Abstract
The uptake of tritium-labeled decamethonium by denervated muscle (8-14 days) in rats and guinea pigs was considerably greater than in controls, both in vivo and in vitro, and in the extrajunctional region of the muscle the radioactivity approached that at the end-plate. Tubocurarine reduced the uptake of labeled decamethonium in normal and in denervated muscles, and also in denervated muscles which had been depolarized by immersion in a solution which contained potassium methyl sulfate. In acutely denervated muscles the uptake of decamethonium was reduced in vivo as compared with the opposite hemidiaphragm which was able to contract.
Footnotes
- Received June 22, 1970.
- Accepted October 12, 1970.
- © 1971 by The Williams & Wilkins Co.
Log in using your username and password
Pay Per Article - You may access this article (from the computer you are currently using) for 1 day for US$35.00
Regain Access - You can regain access to a recent Pay per Article purchase if your access period has not yet expired.