Abstract
Experiments on normal humans confirm the reports previously made (1) (2) that desiccated spleen and red bone marrow are more efficient erythropoietic agents in combination than singly. While the hemoglobin content is considerably increased under the influence of the combined extracts, its rise is not as great nor as rapid as the increase in the number of circulating red blood cells, but is better maintained. The increase in the erythrocytes seems to be due to increased bone marrow activity. The combined spleen and marrow also cause a slight increase in the number of polymorphonuclear neutrophils. No side actions were noted. It is suggested that the hematopoietic response of normal humans to combined red bone marrow and spleen extracts may be used as a prophylaxis against mountain sickness, and in affording rapid acclimatization to high altitudes.
Footnotes
- Received November 29, 1923.
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