ON THE MEASUREMENT OF THE AFFINITY OF PARTIAL AGONISTS FOR RECEPTORS

  1. D. R. WAUD
  1. Department of Pharmacology, Harvard Medical School, Boston, Massachusetts

    Abstract

    The dissociation constants for the drug-receptor reaction between muscarinic receptors and piocarpine or n-C7H15N†(CH3)3, have been measured in the smooth muscle of guinea-pig ileum. The measurements were obtained from a comparison of the dose-response curves to these partial agonists with the doseresponse curve to a strong agonist, carbachol. The results were compared with those obtained with the use of an irreversible competitive blocking agent. Both approaches gave similar values.

    Footnotes

      • Received May 14, 1969.
      • Accepted July 31, 1969.
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    1. JPET November 1969 vol. 170 no. 1 117-122
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