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Abstract

O2-sensitivity of beta adrenergic responsiveness in isolated bovine and porcine coronary arteries.

G Rubanyi and R J Paul
Journal of Pharmacology and Experimental Therapeutics September 1984, 230 (3) 692-698;
G Rubanyi
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R J Paul
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Abstract

The relation between pO2 and beta adrenergic responsiveness was studied in isolated bovine and porcine coronary artery rings. Isoproterenol elicited a concentration-dependent relaxation of bovine and porcine coronary artery rings precontracted with KCI (2 X 10(-2) M) or histamine (10(-6) M); beta adrenergic responsiveness was significantly lower in K+-depolarized coronary arteries. A decrease of bath pO2 from 95 to 40% significantly reduced beta adrenergic responsiveness in both coronary preparations precontracted with either KCI or histamine. Similarly, exogenous arachidonic acid (3 X 10(-6) to 3 X 10(-5) M) depressed isoproterenol-induced relaxations in both tissues. Indomethacin (5 X 10(-6) M) augmented beta adrenergic responsiveness in the presence of 95% O2 and prevented the inhibitory effects of the decrease in bath pO2 and arachidonic acid in both preparations. The experimental data suggest that the demonstrated O2-sensitivity of beta adrenergic responsiveness is mediated by vascular prostaglandin synthesis in isolated large coronary arteries.

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Journal of Pharmacology and Experimental Therapeutics
Vol. 230, Issue 3
1 Sep 1984
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Abstract

O2-sensitivity of beta adrenergic responsiveness in isolated bovine and porcine coronary arteries.

G Rubanyi and R J Paul
Journal of Pharmacology and Experimental Therapeutics September 1, 1984, 230 (3) 692-698;

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Abstract

O2-sensitivity of beta adrenergic responsiveness in isolated bovine and porcine coronary arteries.

G Rubanyi and R J Paul
Journal of Pharmacology and Experimental Therapeutics September 1, 1984, 230 (3) 692-698;
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