • S R Wachtel and
    • F J White

    Electrophysiological effects of BMY 14802, a new potential antipsychotic drug, on midbrain dopamine neurons in the rat: acute and chronic studies.

    J Pharmacol Exp Ther January 1988 244:410-416
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