Abstract
The excretion of a standard water load was significantly delayed in conscious rats given 1-deamino-[8-D-arginine]-vasopressin (DDAVP) in doses of 0.0005 to 0.005 µg/kg s.c. About 500 times higher doses of lysine-vasopressin were needed to achieve similar antidiuretic effect. A significant antidiuretic response was observed in water-loaded rats after oral administration of DDAVP (0.1-0.4 µg/rat). DDAVP caused also a decrease in urine flow of rats allowed water ad libitum. The effects on sodium and potassium excretion were less marked than those of antidiuretically equiactive or less active doses of lysinevasopressin.
Footnotes
- Received March 12, 1973.
- Accepted September 10, 1973.
- © 1974 by The Williams & Wilkins Company
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