Abstract
The effects of halluncinogenic drugs on helically cut strips of human umbilical veins and sheep umbilical arteries were studied. Muscle activity at 37°C was recorded isotonically under 1 g of tension. Bufotenine, psilocin, psilocybin, mescaline and d-lysergic acid diethylamide (LSD) all produced contractions of umbilical vasculature with LSD being the most potent. The contractions to all hallucinogens were antagonized by cinanserin. In addition, 2-bromolysergic acid diethylamide anatagonized responses to mescaline and LSD on sheep umbilical arteries. Concentrations of piperoxan, tripelennamine and atropine which antagonized responses to epinephrine, histamine and acetylcholine, respectively, did not antagonize responses to LSD, bufotenine or serotonin. We conclude that all of the hallucinogens studied produced constractions via serotoniergic receptors on umbilical vasculature.
Footnotes
- Received November 8, 1971.
- Accepted October 10, 1972.
- © 1973 by The Williams & Wilkins Co.
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