Abstract

The uptake of tritium-labeled decamethonium by denervated muscle (8-14 days) in rats and guinea pigs was considerably greater than in controls, both in vivo and in vitro, and in the extrajunctional region of the muscle the radioactivity approached that at the end-plate. Tubocurarine reduced the uptake of labeled decamethonium in normal and in denervated muscles, and also in denervated muscles which had been depolarized by immersion in a solution which contained potassium methyl sulfate. In acutely denervated muscles the uptake of decamethonium was reduced in vivo as compared with the opposite hemidiaphragm which was able to contract.