Abstract
Ketamine-induced renin release was characterized, both in time and dose response, in normal rats and correlated with cardiovascular parameters. Serum renin activity increased 5-fold at the anesthetic dose of 100 mg/kg, peaked at 20 minutes and gradually returned to control levels within 2 hours. Elevation of blood pressure and heart rate were parallel to, and followed the increase in serum renin activity. Propranolol, a beta adrenergic receptor blocking agent impaired renin release and prevented the elevation of blood pressure and heart rate which followed ketamine administration. Removal of the renin source by nephrectomy prevented blood pressure elevation due to ketamine. Pretreatment with 1-Sar-8-Ala-angiotensin II, a selective antagonist of angiotensin II, prevented the blood pressure elevation after ketamine. Nephrectomy and P-113 did not alter ketamine-induced chronotropic activity. These results indicate that beta adrenergically mediated renin release contributes to ketamine-induced blood pressure elevation in the rat. Also, they suggest that central nervous system effects of angiotensin are not important in ketamine-induced cardiac stimulation.
Footnotes
- Received June 7, 1973.
- Accepted September 13, 1973.
- © 1974 by The Williams & Wilkins Company
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