Abstract
In order to explore the possibility of lowering blood pressure in hypertensive animals by chronic administration of vasoconstrictor agents that would persistently stimulate baroreceptors, a group of sympathomimetic amines was administered for two months to dogs made hypertensive by prolonged treatment with mecamylamine. Phentermine, chlorphentermine, pseudoephedrine, benzphetamine, methylphenidate and isometheptene did not lower blood pressure; ephedrine, phenylephrine, methoxamine, isoxsuprine, propylhexedrine, fenfluramine and phenmetrazine decreased pressure only during the first weeks of treatment, whereas amphetamine, methamphetamine, hydroxyamphetamine, mephentermine, metaraminol and tetrahydrozoline induced a persistent antihypertensive effect. The latter results were confirmed in renal hypertensive dogs. It was concluded that, in addition to the originally postulated influence of the amines on baroreceptors, other mechanisms, such as peripheral vasodilatation, formation of false adrenergic transmitters and depression of central vasomotor functions, could also be involved in the production of the antihypertensive effects observed.
Footnotes
- Received March 12, 1973.
- Accepted July 6, 1973.
- © 1973 by The Williams & Wilkins Co.
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